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Special Review:
The long-awaited update
to Cell's most cited
article of all time,
"Hallmarks of Cancer ." |
In the March 4th issue of Cell we feature the long-awaited update to the classic Review "Hallmarks of Cancer " by Douglas Hanahan and Robert Weinberg, with content made freely available at www.cell.com through April 3rd, 2011, brought to you by Perkin Elmer .
The review article by Douglas Hanahan of École Polytechnique Fédérale in Switzerland and Robert Weinberg of the Whitehead Institute for Biomedical Research appearing in the March 4th print issue of Cell, updates and expands on the authors' classic review, "Hallmarks of Cancer ," the most cited Cell article of all time.
The approach, as Hanahan and Weinberg explain it, was to stand back and attempt to produce an overarching conceptual scaffold, imposing some order on the vast and seemingly unmanageable flood of observations and conceptual models that had poured out of the cancer field since the discovery of the first oncogene in the 1970s.
As the new work details, much has been revealed in the last decade about the molecular and genetic underpinnings of the six original hallmarks of cancer and the authors have synthesized the vast literature to produce a next-generation view of the features that are shared amongst all cancer cells.
The authors also introduce two enabling hallmarks - genomic instability and inflammation - and two emerging hallmarks - evasion of the immune system and reprogrammed energy metabolism.
Click here to read this freely available review,
"Hallmarks of Cancer: The Next Generation ." | | 
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