From Molecule to Matrix: An Option for the Management of Moderate to Severe Chronic Pain Joseph V. Pergolizzi Jr, Robert B Raffa. Pain Medicine News 2011;9:08 Butrans (buprenorphine) Transdermal System CIII is the first FDA-approved transdermal formulation of buprenorphine indicated for the management of moderate to severe chronic pain in patients who require a continuous, around-the-clock opioid analgesic for an extended period of time.
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