Camilo Golgi y Louis Antoine Ranvier

Golgi y Ranvier: de la reacción negra a la teoría del dolor referido Golgi and Ranvier: from the black reaction to a theory of referred pain. Cani V, Mazzarello P. Funct Neurol. 2015 Apr 13:1-5. [Epub ahead of print] Abstract In his brief report on the structure of the gray matter of the central nervous system (1873), in which he described the "black reaction", Golgi noted the ramifications of the axon. This discovery prompted the French histologist Louis Antoine Ranvier, one of the first to try the black reaction outside Italy, to propose an ingenious theory of referred pain in his Traité technique d'histologie. Ranvier suggested that the nerve fibers originating from the irritated area and those coming from the region to which the sensation is referred converge on the same axon and thus the same cell body, causing the spatial dislocation of sensation. This theory of referred pain is a powerful example of the extraordinary clinical-physiological impact of the first of Golgi's neurocytological discoveries.PDF Como Camilo Golgi se convirtió en el "Aparato de Golgi" How Camillo Golgi became "the Golgi". Mazzarello P, Garbarino C, Calligaro A. FEBS Lett. 2009 Dec 3;583(23):3732-7. doi: 10.1016/j.febslet.2009.10.018. Epub 2009 Oct 13. Abstract On April 1898 Camillo Golgi communicated to the Medical-Surgical Society of Pavia, the discovery of the "internal reticular apparatus", a novel intracellular organelle which he observed in nerve cells with the silver impregnation he had introduced for the staining of the nervous system. Soon after the discovery it became evident that this cellular component, which was also named the "Golgi apparatus", was a ubiquitous structure in eukaryotic cells. However the reality of the organelle was questioned for years and many cytologists considered the internal reticular apparatus as an artefact due to the fixation and/or metallic impregnation procedure. The controversy was finally solved in the mid-1950s by electron microscopy when the Golgi apparatus definitely acquired its dignity of being a genuine cell organelle. The designation of "Golgi complex" entered officially in the literature in 1956. Both the terms Golgi apparatus and Golgi complex are currently interchangeable. However a quick "the Golgi" and the introduction of Golgi in adjectival form are now prevalent in the blooming scientific literature on the organelle. Thus Camillo Golgi underwent his final transformation and, becoming the eponym of the organelle he had discovered, he found a way to immortality. PDF

Atentamente Anestesia y Medicina del Dolor anestesia-dolor.org

Más de clonidina IT en cesárea / More IT clonidine for C-section

Evaluación de los efectos analgésicos de la clonidina intratecal junto con bupivacaína en cesárea. Evaluation of analgesic effects of intrathecal clonidine along with bupivacaine in cesarean section. Kothari N, Bogra J, Chaudhary AK. Saudi J Anaesth. 2011 Jan;5(1):31-5. doi: 10.4103/1658-354X.76499. PDF Raquia para cesárea electiva. Tres dosis diferentes de bupivacaína hiperbárica asociada con morfina y clonidina Spinal anesthesia for elective ceasarean section: use of different doses of hyperbaric bupivacaine associated with morphine and clonidine. Braga Ade F1, Frias JA, Braga FS, Pereira RI, Titotto SM. Acta Cir Bras. 2013 Jan;28(1):26-32. PDF Efecto de adicionar clonidina intratecal a la bupivacaína hiperbárica sobre el dolor postoperatorio y los requerimientos de morfina después de cesárea. Estudio randomizado controlado The effect of addition of intrathecal clonidine to hyperbaric bupivacaine on postoperative pain and morphine requirements after Caesarean section: a randomized controlled trial. van Tuijl I1, van Klei WA, van der Werff DB, Kalkman CJ. Br J Anaesth. 2006 Sep;97(3):365-70. Epub 2006 Jul 21. PDF Raquia en cesárea. Uso de bupivacaína hiperbárica (10 mg) combinada con diferentes adyuvantes Spinal anesthesia for cesarean section. Use of hyperbaric bupivacaine (10mg) combined with different adjuvants. Braga AA, Frias JA, Braga FS, Potério GB, Hirata ES, Torres NA. Rev Bras Anestesiol. 2012 Nov-Dec;62(6):775-87. doi: 10.1016/S0034-7094(12)70178-2. PDF

Atentamente Anestesia y Medicina del Dolor anestesia-dolor.org

La dieta mediterránea con frutos secos detiene la demencia asociada a la edad

Fuente

Este artículo es originalmente publicado en:

http://www.madrimasd.org/informacionidi/noticias/noticia.asp?id=63651&origen=notiweb&dia_suplemento=martes


La dieta mediterránea con frutos secos detiene la demencia asociada a la edad


¿Hay algo más saludable que la dieta mediterránea? Pues sí, la misma dieta tradicional pero con frutos secos o aceite de oliva extra virgen. Lo afirma un estudio español en el que se ha visto que este 'cóctel' saludable, rico en antioxidantes, se asocia con una mejor función cognitiva en personas mayores. En el artículo que publica la revista JAMA Internal Medicine se demuestran los beneficios de la dieta mediterránea para prevenir o retrasar el deterioro cognitivo asociado al envejecimiento que eventualmente termina en demencia o alzhéimer. El estudio, derivado del ensayo PREDIMED, Prevención con Dieta Mediterránea, revela que, después de 4 años de seguimiento, las personas que siguen esta dieta complementada con aceite de oliva virgen extra o frutos secos tienen una mejor función cognitiva que las personas asignadas a la dieta control....

Tópicos de pediatría/Pediatric topics

Ultrasound Imaging for Pediatric Anesthesia: A Review . Santhanam Suresh, Lauren J. Taylor and Amar S. Minhas Ultrasound Imaging. Masayuki Tanabe (Ed.),2011 ISBN: 978-953-307-239-5, InTech, PDF Parámetros de anestesia-sedación en niños con radioterapia Parameters of anesthesia/sedation in children receiving radiotherapy. McMullen KP, Hanson T, Bratton J, Johnstone PA. Radiat Oncol. 2015 Mar 11;10(1):65. doi: 10.1186/s13014-015-0363-2. PDF Efectos analgésicos, ansiolíticos y anestésicos de la melatonina. Usos potenciales en pediatría Analgesic, anxiolytic and anaesthetic effects of melatonin: new potential uses in pediatrics. Marseglia L, D'Angelo G, Manti S, Aversa S, Arrigo T, Reiter RJ, Gitto E. Int J Mol Sci. 2015 Jan 6;16(1):1209-20. doi: 10.3390/ijms16011209. PDF Anestesia y el cerebro en desarrolo. Relevancias en cirugía cardiaca pediátrica Anesthesia and the developing brain: relevance to the pediatric cardiac surgery. Wise-Faberowski L, Quinonez ZA, Hammer GB. Brain Sci. 2014 Apr 16;4(2):295-310. doi: 10.3390/brainsci4020295. PDF

Atentamente Anestesia y Medicina del Dolor anestesia-dolor.org

Ultrasonido pulmonar/Lung ultrasound

Ultrasonido pulmonar: Presente y futuro Lung ultrasound: Present and future. Saraogi A. Lung India 2015;32:250-7 Abstract The scope of lung ultrasound (LUS) in emergency and critical care settings has been studied extensively. LUS is easily available at bedside, free of radiation hazard and real time. All these features make it useful in reducing need of bedside X-rays and CT scan of chest. LUS has been proven to be superior to the bedside chest X-ray and equal to chest CT in diagnosing many pleural and lung pathologies. The first International Consensus Conference on Lung Ultrasound (ICC-LUS) has given recommendations for unified approach and language in major six areas of LUS. The LUS diagnosis is to be given after integration of findings of both lungs. The BLUE protocol is first LUS-based systematic approach in diagnosing pleural and lung pathologies. The protocol suggested in this article includes history and conventional clinical assessment along with LUS features. Keywords: Interstitial syndrome, lung ultrasound, pneumothorax, pulmonary edema PDF Precisión diagnóstica del ultrasonido pulmonar en el protocolo de emergencia para el diagnóstico de la insuficiencia respiratoria aguda en pacientes con respiración espontánea. Diagnostic accuracy of the Bedside Lung Ultrasound in Emergency protocol for the diagnosis of acute respiratory failure in spontaneously breathing patients. Neto FL, de Andrade JM, Raupp AC, Townsend Rda S, Beltrami FG, Brisson H, Lu Q, Dalcin Pde T. J Bras Pneumol. 2015 Jan-Feb;41(1):58-64. doi: 10.1590/S1806-37132015000100008. Abstract OBJECTIVE: Bedside lung ultrasound (LUS) is a noninvasive, readily available imaging modality that can complement clinical evaluation. TheBedside Lung Ultrasound in Emergency (BLUE) protocol has demonstrated a high diagnostic accuracy in patients with acute respiratory failure (ARF). Recently, bedside LUS has been added to the medical training program of our ICU. The aim of this study was to investigate the accuracy of LUS based on the BLUE protocol, when performed by physicians who are not ultrasound experts, to guide the diagnosis of ARF. METHODS: Over a one-year period, all spontaneously breathing adult patients consecutively admitted to the ICU for ARF were prospectively included. After training, 4 non-ultrasound experts performed LUS within 20 minutes of patient admission. They were blinded to patient medical history. LUS diagnosis was compared with the final clinical diagnosis made by the ICU team before patients were discharged from the ICU (gold standard). RESULTS: Thirty-seven patients were included in the analysis (mean age, 73.2 ± 14.7 years; APACHE II, 19.2 ± 7.3). LUS diagnosis had a good agreement with the final diagnosis in 84% of patients (overall kappa, 0.81). The most common etiologies for ARF were pneumonia (n = 17) and hemodynamic lung edema (n = 15). The sensitivity and specificity of LUS as measured against the final diagnosis were, respectively, 88% and 90% for pneumonia and 86% and 87% for hemodynamic lung edema. CONCLUSIONS: LUS based on the BLUE protocol was reproducible by physicians who are not ultrasound experts and accurate for the diagnosis of pneumonia and hemodynamic lung edema. KEYWORDS: Intensive care units; Respiratory insufficiency; Ultrasonography, interventional PDF

Atentamente Anestesia y Medicina del Dolor anestesia-dolor.org

Bibliotecas populares. Alerta

bibliotecas populares
Notificaciones semanales ⋅ 13 de mayo de 2015
NOTICIAS


Nuevo Diario de Santiago del Estero

Una gran oportunidad para las bibliotecas populares
Diario Democracia
Con la Feria Internacional del Libro en Buenos Aires en pleno desarrollo, distintas bibliotecas buscan renovar su stock, a través de promociones, ...




LaCapital.com.ar

Bautizan con el nombre "Obispo Federico Pagura" a la biblioteca de una cárcel
LaCapital.com.ar
La biblioteca se puso en marcha a fines del año pasado con unos 500 ... del que participan distintas organizaciones sociales y bibliotecas populares.



Refugios del sentido
LaCapital.com.ar
Las bibliotecas populares son refugios del sentido, sinónimos de inclusión, respuestas que se dio el pueblo a sí mismo. Hijas de la solidaridad —que ...




Nuevo Diario de Santiago del Estero

Las bibliotecas de Añatuya visitaron la Feria del Libro
Nuevo Diario de Santiago del Estero
Durante el fin de semana pasado, representantes de las bibliotecas populares Almafuerte y Sarmiento de la ciudad de Añatuya participaron de la ...



El Club de Leones presentará su “Biblioteca Parlante”
Diario San Rafael
El Club de Leones presentará su “Biblioteca Parlante” ... eso que convocamos a todas las bibliotecas populares de San Rafael para hacer entregas a ...



Bienio de la lectura y de las bibliotecas públicas (2015-2016)
ABC.es
Estos años de crisis y recortes han afectado mucho a las bibliotecas ... de la creación de la Red de Bibliotecas Populares de la Mancomunidad de ...



Ángela Signes, la promotora de la literatura nac & pop que tiende lazos con el mundo editorial
lanacion.com (Argentina)
Ángela Signes, presidenta de la Comisión Nacional de Bibliotecas Populares (Conabip), sin embargo, es la mujer de Oscar Parrilli, el actual jefe de ...


Anunciaron talleres y adquisición de libros desde la Biblioteca Estrada
InfoPico.com
Los interesados en participar pueden acercarse, de lunes a viernes, en horario de 9:00 a 18:00 horas, a la Biblioteca Popular Municipal “José M.




Diario La Provincia SJ

Los sanjuaninos quisieron estar en los billetes de 100 pesos
Diario La Provincia SJ
Los representantes de bibliotecas populares y algunos periodistas se acercaron al stand del Banco Central para acceder a una divertida iniciativa: ...



“Hace mucho, mucho tiempo...La Pampa se llenó e cuentos”
InfoPico.com
Los libros fueron a Bibliotecas Populares de Ecuador, Panamá, Uruguay, Entre Ríos, San Juan, Buenos Aires, Catamarca y Santiago del Estero.

Tecnicos Radiologos: ¿El vino tinto reduce efectos de radiación ionizan...

Tecnicos Radiologos: ¿El vino tinto reduce efectos de radiación ionizan...: Desde que vi la película K-19 'The Widowmaker' (Una avería del  sistema de refrigeración del reactor de un submarino nuclear s...



El vino tinto contiene diversos polifenoles que contribuyen a la reducción y eliminación de radicales libres, combate la oxidación, induce apóptosis de determinadas células cancerígenas, es quimiopreventivo.

Y, después de, ojo que no pararé de seguir Aprendiendo, es posible afirmar que el vino tino que bebía la tripulación del Submarino K 19, era una herramienta preventiva ante los efectos ionizantes que estaban recibiendo por su continua proximidad a las fuentes radiactivas. Es muy posible que la investigación en Protección Radiólogica de los años 60, y anteriores, sea mucho menos avanzada que la actual, y las barreras y sistemas de protección radiológica actuales sean mucho mayores en los Submarinos Nucleares. Lamentablemente, beber Vino Tinto, en cantidades moderadas, no puede evitar los efectos letales de una exposición tan alta como la que tuvieron los tripulantes.

Medwave

A continuación le informamos los artículos recientemente publicados en Medwave


ESTUDIOS PRIMARIOS

Conocimientos, prácticas y actitudes hacia el voluntariado ante una influenza pandémica: estudio transversal con estudiantes de medicina en Perú
Julio A. Huapaya, Julio Maquera-Afaray, Patricia J. García, César Cárcamo, Javier A. Cieza (Perú)

Medwave 2015 May;15(4):e6136
http://dx.doi.org/10.5867/medwave.2015.04.6136


Hepatotoxicidad medicamentosa y tuberculosis en un hospital del noreste argentino: estudio transversal
Alfredo Sebastián Golemba, Francisco Gastón Emmanuel Ferreyra, Ricardo Enrique Martearena, Fernando Ramón Achinelli, Gloria Beatriz Rovai (Argentina)

Medwave 2015 May;15(4):e6135
http://dx.doi.org/10.5867/medwave.2015.04.6135


RESÚMENES EPISTEMONIKOS

¿Tienen un rol los digitálicos en la insuficiencia cardíaca crónica?
Carmen Rain, Gabriel Rada (Chile)

Medwave 2015 Abr;15(3):e6129
http://dx.doi.org/10.5867/medwave.2015.03.6129


¿Es beneficiosa la profilaxis antibiótica en la pancreatitis aguda? - Primera actualización
Gabriel Rada, José Peña (Chile)

Medwave 2015 Abr;15(3):e6125
http://dx.doi.org/10.5867/medwave.2015.03.6125


EDITORIAL

La evidencia y la región - ¿conversan o colisionan?
Vivienne C. Bachelet

Medwave 2015 Abr;15(3):e6127
http://dx.doi.org/10.5867/medwave.2015.03.6127



PORTADA MEDWAVE
www.medwave.cl

Dolor crónico y obesidad/Chronic pain and obesity

Migraña y el IMC. Revisión sistemática y meta-análisis de estudios observacionales Migraine and body mass index categories: a systematic review and meta-analysis of observational studies. Ornello R, Ripa P, Pistoia F, Degan D, Tiseo C, Carolei A, Sacco S. J Headache Pain. 2015 Mar 28;16(1):27. doi: 10.1186/s10194-015-0510-z. PDF Manejo del dolor crónico en el obeso. Revisión focalizada de desafíos y soluciones potenciales de ejercicio. Chronic pain management in the obese patient: a focused review of key challenges and potential exercise solutions. Zdziarski LA, Wasser JG, Vincent HK. J Pain Res. 2015 Feb 9;8:63-77. doi: 10.2147/JPR.S55360. eCollection 2015. PDF Como la obesidad modifica los tendones (implicaciones para actividades atléticas) How obesity modifies tendons (implications for athletic activities). Abate M. Muscles Ligaments Tendons J. 2014 Nov 17;4(3):298-302. eCollection 2014. PDF Un ensayo clínico aleatorizado de una intervención integrada de auto-manejo conductual Simultáneamente Orientación obesidad y el dolor: el ensayo STOP. A randomized clinical trial of an integrated behavioral self-management intervention Simultaneously Targeting Obesity and Pain: the STOP trial. Janke EA, Fritz M, Hopkins C, Haltzman B, Sautter JM, Ramirez ML. BMC Public Health. 2014 Jun 18;14:621. doi: 10.1186/1471-2458-14-621. PDF Bupivacaína liposonal para dolor postoperatorio en una obesa con dolor crónico sometida a gastrectomía laparoscópica. Informe de caso Liposome bupivacaine for postsurgical pain in an obese woman with chronic pain undergoing laparoscopic gastrectomy: a case report. Bertin PM. J Med Case Rep. 2014 Jan 22;8:21. doi: 10.1186/1752-1947-8-21. PDF El efecto mediador del dolor crónico en la relación entre la obesidad y la función física y la discapacidad en los adultos mayores. The mediating effect of chronic pain on the relationship between obesity and physical function and disability in older adults. Fowler-Brown A, Wee CC, Marcantonio E, Ngo L, Leveille S. J Am Geriatr Soc. 2013 Dec;61(12):2079-86. doi: 10.1111/jgs.12512. Epub 2013 Nov 1. PDF

Atentamente Anestesia y Medicina del Dolor anestesia-dolor.org

Estudio comparativo de ondansetron intravenoso y dosis subhipnóticas de propofol en el control y manejo del prurito inducido por sufentanilo intratecal en cesárea electiva

Estudio comparativo de ondansetron intravenoso y dosis subhipnóticas de propofol en el control y manejo del prurito inducido por sufentanilo intratecal en cesárea electiva The comparative study of intravenous Ondansetron and sub-hypnotic Propofol dose in control and treatment of intrathecal Sufentanil-induced pruritus in elective caesarean surgery. Hirmanpour A, Safavi M, Honarmand A, Hosseini AZ, Sepehrian M. J Res Pharm Pract 2015;4:57-63 Abstract Objective: Pruritus is a common and disturbing side effect of neuraxial opioids after cesarean section. The purpose of this study was to compare the efficacy of intravenous ondansetron and sub-hypnotic dose of propofol in control and treatment of intrathecal sufentanil induced pruritus in cesarean surgery. Methods: Totally, 90 parturient with American Society of Anesthesiology physical status grade I-II, undergoing spinal anesthesia with 2.5 μg sufentanil and 10 mg bupivacaine 0.5% were enrolled to this randomized, prospective, double-blind study. The women were randomly assigned to two groups who received 8 mg ondansetron or 10 mg propofol to treat pruritus grade ≥3. The patient was evaluated after 5 min and in the lack of successful treatment, the doses of two drugs repeated and if the pruritus is on-going, the exact treatment with naloxone was done. Findings: The incidence of pruritus was 69.3%. Both groups were well-matched. The peak time pruritus was 30-75 min after injection. The percentage of individuals consumed naloxone were 6.8% and 15.9% in ondansetron and propofol groups, respectively (P = 0.18). The mean score of satisfaction (according to visual analog scale criteria) was 9.09 ± 1.1 in ondansetron group and 9.3 ± 1.07 in the propofol group (P = 0.39). Conclusion: Ondansetrone and sub-hypnotic dose of propofol are both safe and well-tolerated. Due to their same efficacy in the treatment of intrathecal sufentanil-induced pruritus, they can be widely used in clinical practice.Keywords: Caesarean surgery; intrathecal opioid; Ondansetron; Propofol; pruritus PDF

Atentamente Anestesia y Medicina del Dolor anestesia-dolor.org

Bibliotecas populares. Alerta

bibliotecas populares
Notificaciones semanales ⋅ 6 de mayo de 2015
NOTICIAS


Página 12 (Registro)

Silvina Friera
Página 12 (Registro)
Como todos los años, la Conabip entregará la distinción Amigo de las Bibliotecas Populares. En esta edición será un reconocimiento colectivo a ...




El Diario Nuevo Dia

Goicoechea inauguró la Biblioteca Popular Néstor Kirchner
El Diario Nuevo Dia
El acto se llevó a cabo ayer, cuando el Decano de la Facultad Regional Santa Cruz junto a la Vicepresidenta de la Red de Bibliotecas Populares para ...




Télam

El Programa Libro Por Ciento, Celebra 10 Años del 1 al 3 de Mayo
Télam
La Comisión Nacional de Bibliotecas Populares (Conabip) celebra los primeros 10 años del programa "Libro por ciento" que desde hace una década ...




Diario La Provincia SJ

Libros sobre educación emocional son éxito de ventas en el stand de San Juan en la Feria del Libro
Diario La Provincia SJ
Así lo aseguró Liliana Alaniz, directora de Bibliotecas Populares, a Diario La Provincia quien señaló que se han visto sorprendidos por la repercusión ...




InfoRegión

Libros e Internet: ¿quién cede en la apuesta?
InfoRegión
Entre libros y talleres La encargada de la Biblioteca Popular “Juan Manuel Gutierrez”, Beatriz Laneri, indica que con la facilidad que hoy tiene gran ...




enREDando.org.ar

Los cinco años de la Flia
enREDando.org.ar
Los dos primeros días serán codo a codo con la Biblioteca Popular Juana Azurduy (en zona sudoeste de Rosario). Viernes 1º: en la Biblio, Dr. Riva ...

Obesidad neonatal/Neonatal obesity

Evolución perinatal de los infantes de término de las madres con sobrepeso y obesidad. Un estudio de cohorte de base poblacional en Canadá Perinatal outcomes of maternal overweight and obesity in term infants: a population-based cohort study in Canada. Vinturache AE, McDonald S, Slater D, Tough S. Sci Rep. 2015 Mar 20;5:9334. doi: 10.1038/srep09334. Abstract The objective of this study was to assess the impact of increased pre-pregnancy maternal body mass index (BMI) on perinatal outcomes in term, singleton pregnancies who received prenatal care in community-based practices. The sample of 1996 infants included in the study was drawn from the All Our Babies Study, a prospective pregnancy cohort from Calgary. Multivariable logistic regression explored the relationship between the main outcomes, infant birth weight, Apgar score, admission to neonatal intensive care (NICU) and newborn duration of hospitalization, and BMI prior to pregnancy. Approximately 10% of the infants were macrosoms, 1.5% had a low Apgar score (<7 at 5 min), 6% were admitted to intensive care and 96% were discharged within 48 h after delivery. Although the infants of overweight and obese women were more likely to have increased birth weight as compared to infants of normal weight women, there were no differences in Apgar score, admission to NICU, or length of postnatal hospital stay among groups. This study suggests that in otherwise healthy term, singleton pregnancies, obesity does not seem to increase the risk of severe fetal impairment, neonatal admission to intensive care or duration of postnatal hospitalization. PDF Inicio de la lactancia. Impacto de la obesidad en un estudio Canadiense perinatal de cohorte Breastfeeding initiation: impact of obesity in a large Canadian perinatal cohort study. Verret-Chalifour J, Giguère Y, Forest JC, Croteau J, Zhang P, Marc I. PLoS One. 2015 Feb 6;10(2):e0117512. doi: 10.1371/journal.pone.0117512. eCollection 2015. Abstract OBJECTIVE: To evaluate incidence of breastfeeding initiation according to maternal pre-pregnancy body mass index (BMI) in "Grossesse en Santé", a large prospective birth cohort in Quebec City. METHODS: Breastfeeding initiation in the post-partum period, pre-pregnancy BMI, sociodemographic determinants and obstetrical and neonatal factors were collected from years 2005 to 2010 in 6592 women with single pregnancies. Prenatal non-intention to breastfeed was documented in a subgroup of the cohort (years 2009-2010). Log-binomial regression analyses were performed to assess relative risk (RR) of non-initiation of breastfeeding between maternal BMI categories in models including pre- and post-natal determinants, after exclusion of variables with a mediating effect. RESULTS: Twenty percent (20%) of obese women did not initiate breastfeeding in the post-natal period at hospital compared to 12% for normal weight women. Compared with those having a normal pre-pregnancy BMI, obese women had a higher risk of non-initiation of breastfeeding (RRunadj 1.69, 95% CI 1.44-1.98), even after adjustment for prenatal and sociodemographic factors (RRadj 1.26, 95% CI 1.08-1.46). Furthermore, the risk of non-initiation of breastfeeding in obese women still remained higher after introduction of per- and post-natal factors (RR 1.22, 95% CI 1.04-1.42). The prenatal non-intention to breastfeed was strongly associated with the non-initiation of breastfeeding for all categories of BMI. CONCLUSION: Maternal obesity is associated with a two-fold rate of non-initiation of breastfeeding. Considering the benefits of breastfeeding and the increasing obesity rate, adapted interventions and specialized support should target both pre- and immediate post-natal periods in this population. PDF La obesidad inducida por sobrealimentación neonatal empeora la hiper reactividad e inflamación de la vía aérea Obesity induced by neonatal overfeeding worsens airway hyperresponsiveness and inflammation. Ye Z, Huang Y, Liu D, Chen X, Wang D, Huang D, Zhao L, Xiao X. PLoS One. 2012;7(10):e47013. doi: 10.1371/journal.pone.0047013. Epub 2012 Oct 8. Abstract BACKGROUND:Obesity is a risk factor for the development of certain respiratory diseases, and neonatal overfeeding results in an early onset ofobesity in adulthood. However, the influence of neonatal overfeeding on respiratory diseases has rarely been studied. Therefore, this paper is aimed at investigating the effect of neonatal overfeeding on airway responsiveness and inflammation.METHODOLOGY/PRINCIPAL FINDINGS: The neonatal overfeeding was induced by reducing litter size to three pups per litter (small litter, SL) in contrast to the normal litter size with ten pups per litter (NL) on postnatal day 3 (P3) in male ICR mice. On P21, mice were weaned to standard chow diet. Airway responsiveness to methacholine was measured either on P21 or P150. Total and classified inflammatory cells in bronchoalveolar lavage fluid (BALF) were counted, lung inflammatory cells were evaluated through staining with hematoxylin & eosin and F4/80 immunohistochemistry; lung fibrosis was evaluated through staining with Masson and α-SAM immunohistochemistry. Leptin levels in serum were measured by RIA; TNF-α levels in serum and BALF were quantified by ELISA; mRNA levels of TNF-α, CTGF and TGF-β1 in lung tissues were measured using real-time PCR. Mice from SL exhibited accelerated body weight gain, impaired glucose tolerance and hyperleptinemia. Enhanced airway responsiveness to methacholine was observed in SL mice on P150, but not on P21. Pulmonary inflammation was evident in SL mice on P150, as reflected by inflammatory cells especially macrophages around bronchi and interstitium. BALF and serum TNF-α levels and lung TNF-α mRNA expression were significantly increased in SL mice on P150. More collagen accumulated surrounding the bronchi on P150; lung mRNA levels of TGF-β1 and CTGF were also increased on P150. CONCLUSION: In addition to inducing a variety of metabolic defects, neonatal overfeeding enhanced lung inflammation, which may lead to airway remodeling and airway hyperresponsiveness in adulthood. PDF Los efectos de la dieta prenatal y consejos de estilo de vida para las mujeres que tienen sobrepeso u obesidad en la salud neonatal : el ensayo aleatorio LIMIT. The effects of antenatal dietary and lifestyle advice for women who are overweight or obese on neonatal health outcomes: the LIMIT randomised trial. Dodd JM1,2, McPhee AJ3, Turnbull D4, Yelland LN5,6,7, Deussen AR8, Grivell RM9,10, Crowther CA11,12, Wittert G13, Owens JA14, Robinson JS15; LIMIT Randomised Trial Group. BMC Med. 2014 Oct 13;12(1):163. doi: 10.1186/s12916-014-0163-9. PDF

Atentamente Anestesia y Medicina del Dolor anestesia-dolor.org