viernes, 15 de mayo de 2015

Camilo Golgi y Louis Antoine Ranvier

Golgi y Ranvier: de la reacción negra a la teoría del dolor referido
Golgi and Ranvier: from the black reaction to a theory of referred pain.
Cani V, Mazzarello P.
Funct Neurol. 2015 Apr 13:1-5. [Epub ahead of print]
In his brief report on the structure of the gray matter of the central nervous system (1873), in which he described the "black reaction", Golgi noted the ramifications of the axon. This discovery prompted the French histologist Louis Antoine Ranvier, one of the first to try the black reaction outside Italy, to propose an ingenious theory of referred pain in his Traité technique d'histologie. Ranvier suggested that the nerve fibers originating from the irritated area and those coming from the region to which the sensation is referred converge on the same axon and thus the same cell body, causing the spatial dislocation of sensation. This theory of referred pain is a powerful example of the extraordinary clinical-physiological impact of the first of Golgi's neurocytological discoveries.
Como Camilo Golgi se convirtió en el "Aparato de Golgi"
How Camillo Golgi became "the Golgi".
Mazzarello P, Garbarino C, Calligaro A.
FEBS Lett. 2009 Dec 3;583(23):3732-7. doi: 10.1016/j.febslet.2009.10.018. Epub 2009 Oct 13.
On April 1898 Camillo Golgi communicated to the Medical-Surgical Society of Pavia, the discovery of the "internal reticular apparatus", a novel intracellular organelle which he observed in nerve cells with the silver impregnation he had introduced for the staining of the nervous system. Soon after the discovery it became evident that this cellular component, which was also named the "Golgi apparatus", was a ubiquitous structure in eukaryotic cells. However the reality of the organelle was questioned for years and many cytologists considered the internal reticular apparatus as an artefact due to the fixation and/or metallic impregnation procedure. The controversy was finally solved in the mid-1950s by electron microscopy when the Golgi apparatus definitely acquired its dignity of being a genuine cell organelle. The designation of "Golgi complex" entered officially in the literature in 1956. Both the terms Golgi apparatus and Golgi complex are currently interchangeable. However a quick "the Golgi" and the introduction of Golgi in adjectival form are now prevalent in the blooming scientific literature on the organelle. Thus Camillo Golgi underwent his final transformation and, becoming the eponym of the organelle he had discovered, he found a way to immortality.
Anestesia y Medicina del Dolor
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