Efectos de la lidocaína, la ketamina y remifentanilo sobre la respuesta de retirada de rocuronio.
Effects of lidocaine, ketamine, and remifentanil on withdrawal response of rocuronium.
Jung KT, Kim HJ, Bae HS, Lee HY, Kim SH, So KY, Lim KJ, Yu BS, Jung JD, An TH, Park HC.
Korean J Anesthesiol. 2014 Sep;67(3):175-80. doi: 10.4097/kjae.2014.67.3.175. Epub 2014 Sep 24
Abstract
BACKGROUND: Rocuronium has been well known to produce withdrawal response in 50-80% patients when administered intravenously. Several drugs are administered prior injection of rocuronium to prevent the withdrawal response. We compared the preventive effect of lidocaine, ketamine, and remifentanil on the withdrawal response of rocuronium. METHODS: A total of 120 patients undergoing various elective surgeries were enrolled. Patients were allocated into 4 groups according to the pretreatment drugs (Group N, normal saline; Groups L, lidocaine 40 mg; Group K, ketamine 0.5 mg/kg; Group R, remifentanil 1 µg/kg). Patients received drugs prepared by dilution to 3 ml volume before injection of rocuronium. Withdrawal responses after injection of rocuronium were graded on a 4-point scale. Hemodynamic changes were observed before and after administration of pretreatment drugs and after endotracheal intubation. RESULTS: Incidence of withdrawal response was significantly lower in group L (20%), group K (30%), and group R (0%), than group N (87%). Severe withdrawal response was observed in 5 of the 30 patients (17%) in group L, and in 9 of the 30 patients (30%) in group K. There was no severe withdrawal response in group R. Mean blood pressure and heart rate were significantly decreased in group R compared to other groups. CONCLUSIONS: It seems that remifentanil (1 µg/kg intravenously) was the strongest and most effective in prevention of withdrawal response afterrocuronium injection among the 3 drugs.
KEYWORDS: Ketamine; Lidocaine; Pain; Remifentanil; Rocuronium
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188762/pdf/kjae-67-175.pdf
Transplante de riñón
Efecto de la albúmina humana intraoperatoria sobre la función temprana del injerto en transplante renal
Effect of intraoperative human albumin on early graft function in renal transplantation
http://www.sjkdt.org/article.asp?issn=1319-2442;year=2014;volume=25;issue=6;spage=1148;epage=1153;aulast=Shah
http://www.sjkdt.org/text.asp?2014/25/6/1148/144246
El efecto de la administración de manitol al donante de riñón en los resultados a corto plazo del trasplante de riñón.
The effect of mannitol administration to kidney donor on short-term outcomes of kidney transplantation.
http://www.sjkdt.org/article.asp?issn=1319-2442;year=2014;volume=25;issue=6;spage=1154;epage=1159;aulast=Esfahani
http://www.sjkdt.org/text.asp?2014/25/6/1154/144247
Atentamente
Anestesiología y Medicina del Dolor
www.anestesia-dolor.org
Effects of lidocaine, ketamine, and remifentanil on withdrawal response of rocuronium.
Jung KT, Kim HJ, Bae HS, Lee HY, Kim SH, So KY, Lim KJ, Yu BS, Jung JD, An TH, Park HC.
Korean J Anesthesiol. 2014 Sep;67(3):175-80. doi: 10.4097/kjae.2014.67.3.175. Epub 2014 Sep 24
Abstract
BACKGROUND: Rocuronium has been well known to produce withdrawal response in 50-80% patients when administered intravenously. Several drugs are administered prior injection of rocuronium to prevent the withdrawal response. We compared the preventive effect of lidocaine, ketamine, and remifentanil on the withdrawal response of rocuronium. METHODS: A total of 120 patients undergoing various elective surgeries were enrolled. Patients were allocated into 4 groups according to the pretreatment drugs (Group N, normal saline; Groups L, lidocaine 40 mg; Group K, ketamine 0.5 mg/kg; Group R, remifentanil 1 µg/kg). Patients received drugs prepared by dilution to 3 ml volume before injection of rocuronium. Withdrawal responses after injection of rocuronium were graded on a 4-point scale. Hemodynamic changes were observed before and after administration of pretreatment drugs and after endotracheal intubation. RESULTS: Incidence of withdrawal response was significantly lower in group L (20%), group K (30%), and group R (0%), than group N (87%). Severe withdrawal response was observed in 5 of the 30 patients (17%) in group L, and in 9 of the 30 patients (30%) in group K. There was no severe withdrawal response in group R. Mean blood pressure and heart rate were significantly decreased in group R compared to other groups. CONCLUSIONS: It seems that remifentanil (1 µg/kg intravenously) was the strongest and most effective in prevention of withdrawal response afterrocuronium injection among the 3 drugs.
KEYWORDS: Ketamine; Lidocaine; Pain; Remifentanil; Rocuronium
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188762/pdf/kjae-67-175.pdf
Transplante de riñón
Efecto de la albúmina humana intraoperatoria sobre la función temprana del injerto en transplante renal
Effect of intraoperative human albumin on early graft function in renal transplantation
http://www.sjkdt.org/article.asp?issn=1319-2442;year=2014;volume=25;issue=6;spage=1148;epage=1153;aulast=Shah
http://www.sjkdt.org/text.asp?2014/25/6/1148/144246
El efecto de la administración de manitol al donante de riñón en los resultados a corto plazo del trasplante de riñón.
The effect of mannitol administration to kidney donor on short-term outcomes of kidney transplantation.
http://www.sjkdt.org/article.asp?issn=1319-2442;year=2014;volume=25;issue=6;spage=1154;epage=1159;aulast=Esfahani
http://www.sjkdt.org/text.asp?2014/25/6/1154/144247
Atentamente
Anestesiología y Medicina del Dolor
www.anestesia-dolor.org
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