| Nitroglicerina transdérmica aumenta el efecto analgésico de la clonidina intratecal en histerectomía abdominal |
Transdermal nitroglycerine enhances the post-operative analgesic effect of intrathecal clonidine in abdominal hysterectomies.
Khandelwal M, Ahmed F, Garg A, Verma AP, Aquil, Chatterjee CS.
Indian J Anaesth [serial online] 2012 [cited 2012 Feb 29];56:79-81.
Clonidine is frequently used as an adjuvant in spinal anaesthesia to enhance the quality and duration of post-operative analgesia, [1],[2],[3] transdermal nitroglycerine (tNTG) has been found to be useful for enhancing the post-operative analgesic effect of intrathecal (IT) sufentanil [4] and neostigmine [5] by release of nitric oxide (NO). This NO increases the intracellular concentration of cyclic guanosine monophosphate (cGMP), which produces pain modulation in the central and peripheral nervous system. [6],[7] We have carried out this study to evaluate the effect of tNTG on IT clonidine.
http://www.ijaweb.org/text.asp?2012/56/1/79/93352 |
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