MECANISMOS EN ENDOCRINOLOGÍA: Envejecimiento y antienvejecimiento: una visión general en combo-endocrinología.
MECHANISMS IN ENDOCRINOLOGY: Aging and anti-aging: a Combo-Endocrinology overview.
Diamanti-Kandarakis E1, Dattilo M2, Macut D3, Duntas L4,5, Gonos ES6, Goulis DG7, Gantenbein CK8, Kapetanou M6, Koukkou E9, Lambrinoudaki I10, Michalaki M11, Eftekhari-Nader S12, Pasquali R13, Peppa M14, Tzanela M15, Vassilatou E16, Vryonidou A17; COMBO ENDO TEAM: 2016.
Eur J Endocrinol. 2017 Jun;176(6):R283-R308. doi: 10.1530/EJE-16-1061. Epub 2017 Mar 6.
Abstract
Aging and its underlying pathophysiological background has always attracted the attention of the scientific society. Defined as the gradual, time-dependent, heterogeneous decline of physiological functions, aging is orchestrated by a plethora of molecular mechanisms, which vividly interact to alter body homeostasis. The ability of an organism to adjust to these alterations, in conjunction with the dynamic effect of various environmental stimuli across lifespan, promotes longevity, frailty or disease. Endocrine function undergoes major changes during aging, as well. Specifically, alterations in hormonal networks and concomitant hormonal deficits/excess, augmented by poor sensitivity of tissues to their action, take place. As hypothalamic-pituitary unit is the central regulator of crucial body functions, these alterations can be translated in significant clinical sequelae that can impair the quality of life and promote frailty and disease. Delineating the hormonal signaling alterations that occur across lifespan and exploring possible remedial interventions could possibly help us improve the quality of life of the elderly and promote longevity.
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