Análogos de la insulina de acción corta versus insulina humana regular en la glucosa posprandial e hipoglucemia en la diabetes mellitus tipo 1: una revisión sistemática y un metanálisis.
Short-acting insulin analogues versus regular human insulin on postprandial glucose and hypoglycemia in type 1 diabetes mellitus: a systematic review and meta-analysis.
Melo KFS1,2,3, Bahia LR2,4, Pasinato B5, Porfirio GJM6, Martimbianco AL6, Riera R6,7, Calliari LEP8, Minicucci WJ2, Turatti LAA2, Pedrosa HC2, Schaan BD5,9.
Abstract
INTRODUCTION: Strict glucose control using multiple doses of insulin is the standard treatment for type 1 diabetes mellitus (T1DM), but increased risk of hypoglycemia is a frequent drawback. Regular insulin in multiple doses is important for achieving strict glycemic control for T1DM, but short-acting insulin analogues may be better in reducing hypoglycemia and postprandial glucose levels....... CONCLUSIONS: Short-acting insulin analogues are superior to regular human insulin in T1DM patients for the following outcomes: total hypoglycemic episodes, nocturnal hypoglycemia, severe hypoglycemia, postprandial glucose, and HbA1c.
KEYWORDS: Aspart insulin; Diabetes mellitus; Glulisine insulin; Insulin; Lispro insulin; Meta-analysis; Systematic review; Type 1 diabetes
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