| Síndrome antifosfolípido durante el embarazo: estado actual |
Antiphospholipid Syndrome during pregnancy: the state of the art.
Di Prima FA, Valenti O, Hyseni E, Giorgio E, Faraci M, Renda E, De Domenico R, Monte S.
Policlinico Hospital, Department of Obstetrics and Gynecology, University of Catania, Italy.
J Prenat Med. 2011 Apr;5(2):41-53.
Abstract
Obstetric complications are the hallmark of antiphospholipid syndrome. Recurrent miscarriage, early delivery, oligohydramnios, prematurity, intrauterine growth restriction, fetal distress, fetal or neonatal thrombosis, pre-eclampsia/eclampsia, HELLP syndrome, arterial or venous thrombosis and placental insufficiency are the most severe APS-related complication for pregnant women. Antiphospholipid antibodies promote activation of endothelial cells, monocytes and platelets, causing an overproduction of tissue factor and thromboxane A2. Complement activation might have a central pathogenetic role. These factors, associated with the typical changes in the hemostatic system during normal pregnancy, result in a hypercoagulable state. This is responsible of thrombosis that is presumed to provoke many of the pregnancy complications associated with APS. Obstetric care is based on combined medical-obstetric high-risk management and treatment with the association between aspirin and heparin. This review aims to deter- mine the current state of the art of APS by investigating the knowledge achievements of recent years, to provide the most appropriate diagnostic and therapeutic management for pregnant women suffering from this syndrome.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279165/?tool=pubmed
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| Libro sobre Síndrome antifosfolípidos |
Antiphospholipid Syndrome
Edited by Alena Bulikova, ISBN 978-953-51-0526-8, Hard cover, 232 pages, Publisher: InTech, Published: April 20, 2012 under CC BY 3.0 license, in subject Immunology, Allergology and Rheumatology
The antiphospholipid syndrome has been described for the first time by Graham Hughes in 1983 as a condition connected with thromboses or foetal losses and antiphospholipid antibodies presence. Form that time there has been a great progress in knowledge, including antiphospholipid antibodies characterisation, their probable and also possible action, clinical manifestations, laboratory detection and treatment possibilities . This book provides a wide spectrum of clinical manifestations through Chapters written by well known researchers and clinicians with a great practical experience in management of diagnostics or treatment of antiphospholipid antibodies' presence.
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