Administración intravenosa perioperatoria de sulfato de magnesio y dolor postoperatorio: un metaanálisis
Peri-operative intravenous administration of magnesium sulphate and postoperative pain: a meta-analysis
E. Albrecht, K. R. Kirkham, S. S. Liu and R. Brull.
Anaesthesia 2013, 68, 79-90
Summary
Intravenous magnesium has been reported to improve postoperative pain; however, the evidence is inconsistent. The objective of this quantitative systematic review is to evaluate whether or not the peri-operative administration of intravenous magnesium can reduce postoperative pain. Twenty-five trials comparing magnesium with placebo were identified. Independent of the mode of administration (bolus or continuous infusion), peri-operative magnesium reduced cumulative intravenous morphine consumption by 24.4% (mean difference: 7.6 mg, 95% CI )9.5 to )5.8 mg;
p < 0.00001) at 24 h postoperatively. Numeric pain scores at rest and on movement at 24 h postoperatively were reduced by 4.2 (95% CI )6.3 to )2.1; p < 0.0001) and 9.2 (95% CI )16.1 to )2.3; p = 0.009) out of 100, respectively. We conclude that peri-operative intravenous magnesium reduces opioid consumption, and to a lesser extent, pain scores, in the first 24 h postoperatively, without any reported serious adverse effects.
http://xa.yimg.com/kq/groups/1099152/209914451/name/magnesium.pdf
Atentamente
Anestesiología y Medicina del Dolor
www.anestesia-dolor.org
Peri-operative intravenous administration of magnesium sulphate and postoperative pain: a meta-analysis
E. Albrecht, K. R. Kirkham, S. S. Liu and R. Brull.
Anaesthesia 2013, 68, 79-90
Summary
Intravenous magnesium has been reported to improve postoperative pain; however, the evidence is inconsistent. The objective of this quantitative systematic review is to evaluate whether or not the peri-operative administration of intravenous magnesium can reduce postoperative pain. Twenty-five trials comparing magnesium with placebo were identified. Independent of the mode of administration (bolus or continuous infusion), peri-operative magnesium reduced cumulative intravenous morphine consumption by 24.4% (mean difference: 7.6 mg, 95% CI )9.5 to )5.8 mg;
p < 0.00001) at 24 h postoperatively. Numeric pain scores at rest and on movement at 24 h postoperatively were reduced by 4.2 (95% CI )6.3 to )2.1; p < 0.0001) and 9.2 (95% CI )16.1 to )2.3; p = 0.009) out of 100, respectively. We conclude that peri-operative intravenous magnesium reduces opioid consumption, and to a lesser extent, pain scores, in the first 24 h postoperatively, without any reported serious adverse effects.
http://xa.yimg.com/kq/groups/1099152/209914451/name/magnesium.pdf
Atentamente
Anestesiología y Medicina del Dolor
www.anestesia-dolor.org
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