Neonatal tumours

REVIEW ARTICLE
Neonatal tumours
Kokila Lakhoo • Helen Sowerbutts
Accepted: 26 September 2010 / Published online: 19 October 2010
Springer-Verlag 2010
Keywords Neonatal tumours

REVIEW ARTICLE
Neonatal tumours
Kokila Lakhoo • Helen Sowerbutts
Accepted: 26 September 2010 / Published online: 19 October 2010
Springer-Verlag 2010
Keywords Neonatal tumours
Introduction
Tumours in the neonatal age group are rare, and estimates
of incidence range from 1:12,500 to 1:17,300 [1]. It has
been predicted that most neonatal units will see only one
case every 1–2 years. It is therefore an area in which many
clinicians have little experience.
However, greater use of routine antenatal ultrasound
scans and technological improvements in image quality
means that lesions are being picked up more frequently
and, crucially, at an earlier gestational age. Suspicious
lesions can now be further investigated with more specialised
imaging such as foetal MRI, and in some cases,
treatment before birth is now a real possibility.
In contrast to tumours in older children, neonatal
tumours are generally solid and mesenchymally derived.
The majority are benign, and indeed, ‘malignant’ tumours
may show regression, and histological classification may
not always correlate with clinical behaviour [2].
These factors combine to make tumours in the neonatal
period a unique domain for studying tumourgenesis, as
well as a diagnostic and therapeutic challenge to clinicians.
As such, this article aimed to give a broad introand the general
principles involved in their management.duction to
the main tumour types found in the neonate and the general
principles involved in their management.


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