Administración transdérmica de drogas en el manejo del dolor
Transdermal drug delivery in pain management
Sanjay Bajaj MD DNB FRCA, Abigail Whiteman MA MB BChir FRCA, Brigitta Brandner MD FRCA FFFPMRCA
Continuing Education in Anaesthesia, Critical Care & Pain | Volume 11 Number 2 2011
Key points
Transdermal drug delivery offers pharmacokinetic and practical advantages over the oral or parenteral routes for some patients. Patch design has important implications, for example, reservoir patches should never be cut whereas matrix patches can be trimmed. Topical diclofenac is at least as effective as the oral form; it may be superior. Development of a local subcutaneous drug reservoir beneath the patch means that buprenorphine and fentanyl patches require 24-72 h before the peak effect is achieved and there is delayed elimination after patch removal. New technology to actively drive drug molecules through the transdermal barrier may reduce time to onset and allow patch delivery to be useful in the management of acute pain.
http://ceaccp.oxfordjournals.org/content/11/2/39.full.pdf
Atentamente
Anestesiología y Medicina del Dolor
www.anestesia-dolor.org
Transdermal drug delivery in pain management
Sanjay Bajaj MD DNB FRCA, Abigail Whiteman MA MB BChir FRCA, Brigitta Brandner MD FRCA FFFPMRCA
Continuing Education in Anaesthesia, Critical Care & Pain | Volume 11 Number 2 2011
Key points
Transdermal drug delivery offers pharmacokinetic and practical advantages over the oral or parenteral routes for some patients. Patch design has important implications, for example, reservoir patches should never be cut whereas matrix patches can be trimmed. Topical diclofenac is at least as effective as the oral form; it may be superior. Development of a local subcutaneous drug reservoir beneath the patch means that buprenorphine and fentanyl patches require 24-72 h before the peak effect is achieved and there is delayed elimination after patch removal. New technology to actively drive drug molecules through the transdermal barrier may reduce time to onset and allow patch delivery to be useful in the management of acute pain.
http://ceaccp.oxfordjournals.org/content/11/2/39.full.pdf
Atentamente
Anestesiología y Medicina del Dolor
www.anestesia-dolor.org
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