https://www.columnavertebralpediatricaygeriatrica.com.mx/academia/la-gravedad-de-la-anemia-preoperatoria-aumenta-el-riesgo-de-malos-resultados-a-corto-plazo-despues-de-la-fusion-de-la-columna-lumbar/

La gravedad de la anemia preoperatoria aumenta el riesgo de malos resultados a corto plazo después de la fusión de la columna lumbar

junio 7, 2023 por admin

Consulte este artículo sobre la gravedad de la anemia preoperatoria que aumenta el riesgo de malos resultados a corto plazo después de la fusión de la columna lumbar.

The severity of preoperative anemia escalates risk of poor short-term outcomes after lumbar spine fusion | European Spine Journal

Evaluar cómo la gravedad de la anemia preoperatoria afecta los resultados a los 90 días de la cirugía de fusión espinal.
Los pacientes con anemia preoperatoria de moderada a grave tienen un mayor riesgo de hospitalización prolongada, transfusiones y alta no domiciliaria. La optimización mejorada de la anemia preoperatoria puede reducir significativamente la utilización de la atención médica, y los cirujanos deben considerar estos riesgos en la planificación preoperatoria.

• Este artículo es un estudio retrospectivo que evaluó cómo la gravedad de la anemia preoperatoria afecta los resultados a los 90 días de la cirugía de fusión espinal. Los autores clasificaron a los pacientes según las definiciones de gravedad de la anemia de la Organización Mundial de la Salud para las comparaciones. Los resultados principales fueron los requerimientos de transfusión, el alta no domiciliaria, las readmisiones, las complicaciones y la duración de la estancia hospitalaria. Los autores utilizaron modelos de regresión multivariante para controlar las variables de confusión.
• El estudio incluyó a 2582 pacientes: el 2.7% con anemia moderada-grave, el 11.0% con anemia leve y el 86.3% sin anemia. Los pacientes con anemia moderada-grave tuvieron la estancia hospitalaria más larga (5.03 días frente a 4.14 y 3.59 días, p < 0.001) y el mayor riesgo de transfusión (52.2% frente a 13.0% frente a 2.69%, p < 0.001), alta no domiciliaria (39.1% frente a 27.8% frente a 15.4%, p < 0.001), readmisión (7.25% frente a 5.99% frente a 3.36%, p = 0.023) y complicaciones (13.0% frente a 9.51% frente a 6.20%, p = 0.012). En la regresión logística multivariante, tanto los pacientes con anemia leve como moderada-grave tuvieron un mayor riesgo de transfusión (OR: 37.3, p < 0.001; OR: 5.25, p < 0.001, respectivamente) y alta no domiciliaria (OR: 2.00, p = 0.021; OR: 1.71, p = 0.001, respectivamente) en comparación con los pacientes sin anemia. La gravedad de la anemia no se asoció independientemente con complicaciones o readmisión a los 90 días. En la regresión lineal multivariante, la anemia leve (β: 0.37, p = 0.001) y moderada-grave (β: 1.07, p < 0.001) se asociaron independientemente con la duración de la estancia hospitalaria.
• Los autores concluyeron que los pacientes con anemia preoperatoria moderada-grave tienen un mayor riesgo de mayor duración de la estancia, transfusiones y alta no domiciliaria. La optimización mejorada de la anemia preoperatoria puede reducir significativamente la utilización de los servicios de salud, y los cirujanos deben considerar estos riesgos en la planificación preoperatoria.

The severity of preoperative anemia escalates risk of poor short-term outcomes after lumbar spine fusion – PubMed (nih.gov)

The severity of preoperative anemia escalates risk of poor short-term outcomes after lumbar spine fusion | SpringerLink

The severity of preoperative anemia escalates risk of poor short-term outcomes after lumbar spine fusion | European Spine Journal

Issa TZ, Lee Y, Heard JC, Lambrechts MJ, Giakas A, Mazmudar AS, Vaccaro A Jr, Henry TW, Kalra A, Fras S, Canseco JA, Kaye ID, Kurd MF, Hilibrand AS, Vaccaro AR, Schroeder GD, Kepler CK. The severity of preoperative anemia escalates risk of poor short-term outcomes after lumbar spine fusion. Eur Spine J. 2023 May 31. doi: 10.1007/s00586-023-07789-z. Epub ahead of print. PMID: 37253836.

© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

© 2023 Springer Nature Switzerland AG. Part of Springer Nature.

© 2023 European Spine Journal – All Rights Reserved

Ácido tranexámico (TXA) / Transfusión y pérdida de sangre operatoria

 https://www.ortopediainfantil.com.mx/academia/acido-tranexamico-txa-transfusion-y-perdida-de-sangre-operatoria/

Ácido tranexámico (TXA) / Transfusión y pérdida de sangre operatoria

 ácido tranexámico (TXA) es un derivado de la lisina que bloquea los sitios de unión de plasmin en la fibrina, lo que resulta en una disminución en la fibrinolisis y estabiliza la formación de coágulos. Existen múltiples regímenes de dosificación y rutas de administración, incluyendo IV, oral y tópico, que todos han demostrado ser igualmente eficaces. TXA también ha demostrado tasas de transfusión de menos del 3 % para TKA y menos del 10 % para THA.Revisa más conceptos de alto rendimiento sobre el Operativo Blood Loss & Transfusion en nuestro sitio web / app o The Orthobullets Podcast!

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Transfusión en trauma craneoencefálico / Transfusion traumatic brain injury

Julio 16, 2018. No. 3143

Lo Mejor de Octavio Paz. PDF Trasfusión en trauma craneoencefálico Transfusion practices in traumatic brain injury Curr Opin Anaesthesiol. 2018 Apr;31(2):219-226. doi: 10.1097/ACO.0000000000000566. East JM1, Viau-Lapointe J1, McCredie VA1,2. Author information Abstract PURPOSE OF REVIEW: The aim of this review is to summarize the recent studies looking at the effects of anemia and red blood cell transfusion in critically-ill patients with traumatic brain injury (TBI), describe the transfusion practice variations observed worldwide, and outline the ongoing trials evaluating restrictive versus liberal transfusion strategies for TBI. RECENT FINDINGS: Anemia is common among critically-ill patients with TBI, it is also thought to exacerbate secondary brain injury, and is associated with an increased risk of poor outcome. Conversely, allogenic red blood cell transfusion carries its own risks and complications, and has been associated with worse outcomes. Globally, there are large reported differences in the hemoglobin threshold used for transfusion after TBI. Observational studies have shown differential results for improvements in cerebral oxygenation and metabolism after red blood cell transfusion in TBI. SUMMARY: Currently, there is insufficient evidence to make strong recommendations regarding which hemoglobin threshold to use as a transfusion trigger in critically-ill patients with TBI. There is also uncertainty whether the restrictive transfusion strategy used in general critical care can be extrapolated to acutely brain injured patients. Ultimately, the consequences of anemia-induced cerebral injury need to be weighed up against the risks and complications associated with red blood cell transfusion. PDF Lesión hemorrágica progresiva después de una lesión cerebral traumática grave: efecto de los umbrales de transfusión de hemoglobina. Progressive hemorrhagic injury after severe traumatic brain injury: effect of hemoglobin transfusion thresholds. Vedantam A1, Yamal JM2, Rubin ML2, Robertson CS1, Gopinath SP1. Author information J Neurosurg. 2016 Nov;125(5):1229-1234. Epub 2016 Mar 4. Abstract OBJECT. There is limited literature available to guide transfusion practices for patients with severe traumatic brain injury (TBI). Recent studies have shown that maintaining a higher hemoglobin threshold after severe TBI offers no clinical benefit. The present study aimed to determine if a higher transfusion threshold was independently associated with an increased risk of progressive hemorrhagic injury (PHI), thereby contributing to higher rates of morbidity and mortality. METHODS The authors performed a secondary analysis of data obtained from a recently performed randomized clinical trial studying the effects of erythropoietin and blood transfusions on neurological recovery after severe TBI. Assigned hemoglobin thresholds (10 g/dl vs 7 g/dl) were maintained with packed red blood cell transfusions during the acute phase after injury. PHI was defined as the presence of new or enlarging intracranial hematomas on CT as long as 10 days after injury. A severe PHI was defined as an event that required an escalation of medical management or surgical intervention. Clinical and imaging parameters and transfusion thresholds were used in a multivariate Cox regression analysis to identify independent risk factors for PHI. RESULTS Among 200 patients enrolled in the trial, PHI was detected in 61 patients (30.5%). The majority of patients with PHI had a new, delayed contusion (n = 29) or an increase in contusion size (n = 15). The mean time interval between injury and identification of PHI was 17.2 ± 15.8 hours. The adjusted risk of severe PHI was 2.3 times higher for patients with a transfusion threshold of 10 g/dl (95% confidence interval 1.1-4.7; p = 0.02). Diffuse brain injury was associated with a lower risk of PHI events, whereas higher initial intracranial pressure increased the risk of PHI (p < 0.001). PHI was associated with a longer median length of stay in the intensive care unit (18.3 vs 14.4 days, respectively; p = 0.04) and poorer Glasgow Outcome Scale scores (42.9% vs 25.5%, respectively; p = 0.02) at 6 months. CONCLUSIONS A higher transfusion threshold of 10 g/dl after severe TBI increased the risk of severe PHI events. These results indicate the potential adverse effect of using a higher hemoglobin transfusion threshold after severe TBI. KEYWORDS: EPO = erythropoietin; ER = emergency room; GCS = Glasgow Coma Scale; GOS = Glasgow Outcome Scale; ICP = intracranial pressure; PHI = progressive hemorrhagic injury; PT = prothrombin time; PTT = partial thromboplastin time; RCT = randomized controlled trial; TBI = traumatic brain injury; hemoglobin transfusion threshold; progressive hemorrhagic injury; secondary brain injury; severe traumatic brain injury PDF Efecto de la eritropoyetina y el umbral de transfusión en la recuperación neurológica después de la lesión cerebral traumática: un ensayo clínico aleatorizado. Effect of erythropoietin and transfusion threshold on neurological recovery after traumatic brain injury: a randomized clinical trial. Robertson CS1, Hannay HJ2, Yamal JM3, Gopinath S1, Goodman JC4, Tilley BC3; Epo Severe TBI Trial Investigators, Baldwin A1, Rivera Lara L1, Saucedo-Crespo H1, Ahmed O1, Sadasivan S1, Ponce L1, Cruz-Navarro J1, Shahin H1, Aisiku IP5, Doshi P5, Valadka A5, Neipert L2, Waguspack JM2, Rubin ML3, Benoit JS3, Swank P3. Author information JAMA. 2014 Jul 2;312(1):36-47. doi: 10.1001/jama.2014.6490. Abstract IMPORTANCE: There is limited information about the effect of erythropoietin or a high hemoglobin transfusion threshold after a traumatic brain injury. OBJECTIVE: To compare the effects of erythropoietin and 2 hemoglobin transfusion thresholds (7 and 10 g/dL) on neurological recovery after traumatic brain injury. ...Intravenous erythropoietin (500 IU/kg per dose) or saline. Transfusion threshold maintained with packed red blood cells. ....CONCLUSIONS AND RELEVANCE: In patients with closed head injury, neither the administration of erythropoietin nor maintaining hemoglobin concentration of greater than 10 g/dL resulted in improved neurological outcome at 6 months. The transfusion threshold of 10 g/dL was associated with a higher incidence of adverse events. These findings do not support either approach in this setting. PDF Curso de Alta Especialidad en Medicina del Dolor y Paliativa 2019 Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Ciudad de México Convocatoria / Announcement  Ver Programa Información / Information Congresos Médicos por Especialidades en todo Mundo Medical Congresses by Specialties around the World Información / Information Curso Regional de Sur Sureste de Medicina del Dolor y Cuidados Paliativos Agosto 24-25. Oaxaca, México Informacion / Information Safe Anaesthesia Worldwide Delivering safe anaesthesia to the world's poorest people Informes / Information

Anestesiología y Medicina del Dolor 52 664 6848905 vwhizar@anestesia-dolor.org anestesia-dolor.org

Más de transfusión masiva / More on massive transfusion

Abril 20, 2017. No. 2665

La implementación del protocolo de tratamiento para hemorragia masiva reduce la mortalidad en pacientes no traumatizados Implementation of a management protocol for massive bleeding reduces mortality in non-trauma patients: Results from a single centre audit. [Article in English, Spanish] Martínez-Calle N1, Hidalgo F2, Alfonso A1, Muñoz M3, Hernández M1, Lecumberri R1, Páramo JA4. Med Intensiva. 2016 Dec;40(9):550-559. doi: 10.1016/j.medin.2016.05.003. Epub 2016 Jul 15. Abstract OBJECTIVE: To audit the impact upon mortality of a massive bleeding management protocol (MBP) implemented in our center since 2007. DESIGN: A retrospective, single-center study was carried out. Patients transfused after MBP implementation (2007-2012, Group 2) were compared with a historical cohort (2005-2006, Group 1). BACKGROUND: Massive bleeding is associated to high mortality rates. Available MBPs are designed for trauma patients, whereas specific recommendations in the medical/surgical settings are scarce. PATIENTS: After excluding patients who died shortly (<6h) after MBP activation (n=20), a total of 304 were included in the data analysis (68% males, 87% surgical). INTERVENTIONS: Our MBP featured goal-directed transfusion with early use of adjuvant hemostatic medications. VARIABLES OF INTEREST: Primary endpoints were 24-h and 30-day mortality. Fresh frozen plasma-to-red blood cells (FFP:RBC) and platelet-to-RBC (PLT:RBC) transfusion ratios, time to first FFP unit and the proactive MBP triggering rate were secondary endpoints. RESULTS: After MBP implementation (Group 2; n=222), RBC use remained stable, whereas FFP and hemostatic agents increased, when compared with Group 1 (n=82). Increased FFP:RBC ratio (p=0.053) and earlier administration of FFP (p=0.001) were also observed, especially with proactive MBP triggering. Group 2 patients presented lower rates of 24-h (0.5% vs. 7.3%; p=0.002) and 30-day mortality (15.9% vs. 30.2%; p=0.018) - the greatest reduction corresponding to non-surgical patients. Logistic regression showed an independent protective effect of MBP implementation upon 30-day mortality (OR=0.3; 95% CI 0.15-0.61). CONCLUSIONS: These data suggest that the implementation of a goal-directed MBP for prompt and aggressive management of non-trauma, massive bleeding patients is associated to reduced 24-h and 30-day mortality rates. KEYWORDS: Hemorragia no traumática; Hemostasia; Hemostatics; Massive bleeding protocol; Mortalidad; Mortality; Non-trauma bleeding; Protocolo de hemorragia masiva; Tasa transfusional; Transfusion ratio PDF  Uso del protocolo de transfusión masiva en pacientes civiles con y sin trauma. ¿Qué se puede hacer mejor? The use of massive transfusion protocol for trauma and non-trauma patients in a civilian setting: what can be done better? Wijaya R1, Cheng HM2, Chong CK1. Singapore Med J. 2016 May;57(5):238-41. doi: 10.11622/smedj.2016088.Abstract INTRODUCTION: Massive transfusion protocol (MTP) is increasingly used in civilian trauma cases to achieve better haemostatic resuscitation in patients requiring massive blood transfusions (MTs), with improved survival outcomes. However, in non-trauma patients, evidence for MTP is lacking. This study aims to assess the outcomes of a newly established MTP in a civilian setting, for both trauma and non-trauma patients, in an acute surgical care unit. METHODS: A retrospective cohort analysis was performed on 46 patients for whom MTP was activated in Changi General Hospital, Singapore. The patients were categorised into trauma and non-trauma groups. Assessment of Blood Consumption (ABC) score was used to identify MTP trauma patients and analyse over-activation rates. RESULTS: Only 39.1% of all cases with MTP activation eventually received MTs; 39.8% of the MTs were for non-trauma patients. Mean fresh frozen plasma to packed red blood cells (pRBC) ratio achieved with MTP was 0.741, while mean platelet to pRBC ratio was 0.213. The 24-hour mortality rate for all patients who received an MT upon MTP activation was 33.3% (trauma vs. non-trauma group: 45.5% vs. 14.3%). The ABC scoring system used for trauma patients had a sensitivity and specificity of 81.8% and 41.2%, respectively. CONCLUSION: MTP may be used for both trauma and non-trauma patients in acute care surgery. Scoring systems to predict the need for an MT, improved compliance to predefined transfusion ratios and regular reviews of the MTP are necessary to optimise MTPs and to improve the outcomes of patients receiving MTs. KEYWORDS: blood components; massive transfusion protocol; mortality; scoring system; trauma PDF Reanimación del trauma que requiere transfusión masiva: un análisis descriptivo del papel de la relación y del tiempo. Trauma resuscitation requiring massive transfusion: a descriptive analysis of the role of ratio and time. Peralta R1, Vijay A1, El-Menyar A2, Consunji R1, Abdelrahman H1, Parchani A1, Afifi I1, Zarour A3, Al-Thani H1, Latifi R4. World J Emerg Surg. 2015 Aug 14;10:36. doi: 10.1186/s13017-015-0028-3. eCollection 2015 Abstract OBJECTIVE: We aimed to evaluate whether early administration of high plasma to red blood cells ratios influences outcomes in injured patients who received massive transfusion protocol (MTP).  CONCLUSIONS: Aggressive attainment of high FFP/PRBC ratios as early as 4 h post-injury can substantially improve outcomes in trauma patients. KEYWORDS: Massive transfusion protocol; Outcome; Transfusion ratio; Trauma PDF

Anestesiología y Medicina del Dolor 52 664 6848905 vwhizar@anestesia-dolor.org anestesia-dolor.org