The optimal succinylcholine dose for intubating
emergency patients: retrospective comparative study.
Ezzat A, Fathi E, Zarour A, Singh R, Abusaeda MO,
Hussien MM.
Anesthesia, ICU & Pain Management, Hamad General Hospital, Doha, Qatar.
Libyan J Med. 2011;6. doi: 10.3402/ljm.v6i0.7041. Epub 2011 Jul
14.
Abstract
BACKGROUND: Succinylcholine remains the drug of choice for satisfactory
rapid-sequence tracheal intubation. It is not clear from the literature why
the 1 mg/kg dose of succinylcholine has been traditionally used. The
effective dose (ED95) of succinylcholine is less than 0.3 mg/kg. The dose
of 1 mg/kg represents 3.5 to 4 times the ED(95). OBJECTIVES: To compare the
effect of the traditionally used 1 mg/kg of succinylcholine with lower
doses of 0.6 mg/kg and 0.45 mg/kg on intubation condition regarding the
onset time, duration of action, duration of abdominal fasciculation, and
the intubation grading. METHODS: This retrospective comparative study was
carried into three groups of ASA III & IV (American Society of
Anesthesiologist's Physical Status III and IV) non-prepared emergency
patients who were intubated at emergency department of Hamad General
Hospital, Doha, Qatar during January 1st 2007 to August 31, 2010. The
Institutional Research Board (IRB) approval was obtained. This study was
limited to 88 patients who received fentanyl 1µg/kg followed by etomidate
0.3 mg/kg intravenously as induction agents and succinylcholine as a muscle
relaxant agent in doses of 0.45 mg/kg, 0.6 mg/kg, or 1 mg/kg. RESULTS: Increasing
the succinylcholine dosage shortened the onset time, prolonged the duration
of action, and prolonged the duration of abdominal fasciculation
significantly (P<.001). Tracheal intubation was 100% successful in the
three groups of patients. CONCLUSION: Succinylcholine dose of 0.45 mg/kg
provides an optimal intubation condition in ASA III & IV emergency
non-prepared patients. Duration of action of succinylcholine is dose
dependent; reducing the dose allows a more rapid return of spontaneous respiration
and airway reflexes.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139274/pdf/LJM-6-7041.pdf
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