jueves, 23 de junio de 2011

GABA: ¿dualidad funcional? Transición durante el neurodesarrollo


GABA: ¿dualidad funcional? Transición durante el neurodesarrollo
Celso Cortes-Romero, Fabian Galindo, Salvador Galicia-Isasmendi, Amira Flores
Rev Neurol 2011; 52 (11): 665-675
Introducción. El acido gamma-aminobutírico (GABA) es el principal neurotransmisor de tipo inhibitorio y sus acciones son mediadas por receptores de tipo inotrópico (GABAA) y metabotropico (GABAB), ampliamente distribuidos en el tejido nervioso central. Objetivo. Revisar la estructura de los receptores GABA y su implicación en procesos fisiológicos en el sistema nervioso central. Desarrollo. Se aborda el estudio de la estructura y diversidad de los receptores GABA, especialmente durante el neurodesarrollo, y se hace referencia a la naturaleza excitatoria e inhibitoria de la transmisión gabergica, donde la participación de los
cotransportadores NKCC1 y KCC2 tiene un papel clave en dicha dualidad funcional en la transición de un estadio embrionario a uno posnatal. De igual forma, se plasma el interés por los receptores GABA como diana farmacológica de uso clínico, lo que se manifiesta por la presencia de sitios de modulación alostérica poco explorados en dicho complejo-receptor. Conclusiones. El conocimiento fisiológico y farmacológico de la gran diversidad de subunidades que conforman un determinado subtipo de receptor GABA, así como la correcta expresión en tiempo y espacio para garantizar la viabilidad de un organismo, prometen ser la respuesta a trastornos graves y anejos como la epilepsia o la drogadicción, y tan complejos como el neurodesarrollo.
Palabras clave. Alcohol. Benzodiacepinas. Cloro. KCC2. Neurodesarrollo. NKCC1. Nocicepcion. Receptores GABA.

http://www.neurologia.com/pdf/Web/5211/bf110665.pdf  

Atentamente
Anestesiología y Medicina del Dolor

BIBLIOTECA MEDICA


BIBLIOTECA MEDICA



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