Midazolam

Abril 4, 2017. No. 2649

¿Se puede mejorar la calidad de la recuperación mediante la premedicación con midazolam ?: Estudio prospectivo, aleatorizado, doble ciego, en mujeres sometidas a cirugía mamaria. Can quality of recovery be enhanced by premedication with midazolam?: A prospective, randomized, double-blind study in females undergoing breast surgery. Kim MH1, Kim MS, Lee JH, Seo JH, Lee JR. Medicine (Baltimore). 2017 Feb;96(7):e6107. doi: 10.1097/MD.0000000000006107. Abstract BACKGROUND: Preoperative anxiety is known to be related with the postoperative outcomes, although it remains unclear whether pharmacologic anxiolysis preoperatively leads to better postanesthesia recovery. Hence, the purpose of this study was to assess whether midazolam premedication would result in improved Quality of Recovery-40 survey scores, as a postoperative recovery parameter, in female patients undergoing mastectomy. CONCLUSION: Midazolam premedication does not seem to improve the postoperative quality of recovery, though group M showed faster induction and less propofol consumption. PDF Curso sobre Anestesia en Trasplantes, Cirugía abdominal, Plástica, Oftalmología y Otorrinolaringología. Committee for European Education in Anaesthesiology (CEEA)  y el Colegio de Anestesiólogos de León A.C. Abril 7-9, 2017, León Guanajuato, México Informes  (477) 716 06 16, kikinhedz@gmail.com Vacante para Anestesiología Pediátrica El Hospital de Especialidades Pediátricas de León, Guanajuato México ofrece una base en el departamento de anestesiología  Informes con la Dra Angélica García Álvarez  angy.coachanestped@gmail.com o al teléfono 477 101 8700 Ext 1028

Anestesiología y Medicina del Dolor 52 664 6848905 vwhizar@anestesia-dolor.org anestesia-dolor.org

Enero 23, 2017. No. 2578

Dexmedetomidina versus midazolam en sedación para procedimientos. Revisión sistemática de eficacia y seguridad Dexmedetomidine versus Midazolam in Procedural Sedation. A Systematic Review of Efficacy and Safety. Barends CR1, Absalom A1, van Minnen B2, Vissink A2, Visser A2. PLoS One. 2017 Jan 20;12(1):e0169525. doi: 10.1371/journal.pone.0169525. eCollection 2017. Abstract OBJECTIVES: To systematically review the literature comparing the efficacy and safety of dexmedetomidine and midazolam when used for procedural sedation. MATERIALS AND METHODS: We searched MEDLINE, EMBASE and COCHRANE for clinical trials comparing dexmedetomidine and midazolam for procedural sedation up to June 20, 2016. Inclusion criteria: clinical trial, human subjects, adult subjects (≥18 years), article written in English, German, French or Dutch, use of study medication for conscious sedation and at least one group receiving dexmedetomidine and one group receiving midazolam. Exclusion criteria: patients in intensive care, pediatric subjects and per protocol use of additional sedative medication other than rescue medication. Outcome measures for efficacy comparison were patient and clinician satisfaction scores and pain scores; outcome measures for safety comparison were hypotension, hypoxia, and circulatory and respiratory complications. RESULTS: We identified 89 papers, of which 12 satisfied the inclusion and exclusion criteria; 883 patients were included in these studies. Dexmedetomidine was associated with higher patient and operator satisfaction than midazolam. Patients receiving dexmedetomidine experienced less pain and had lower analgesic requirements. Respiratory and hemodynamic safety were similar. CONCLUSIONS: Dexmedetomidine is a promising alternative to midazolam for use in procedural sedation. Dexmedetomidine provides more comfort during the procedure for the patient and clinician. If carefully titrated, the safety profiles are similar. PDF Comparación de sedación con midazolam-ketamina versus propofol-fentanil durante endoscopía en niños A comparison of sedation with midazolam-ketamine versus propofol-fentanyl during endoscopy in children: a randomized trial. Akbulut UE1, Saylan S, Sengu B, Akcali GE, Erturk E, Cakir M. Eur J Gastroenterol Hepatol. 2017 Jan;29(1):112-118. Abstract PURPOSE: We aimed to compare the efficacy and safety of midazolam plus ketamine versus fentanyl plus propofol combination administered to children undergoing upper gastrointestinal endoscopy (UGE) and to determine the most appropriate sedation protocol. CONCLUSION: In children, UGE procedures can be quite comfortable when using the midazolam-ketamine combination. However, adverse effects related to ketamine were observed during recovery. PDF Concentraciones plasmáticas de midazolam después de premedicación anestésica en la rutina clínica. Midazolam plasma concentration after anesthesia premedication in clinical routine - an observational study : Midazolam plasma concentration after anesthesia premedication. Steiner C1, Steurer MP2, Mueller D3, Zueger M4, Dullenkopf A5. BMC Anesthesiol. 2016 Oct 24;16(1):105. Abstract BACKGROUND: Midazolam is commonly used as a pre-anesthesia anxiolytic. It`s elimination may not be fast enough for short procedures. In orally premedicated patients we obtained midazolam plasma concentrations at the end of surgical procedures and compared those to concentrations at anesthesia induction.  CONCLUSIONS: The elimination half-life of oral Midazolam can lead to higher plasma levels at the end of a short procedure compared to those at induction of anesthesia. KEYWORDS: Anesthesia; Anxiolysis; Midazolam; Premedication PDF Regional Anesthesiology and Acute Pain Medicine Meeting April 6-8, 2017, San Francisco, California, USA ASRA American Society of Regional Anesthesia and Pain Medicine Información / Information California Society of Anesthesiologists Annual Meeting April 27-30, 2017 San Francisco California Información / Information

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