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Prevalencia de baja saturación venosa central de oxígeno en las primeras horas de ingreso en UCI y la mortalidad asociada en pacientes con shock séptico: un estudio multicéntrico prospectivo
Prevalence of low central venous oxygen saturation in the first hours of intensive care unit admission and associated mortality in septic shock patients: a prospective multicentre study.
Boulain T, Garot D, Vignon P, Lascarrou J, Desachy A, Botoc V, Follin A, Frat J, Bellec F, Quenot JP, Mathonnet A, Dequin PF; for the Clinical Research in Intensive Care and Sepsis Group.
Crit Care. 2014 Nov 6;18(6):609.
INTRODUCTION: In septic shock patients, the prevalence of low (<70%) central venous oxygen saturation (ScvO2) on admission to the intensive care unit (ICU) and its relationship to outcome are unknown. The objectives of the present study were to estimate the prevalence of low ScvO2 in the first hours of ICU admission and to assess its potential association with mortality in patients with severe sepsis or septic shock. METHODS: This was a prospective, multicentre, observational study conducted over a one-year period in ten French ICUs. Clinicians were asked to include patients with severe sepsis or septic shock preferably within 6 hours of ICU admission and as soon as possible without changing routine practice. ScvO2 was measured at inclusion and 6 hours later (H6), by blood sampling. ..... CONCLUSIONS: Low ScvO2 was common in the first hours of admission to the ICU for severe sepsis or septic shock even when clinical resuscitation endpoints were achieved and even when arterial lactate was normal. A ScvO2 below 70% in the first hours of ICU admission and six hours later was associated with day-28 mortality.