Dolor experimental y analgesia opioide en voluntarios con alto riesgo de apnea obstructiva del sueño
Experimental pain and opioid analgesia in volunteers at high risk for obstructive sleep apnea.
Doufas AG, Tian L, Padrez KA, Suwanprathes P, Cardell JA, Maecker HT, Panousis P.
Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, United States of America ; Outcomes Research Consortium, the Cleveland Clinic, Cleveland, Ohio, United States of America.
PLoS One. 2013;8(1):e54807. doi: 10.1371/journal.pone.0054807. Epub 2013 Jan 29.
Abstract
BACKGROUND: Obstructive sleep apnea (OSA) is characterized by recurrent nocturnal hypoxia and sleep disruption. Sleep fragmentation caused hyperalgesia in volunteers, while nocturnal hypoxemia enhanced morphine analgesic potency in children with OSA. This evidence directly relates to surgical OSA patients who are at risk for airway compromise due to postoperative use of opioids. Using accepted experimental pain models, we characterized pain processing and opioid analgesia in male volunteers recruited based on their risk for OSA. ......CONCLUSIONS: Nocturnal hypoxemia in subjects at high risk for OSA was associated with an increased potency of opioid analgesia. A serum hypoxia marker (IGFBP-1) was associated with hypoalgesia and increased potency to opioid analgesia; other pro-inflammatory mediators also predicted an enhanced opioid potency.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558510/pdf/pone.
0054807.pdf
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0054807
Atentamente
Anestesiología y Medicina del Dolor
www.anestesia-dolor.org
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