martes, 5 de abril de 2016

Sugammadex


Abril 5, 2016. No. 2275


 



Sugammadex para revertir bloqueo neuromuscular inducido por vecuronio en cirugía intracraneal
The use of sugammadex for the reversal of vecuronium-induced neuromuscular block following intracranial surgery.
Anaesthesiol Intensive Ther. 2015;47(4):297-302. doi: 10.5603/AIT.2015.0042.
Abstract
BACKGROUND: Total intravenous anaesthesia with propofol and remifentanil is widely used in neuroanaesthesiology and enables the quick recovery and early neurological assessment of patients. The administration of muscle relaxants carries a risk of residual relaxation following surgery. The administration of a suitable dose of sugammadex reverses the neuromuscular block irrespective of its depth and has none of the side effects associated with acetylcholinesterase inhibitors. The aim of the present study was to evaluate the usefulness of sugammadex for the reversal ofvecuronium-induced effects following intracranial surgery. 
CONCLUSION: The use of sugammadex following craniotomy accelerates the achievement of optimal extubation conditions.
KEYWORDS:craniotomy; neuromuscular block; reversal agent; sugammadex; target-controlled infusion
Sugammadex. Un droga revolucionaria en farmacología neuromuscular
Sugammadex: A revolutionary drug in neuromuscular pharmacology.
Anesth Essays Res. 2013 Sep-Dec;7(3):302-6. doi: 10.4103/0259-1162.123211.
Abstract
Sugammadex (ORG 25969) is a unique neuromuscular reversal drug; a novel cyclodextrin, the first in a new class of selective relaxant binding agents, which reverse neuromuscular blockade (NMB) with the aminosteroid non-depolarizing muscle relaxants rocuronium and vecuronium.Sugammadex can reverse moderate or deep NMB. The clinical use of sugammadex promises to eliminate many of the shortcomings in current anesthetic practice with regard to antagonism of rocuronium and other aminosteroid muscle relaxants.
KEYWORDS: Encapsulation; residual paralysis; rocuronium; selective relaxant binding agent; sugammadex
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