jueves, 19 de enero de 2017

Dexmedetomidina / Dexmedetomidine

Enero 19, 2017. No. 2574

Eficacia de la dexmedetomidina-remifentanil versus dexmedetomidina-propofol en niños programados para broncoscopía flexible
The efficacy of dexmedetomidine-remifentanil versus dexmedetomidine-propofol in children undergoing flexible bronchoscopy: A retrospective trial.
Medicine (Baltimore). 2017 Jan;96(1):e5815. doi: 10.1097/MD.0000000000005815.
Flexible bronchoscopy has been more and more used for diagnosis and management diseases of respiratory system in pediatrics. Previous studies have reported that remifentanil (RF) and propofol are safe and effective for flexible bronchoscopy in adults, however, there have no trials evaluate the efficacy of DEX-RF versus dexmedetomidine-propofol in children undergoing flexible bronchoscopy.
DEX-RF resulted in more stable hemodynamic profiles and bronchoscopist-satisfaction scores, lesser patient movements, and can hence be more effectively used in children undergoing flexible bronchoscopy than dexmedetomidine-propofol.

Dexmedetomidina previene nausea y vomito postoperatorios en pacientes con anestesia general
Dexmedetomidine prevent postoperative nausea and vomiting on patients during general anesthesia: A PRISMA-compliant meta analysis of randomized controlled trials.
Medicine (Baltimore). 2017 Jan;96(1):e5770. doi: 10.1097/MD.0000000000005770.
BACKGROUND: Postoperative nausea and vomiting (PONV) is a frequent complication in postoperative period. The aim of this article was to evaluate the effect of dexmedetomidine on PONV. 
CONCLUSIONS: Dexmedetomidine administrated in continuous infusion mode has the advantage to prevent PONV as well as reduce side effects such as bradycardia and hypotension.

Uso de alfa2 agonistas en neuroanestesia. Una revisión
Use of α(2)-Agonists in Neuroanesthesia: An Overview.
Ochsner J. 2011 Spring;11(1):57-69.
α(2)-Agonists are a novel class of drugs with mechanisms of action that differ from other commonly used anesthetic drugs. They have neuroprotective, cardioprotective, and sedative effects. These unique characteristics make them potentially useful during neuroanesthesia and intensive care. We review the effects of dexmedetomidine on cerebral blood flow and cerebral metabolism, along with recent advances in using α(2)-agonists in neuroanesthesia and neurointensive care.
KEYWORDS: Alpha-2 agonist; anesthesia; dexmedetomidine; neuroanesthesia; neuroprotection
5to curso internacional Anestesiologia cardiotoracica_ vascular_ ecocardiografia y circulaci_n extracorporea.

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