lunes, 22 de enero de 2018

Dolor en pediatría / Pediatric pain

Enero 20, 2018. No. 2969
Los enfoques metodológicos actuales en la evaluación de la modulación condicionada del dolor en pediatría.
Current methodological approaches in conditioned pain modulation assessment in pediatrics.
Hwang PS1, Ma ML1,2,3, Spiegelberg N1, Ferland CE1,2,3,4,5.
J Pain Res. 2017 Dec 12;10:2797-2802. doi: 10.2147/JPR.S150857. eCollection 2017.
Conditioned pain modulation (CPM) paradigms have been used in various studies with healthy and non-healthy adult populations in an attempt to elucidate the mechanisms of pain processing. However, only a few studies so far have applied CPM in pediatric populations. Studies finding associations with chronic pain conditions suggest that deficiencies in underlying descending pain pathways may play an important role in the development and persistence of pain early in life. Twelve studies were identified using a PubMed search which examine solely pediatric populations, and these are reviewed with regard to demographics studied, methodological approaches, and conclusions reached. This review aimed to provide both clinicians and researchers with a brief overview of the current state of research regarding the use of CPM in children and adolescents, both healthy and clinical patients. The implications of CPM in experimental and clinical settings and its potential to aid in refining considerations to individualize treatment of pediatric pain syndromes will be discussed.
KEYWORDS: chronic pain; conditioned pain modulation; descending endogenous pain inhibition; pediatrics
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