lunes, 21 de septiembre de 2015

Sugammadex

No. 2035                                                                                  
Uso de sugammadex en quemados. Estudio descriptivo
Use of sugammadex on burn patients: descriptive study.
Braz J Anesthesiol. 2015 Jul-Aug;65(4):240-3. doi: 10.1016/j.bjane.2014.10.001. Epub 2015 Jun 7.
Abstract
OBJECTIVES: A burn patient is a challenge for any anesthesiologist, undergoing several surgeries during admission, and requiring general anesthesia and muscle relaxation most of the times. The victim may have respiratory system impairment and a response to muscle relaxants that differs from the healthy patient, thus proper monitoring and reversal is crucial. We analyzed sugammadex effectiveness and safety in this population. MATERIALS AND METHODS: It was a prospectively descriptive study, including 4 patients, and all of them were considered major burn patients, who underwent escharotomy with general anesthesia and neuromuscular relaxation. The main variable was the time for recovery of a TOF higher than 0.9 after the administration of sugammadex before extubation. RESULTS: Mean time of recovery from a TOF ratio higher than 0.9 following the administration of Sugammadex was of 4.95min 95% CI (3.25-6.64, p=.53). CONCLUSIONS: The reversion of neuromuscular relaxation with sugammadex appears to be effective and safe in the burn patient. More analytical, comparative studies of larger populations would be necessary to confirm these data.
KEYWORDS: Bloqueio neuromuscular; Burn injury; Cyclodextrin; Gama-Ciclodextrinas; Neostigmina; Neostigmine; Neuromuscular block; Queimaduras; Rocuronium; Rocurônio; Sugammadex

La influencia de hipotermia moderada sobre la reversión del bloqueo neuromuscular profundo por rocuronio con sugammadex
The influence of mild hypothermia on reversal of rocuronium-induced deep neuromuscular block with sugammadex.
BMC Anesthesiol. 2015 Jan 21;15:7. doi: 10.1186/1471-2253-15-7.
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Beneficios y riesgos de sugammadex
Benefits and risks of sugammadex.
Korean J Anesthesiol. 2015 Feb;68(1):1-2. doi: 10.4097/kjae.2015.68.1.1.
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Atentamente
Anestesia y Medicina del Dolor
Safe Anesthesia World Wide  

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