Estudio randomizado, controlado sobre la efectividad de midazolam intraarticular versus midazolam i.v. en dolor después de artroscopía
A randomized controlled trial for the effectiveness of intraarticular versus intravenous midazolam on pain after knee arthroscopy.
Sajedi P, Nemati M, Mosavi SH, Honarmand A, Safavi MR.
J Res Med Sci. 2014 May;19(5):439-44.
Abstract
BACKGROUND: This double-blinded, randomized clinical trial was designed to evaluate the comparison of intravenous versus intraarticular (IA) administration of midazolam on postoperative pain after knee arthroscopy. MATERIALS AND METHODS: In this study, 75 patients randomized in three groups to receive 75 mc/kg IA injection of midazolam and 10 ml intravenous injection of isotonic saline (Group I), 75 mc/kg intravenous injection of midazolam and 10 cc IA injection of isotonic saline (Group II) or IA and intravenous injection of isotonic saline (Group III) at the end of knee arthroscopy. Pain scores, time until the first request for analgesics, cumulative analgesic consumption, satisfaction, sedation, and complications as studied outcomes were assessed. Patients were observed for 24-h. RESULTS: IA administration of midazolam significantly reduced pain scores in the early postoperative period compared with intravenous injection. Mean of time to first analgesic requirement in Group III (33.6 min) was significantly lower than Group II (288.8 min) and Group I (427.5 min). Cumulative analgesic consumption was increased in Groups II (35.5 mg), and III (70 mg) compared with Group I (16 mg), (P < 0.0001). Complications significantly occurred in 3 of 25 patients in Group I in contrast to 20 of 25 patients in Group III (P < 0.0001). At 2-, 4- and 8-h after arthroscopy pain score significantly decreased in Group I than other groups (P < 0.0001). Patients in Group I were significantly satisfy than other groups (P < 0.0001). CONCLUSION: Results show the greater analgesic effect after IA administration of midazolam than after intravenous injection and hence, IA administration may be is the method of choice for pain relief after knee arthroscopy.
KEYWORDS: Intraarticular administration; knee arthroscopy; midazolam; postoperative pain
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116576/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116576/?report=classic
Efecto analgésico de midazolam cuando se agrega a lidocaína i.v. para anestesia regional intravenosa
The analgesic effect of midazolam when added to lidocaine for intravenous regional anaesthesia.
Kashefi P, Montazeri K, Honarmand A, Safavi M, Hosseini HM.
J Res Med Sci. 2011 Sep;16(9):1139-48.
Abstract
BACKGROUND:Midazolam has analgesic properties. The aim of the present study was to assess the analgesic effect of midazolam when added tolidocaine in intravenous regional anesthesia (IVRA). METHODS: Sixty patients undergoing hand surgery were randomly allocated into two groups to receive 3 mg/kg 2% lidocaine diluted with saline to a total volume of 40 mL in the control group (group lidocaine saline ~ LS, n=30) or 50 μg/kg midazolam plus 3 mg/kg 2% lidocaine diluted with saline to a total volume of 40 mL in the midazolam group (group lidocaine midazolam ~ LM, n=30). Before and after the tourniquet application, hemodynamic variables, tourniquet pain, sedation, and analgesic use were recorded.RESULTS:
Shortened sensory and motor block onset time [4.20 (0.84) vs. 5.94 (0.83) min, p = 0.001 and 6.99 (0.72) vs. 9.07 (0.99) min, p = 0.001 in LM and LS groups, respectively], prolonged sensory and motor block recovery times [8.41 (0.94) vs. 5.68 (0.90) min, p = 0.001 and 11.85 (1.18) vs. 7.06 (0.82) min, p = 0.001 in LM and LS groups, respectively], shortened visual analog scale (VAS) scores of tourniquet pain (p < 0.05), and improved quality of anesthesia were found in group LM (p < 0.05). VAS scores were lower in group LM in the postoperative period (p = 0.001). Postoperativeanalgesic requirements were significantly smaller in group LM (p = 0.001). CONCLUSIONS: The addition of 50 μg/kg midazolam to lidocaine for IVRA shortens the onset of sensory and motor block, and improves quality of anesthesia and perioperative analgesia without causing side effects.
KEYWORDS: Anaesthetic Techniques; Analgesics; IV Regional Lidocaine; Midazolam; Postoperative; Tourniquet Pain
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430038/
Atentamente
Anestesiología y Medicina del Dolor
www.anestesia-dolor.org
Fiabilidad de la escala estado físico de la American Society of Anesthesiologists en la práctica clínica.
Reliability of the American Society of Anesthesiologists physical status scale in clinical practice.
Sankar A, Johnson SR, Beattie WS, Tait G, Wijeysundera DN.
Br J Anaesth. 2014 Sep;113(3):424-32. doi: 10.1093/bja/aeu100. Epub 2014 Apr 11.
Abstract
BACKGROUND: Previous studies, which relied on hypothetical cases and chart reviews, have questioned the inter-rater reliability of the ASA physicalstatus (ASA-PS) scale. We therefore conducted a retrospective cohort study to evaluate its inter-rater reliability and validity in clinical practice. METHODS: The cohort included all adult patients (≥18 yr) who underwent elective non-cardiac surgery at a quaternary-care teaching institution in Toronto, Ontario, Canada, from March 2010 to December 2011. We assessed inter-rater reliability by comparing ASA-PS scores assigned at the preoperative assessment clinic vs the operating theatre. We also assessed the validity of the ASA-PS scale by measuring its association with patients' preoperative characteristics and postoperative outcomes. RESULTS: The cohort included 10 864 patients, of whom 5.5% were classified as ASA I, 42.0% as ASA II, 46.7% as ASA III, and 5.8% as ASA IV. The ASA-PS score had moderate inter-rater reliability (κ 0.61), with 67.0% of patients (n=7279) being assigned to the same ASA-PS class in the clinic and operating theatre, and 98.6% (n=10 712) of paired assessments being within one class of each other. The ASA-PS scale was correlated with patients' age (Spearman's ρ, 0.23), Charlson comorbidity index (ρ=0.24), revised cardiac risk index (ρ=0.40), and hospital length of stay (ρ=0.16). It had moderate ability to predict in-hospital mortality (receiver-operating characteristic curve area 0.69) and cardiac complications (receiver-operating characteristic curve area 0.70).
CONCLUSIONS: Consistent with its inherent subjectivity, the ASA-PS scale has moderate inter-rater reliability in clinical practice. It also demonstrates validity as a marker of patients' preoperative health status.
http://bja.oxfordjournals.org/content/113/3/424.full.pdf
Variabilidad de la escala de estado físico de la American Society of Anesthesiologists
Variability in the American Society of Anesthesiologists Physical Status Classification Scale.
Aronson WL, McAuliffe MS, Miller K.
AANA J. 2003 Aug;71(4):265-74.
Abstract
The American Society of Anesthesiologists (ASA) Physical Status (PS) Classification is used worldwide by anesthesia providers as an assessment of the preoperative physical health of patients. This score also has been used in policy-making, performance evaluation, resource allocation, and reimbursement of anesthesia services and frequently is cited in clinical research. The purpose of this study was to assess interrater reliability and describe sources of variability among anesthesia providers in assigning ASA PS scores. A questionnaire with 10 hypothetical patients scenarios was given to 70 anesthesia providers who were asked to assign ASA PS scores in each scenario and to provide rationale for their decisions. The data were summarized and stratified according to nurse anesthetist or anesthesiologist and military or nonmilitary anesthesia providers. We hypothesized there would be no difference between any of the anesthesia provider groups in assignment of ASA PS scores. A lack of interrater reliability in assigning ASA PS scores was demonstrated. There were no significant differences between the anesthesia provider groups. There was no correlation between ASA PS scoring and years practicing or any of the other demographic variables. Several sources of variability were identified: smoking, pregnancy, nature of the surgery, potential difficult airway, and acute injury.
http://www.aana.com/newsandjournal/documents/p265-274.pdf
Clasificación del estado físico de la American Society of Anaesthesiologists
American Society of Anaesthesiologists physical status classification.
Daabiss M.
Indian J Anaesth [serial online] 2011 [cited 2014 Aug 21];55:111-5.
Abstract
Although the American Society of Anaesthesiologists' (ASA) classification of Physical Health is a widely used grading system for preoperative health of the surgical patients, multiple variations were observed between individual anaesthetist's assessments when describing common clinical problems. This article reviews the current knowledge and evaluation regarding ASA Classification of Physical Health as well as trials for possible modification.
http://medind.nic.in/iad/t11/i2/iadt11i2p111.pdf
http://www.ijaweb.org/text.asp?2011/55/2/111/79879
http://www.ijaweb.org/article.asp?issn=0019-5049;year=2011;volume=55;issue=2;spage=111;epage=115;aulast=Daabiss
Atentamente
Anestesiología y Medicina del Dolor
www.anestesia-dolor.org
Biblioteca
Notificaciones diarias ⋅ 27 de agosto de 2014
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Práctica actual y recomendaciones para la valoración cardiaca preoperatoria en pacientes con cirugía no cardiaca
Current Practice and Recommendation for Presurgical Cardiac Evaluation in Patients Undergoing Noncardiac Surgeries.
Padma S, Sundaram P S.
World J Nucl Med [serial online] 2014 [cited 2014 Aug 12];13:6-15.
Abstract
The increasing number of patients with coronary artery disease (CAD) undergoing major noncardiac surgery justifies guidelines concerning preoperative cardiac evaluation. This is compounded by increasing chances for a volatile perioperative period if the underlying cardiac problems are left uncorrected prior to major noncardiac surgeries. Preoperative cardiac evaluation requires the clinician to assess the patient's probability to have CAD, severity and stability of CAD, placing these in perspective regarding the likelihood of a perioperative cardiac complication based on the planned surgical procedure. Coronary events like new onset ischemia, infarction, or revascularization, induce a high-risk period of 6 weeks, and an intermediate-risk period of 3 months before performing noncardiac surgery. This delay is unwarranted in cases where surgery is the mainstay of treatment. The objective of this review is to offer a comprehensive algorithm in the preoperative assessment of patients undergoing noncardiac surgery and highlight the importance of myocardial perfusion imaging in risk stratifying these patients.
Keywords: Cardiac risk stratification, coronary artery disease, heart, noncardiac surgeries, stress myocardial perfusion imaging, surgery
http://www.wjnm.org/temp/WorldJNuclMed1316-4797246_131932.pdf
http://www.wjnm.org/downloadpdf.asp?issn=1450-1147;year=2014;volume=13;issue=1;spage=6;epage=15;aulast=Padma;type=2
http://www.wjnm.org/text.asp?2014/13/1/6/138568
Atentamente
Anestesiología y Medicina del Dolor
www.anestesia-dolor.org
E-Books
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Efectos de dexmedetomidina intravenosa sobre bupivacaína hiperbárica espinal. Estudio radomizado
Effects of intravenous dexmedetomidine on hyperbaric bupivacaine spinal anesthesia: A randomized study.
Dinesh CN, Sai Tej NA, Yatish B, Pujari VS, Mohan Kumar RM, Mohan CV.
Saudi J Anaesth. 2014 Apr;8(2):202-8. doi: 10.4103/1658-354X.130719.
Abstract
BACKGROUND AND OBJECTIVES:The present study was designed to evaluate the effect of intravenous dexmedetomidine on spinal anesthesia with 0.5% of hyperbaric bupivacaine. MATERIALS AND METHODS:One hundred American Society of Anesthesiologists (ASA) physical status I/II patients undergoing elective surgeries under spinal anesthesia were randomized into two groups of 50 each. Immediately after subarachnoid block with 3 ml of 0.5% hyperbaric bupivacaine, patients in group D received a loading dose of 1 μg/kg of dexmedetomidine intravenously by infusion pump over 10 min followed by a maintenance dose of 0.5 μg/kg/h till the end of surgery, whereas patients in group C received an equivalent quantity of normal saline. RESULTS:The time taken for regression of motor blockade to modified Bromage scale 0 was significantly prolonged in group D (220.7 ± 16.5 min) compared to group C (131 ± 10.5 min) (P < 0.001). The level of sensory block was higher in group D (T 6.88 ± 1.1) than group C (T 7.66 ± 0.8) (P < 0.001). The duration for two-dermatomal regression of sensory blockade (137.4 ± 10.9 min vs. 102.8 ± 14.8 min) and the duration of sensory block (269.8 ± 20.7 min vs. 169.2 ± 12.1 min) were significantly prolonged in group D compared to group C (P < 0.001). Intraoperative Ramsay sedation scores were higher in group D (4.4 ± 0.7) compared to group C (2 ± 0.1) (P < 0.001). Higher proportion of patients in group D had bradycardia (33% vs. 4%) (P < 0.001), as compared to group C. The 24-h mean analgesic requirement was less and the time to first request for postoperative analgesic was prolonged in group D than in group C (P < 0.001). CONCLUSION: Intravenous dexmedetomidine significantly prolongs the duration of sensory and motor block of bupivacaine spinal anesthesia. The incidence of bradycardia is significantly higher when intravenous dexmedetomidine is used as an adjuvant to bupivacaine spinal anesthesia.Dexmedetomidine provides excellent intraoperative sedation and postoperative analgesia.
KEYWORDS:Dexmedetomidine; Ramsay sedation scale; hyperbaric bupivacaine; intrathecal; spinal anesthesia
http://www.saudija.org/downloadpdf.asp?issn=1658-354X;year=2014;volume=8;issue=2;spage=202;epage=208;aulast=Dinesh;type=2
Administración perineural de dexmedetomidina combinada con ropivacaína prolonga el bloqueo braquial axilar
Perineural administration of dexmedetomidine in combination with ropivacaine prolongs axillary brachial plexus block.
Zhang Y, Wang CS, Shi JH, Sun B, Liu SJ, Li P, Li EY.
Int J Clin Exp Med. 2014 Mar 15;7(3):680-5. eCollection 2014.
Abstract
To evaluate the hypothesis that adding dexmedetomidine to ropivacaine prolongs axillary brachial plexus block. Forty-five patients of ASA I~II and aged 25-60 yr who were scheduled for elective forearm and hand surgery were randomly divided into 3 equal groups and received 40 ml of 0.33% ropivacaine + 1 ml dexmedetomidine (50 μg) (Group DR1), 40 ml of 0.33% ropivacaine + 1 ml dexmedetomidine (100 μg) (group DR2) or 40 ml of 0.33% ropivacaine + 1 ml saline (group R) in a double-blind fashion. The onset and duration of sensory and motor blocks and side effects were recorded. The demographic data and surgical characteristics were similar in each group. Sensory and motor block onset times were the same in the three groups. Sensory and motor blockade durations were longer in group DR2 than in group R (P < 0.05). There was no significant difference in the sensory blockade duration between group DR1 and group R. Bradycardia, hypertension and hypotension were not observed in group R and occurred more often in group DR2 than in group DR1. Dexmedetomidine added to ropivacaine for an axillary brachial plexus block prolongs the duration of the block. However, dexmedetomidine may also lead to side effects such as bradycardia, hypertension, and hypotension.
KEYWORDS: Dexmedetomidine; brachial plexus; ropivacaine
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992408/pdf/ijcem0007-0680.pdf
Atentamente
Anestesiología y Medicina del Dolor
www.anestesia-dolor.org
Bibliotecas
Notificaciones semanales ⋅ 10 de agosto de 2014
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La cuantía a desembolsar correrá a cargo de los presupuestos de la biblioteca y no del Ministerio de Educación como hasta ahora.
Pago en las Bibliotecas Públicas: a más libros prestados, menos dinero para comprar nuevos -Vozpopuli
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Bibliotecas de la entidad son visitadas por 800 mil queretanos al año
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“A veces la equipación de las bibliotecas es muy complicada, porque cada centro de lectura es responsabilidad de cada municipio, lo que hemos ...
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Libro sobre Parestesias
Paresthesia
Edited by Luiz E. Imbelloni and Marildo A. Gouveia, ISBN 978-953-51-0085-0, 100 pages, Publisher: InTech, Chapters published February 29, 2012 under CC BY 3.0 license
DOI: 10.5772/1567
Paresthesias are spontaneous or evoked abnormal sensations of tingling, burning, pricking, or numbness of a person's skin with no apparent long-term physical effect. Patients generally describe a lancinating or burning pain, often associated with allodynia and hyperalgesia. The manifestation of paresthesia can be transient or chronic. Transient paresthesia can be a symptom of hyperventilation syndrome or a panic attack, and chronic paresthesia can be a result of poor circulation, nerve irritation, neuropathy, or many other conditions and causes. This book is written by authors that are respected in their countries as well as worldwide. Each chapter is written so that everyone can understand, treat and improve the lives of each patient.
http://www.intechopen.com/books/paresthesia
Parestesias y anestesia neuroaxial
Parestesias y déficits sensoriales en la pierna unilateral que surge después de la anestesia espinal por un tumor intramedular no reconocido
Paresthesia and sensory deficits on the unilateral leg arising from an unrecognized intramedullary tumor after spinal anesthesia.
Jeon DG, Kang BJ, Jeon SM.
Korean J Anesthesiol. 2013 May;64(5):472-3. doi: 10.4097/kjae.2013.64.5.472.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668114/pdf/kjae-64-472.pdf
Dirección de la inserción del catéter y la incidencia de parestesias durante anestesia peridural continua en ancianos
Direction of catheter insertion and the incidence of paresthesia during continuous epidural anesthesia in the elderly patients.
Kim JH, Lee JS, Kim DY.
Korean J Anesthesiol. 2013 May;64(5):443-7. doi: 10.4097/kjae.2013.64.5.443. Epub 2013 May 24.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668107/pdf/kjae-64-443.pdf
Factores en la insatisfacción de los pacientes y la negativa con respecto a la anestesia espinal.
Factors in patient dissatisfaction and refusal regarding spinal anesthesia.
Rhee WJ, Chung CJ, Lim YH, Lee KH, Lee SC.
Korean J Anesthesiol. 2010 Oct;59(4):260-4. doi: 10.4097/kjae.2010.59.4.260. Epub 2010 Oct 21.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966707/pdf/kjae-59-260.pdf
Atentamente
Anestesiología y Medicina del Dolor
www.anestesia-dolor.org
Consideraciones prácticas del tratamiento farmacológico de la neuralgia postherpética para el médico general
Practical considerations in the pharmacological treatment of postherpetic neuralgia for the primary care provider.
Massengill JS, Kittredge JL.
J Pain Res. 2014 Mar 10;7:125-32. doi: 10.2147/JPR.S57242. eCollection 2014.
Abstract
An estimated one million individuals in the US are diagnosed with herpes zoster (HZ; shingles) each year. Approximately 20% of these patients will develop postherpetic neuralgia (PHN), a complex HZ complication characterized by neuropathic pain isolated to the dermatome that was affected by the HZ virus. PHN is debilitating, altering physical function and quality of life, and commonly affects vulnerable populations, including the elderly and the immunocompromised. Despite the availability of an immunization for HZ prevention and several approved HZ treatments, the incidence of PHN is increasing. Furthermore, management of the neuropathic pain associated with PHN is often suboptimal, and the use of available therapeutics may be complicated by adverse effects and complex, burdensome treatment regimens, as well as by patients' comorbidities and polypharmacy, which may lead to drug-drug interactions. Informed and comprehensive assessments of currently available pharmacological treatment options to achieve effective pain control in the primary care setting are needed. In this article, we discuss the situation in clinical practice, review currently recommended prevention and treatment options for PHN, and outline practical considerations for the management of this neuropathic pain syndrome, with a focus on optimal, individual-based treatment plans for use in the primary care setting.
KEYWORDS:clinical practice; herpes zoster; pharmacological treatment; postherpetic neuralgia; practical guidelines; primary care
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956687/pdf/jpr-7-125.pdf
Prescripción de antivirales después de herpes zoster en medicina general. ¿Quién recibe tratamiento?
Prescription of antiviral therapy after herpes zoster in general practice: who receives therapy?
Forbes HJ, Thomas SL, Smeeth L, Langan SM.
Br J Gen Pract. 2012 Dec;62(605):e808-14. doi: 10.3399/bjgp12X659277.
Abstract
BACKGROUND: Antivirals can accelerate rash healing during an acute zoster episode and can limit the severity and duration of pain. Their use within 7 days of rash onset is recommended among specific patient groups. AIM: To describe antiviral prescription patterns and patient characteristics associated with antiviral receipt after zoster diagnosis. DESIGN AND SETTING:
Descriptive study and risk factor analysis using electronic healthcare records from UK general practice. METHOD: Incident adult zoster cases occurring between 2000 and 2011 were identified in the General Practice Research Database. Therapy records were searched for antiviral prescriptions of aciclovir, famciclovir, or valaciclovir within 7 days of zoster diagnosis. The proportion of incident zostercases receiving antivirals was calculated and multivariable logistic regression used to assess associations between patient characteristics and antiviral use. RESULTS: Of 142 216 incident zoster cases 58.1% received an antiviral prescription. The majority (69.0%) were aciclovir. The proportion receiving antiviral prescriptions increased with age up to 65 years, then declined to 56.8% among patients aged ≥85 years. Being female and of higher socioeconomic status were associated with higher antiviral receipt. Antivirals were more commonly prescribed to immunosuppressed patients withherpes zoster (odds ratio 1.27; 95% CI = 1.22 to 1.33), however they were not given routinely to this patient group. CONCLUSION: Antiviral therapies for zoster are under-prescribed in UK general practice even among groups, such as immunosuppressed and older individuals, for whom guidelines recommend treatment. Patients may present too late to receive treatment or physicians may decide that antivirals are not essential treatment. Consideration could be given to reviewing the guidelines.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505413/pdf/bjgp62-e808.pdf
Diagnóstico y tratamiento de la neuralgia postherpética
Diagnosing and managing postherpetic neuralgia.
Nalamachu S, Morley-Forster P.
Drugs Aging. 2012 Nov;29(11):863-9. doi: 10.1007/s40266-012-0014-3
Abstract
Postherpetic neuralgia (PHN) represents a potentially debilitating and often undertreated form of neuropathic pain that disproportionately affects vulnerable populations, including the elderly and the immunocompromised. Varicella zoster infection is almost universally prevalent, making prevention of acute herpes zoster (AHZ) infection and prompt diagnosis and aggressive management of PHN of critical importance. Despite the recent development of a herpes zoster vaccine, prevention of AHZ is not yet widespread or discussed in PHN treatment guidelines. Diagnosis of PHN requires consideration of recognized PHN signs and known risk factors, including advanced age, severe prodromal pain, severe rash, and AHZ location on the trigeminal dermatomes or brachial plexus. PHN pain is typically localized, unilateral and chronic, but may be constant, intermittent, spontaneous and/or evoked. PHN is likely to interfere with sleep and daily activities. First-line therapies for PHN include tricyclic antidepressants, gabapentin and pregabalin, and the lidocaine 5 % patch. Second-line therapies include strong and weak opioids and topical capsaicin cream or 8 % patch. Tricyclic antidepressants, gabapentinoids and strong opioids are effective but are also associated with systemic adverse events that may limit their use in many patients, most notably those with significant medical comorbidities or advanced age. Of the topical therapies, the topical lidocaine 5 % patch has proven more effective than capsaicin cream or 8 % patch and has a more rapid onset of action than the other first-line therapies or capsaicin. Given the low systemic drug exposure, adverse events with topical therapies are generally limited to application-site reactions, which are typically mild and transient with lidocaine 5 % patch, but may involve treatment-limiting discomfort with capsaicin cream or 8 % patch. Based on available clinical data, clinicians should consider administering the herpes zoster vaccine to all patients aged 60 years and older. Clinicians treating patients with PHN may consider a trial of lidocaine 5 % patch monotherapy before resorting to a systemic therapy, or alternatively, may consider administering the lidocaine 5 % patch in combination with a tricyclic antidepressant or a gabapentinoid to provide more rapid analgesic response and lower the dose requirement of systemic therapies.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693437/pdf/40266_2012_Article_14.pdf
Atentamente
Anestesiología y Medicina del Dolor
www.anestesia-dolor.org
Comparación de clonidina y dexmedetomidina para sedación por corto tiempo en la UCI
Comparison of clonidine and dexmedetomidine for short-term sedation of intensive care unit patients.
Srivastava U, Sarkar ME, Kumar A, Gupta A, Agarwal A, Singh TK, Badada V, Dwivedi Y.
Indian J Crit Care Med. 2014 Jul;18(7):431-6. doi: 10.4103/0972-5229.136071.
Abstract
BACKGROUND AND OBJECTIVES: Patients on mechanical ventilation in intensive care unit (ICU) are often uncomfortable because of anxiety, pain, and endotracheal intubation; therefore, require sedation. Alpha-2 agonists are known to produce sedation. We compared clonidine and dexmedetomidine as sole agents for sedation. STUDY DESIGN: Prospective, randomized, controlled open-label study. MATERIALS AND METHODS: A total of 70 patients requiring a minimum of 12 h of mechanical ventilation with concomitant sedation, were randomly allocated into two groups. Group C (n = 35) received intravenous (IV) clonidine (1 μg/kg/h titrated up to 2 μg/kg/h to attain target sedation), and Group D (n = 35) received IV dexmedetomidine for sedation (loading 0.7 μg/kg and maintenance 0.2 μg/kg/h titrated up to 0.7 μg/kg/h to achieve target sedation). A Ramsay Sedation Score of 3-4 was considered as target sedation. Additional sedation with diazepam was given when required to achieve target sedation. The quality of sedation, hemodynamic changes and adverse effects were noted and compared between the two groups. RESULTS: Target sedation was achieved in 86% observations in Group D and 62% in Group C (P = 0.04). Additional sedation was needed by more patients in Group C compared with Group D (14 and 8 in Groups C and D, respectively, P = 0.034), mainly due to concomitant hypotension on increasing the dose of clonidine. Hypotension was the most common side-effect in Group C, occurring in 11/35 patients of Group C and 3/35 patients of Group D (P = 0.02). Rebound hypertension was seen in four patients receiving clonidine, but none in receiving dexmedetomidine. CONCLUSION: Both clonidine and dexmedetomidine produced effective sedation; however, the hemodynamic stability provided by dexmedetomidine gives it an edge over clonidine for short-term sedation of ICU patients.
KEYWORDS:Clonidine; dexmedetomidine; intensive care unit sedation
http://www.ijccm.org/downloadpdf.asp?issn=0972-5229;year=2014;volume=18;issue=7;spage=431;epage=436;aulast=Srivastava;type=2
http://www.ijccm.org/temp/IJCCM187431-5422819_013022.pdf
Dexmedetomidina para intubación despierta y anestesia general libre de opioides en un paciente superobeso con sospecha de intubación difícil
Dexmedetomidine for awake intubation and an opioid-free general anesthesia in a superobese patient with suspected difficult intubation.
Gaszynski T, Gaszynska E, Szewczyk T.
Drug Des Devel Ther. 2014 Jul 7;8:909-12. doi: 10.2147/DDDT.S64587. eCollection 2014.
Abstract
Super-obese patients (body mass index [BMI] >50 kg/m(2)) are at a particularly high risk of anesthesia-related complications during postoperative period, eg, critical respiratory events including respiratory arrest, and over-sedation leading to problems with maintaining airway open, hypoxia and hypercapnia. In this paper authors present a case of a 39-year-old super-obese (BMI 62.3 kg/m(2)) female patient who was admitted for surgical treatment of obesity. Preanesthesia evaluation revealed hypertension and type 2 diabetes mellitus (DM) as comorbidities as well as potential for a difficult intubation- neck circumference of 46 cm, reduced neck mobility and DM type 2. Patient was intubated using "awake intubation" method using topical anesthesia and dexmedetomidine infusion. General anesthesia was maintained with sevoflurane and dexmedetomidine infusion instead of opioid administration in "opioid-free anesthesia method".
KEYWORDS:dexmedetomidine; morbid obesity; non-opioid anesthesia
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094577/pdf/dddt-8-909.pdf
Atentamente
Anestesiología y Medicina del Dolor
www.anestesia-dolor.org
EDITORIAL
La financiación privada en infraestructura de salud pública: llamado a publicar experiencias nacionales
Vivienne C. Bachelet (Chile)
Medwave 2014;14(7):e6009
http://dx.doiorg/10.5867/medwave.2014.07.6009
RESÚMENES EPISTEMONIKOS DE LA EVIDENCIA
¿Es efectivo el uso de quimioterapia perioperatoria en pacientes con cáncer gástrico resecable?
José Peña, Marcelo Garrido, Gabriel Rada (Chile)
Medwave 2014 Ago;14(7):e6008
http://dx.doiorg/10.5867/medwave.2014.07.6008
¿Es beneficiosa la profilaxis antibiótica en la pancreatitis aguda?
Gabriel Rada, José Peña (Chile)
Medwave 2014 Ago;14(7):e6004
http://dx.doiorg/10.5867/medwave.2014.07.6004
ESTUDIOS PRIMARIOS
Perfil lipídico en pacientes con diagnóstico reciente de cardiopatía isquémica: estudio transversal en 2012 y 2013, Hospital Luis Vernaza, Ecuador
Diego Antonio Vásquez Cedeño, Esteban Tamariz Amador, María Isabel Cevallos Abad (Ecuador)
Medwave 2014 Ago;14(7):e6007
http://dx.doiorg/10.5867/medwave.2014.07.6007
Características del uso de estimulación nerviosa eléctrica transcutánea en la Unidad del Dolor del Hospital Universitario Fundación Alcorcón
Andrea Isabel Martínez Tapia (Chile)
Medwave 2014 Ago;14(7):e6006
http://dx.doiorg/10.5867/medwave.2014.07.6006
PORTADA MEDWAVE
http://www.medwave.cl
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Combinación de ketofol-dexmedetomidina en terapia electroconvulsiva para depresión y aguitación
Ketofol-Dexmedetomidine combination in ECT: A punch for depression and agitation.
Shams T, El-Masry R.
Indian J Anaesth. 2014 May;58(3):275-80. doi: 10.4103/0019-5049.135037.
Abstract
BACKGROUND AND AIMS: The choice of anaesthetic agent for electroconvulsive therapy (ECT) depends on seizure duration, haemodynamic, and recovery parameters. The aim of the study was to assess the effects of ketamine-propofol induction with dexmedetomidine preadministration (ketofol-dex group) and without its preadministration (ketofol group) on haemodynamics, depression, seizure duration, recovery characteristics, and agitation following ECT in patients with depression. METHODS: 40 patients aged 18-60 years were scheduled for ECT for treatment of depression. Dexmedetomidine (0.5 μg/kg) diluted to a volume of 10 ml with 0.9% saline or 10 ml 0.9% saline were infused intravenously over 10 minutes before induction of anaesthesia with ketamine and propofol (ketofol). Statistical analysis was carried out using the Statistical Software for the Social Sciences (SPSS) package. RESULTS: Motor seizure duration in ketofol group was significantly less compared to ketofol-dex group (35.8 ± 6.6s versus 38.9 ± 4.9s). Total ketofol used was significantly less in ketofol-dex group compared to ketofol group (78.5 ± 10.8mg versus 90 ± 13.2mg). The number of patients with agitation score >2 was significantly lower in ketofol-dex group (1.4%) compared to ketofol group (8.6%). There was significant decrease (P = 0.000) in mean arterial pressure (MAP) and heart rate (HR) in ketofol-dex group compared to ketofol group at 20, 30, and 40 minutes for MAP and at 10, 20, 30, and 40 minutes for HR. CONCLUSIONS: Ketofol-dex mixture in ECT is associated with longer mean seizure duration, effective anti-depression, less incidence of agitation, more patient satisfaction, and acceptable decreases in blood pressure and HR when compared to ketofol alone.
KEYWORDS: Agitation; depression; dexmedetomidine; electroconvulsive therapy; ketofol
http://www.ijaweb.org/downloadpdf.asp?issn=0019-5049;year=2014;volume=58;issue=3;spage=275;epage=280;aulast=Shams;type=2
Comparación de dos esquemas de dosis de la dexmedetomidina por vía intravenosa en pacientes ancianos durante la anestesia espinal.
Comparison of two dosing schedules of intravenous dexmedetomidine in elderly patients during spinal anesthesia.
Park SH, Shin YD, Yu HJ, Bae JH, Yim KH.
Korean J Anesthesiol. 2014 May;66(5):371-6. doi: 10.4097/kjae.2014.66.5.371. Epub 2014 May 26.
Abstract
BACKGROUND:As the number of elder patients grows, spinal anesthesia for such patients are increasing significantly. Any effort is needed to use the least anesthetic drug for maintaining the anesthesia while avoiding hazards of cardio-pulmonary complications. METHODS:American Society of Anesthesiologists physical status classification I and II, Forty five elderly patients (≥ 60 years) who received transurethral resection of the prostate or transurethral resection of the bladder tumor were allocated randomly into three treatment groups. The DMT 0.5 group was designed as with dexmedetomidine 0.5 µg/kg while the DMT 1.0 group has a 1 µg/kg intravenous injection over 10 min before anesthetic induction. The Control group was designed to get a normal saline. Each group was compared regarding the maximum sensory block level, extension of anesthesia, degree of motor block, level of sedation, VAS score and complications.
RESULTS: There were no significant differences among the 3 treatment groups regarding the maximum level of sensory block and motor block. However, the duration of sensory block was significantly longer in DMT 1.0 group than in the control group (P = 0.045). Both DMT 1.0 group (median = 3, range = 2-6) and DMT 0.5 group (median = 3, range = 1-6) showed a mean value of 3-4 Ramsay sedation score, which resulted in more excessive sedation and significantly greater incidence of bradycardia compared to the control group. No complications such as hypotension, nausea, tremor, and hypoxia were found during this investigation. CONCLUSIONS: In elder patients, the DMT 1.0 group is effective in duration of sensory block and is superior in the aspect of prolonged duration of sensory block compared to the DMT 0.5 group.
KEYWORDS:Dexmedetomidine; Spinal anesthesia
http://ekja.org/Synapse/Data/PDFData/0011KJAE/kjae-66-371.pdf
Atentamente
Anestesiología y Medicina del Dolor
www.anestesia-dolor.org