Libro sobre AINES / Book on NSAIDs

Agosto 26, 2017. No. 2792

Fármacos anti-inflamatorios no esteroideos Nonsteroidal Anti-Inflammatory Drugs Edited by Ali Gamal Ahmed Al-kaf, ISBN 978-953-51-3444-2, Print ISBN 978-953-51-3443-5, 160 pages, Publisher: InTech, Chapters published August 23, 2017 under CC BY 3.0 license Edited Volume This book intends to provide the reader with a comprehensive overview about the state of the art regarding the use of nonsteroidal anti-inflammatory drugs (NSAIDs) in physical and rehabilitation medicine and the study of the pharmacodynamics of existing and newly introduced NSAIDs in the management of pain and inflammation. It will also elaborate and refine already known knowledge on the mechanism(s) of nonsteroidal anti-inflammatory agents. This book may provide additional knowledge about the design and development of new drug delivery systems loaded with NSAIDs potentially useful in the treatment of chronic inflammatory-based diseases following circadian cycle, uses of NSAIDs as a source of medicinal plants, and the adverse effects and drug interactions of the nonsteroidal anti-inflammatory drugs. LIBRO / BOOK Convocatoria para el Curso de Posgrado en Medicina del Dolor y Paliativa 2018 para Mexicanos y extranjeros. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Informes en el teléfono (52) 55 5487 0900 ext. 5011 de lunes a viernes de 9.00 a 14 h (hora de México).  Informes / Information XIV Congreso Virtual Mexicano de Anestesiología 2017 Octubre 1-Diciembre 31, 2017 Información / Information

Anestesiología y Medicina del Dolor 52 664 6848905 vwhizar@anestesia-dolor.org anestesia-dolor.org

Eficacia y seguridad de diferentes tratamientos con aceclofenac para el dolor crónico de espalda baja: Ensayos clínicos prospectivos, aleatorizados, de un solo centro y de etiqueta abierta

http://www.columnavertebralpediatricaygeriatrica.com.mx/academia/eficacia-y-seguridad-de-diferentes-tratamientos-con-aceclofenac-para-el-dolor-cronico-de-espalda-baja-ensayos-clinicos-prospectivos-aleatorizados-de-un-solo-centro-y-de-etiqueta-abierta/

Efficacy and Safety of Different Aceclofenac Treatments for Chronic Lower Back Pain: Prospective, Randomized, Single Center, Open-Label Clinical Trials

Fuente
Este artículo es originalmente publicado en:

https://www.ncbi.nlm.nih.gov/pubmed/28332372

https://synapse.koreamed.org/search.php?where=aview&id=10.3349/ymj.2017.58.3.637&code=0069YMJ&vmode=FULL

De:

Yang JH1,Suk KS1,Lee BH2,Jung WC1,Kang YM1,Kim JH1,Kim HS1,

Lee HM1,Moon SH3.Yonsei Med J.

2017 May;58(3):637-643. doi: 10.3349/ymj.2017.58.3.637.

Todos los derechos reservados para:

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-CommercialLicense(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

PURPOSE:

Nonsteroidal anti-inflammatory drugs are a mainstay for medical treatment of chronic lower back pain (CLBP). Increased dose intervals for medication have been associated with increased patient adherence to prescriptions. The purpose of this clinical trial was to compare the efficacy and safety of a once daily dose of aceclofenac controlled release (CR) and a twice daily dose of aceclofenac for CLBP management.

CONCLUSION:

In patients with CLBP, aceclofenac CR and aceclofenac demonstrated significant symptomatic pain relief, improvement in quality of life and functional scores. Aceclofenac CR slightly increased gastrointestinal adverse effects, such as heartburn and indigestion.

KEYWORDS:

Chronic lower back pain; NSAIDs; aceclofenac

Resumen
PROPÓSITO:
Los fármacos antiinflamatorios no esteroideos son un pilar para el tratamiento médico del dolor lumbar crónico (CLBP). Los intervalos de dosis aumentados para la medicación se han asociado con una mayor adherencia del paciente a las recetas. El propósito de este ensayo clínico fue comparar la eficacia y seguridad de una dosis diaria de aceclofenaco de liberación controlada (CR) y una dosis de aceclofenaco dos veces al día para el tratamiento del CLBP.

CONCLUSIÓN:
En los pacientes con CLBP, el aceclofenac CR y el aceclofenaco demostraron alivio significativo del dolor sintomático, mejoría en la calidad de vida y puntuaciones funcionales. Aceclofenac CR ligeramente aumento de los efectos adversos gastrointestinales, como la acidez estomacal y la indigestión.

PALABRAS CLAVE:
Dolor de espalda crónico; AINEs; Aceclofenaco

PMID:   28332372    DOI:  

10.3349/ymj.2017.58.3.637

#Dolor de espalda crónico#AINES

Analgésicos / Analgesics

Enero 12, 2017. No. 2567

Reacciones de hipersensibilidad a AINES en niños y adolescentes: reacciones selectivas Hypersensitivity Reactions to Nonsteroidal Anti-inflammatory Drugs in Children and Adolescents: Selective Reactions. Blanca-López N, Cornejo-García JA, Pérez-Alzate D, Pérez-Sánchez N, Plaza-Serón MC, Doña I, Torres MJ, Canto G, Kidon M, Perkins JR, Blanca M. Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs) are used throughout the world to treat pain and inflammation; however, they can trigger several types of drug hypersensitivity reactions (DHRs) in all age groups. Although most such reactions occur through activation of the leukotriene pathway without specific immunological recognition (cross-intolerance), a significant number of DHRs to NSAIDs are due to immunological mechanisms (selective reactions [SRs]). SRs are thought to be induced by specific IgE antibodies or by T cells. In this manuscript, we focus on SRs, which are of great concern in children and adolescents and comprise a heterogeneous set of clinical pictures ranging from mild entities such as urticaria/angioedema to potentially life-threatening conditions such as Stevens-Johnson syndrome/toxic epidermal necrolysis. Paracetamol and ibuprofen are the most frequent elicitors of IgE-mediated SRs, although pyrazolones have also been implicated. T cell-mediated reactions are infrequent in children but have been associated with ibuprofen, naproxen, and dipyrone. In this review, we analyze the available literature on SRs in children and adolescents, with emphasis on epidemiological data, mechanisms, and drugs involved, as well as on diagnostic procedures. PDF  Aspectos de seguridad de los analgésicos actuales: una actualización. Safety issues of current analgesics: an update. Cazacu I1, Mogosan C1, Loghin F2. Clujul Med. 2015;88(2):128-36. doi: 10.15386/cjmed-413. Epub 2015 Apr 15. Abstract Pain represents a complex experience which can be approached by various medicines. Non-opioid and opioid analgesics are the most common drugs used to manage different types of pain. The increased attention nowadays to pain management entailed concomitantly more frequent adverse drug reactions (ADRs) related to analgesic use. Drug-drug interactions can be sometimes responsible for the adverse effects. However, a significant proportion of analgesic ADRs are preventable, which would avoid patient suffering. In order to draw the attention to analgesics risks and to minimize the negative consequences related to their use, the present review comprises a synthesis of the most important safety issues described in the scientific literature. It highlights the potential risks of the most frequently used analgesic medicines: non-opioid (paracetamol, metamizole, non-steroidal anti-inflammatory drugs) and opioid analgesics. Even if there is a wide experience in their use, they continue to capture attention with safety concerns and with potential risks recently revealed. Acknowledging potential safety problems represents the first step for health professionals in assuring a safe and efficient analgesic treatment with minimum risks to patients. Taking into consideration all medical and environmental factors and carefully monitoring the patients are also essential in preventing and early detecting analgesic ADRs. KEYWORDS: adverse drug reactions; analgesics; drug-drug interactions PDF Farmacología de los analgésicos no opiáceos (AINES) PDF El uso de aspirina y AINES reduce el riesgo de cáncer gástrico. Meta-análisis de dosis respuesta Aspirin and non-steroidal anti-inflammatory drugs use reduce gastric cancer risk: A dose-response meta-analysis. Huang XZ1, Chen Y2, Wu J1, Zhang X1, Wu CC1, Zhang CY1, Sun SS1, Chen WJ1. Oncotarget. 2016 Nov 25. doi: 10.18632/oncotarget.13591. [Epub ahead of print] Abstract BACKGROUND: The association between non-steroidal anti-inflammatory drugs (NSAIDs) and gastric cancer (GC) risk is controversial. The aim of this study is to evaluate the chemopreventive effect of NSAIDs for GC. METHODS: A literature search was performed for relevant studies using the PubMed and Embase database (up to March 2016). Risk ratios (RRs) and 95% confidence intervals (CIs) were used as the effect measures. The dose-response analysis and subgroup analysis were also performed. RESULTS: Twenty-four studies were included. Our results indicated that NSAIDs could reduce GC risk (any NSAIDs: RR=0.78, 96%CI=0.72-0.85; aspirin: RR=0.70, 95%CI=0.62-0.80; non-aspirin NSAIDs: RR=0.86, 95%CI=0.80-0.94), especially for non-cardia GC risk. Moreover, the dose-response analysis indicated the risk of GC decreased by 11% and 5% for 2 years increment of any NSAIDs and aspirin use, respectively. There were nonlinear relationships between the frequency of any NSAIDs use and aspirin use and GC risk (P for non-linearity<0.01), with a threshold effect of 5 times/week. A monotonically decreasing trend was observed only for the frequency of less than 5 times/week. CONCLUSIONS: Our results indicate that NSAIDs is inversely associated with GC risk, especially for non-cardia GC risk. NSAIDs use may become a feasible approach to prevent GC. KEYWORDS: aspirin; chemoprevention; gastric cancer; meta-analysis; non-steroidal anti-inflammatory drugs PDF 5to Curso Internacional de Anestesiología cardiotorácica, vascular, ecocardiografía y circulación extracorpórea. SMACT Mayo 4-6, 2017, Ciudad de México Informes Dr. Hugo Martínez Espinoza bajamed@hotmail.com  Regional Anesthesiology and Acute Pain Medicine Meeting April 6-8, 2017, San Francisco, California, USA ASRA American Society of Regional Anesthesia and Pain Medicine Información / Information California Society of Anesthesiologists Annual Meeting April 27-30, 2017 San Francisco California Información / Information