Niveles séricos de procalcitonina son indicadores tempranos de diagnóstico de sepsis
Serum procalcitonine levels as an early diagnostic indicator of sepsis.
Beqja-Lika A1, Bulo-Kasneci A, Refatllari E, Heta-Alliu N, Rucaj-Barbullushi A, Mone I, Mitre A. Mater Sociomed. 2013;25(1):23-5. doi: 10.5455/msm.2013.25.23-25. Abstract INTRODUCTION: Prompt and accurate diagnosis of sepsis is of high importance for clinicians. Procalcitonine (PCT) and C-reactive protein (CRP) have been proposed as markers for this purpose. Our aim was to evaluate the levels of PCT and CRP in early sepsis and its correlation with severity of sepsis. METHODS: Levels of PCT and CRP were taken from 60 patients with sepsis criteria and 39 patients with SIRS symptoms from the University Hospital Center "Mother Teresa" in Tirana, Albania during 2010-2012. Sensitivity, specificity and predictive values for PCT and CRP were calculated. RESULTS: PCT and CRP levels increased in parallel with the severity of the clinical conditions of the patients. The mean PCT level in patients withsepsis was 11.28 ng/ml versus 0.272 ng/ml in patients with SIRS symptoms, with a sensitivity of 97.4% and a specificity of 96.6% for PCT >0.5ng/ml. The mean CRP level in septic patients was 146.58 mg/l vs. 34.4 mg/l in patients with SIRS, with a sensitivity of 98.6% for sepsis and a specificity of 75 % for CRP >11mg/l. CONCLUSION: PCT and CRP values are useful markers to determine early diagnosis and severity of an infection. In the present study, PCT was found to be a more accurate diagnostic parameter for differentiating SIRS from sepsis and may be helpful in the follow-up of critically ill patients. KEYWORDS: Albania; C-reactive protein; procalcitonine; sepsis. PDF
En pacientes graves la procalcitonina sérica es más útil para diferenciar entre sepsis y SIRS que PCR, IL-6, o LPB.
In Critically Ill Patients, Serum Procalcitonin Is More Useful in Differentiating between Sepsis and SIRS than CRP, Il-6, or LBP. Meynaar IA1, Droog W, Batstra M, Vreede R, Herbrink P. Crit Care Res Pract. 2011;2011:594645. doi: 10.1155/2011/594645. Epub 2011 May 15. Abstract We studied the usefulness of serum procalcitonin (PCT), interleukin-6 (IL-6), lipopolysaccharide binding protein (LBP) levels and C-reactive protein (CRP) levels, in differentiating between systemic inflammatory response syndrome (SIRS) and sepsis in critically ill patients...... Discussion. This study showed that PCT is more useful than LBP, CRP and IL-6 in differentiating sepsis from SIRS. PDF
Utilidad de procalcitonina como marcador diagnóstico temprano en choque séptico
Celso Montoya González, Ariadna Hernández Luna, José Antonio Villalobos Silva, Janet Aguirre Sánchez, Juvenal Franco Granillo Rev Asoc Mex Med Crit y Ter Int 2009;23(4):211-217 PDF