Mecanismos de la anestesia general/Mechanisms of general anesthesia.

Diciembre 13, 2015. No. 2174

Anestésicos generales y mecanismos moleculares de la inconciencia General anesthetics and molecular mechanisms of unconsciousness. Forman SA, Chin VA. Int Anesthesiol Clin. 2008 Summer;46(3):43-53. doi: 10.1097/AIA.0b013e3181755da5. PDF Mecanismos moleculares de la anestesia general Molecular mechanisms of general anesthesia. Son Y. Korean J Anesthesiol. 2010 Jul;59(1):3-8. doi: 10.4097/kjae.2010.59.1.3. Epub 2010 Jul 21. PDF Anestesia general mediada por efectos en los canales iónicos General anesthesia mediated by effects on ion channels. Zhou C, Liu J, Chen XD. World J Crit Care Med. 2012 Jun 4;1(3):80-93. doi: 10.5492/wjccm.v1.i3.80. eCollection 2012. PDF

Anestesiología y Medicina del Dolor 52 664 6848905 vwhizar@anestesia-dolor.org anestesia-dolor.org Copyright © 2015

Raquia y obesidad / Spinal anesthesia and obesity

Diciembre 14, 2015. No. 2175

La obesidad se asocia de forma independiente con los resultados de la anestesia espinal: un estudio observacional prospectivo Obesity is independently associated with spinal anesthesia outcomes: a prospective observational study. Kim HJ, Kim WH, Lim HW, Kim JA, Kim DK, Shin BS, Sim WS, Hahm TS, Kim CS, Lee SM. PLoS One. 2015 Apr 21;10(4):e0124264. doi: 10.1371/journal.pone.0124264. eCollection 2015. Abstract The influence of body-mass index (BMI) on spinal anesthesia is still controversial, with discrepant results reported in previous studies. To compare spinal anesthesia in obese and non-obese subjects, the anesthesia profiles in patients who underwent spinal anesthesia using intrathecal hyperbaric bupivacaine were compared. A total of 209 patients undergoing elective total knee replacement arthroplasty (TKRA) surgery under spinal anesthesia were divided into an NO (non-obese) group (BMI < 30 kg/m2, n = 141) and an O (obese) group (BMI ≥ 30 kg/m2, n = 68). Anesthesia was deemed successful if a bilateral T12 sensory block occurred within 15 minutes of intrathecal drug administration, and if the level of sensory block was higher than T12 when the surgery ended. Logistic regression analysis with multiple variables known to influence spinal anesthesia was performed to identify which parameters independently determined the spinal anesthesia outcome. Similar doses of bupivacaine were administered to the NO and O groups. The incidence of anesthesia failure was significantly lower in the O group [n = 43 (30.5%) in the NO group vs. n = 10 (18.9%) in the O group, p = 0.014]. The independent predictors for successful anesthesia in all patients were dose of hyperbaric bupivacaine [odds ratio (OR) 2.12, 95% CI: 1.64-2.73] and obese status (BMI ≥ 30 kg/m2, OR 2.86, 95% CI: 1.25-6.52). Time to first report of postoperative pain and time to first self-void were significantly longer in the O group. These results suggest that the duration of block with hyperbaric bupivacaine is prolonged in obese patients and obesity is independently associated with spinal anesthesia outcomes, as is bupivacaine dosage. A further study enrolling patients with morbid obesity and using a fixed bupivacaine dosage is required to confirm the effect of obesity on spinal anesthesia. PDF

Anestesiología y Medicina del Dolor 52 664 6848905 vwhizar@anestesia-dolor.org anestesia-dolor.org Copyright © 2015

Monitoreo en anestesia / Monitoring in anesthesia

Diciembre 11, 2015. No. 2172

Recomendaciones para monitoreo estándar durante anesthesia y recuperación 2015: Association of Anaesthetists of Great Britain and Ireland. Recommendations for standards of monitoring during anaesthesia and recovery 2015 : Association of Anaesthetists of Great Britain and Ireland. Checketts MR, Alladi R, Ferguson K, Gemmell L, Handy JM, Klein AA, Love NJ, Misra U, Morris C, Nathanson MH, Rodney GE, Verma R, Pandit JJ. Anaesthesia. 2015 Nov 19. doi: 10.1111/anae.13316. [Epub ahead of print] Abstract This guideline updates and replaces the 4th edition of the AAGBI Standards of Monitoring published in 2007. The aim of this document is to provide guidance on the minimum standards for physiological monitoring of any patient undergoing anaesthesia or sedation under the care of an anaesthetist. The recommendations are primarily aimed at anaesthetists practising in the United Kingdom and Ireland. Minimum standards for monitoring patients during anaesthesia and in the recovery phase are included. There is also guidance on monitoring patients undergoing sedation and also during transfer of anaesthetised or sedated patients. There are new sections discussing the role of monitoring depth of anaesthesia, neuromuscular blockade and cardiac output. The indications for end-tidal carbon dioxide monitoring have been updated. PDF

Anestesiología y Medicina del Dolor 52 664 6848905 vwhizar@anestesia-dolor.org anestesia-dolor.org Copyright © 2015

Pregabalina / Pregabalin

Dilemas en la premedicación. ¿Es pregabalina la respuesta? Premedication dilemmas, is Pregabalin the answer? George PE, Chander R, Liddle D, Abraham V. J Res Pharm Pract. 2015 Jul-Sep;4(3):142-6. doi: 10.4103/2279-042X.162364. Abstract OBJECTIVE: Laryngoscopy and intubation are associated with sympathetic stimulation which can prove deleterious in patients with cardiovascular compromise; so, various methods have been tried to obtund this pressor response. In this study, we have assessed the efficacy of pregabalin in attenuating the pressor response to laryngoscopy and intubation. METHODS: This prospective randomized study included 80 patients with American Society of Anesthesiologists physical status grades I-II, in the age group of 18-60 years of age. The patients were randomized into two groups of 40 patients each. Group A received the placebo orally, 90 min prior to surgery. Group B received 150 mg of pregabalin orally, 90 min prior to surgery. These patients were assessed in terms of sedation with Ramsay sedation scale (RSS). In the operation theatre, the heart rate (HR), systolic blood pressure, diastolic blood pressure, mean arterial pressure, and oxygen saturation recorded at baseline and 1, 3, 5, and 10 min after intubation. The rate pressure product (RPP) was calculated for these time intervals. In the postoperative period, patients were assessed for complications like dizziness, nausea, and blurred vision. Statistical analysis was performed using Chi-square and ANOVA tests. FINDINGS: The group receiving 150 mg of pregabalin as premedication was found to be adequately sedated at 1 h post-premedication with 52% patients having a RSS score of 3 compared to 4% with the same RSS score in the placebo group (P < 0.0001). Hemodynamics was more stable post-intubation with significant stability in the HR (P = 0.002) and RPP (P = 0.004) in the pregabalin group. CONCLUSION: Pregabalin when given as a premedication provides adequate sedation and obtunds the pressor response seen with intubation. KEYWORDS: Laryngoscopy; Pregabalin; Ramsay sedation scale; pressor response; rate pressure product PDF

Anestesiología y Medicina del Dolor 52 664 6848905 vwhizar@anestesia-dolor.org anestesia-dolor.org Copyright © 2015

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Bibliotecas populares cierran el año con una nutrida agenda
El Tribuno.com.ar
Las diferentes bibliotecas populares que funcionan en la ciudad de Salta ya están cerrando con actividades especiales un año que fue muy fructífero.



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