Remimazolam: El futuro de su potencial de sedación
Remimazolam: The future of its sedative potential.
Goudra BG, Singh PM.
Saudi J Anaesth [serial online] 2014 [cited 2014 Jul 13];8:388-91.
Remimazolam (CNS 7056) is a new drug innovation in anesthesia. It combines the properties of two unique drugs already established in anesthesia - Midazolam and remifentanil. It acts on GABA receptors like midazolam and has organ-independent metabolism like remifentanil. It is likely to be the sedative of the future, as preliminary phase II trials have shown minimal residual effects on prolonged infusions. It has potential to be used as a sedative in ICU and as a novel agent for procedural sedation. Unlike most rapidly acting intravenous sedatives available presently, the propensity to cause apnea is very low. Availability of a specific antagonist (flumazenil) adds to its safety even in cases of overdose. The present review discusses remimazolam's potential as a new drug in anesthesia along with the presently available literary evidence.
Keywords: CNS 7056, newer sedatives in anesthesia, remimazolam, soft chemistry in anesthesia
http://www.saudija.org/downloadpdf.asp?issn=1658-354X;year=2014;volume=8;issue=3;spage=388;epage=391;aulast=Goudra;type=2
http://www.saudija.org/text.asp?2014/8/3/388/136627
Atentamente
Anestesiología y Medicina del Dolor
www.anestesia-dolor.org
Remimazolam: The future of its sedative potential.
Goudra BG, Singh PM.
Saudi J Anaesth [serial online] 2014 [cited 2014 Jul 13];8:388-91.
Remimazolam (CNS 7056) is a new drug innovation in anesthesia. It combines the properties of two unique drugs already established in anesthesia - Midazolam and remifentanil. It acts on GABA receptors like midazolam and has organ-independent metabolism like remifentanil. It is likely to be the sedative of the future, as preliminary phase II trials have shown minimal residual effects on prolonged infusions. It has potential to be used as a sedative in ICU and as a novel agent for procedural sedation. Unlike most rapidly acting intravenous sedatives available presently, the propensity to cause apnea is very low. Availability of a specific antagonist (flumazenil) adds to its safety even in cases of overdose. The present review discusses remimazolam's potential as a new drug in anesthesia along with the presently available literary evidence.
Keywords: CNS 7056, newer sedatives in anesthesia, remimazolam, soft chemistry in anesthesia
http://www.saudija.org/downloadpdf.asp?issn=1658-354X;year=2014;volume=8;issue=3;spage=388;epage=391;aulast=Goudra;type=2
http://www.saudija.org/text.asp?2014/8/3/388/136627
Atentamente
Anestesiología y Medicina del Dolor
www.anestesia-dolor.org
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