martes, 7 de abril de 2015

Gabapentina en DPO/Gabapentin for POP

Gabapentina en dolor agudo postoperatorio
Gabapentin in acute postoperative pain management.
Chang CY1, Challa CK1, Shah J1, Eloy JD1.
Biomed Res Int. 2014;2014:631756. doi: 10.1155/2014/631756. Epub 2014 Apr 14.
Gabapentin (1-aminomethyl-cyclohexaneacetic acid) is an amino acid that has the structure of the neurotransmitter γ -aminobutyric acid (GABA). It is a novel drug used for the treatment of postoperative pain with antihyperalgesic properties and a unique mechanism of action. Gabapentin and the related, more potent compound pregabalin have been shown to be beneficial in the treatment of neuropathic pain as well as postoperative painfollowing spinal surgery and hysterectomy. This study reviews five aspects of gabapentin: (1) chemical and structural characteristics; (2) pharmacokinetics and pharmacodynamics; (3) application in acute pain management; (4) adverse effects; and (5) drug safety. Overall, gabapentinhas been reported to be a safe and efficacious drug for the treatment of postoperative pain.
Efecto de gabapentina sobre la reducción del dolor después de bypass gástrico laparoscópico en obesos mórbidos. Estudio clínico randomizado
The effect of gabapentin on reducing pain after laparoscopic gastric bypass surgery in patients with morbidobesity: a randomized clinical trial.
Hassani V1, Pazouki A2, Nikoubakht N1, Chaichian S3, Sayarifard A4, Shakib Khankandi A5.
Anesth Pain Med. 2015 Feb 1;5(1):e22372. doi: 10.5812/aapm.22372. eCollection 2015.
BACKGROUND: Pain after laparoscopic gastric bypass surgery (LGBP) is a major problem. Gabapentin is an anticonvulsant drug that can be effective in postoperative pain control. OBJECTIVES: This study examined the effect of preoperative administration of gabapentin on reducing pain after LGBP in patients with morbidobesity. PATIENTS AND METHODS: This randomized clinical trial was performed in Hazrat Rasoul Akram Medical Center in Tehran. A total of 60 patientsundergoing LGBP were randomly allocated into two groups; one group received 100 mg of oral gabapentin and the other group received placebo. Painwas evaluated at recovery time, and at the first, second, fourth and sixth hour of surgery by visual analog scale. The number and dose of opioid useafter surgery and incidence of postoperative complications, such as nausea and vomiting, agitation, and headache, were also recorded. RESULTS: The mean pain score in the group receiving gabapentin was significantly lower than the placebo group (P < 0.001). Indications and dose of opioid consumption between the two groups were not statistically significant. Incidence of nausea/vomiting (P = 0.028) as well as agitation (P = 0.037) was significantly lower in the gabapentin group. CONCLUSIONS: Administration of gabapentin before surgery can reduce pain after LGBP. Furthermore, it is not accompanied by significant short-term adverse effects.
KEYWORDS: Gabapentin; Morbid Obesity; Postoperative Pain; laparoscopic Gastric Bypass Surgery
Anestesia y Medicina del Dolor
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