lunes, 13 de marzo de 2017

Sangrado en trauma / Coagulopathy in trauma

Marzo 13, 2017. No. 2627







Componentes hemáticos en el manejo de la coagulopatía por trauma. Revisión sistemática de la literatura del TUG
Blood Component Therapy and Coagulopathy in Trauma: A Systematic Review of the Literature from the Trauma Update Group.
PLoS One. 2016 Oct 3;11(10):e0164090. doi: 10.1371/journal.pone.0164090. eCollection 2016.
Abstract
BACKGROUND: Traumatic coagulopathy is thought to increase mortality and its treatment to reduce preventable deaths. However, there is still uncertainty in this field, and available literature results may have been overestimated. METHODS: We searched the MEDLINE database using the PubMed platform. We formulated four queries investigating the prognostic weight of traumatic coagulopathy defined according to conventional laboratory testing, and the effectiveness in reducing mortality of three different treatments aimed at contrasting coagulopathy (high fresh frozen plasma/packed red blood cells ratios, fibrinogen, and tranexamic acid administration). Randomized controlled trials were selected along with observational studies that used a multivariable approach to adjust for confounding. Strict criteria were adopted for quality assessment based on a two-step approach. First, we rated quality of evidence according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) criteria. Then, this rating was downgraded if other three criteria were not met: high reporting quality according to shared standards, absence of internal methodological and statistical issues not detailed by the GRADE system, and absence of external validity issues. RESULTS: With few exceptions, the GRADE rating, reporting and methodological quality of observational studies was "very low", with frequent external validity issues. The only two randomized trials retrieved were, instead, of high quality. Only weak evidence was found for a relation between coagulopathy and mortality. Very weak evidence was found supporting the use of fibrinogen administration to reduce mortality in trauma. On the other hand, we found high evidence that the use of 1:1 vs. 1:2 high fresh frozen plasma/packed red blood cells ratios failed to obtain a 12% mortality reduction. This does not exclude lower mortality rates, which have not been investigated. The use of tranexamic acid in trauma was supported by "high" quality evidence according to the GRADE classification but was downgraded to "moderate" for external validity issues. CONCLUSIONS: Tranexamic acid is effective in reducing mortality in trauma. The other transfusion practices we investigated have been inadequately studied in the literature, as well as the independent association between mortality and coagulopathy measured with traditional laboratory testing. Overall, in this field of research literature quality is poor.

Ácido tranexámico en el sangrado por trauma. Beneficios y daño
Tranexamic acid in bleeding trauma patients: an exploration of benefits and harms.
Trials. 2017 Jan 31;18(1):48. doi: 10.1186/s13063-016-1750-1.
Abstract
BACKGROUND: The CRASH-2 trial showed that tranexamic acid (TXA) administration reduces mortality in bleeding trauma patients. However, the effect appeared to depend on how soon after injury TXA treatment was started. Treatment within 3 h reduced bleeding deaths whereas treatment after 3 h increased the risk. We examine how patient characteristics vary by time to treatment and explore whether any such variations explain the time-dependent treatment effect. METHODS: Exploratory analysis were carried out, including per-protocol analyses, of data from the CRASH-2 trial, a randomised placebo-controlled trial of the effect of TXA on mortality in 20,211 trauma patients with, or at risk of, significant bleeding. ...... CONCLUSIONS: The time-dependent effect of TXA in bleeding trauma patients is not explained by the type of injury, the presence or absence of head injury or systolic blood pressure. When given within 3 h of injury, TXA reduces death due to bleeding regardless of type of injury, GCS or blood pressure.

Curso sobre Anestesia en Trasplantes, Cirugía abdominal, Plástica, Oftalmología y Otorrinolaringología.
Committee for European Education in Anaesthesiology (CEEA) 
y el Colegio de Anestesiólogos de León A.C.
Abril 7-9, 2017, León Guanajuato, México

Informes  (477) 716 06 16, kikinhedz@gmail.com
Vacante para Anestesiología Pediátrica
Hospital de Especialidades Pediátrico de León, Guanajuato  México 
Informes con la Dra Angélica García Álvarez 
angy.coachanestped@gmail.com o al teléfono 477 101 8700 Ext 1028
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Anestesiología y Medicina del Dolor

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Copyright © 2015

sábado, 11 de marzo de 2017

La artritis reumatoide en la columna cervical


Cervical Spine in Rheumatoid Arthritis

Fuente
Este artículo es originalmente publicado en:
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Courtesy: Prof Nabil Ebraheim,
University of Toledo, Ohio, USA
Dr. Ebraheim educational animated video illustrates spine concepts associated the cervical spine – rheumatoid arthritis.
Cervical spine involvement occurs in about 90% of the patients with rheumatoid arthritis.
All rheumatoid arthritis patients should have cervical spine examination.
Start with getting cervical spine x-rays, because this helps to diagnose atlantoaxial instability.
Early aggressive medical treatment can decrease this risk.
C1-C2 instability is common and can occur in up to 80%.
It occurs due to transverse ligament pathology.
So you will need to get flexion extension views in patients with rheumatoid arthritis, especially preoperative x-rays, and if it looks bad, you have to stabilize the spine before doing elective total hip or total knee procedures.
Discover the C1-C2 instability and fix it first before doing elective total hip procedure.
You see in the x-rays the Atlanto Dental Interval: A.D.I., if it was more than 3.5 mm that means instability of the upper cervical spine may be present.
If it is more than 7 mm it means disruption of the alar ligament, these patients can have cervical spine myelopathy.
The A.D.I. is an unreliable predictor of paralysis.
The posterior atlanto dental interval is a better predicting test, it can predict the spinal cord injury better.
If the posterior A.D.I. is less than 14 mm it can predict spinal cord injury, get an MRI.
The surgery is done if the A.D.I. is more than 10mm or if the P.A.D.I. is less than 14mm, the operation is C1-C2 fusion.
Clinically: the C1-C2 instability could give neck pain, headache, and myelopathy with abnormal gait, paresthesia and difficulty in fine motor control.
Basilar Invagination: 
Occur in about 40% of the patients with rheumatoid arthritis, basilar invagination is superior migration of the odontoid so the tip of the odontoid is above the foramen magnum; in this case you do occiput to C2 fusion, plus or minus odontoid resection.
The Subaxial Subluxation:
Occur in about 20% of the patients.
Indication of surgery is neurological compromise.
The space available for the cord is less than 14 mm then do posterior fusion surgery; surgery is usually not successful in severe types of neurological impairment.
When do you do surgery in rheumatoid arthritis?
You do it if there is:
• Severe pain
• Neurological deficit
• X-ray showing that the P.A.D.I. is less than 14mm 
• Superior odontoid migration
• Subaxial subluxation and the sagittal canal diameter is less than 14 mm.
If the posterior atlanto- dental interval (P.A.D.I.) is more than 14 mm, the patient will demonstrate significant motor recovery after surgery.
Donate to the University of Toledo Foundation Department of Orthopaedic Surgery Endowed Chair Fund:
https://www.utfoundation.org/foundati…
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ML en niños obesos / LMA in obese children

Marzo 3, 2017. No. 2617






Un ensayo clínico que evalúa la máscara laríngea de la vía aérea-Supreme en niños obesos durante la anestesia general
A clinical trial evaluating the laryngeal mask airway-Supreme in obese children during general anesthesia.
Tian Y1, Wu XY1, Li L1, Ma L1, Li YF1.
Arch Med Sci. 2017 Feb 1;13(1):183-190. doi: 10.5114/aoms.2017.64719. Epub 2016 Dec 19.
Abstract
INTRODUCTION: The laryngeal mask airway (LMA)-Supreme is a disposable double-lumen laryngeal mask airway that is widely used in clinical practice. However, its use in obese children has not been evaluated. The aim of this study was to determine whether the LMA-Supreme could perform equally as well as endotracheal intubation in obese children having a minor surgical procedure. MATERIAL AND METHODS: After ethical board approval, 100 obese male children receiving non-emergent appendectomy for chronic appendicitis or surgery to correct concealed penis were randomly divided into an endotracheal intubation group and an LMA-Supreme group. Endotracheal intubation was performed under direct vision laryngoscopy. In the LMA group, a size-3 LMA-Supreme was placed and a stomach tube inserted via the drainage tube of the mask. Cardiovascular and respiratory parameters, time taken for placement, placement attempts, time to removal of the endotracheal tube/LMA, length of stay in the post-anesthesia care unit (PACU), and complications were recorded. RESULTS: Insertion time was significantly longer (p < 0.001) in the LMA-Supreme group than in the endotracheal intubation group. Peak airway pressure was significantly higher, and pulmonary compliance and PACU stay time lower in the LMA-Supreme group. No significant differences between endotracheal intubation and the LMA-Supreme were seen in other parameters, except for a higher incidence of coughing in the endotracheal intubation group. CONCLUSIONS: The LMA-Supreme can be easily inserted and effectively used for airway management in obese children undergoing minor surgery.
KEYWORDS: airway sealing pressure; laryngeal mask airway; obese children; peripheral oxygen saturation; ventilation


Curso sobre Anestesia en Trasplantes, Cirugía abdominal, Plástica, Oftalmología y Otorrinolaringología.
Committee for European Education in Anaesthesiology (CEEA) 
y el Colegio de Anestesiólogos de León A.C.
Abril 7-9, 2017, León Guanajuato, México

Informes  (477) 716 06 16, kikinhedz@gmail.com
4° Congreso Internacional de Control Total de la Vía Aérea
Asociación Mexicana de Vía  Aérea Difícil, AC
Ciudad de México 21, 22 y 23 de Abril 2017
Informes: 
amvadmexico@gmail.com
Regional Anesthesiology and Acute Pain Medicine Meeting
April 6-8, 2017, San Francisco, California, USA
ASRA American Society of Regional Anesthesia and Pain Medicine
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Anestesiología y Medicina del Dolor

52 664 6848905

Copyright © 2015