viernes, 22 de noviembre de 2013

21 de noviembre de 2013. A continuación le mostramos las novedades de las revistas más importantes en Condroprotección.




21 de noviembre de 2013



A continuación le mostramos las novedades de las revistas más importantes en Condroprotección.









Annals of the Rheumatic Diseases
November 2013, Volume 72, Issue 11

2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative
Frank van den Hoogen, Dinesh Khanna, Jaap Fransen, Sindhu R Johnson, Murray Baron, Alan Tyndall, Marco Matucci-Cerinic, Raymond P Naden, Thomas A Medsger, Jr,Patricia E Carreira, Gabriela Riemekasten, Philip J Clements, Christopher P Denton,Oliver Distler, Yannick Allanore, Daniel E Furst, Armando Gabrielli, Maureen D Mayes,Jacob M van Laar, James R Seibold, Laszlo Czirjak, Virginia D Steen, Murat Inanc, Otylia Kowal-Bielecka, Ulf Müller-Ladner, Gabriele Valentini, Douglas J Veale, Madelon C Vonk,Ulrich A Walker, Lorinda Chung, David H Collier, Mary Ellen Csuka, Barri J Fessler,Serena Guiducci, Ariane Herrick, Vivien M Hsu, Sergio Jimenez, Bashar Kahaleh, Peter A Merkel, Stanislav Sierakowski, Richard M Silver, Robert W Simms, John Varga, Janet E Pope

Value of biomarkers in osteoarthritis: current status and perspectives
M Lotz, J Martel-Pelletier, C Christiansen, M-L Brandi, O Bruyère, R Chapurlat, J Collette,C Cooper, G Giacovelli, J A Kanis, M A Karsdal, V Kraus, W F Lems, I Meulenbelt, J-P Pelletier, J-P Raynauld, S Reiter-Niesert, R Rizzoli, L J Sandell, W E Van Spil, J-Y Reginster

Cardiovascular risk stratification in rheumatic diseases: carotid ultrasound is more sensitive than Coronary Artery Calcification Score to detect subclinical atherosclerosis in patients with rheumatoid arthritis
Alfonso Corrales, José A Parra, Carlos González-Juanatey, Javier Rueda-Gotor, Ricardo Blanco, Javier Llorca, Miguel A González-Gay

Results from systematic screening for cardiovascular risk in outpatients with rheumatoid arthritis in accordance with the EULAR recommendations
Jette Primdahl, Joan Clausen, Kim Hørslev-Petersen

Clinical efficacy, radiographic and safety findings through 2 years of golimumab treatment in patients with active psoriatic arthritis: results from a long-term extension of the randomised, placebo-controlled GO-REVEAL study
Arthur Kavanaugh, Iain B McInnes, Philip J Mease, Gerald G Krueger, Dafna D Gladman,Désirée van der Heijde, Surekha Mudivarthy, Weichun Xu, Michael Mack, Zhenhua Xu,Anna Beutler

Hydroxychloroquine in systemic lupus erythematosus: results of a French multicentre controlled trial (PLUS Study)
Nathalie Costedoat-Chalumeau, Lionel Galicier, Olivier Aumaître, Camille Francès,Véronique Le Guern, Frédéric Lioté, Amar Smail, Nicolas Limal, Laurent Perard, Hélène Desmurs-Clavel, Du Le Thi Huong Boutin, Bouchra Asli, Jean-Emmanuel Kahn, Jacques Pourrat, Laurent Sailler, Félix Ackermann, Thomas Papo, Karim Sacré, Olivier Fain,Jerome Stirnemann, Patrice Cacoub, Moez Jallouli, Gaelle Leroux, Judith Cohen-Bittan,Marie-Laure Tanguy, Jean-Sébastien Hulot, Philippe Lechat, Lucile Musset, Zahir Amoura, Jean-Charles Piette, on behalf of Group PLUS

Efficacy and safety of adalimumab for the treatment of peripheral arthritis in spondyloarthritis patients without ankylosing spondylitis or psoriatic arthritis
Jacqueline E Paramarta, Leen De Rycke, Tanja F Heijda, Carmen A Ambarus, Koen Vos,Huib J Dinant, Paul P Tak, Dominique L Baeten

Construct and criterion validity of several proposed DAS28-based rheumatoid arthritis flare criteria: an OMERACT cohort validation study
Aatke van der Maas, Elisabeth Lie, Robin Christensen, Ernest Choy, Yaël A de Man, Piet van Riel, Thasia Woodworth, Alfons A den Broeder

Efficacy of biological agents in juvenile idiopathic arthritis: a systematic review using indirect comparisons
Marieke H Otten, Janneke Anink, Sandra Spronk, Lisette W A van Suijlekom-Smit

Heart failure risk among patients with rheumatoid arthritis starting a TNF antagonist
Daniel H Solomon, Jeremy A Rassen, Bindee Kuriya, Lang Chen, Leslie R Harrold,David J Graham, James D Lewis, Joyce Lii, Liyan Liu, Marie R Griffin, J R Curtis

Individualised aerobic and resistance exercise training improves cardiorespiratory fitness and reduces cardiovascular risk in patients with rheumatoid arthritis
Antonios Stavropoulos-Kalinoglou, Giorgos S Metsios, Jet JJCS Veldhuijzen van Zanten,Peter Nightingale, George D Kitas, Yiannis Koutedakis

Cardiovascular comorbidities antedating the diagnosis of rheumatoid arthritis
Anne M Kerola, Tuomas Kerola, Markku J Kauppi, Hannu Kautiainen, Lauri J Virta, Kari Puolakka, Tuomo V M Nieminen

Lupuzor/P140 peptide in patients with systemic lupus erythematosus: a randomised, double-blind, placebo-controlled phase IIb clinical trial
Robert Zimmer, Hugo R Scherbarth, Oscar Luis Rillo, Juan Jesus Gomez-Reino,Sylviane Muller

Extent and distribution of CPP deposits in patients affected by calcium pyrophosphate dihydrate deposition disease: an ultrasonographic study
Georgios Filippou, Emilio Filippucci, Marika Tardella, Ilaria Bertoldi, Marco Di Carlo,Antonella Adinolfi, Walter Grassi, Bruno Frediani

Switching between TNF inhibitors in psoriatic arthritis: data from the NOR-DMARD study
Karen Minde Fagerli, Elisabeth Lie, Désirée van der Heijde, Marte Schrumpf Heiberg,Synøve Kalstad, Erik Rødevand, Knut Mikkelsen, Åse Stavland Lexberg, Tore K Kvien

Virtual skin biopsy by optical coherence tomography: the first quantitative imaging biomarker for scleroderma
Giuseppina Abignano, Sibel Zehra Aydin, Concepción Castillo-Gallego, Vasiliki Liakouli,Daniel Woods, Adam Meekings, Richard J Wakefield, Dennis G McGonagle, Paul Emery,Francesco Del Galdo

NKG2D stimulated T-cell autoreactivity in giant cell arteritis and polymyalgia rheumatica
Christian Dejaco, Christina Duftner, Juman Al-Massad, Annette D Wagner, Joon-Keun Park, Johannes Fessler, Ariane Aigelsreiter, Franz Hafner, Sandra Vega, William Sterlacci, Beatrix Grubeck-Loebenstein, Alexander Tzankov, Thomas Ness, Luigi Boiardi,Carlo Salvarani, Michael Schirmer

Interleukin-1 receptor antagonist deficient mice provide insights into pathogenesis of human intervertebral disc degeneration
Kate Louise Eve Phillips, Nikki Jordan-Mahy, Martin J H Nicklin, Christine Lyn Le Maitre

Population-specific influence of SLC2A9 genotype on the acute hyperuricaemic response to a fructose load
Nicola Dalbeth, Meaghan E House, Gregory D Gamble, Anne Horne, Bregina Pool,Lauren Purvis, Angela Stewart, Marilyn Merriman, Murray Cadzow, Amanda Phipps-Green, Tony R Merriman

Regulation of matrixmetalloproteinase-3 and matrixmetalloproteinase-13 by SUMO-2/3 through the transcription factor NF-κB
Svetlana Frank, Marvin A Peters, Corinna Wehmeyer, Simon Strietholt, Christina Koers-Wunrau, Jessica Bertrand, Marianne Heitzmann, Anja Hillmann, Joanna Sherwood,Christine Seyfert, Steffen Gay, Thomas Pap

Identification of the PTPN22 functional variant R620W as susceptibility genetic factor for giant cell arteritis
A Serrano, A Márquez, S L Mackie, F D Carmona, R Solans, J A Miranda-Filloy, J Hernández-Rodríguez, M C Cid, S Castañeda, IC Morado, J Narváez, R Blanco, B Sopeña, M J García-Villanueva, J Monfort, N Ortego-Centeno, A Unzurrunzaga, B Marí-Alfonso, J Sánchez-Martín, E de Miguel, C Magro, E Raya, N Braun, J Latus, O Molberg, B A Lie, F Moosig, T Witte, A W Morgan, M A González-Gay, J Martín, UK GCA Consortium Spanish GCA Consortium








Arthritis & Rheumatism
Volume 65, Issue 11, November 2013

2013 Classification Criteria for Systemic Sclerosis: An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative
Frank van den Hoogen, Dinesh Khanna, Jaap Fransen, Sindhu R. Johnson, Murray Baron, Alan Tyndall, Marco Matucci-Cerinic, Raymond P. Naden, Thomas A. Medsger Jr., Patricia E. Carreira, Gabriela Riemekasten, Philip J. Clements, Christopher P. Denton, Oliver Distler, Yannick Allanore, Daniel E. Furst, Armando Gabrielli, Maureen D. Mayes, Jacob M. van Laar, James R. Seibold, Laszlo Czirjak, Virginia D. Steen, Murat Inanc, Otylia Kowal-Bielecka, Ulf Müller-Ladner, Gabriele Valentini, Douglas J. Veale, Madelon C. Vonk, Ulrich A. Walker, Lorinda Chung, David H. Collier, Mary Ellen Csuka, Barri J. Fessler, Serena Guiducci, Ariane Herrick, Vivien M. Hsu, Sergio Jimenez, Bashar Kahaleh, Peter A. Merkel, Stanislav Sierakowski, Richard M. Silver, Robert W. Simms, John Varga and Janet E. Pope

Association of Paraoxonase 1 Gene Polymorphism and Enzyme Activity With Carotid Plaque in Rheumatoid Arthritis
Christina Charles-Schoeman, Yuen Yin Lee, Ani Shahbazian, Alan H. Gorn, John FitzGerald, Veena K. Ranganath, Mihaela Taylor, Nagesh Ragavendra, Maureen McMahon, David Elashoff and Srinivasa T. Reddy

Familial Risks and Heritability of Rheumatoid Arthritis: Role of Rheumatoid Factor/Anti-Citrullinated Protein Antibody Status, Number and Type of Affected Relatives, Sex, and Age
Thomas Frisell, Marie Holmqvist, Henrik Källberg, Lars Klareskog, Lars Alfredsson and Johan Askling

Rituximab-Induced T Cell Depletion in Patients With Rheumatoid Arthritis: Association With Clinical Response
J. Mélet, D. Mulleman, P. Goupille, B. Ribourtout, H. Watier and G. Thibault

Methotrexate Normalizes Up-Regulated Folate Pathway Genes in Rheumatoid Arthritis
Marjolein Blits, Gerrit Jansen, Yehuda G. Assaraf, Mark A. van de Wiel, Willem F. Lems, Mike T. Nurmohamed, Dirkjan van Schaardenburg, Alexandre E. Voskuyl, Gert-Jan Wolbink, Saskia Vosslamber and Cornelis L. Verweij

Association of Low Baseline Levels of Erythrocyte Folate With Treatment Nonresponse at Three Months in Rheumatoid Arthritis Patients Receiving Methotrexate
M. C. F. J. de Rotte, P. H. P. de Jong, S. M. F. Pluijm, M. Bulatović Ćalasan, P. J. Barendregt, D. van Zeben, P. A. van der Lubbe, P. B. de Sonnaville, J. Lindemans, J. M. W. Hazes and R. de Jonge

Role of ADAM-17, p38 MAPK, Cathepsins, and the Proteasome Pathway in the Synthesis and Shedding of Fractalkine/CX3CL1 in Rheumatoid Arthritis
Brian A. Jones, Sharayah Riegsecker, Ayesha Rahman, Maria Beamer, Wissam Aboualaiwi, Sadik A. Khuder and Salahuddin Ahmed

ADAM15 Adds to Apoptosis Resistance of Synovial Fibroblasts by Modulating Focal Adhesion Kinase Signaling
Beate B. Böhm, Isabell Freund, Kristin Krause, Raimund W. Kinne and Harald Burkhardt

Lipopolysaccharide Increases the Incidence of Collagen-Induced Arthritis in Mice Through Induction of Protease HTRA-1 Expression
Yuzhu Hou, Haijiang Lin, Linnan Zhu, Zhaoting Liu, Fanlei Hu, Jianfeng Shi, Tao Yang, Xiaoyun Shi, Mingzhao Zhu, Bernard F. Godley, Qiang Wang, Zhanguo Li and Yong Zhao

Insufficient Autoantigen Presentation and Failure of Tolerance in a Mouse Model of Rheumatoid Arthritis
Jason Perera, Xiao Liu, Yuzhen Zhou, Nora E. Joseph, Liping Meng, Jerrold R. Turner and Haochu Huang

Periarticular Bone Loss in Antigen-Induced Arthritis
Cecilia Engdahl, Catharina Lindholm, Alexandra Stubelius, Claes Ohlsson, Hans Carlsten and Marie K. Lagerquist

ADAMTS-4_v1 Is a Splice Variant of ADAMTS-4 That Is Expressed as a Protein in Human Synovium and Cleaves Aggrecan at the Interglobular Domain
Shane D. Wainwright, Jan Bondeson, Bruce Caterson and Clare E. Hughes

Transplantation of Achilles Tendon Treated With Bone Morphogenetic Protein 7 Promotes Meniscus Regeneration in a Rat Model of Massive Meniscal Defect
Nobutake Ozeki, Takeshi Muneta, Hideyuki Koga, Hiroki Katagiri, Koji Otabe, Makiko Okuno, Kunikazu Tsuji, Eiji Kobayashi, Kenji Matsumoto, Hirohisa Saito, Tomoyuki Saito and Ichiro Sekiya

Headache in Systemic Lupus Erythematosus: Results From a Prospective, International Inception Cohort Study
John G. Hanly, Murray B. Urowitz, Aidan G. O’Keeffe, Caroline Gordon, Sang-Cheol Bae, Jorge Sanchez-Guerrero, Juanita Romero-Diaz, Ann E. Clarke, Sasha Bernatsky, Daniel J. Wallace, Ellen M. Ginzler, David A. Isenberg, Anisur Rahman, Joan T. Merrill, Michelle Petri, Paul R. Fortin, Dafna D. Gladman, Barri J. Fessler, Graciela S. Alarcón, Ian N. Bruce, Mary Anne Dooley, Kristjan Steinsson, Munther A. Khamashta, Rosalind Ramsey-Goldman, Susan Manzi, Gunnar K. Sturfelt, Ola Nived, Asad A. Zoma, Ronald F. van Vollenhoven, Manuel Ramos-Casals, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, Kenneth C. Kalunian, S. Sam Lim, Murat Inanc, Diane L. Kamen, Christine A. Peschken, Soren Jacobsen, Chris Theriault, Kara Thompson and Vernon Farewell

The Percentage of FoxP3+Helios+ Treg Cells Correlates Positively With Disease Activity in Systemic Lupus Erythematosus
Amit Golding, Sarfaraz Hasni, Gabor Illei and Ethan M. Shevach

Multiple Lupus-Associated ITGAM Variants Alter Mac-1 Functions on Neutrophils
Yebin Zhou, Jianming Wu, Dennis F. Kucik, Nathan B. White, David T. Redden, Alexander J. Szalai, Daniel C. Bullard and Jeffrey C. Edberg

Skin Gene Expression Correlates of Severity of Interstitial Lung Disease in Systemic Sclerosis
Shervin Assassi, Minghua Wu, Filemon K. Tan, Jeffrey Chang, Tiffany A. Graham, Daniel E. Furst, Dinesh Khanna, Julio Charles, Emma C. Ferguson, Carol Feghali-Bostwick and Maureen D. Mayes

Endothelial Injury in a Transforming Growth Factor β-Dependent Mouse Model of Scleroderma Induces Pulmonary Arterial Hypertension
Emma C. Derrett-Smith, Audrey Dooley, Adrian J. Gilbane, Sarah L. Trinder, Korsa Khan, Reshma Baliga, Alan M. Holmes, Adrian J. Hobbs, David Abraham and Christopher P. Denton

Fibrosis Caused by Loss of PTEN Expression in Mouse Fibroblasts Is Crucially Dependent on CCN2
Shangxi Liu, Sunil K. Parapuram and Andrew Leask

Clinically Significant Renal Involvement in Primary Sjögren’s Syndrome: Clinical Presentation and Outcome
Andreas V. Goules, Ioanna P. Tatouli, Haralampos M. Moutsopoulos and Athanasios G. Tzioufas

Most Patients With Cancer-Associated Dermatomyositis Have Antibodies to Nuclear Matrix Protein NXP-2 or Transcription Intermediary Factor 1γ
David F. Fiorentino, Lorinda S. Chung, Lisa Christopher-Stine, Lisa Zaba, Shufeng Li, Andrew L. Mammen, Antony Rosen and Livia Casciola-Rosen

Copy Number Variations of Complement Component C4 Are Associated With Behçet’s Disease but Not With Ankylosing Spondylitis Associated With Acute Anterior Uveitis
Shengping Hou, Jian Qi, Dan Liao, Qi Zhang, Jing Fang, Yan Zhou, Yunjia Liu, Lin Bai, Meifen Zhang, Aize Kijlstra and Peizeng Yang

Increased Intracellular Oxygen Radical Production in Neutrophils During Febrile Episodes of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome
Martina Sundqvist, Per Wekell, Veronica Osla, Johan Bylund, Karin Christenson, Karin Sävman, Dirk Foell, David A. Cabral, Anders Fasth, Stefan Berg, Kelly L. Brown and Anna Karlsson

Transient Receptor Potential Ankyrin 1 Receptor Stimulation by Hydrogen Peroxide Is Critical to Trigger Pain During Monosodium Urate-Induced Inflammation in Rodents
Gabriela Trevisan, Carin Hoffmeister, Mateus F. Rossato, Sara M. Oliveira, Mariane A. Silva, Rafael P. Ineu, Gustavo P. Guerra, Serena Materazzi, Camilla Fusi, Romina Nassini, Pierangelo Geppetti and Juliano Ferreira

Enhanced Activity of Akt in Teff Cells From Children With Lupus Nephritis Is Associated With Reduced Induction of Tumor Necrosis Factor Receptor-Associated Factor 6 and Increased OX40 Expression
Sudhir Kshirsagar, Elisabeth Binder, Magdalena Riedl, Gottfried Wechselberger, Elisabeth Steichen and Monika Edelbauer









The Journal of Rheumatology
November 2013; 40 (11)

Juvenile Versus Adult-onset Ankylosing Spondylitis - Clinical, Radiographic, and Social Outcomes. A Systematic Review
Deepak R. Jadon, Athimalaipet V. Ramanan, and Raj Sengupta

Inflammation and Hypertension in Rheumatoid Arthritis
Siriporn Manavathongchai, Aihua Bian, Young Hee Rho, Annette Oeser,Joseph F. Solus, Tebeb Gebretsadik, Ayumi Shintani, and C. Michael Stein

Comparison of the Disease Activity Score Using Erythrocyte Sedimentation Rate and C-reactive Protein in African Americans with Rheumatoid Arthritis
Ashutosh Tamhane, David T. Redden, Gerald McGwin, Jr., Elizabeth E. Brown, Andrew O. Westfall, Richard J. Reynolds IV, Laura B. Hughes, Doyt L. Conn, Leigh F. Callahan, Beth L. Jonas, Edwin A. Smith, Richard D. Brasington, Jr., Larry W. Moreland, and S. Louis Bridges, Jr.

Determining Best Practices in Early Rheumatoid Arthritis by Comparing Differences in Treatment at Sites in the Canadian Early Arthritis Cohort
Jamie A. Harris, Vivian P. Bykerk, Carol A. Hitchon, E.C. Keystone, J. Carter Thorne, Gilles Boire, Boulos Haraoui, Glen Hazlewood, Ashley J. Bonner,Janet E. Pope, Gilles Boire, Janet Pope, Boulos Haraoui, Carol Hitchon,Shahin Jamal, Carter Thorne, Dianne Mosher, Vandana Ahluwalia, William Bensen, Maggie Larché, Michel Zummer, Majed Khraishi, Bindu Nair, Alice Klinkhoff, Alf Cividino, and Vivian Bykerk

A Randomized Controlled Trial of an Internal Family Systems-based Psychotherapeutic Intervention on Outcomes in Rheumatoid Arthritis: A Proof-of-Concept Study
Nancy A. Shadick, Nancy F. Sowell, Michelle L. Frits, Suzanne M. Hoffman,Shelley A. Hartz, Fran D. Booth, Martha Sweezy, Patricia R. Rogers, Rina L. Dubin, Joan C. Atkinson, Amy L. Friedman, Fernando Augusto, Christine K. Iannaccone, Anne H. Fossel, Gillian Quinn, Jing Cui, Elena Losina, andRichard C. Schwartz

Increased Levels of Interleukin 34 in Serum and Synovial Fluid Are Associated with Rheumatoid Factor and Anticyclic Citrullinated Peptide Antibody Titers in Patients with Rheumatoid Arthritis
Su-Jin Moon, Yeon-Sik Hong, Ji Hyeon Ju, Seung-Ki Kwok, Sung-Hwan Park, and Jun-Ki Min

Orthopedic Surgery in Rheumatoid Arthritis in the Era of Biologic Therapy
Leticia Leon, Lydia Abasolo, Loreto Carmona, Luis Rodriguez-Rodriguez,Jose Ramon Lamas, Cesar Hernandez-Garcia, Juan Angel Jover, for the emAR Study Group, J Alegre, JL Alonso, M Alvarez, B Alvárez, A Aragón, FX Arasa, MJ Arias, J Beltrán, J Babío, C Bohorquez, D Boquet, S Bustabad, A Casado, J Calvet, S Castro, MR Colazo, E Collantes, E Cuende, N Chozas, E Delgado, D de la Fuente, A de Juanes, E del Rincón, E Enríquez, C Escudero,L Espadaler, P Espino, A Fernández, J Fernández, L Fernández, J Fiter, P Font, J Galvez, A Gallego, J García, J García, ME García, F Gamero, E Giménez, S Gómez, B González Álvarez, S González, M Granados, G Iglesias,V Irigoyen, F Jimenez, E Júdez, C López, M López, R López, FJ López-Longo,J Maese, FJ Manero-Ruiz, S Manrique, I Maries, C Martínez, A Martínez-Cristóbal, I Mateo, J Marzo, F Medina, J Medina, M Medrano, P Mesa, R Miguélez, I Monteagudo, C Montilla, I Moreno, ML Muñoz, A Naranjo, R Negueroles, M Nolla, S Ojeda, C Ordás, S Ordóñez, AM Ortíz, E Pagán, A Pecondón, S Esteban, E Pérez-Pampín, JM Pina, JA Piqueras, MJ Pozuelo, V Rios, N Rivera, C Rodríguez, JM Rodríguez, R Roselló, MJ Rubira, D Ruiz, E Saiz, M Sánchez, T Tinturé, C Tornero, J Tornero, E Úcar, I Ureña, C Vázquez, R Veroz, E Vicente, and J Zubieta

Low Levels of Antibodies Against Oxidized but not Nonoxidized Cardiolipin and Phosphatidylserine Are Associated with Atherosclerotic Plaques in Systemic Lupus Erythematosus
Jun Su, Anna G. Frostegård, Xiang Hua, Thomas Gustafsson, Tomas Jogestrand, Ingiäld Hafström, and Johan Frostegård

Impaired Health Status and the Effect of Pain and Fatigue on Functioning in Clinical Trial Patients with Systemic Lupus Erythematosus
Michelle Petri, Ariane K. Kawata, Ancilla W. Fernandes, Kavita Gajria, Warren Greth, Asha Hareendran, and Dominique Ethgen

Herpes Zoster Vaccination in SLE: A Pilot Study of Immunogenicity
Joel M. Guthridge, Abigail Cogman, Joan T. Merrill, Susan Macwana, Krista M. Bean, Tiny Powe, Virginia Roberts, Judith A. James, and Eliza F. Chakravarty

Low Bone Density in Systemic Sclerosis. A Systematic Review
Mohammed A. Omair, Christian Pagnoux, Heather McDonald-Blumer, andSindhu R. Johnson

Vertebral Erosions Associated with Spinal Inflammation in Patients with Ankylosing Spondylitis Identified by Magnetic Resonance Imaging: Changes After 2 Years of Tumor Necrosis Factor Inhibitor Therapy
Xenofon Baraliakos, Joachim Listing, Hildrun Haibel, Joachim Sieper, andJurgen Braun

High Prevalence of Metabolic Syndrome in Takayasu Arteritis: Increased Cardiovascular Risk and Lower Adiponectin Serum Levels
Thiago Ferreira da Silva, Maurício Levy-Neto, Eloisa Bonfá, and Rosa Maria R. Pereira

New Features of Disease After Diagnosis in 6 Forms of Systemic Vasculitis
Peter C. Grayson, David Cuthbertson, Simon Carette, Gary S. Hoffman,Nader A. Khalidi, Curry L. Koening, Carol A. Langford, Kathleen Maksimowicz-McKinnon, Paul A. Monach, Philip Seo, Ulrich Specks, Steven R. Ytterberg, Peter A. Merkel, and for the Vasculitis Clinical Research Consortium

Aberrant CpG Islands' Hypermethylation of ABCB1 in Mesenchymal Stem Cells of Patients with Steroid-associated Osteonecrosis
Zhibo Sun, Shuhua Yang, Shunan Ye, Yukun Zhang, Weihua Xu, Bo Zhang,Xianzhe Liu, Fengbo Mo, and Wenbin Hua








Osteoarthritis and Cartilage
Volume 21, Issue 11, Pages 1627-1812 (November 2013)

Basic science and clinical application of platelet-rich plasma for cartilage defects and osteoarthritis: a review
Y. Zhu, M. Yuan, H.Y. Meng, A.Y. Wang, Q.Y. Guo, Y. Wang, J. Peng

Articular osteochondrosis: a comparison of naturally-occurring human and animal disease
A.M. McCoy, F. Toth, N.I. Dolvik, S. Ekman, J. Ellermann, K. Olstad, B. Ytrehus, C.S. Carlson

What proportion of people with hip and knee osteoarthritis meet physical activity guidelines? A systematic review and meta-analysis
J.A. Wallis, K.E. Webster, P. Levinger, N.F. Taylor

Sustained clinical and structural benefit after joint distraction in the treatment of severe knee osteoarthritis
K. Wiegant, P.M. van Roermund, F. Intema, S. Cotofana, F. Eckstein, S.C. Mastbergen, F.P.J.G. Lafeber

Varus thrust and knee frontal plane dynamic motion in persons with knee osteoarthritis
A.H. Chang, J.S. Chmiel, K.C. Moisio, O. Almagor, Y. Zhang, S. Cahue, L. Sharma

Subsets of symptomatic hand osteoarthritis in community-dwelling older adults in the United Kingdom: prevalence, inter-relationships, risk factor profiles and clinical characteristics at baseline and 3-years
M. Marshall, G. Peat, E. Nicholls, D. van der Windt, H. Myers, K. Dziedzic

Association of cartilage defects, and other MRI findings with pain and function in individuals with mild-moderate radiographic hip osteoarthritis and controls
D. Kumar, C.R. Wyatt, S. Lee, L. Nardo, T.M. Link, S. Majumdar, R.B. Souza

High prevalence of contralateral ankle abnormalities in association with knee osteoarthritis and malalignment
V.B. Kraus, T.W. Worrell, J.B. Renner, R.E. Coleman, C.F. Pieper

Association between aspartic acid repeat polymorphism of the asporin gene and susceptibility to knee osteoarthritis: a genetic meta-analysis
D. Xing, X.-L. Ma, J.-X. Ma, W.-G. Xu, J. Wang, Y. Yang, Y. Chen, B.-Y. Ma, S.-W. Zhu

Differential accumulation of lead and zinc in double-tidemarks of articular cartilage
A. Roschger, J.G. Hofstaetter, B. Pemmer, N. Zoeger, P. Wobrauschek, G. Falkenberg, R. Simon, A. Berzlanovich, H.W. Thaler, P. Roschger, K. Klaushofer, C. Streli

Bone loss at subchondral plate in knee osteoarthritis patients with hypertension and type 2 diabetes mellitus
C.Y. Wen, Y. Chen, H.L. Tang, C.H. Yan, W.W. Lu, K.Y. Chiu

Microstructural alterations of femoral head articular cartilage and subchondral bone in osteoarthritis and osteoporosis
D. Bobinac, M. Marinovic, E. Bazdulj, O. Cvijanovic, T. Celic, I. Maric, J. Spanjol, T. Cicvaric

Electroarthrography: a novel method to assess articular cartilage and diagnose osteoarthritis by non-invasive measurement of load-induced electrical potentials at the surface of the knee
A.-M. Préville, P. Lavigne, M.D. Buschmann, J. Hardin, Q. Han, L. Djerroud, P. Savard

Estrogen reduces mechanical injury-related cell death and proteoglycan degradation in mature articular cartilage independent of the presence of the superficial zone tissue
J. Imgenberg, B. Rolauffs, A.J. Grodzinsky, M. Schünke, B. Kurz

Demineralized bone matrix and platelet-rich plasma do not improve healing of osteochondral defects of the talus: an experimental goat study
C.J.A. van Bergen, G.M.M.J. Kerkhoffs, M. Özdemir, C.M. Korstjens, V. Everts, L.J. van Ruijven, C.N. van Dijk, L. Blankevoort

Rapid in situ chondrocyte death induced by Staphylococcus aureus toxins in a bovine cartilage explant model of septic arthritis
I.D.M. Smith, J.P. Winstanley, K.M. Milto, C.J. Doherty, E. Czarniak, S.G.B. Amyes, A.H.R.W. Simpson, A.C. Hall

Interleukin 6 mediates selected effects of Notch in chondrocytes
S. Zanotti, E. Canalis

Synovial fluid levels of bradykinin correlate with biochemical markers for cartilage degradation and inflammation in knee osteoarthritis
F. Bellucci, S. Meini, P. Cucchi, C. Catalani, A. Nizzardo, A. Riva, G.M. Guidelli, P. Ferrata, A. Fioravanti, C.A. Maggi

Oxidative stress and status of antioxidant enzymes in children with Kashin-Beck disease
W. Wang, S. Wei, M. Luo, B. Yu, J. Cao, Z. Yang, Z. Wang, M.B. Goldring, J. Chen

Oxygen and pH-sensitivity of human osteoarthritic chondrocytes in 3-D alginate bead culture system
J.A. Collins, R.J. Moots, R. Winstanley, P.D. Clegg, P.I. Milner

Monitoring wound healing of elastic cartilage using multiphoton microscopy
X. Zhu, Y. Tang, J. Chen, S. Xiong, S. Zhuo, J. Chen

Targeting of ADAMTS5’s ancillary domain with the recombinant mAb CRB0017 ameliorates disease progression in a spontaneous murine model of osteoarthritis
R. Chiusaroli, M. Visentini, C. Galimberti, C. Casseler, L. Mennuni, S. Covaceuszach, M. Lanza, G. Ugolini, G. Caselli, L.C. Rovati, M. Visintin








The Journal of Bone and Joint Surgery
November 06, 2013 | Vol. 95. Issue 21

Management of the Pediatric Pulseless Supracondylar Humeral Fracture: Is Vascular Exploration Necessary?
Amanda Weller, MD; Sumeet Garg, MD; A. Noelle Larson, MD; Nicholas D. Fletcher, MD; Jonathan R. Schiller, MD; Michael Kwon, MD; Lawson A.B. Copley, MD; Richard Browne, PhD; Christine A. Ho, MD

The Perfused, Pulseless Supracondylar Humeral Fracture: Intermediate-Term Follow-up of Vascular Status and Function
Brian P. Scannell, MD; J. Benjamin Jackson, III, MD; Christopher Bray, MD; Timothy S. Roush, MD; Brian K. Brighton, MD; Steven L. Frick, MD

Latissimus Dorsi Tendon Transfer for Treatment of Irreparable Posterosuperior Rotator Cuff Tears: Long-Term Results at a Minimum Follow-up of Ten Years
Christian Gerber, MD, FRCSEd(Hon); Stefan A. Rahm, MD; Sabrina Catanzaro, MD; Mazda Farshad, MD, MPH; Beat K. Moor, MD

Differences in Outcomes Following Total Ankle Replacement in Patients with Neutral Alignment Compared with Tibiotalar Joint Malalignment
Robin M. Queen, PhD; Samuel B. Adams, Jr., MD; Nicholas A. Viens, MD; Jennifer K. Friend, AS; Mark E. Easley, MD; James K. DeOrio, MD; James A. Nunley, MD

Local Infiltration Analgesia Followed by Continuous Infusion of Local Anesthetic Solution for Total Hip Arthroplasty: A Prospective, Randomized, Double-Blind, Placebo-Controlled Study
Olga Solovyova, MD; Courtland G. Lewis, MD; Jonathan H. Abrams, MD; John Grady-Benson, MD; Michael E. Joyce, MD; Steven F. Schutzer, MD; Sivasenthil Arumugam, MBBS; Stephanie Caminiti, APRN; Sanjay K. Sinha, MBBS

One-to-One Therapy Is Not Superior to Group or Home-Based Therapy After Total Knee Arthroplasty: A Randomized, Superiority Trial
Victoria Ko, BAppSc; Justine Naylor, PhD; Ian Harris, PhD; Jack Crosbie, PhD; Anthony Yeo, PhD; Rajat Mittal, BSc, MBBS, MMed(ClinEpi)

Return of Motor Function After Repair of a 3-cm Gap in a Rabbit Peroneal Nerve: A Comparison of Autograft, Collagen Conduit, and Conduit Filled with Collagen-GAG Matrix
Tatevik Sahakyants, MD; Joo-Yup Lee, MD, PhD; Patricia F. Friedrich, AAS; Allen T. Bishop, MD; Alexander Y. Shin, MD

Topical (Intra-Articular) Tranexamic Acid Reduces Blood Loss and Transfusion Rates Following Total Knee Replacement: A Randomized Controlled Trial (TRANX-K)
Sattar Alshryda, MBChB, MRCS, MRCSEd, FRCS(Tr&Orth), PhD; James Mason, DPhil, MSc, BSc(Hons); Manesh Vaghela, MBBS, MS, MSc; Praveen Sarda, MBBS, MRCS, FRCS(Tr&Orth); Antoni Nargol, MBBS, FRCS, FRCS(Tr&Orth); S. Maheswaran, MBBS, FRCS; Chris Tulloch, FRCS; Sanjeev Anand, MBBS, FRCSI, FRCS(Tr&Orth), MFSEM; Raj Logishetty, MBBS, FRCS, FRCS(Tr&Orth); Brian Stothart, NMC(ENB), NCFE; A. Pali S. Hungin, MD, FRCGP, FRCP, FRSA

The Value of Intraoperative Histology in Predicting Infection in Patients Undergoing Revision Elbow Arthroplasty
Shahryar Ahmadi, MD; Thomas M. Lawrence, MBChB; Bernard F. Morrey, MD; Joaquin Sanchez-Sotelo, MD

Comparison of Distal Soft-Tissue Procedures Combined with a Distal Chevron Osteotomy for Moderate to Severe Hallux Valgus: First Web-Space Versus Transarticular Approach
Yu-Bok Park, MD; Keun-Bae Lee, MD, PhD; Sung-Kyu Kim, MD; Jong-Keun Seon, MD, PhD; Jun-Young Lee, MD, PhD

Mid-Term Outcome After Curettage with Polymethylmethacrylate for Giant Cell Tumor Around the Knee: Higher Risk of Radiographic Osteoarthritis?
Lizz Van Der Heijden, MSc; Michiel A.J. Van De Sande, MD, PhD; Adriaan C. Heineken; Marta Fiocco, PhD; Rob G.H.H. Nelissen, MD, PhD; P.D. Sander Dijkstra, MD, PhD

Functional Outcomes After Total Shoulder Arthroplasty in Obese Patients
Xinning Li, MD; Phillip N. Williams, MD; Joseph T. Nguyen, MPH; Edward V. Craig, MD, MPH; Russell F. Warren, MD; Lawrence V. Gulotta, MD

Mechanisms and Risk Factors o






















f Brachial Plexus Injury in the Treatment of Early-Onset Scoliosis with Distraction-Based Growing Implants
Elizabeth R.A. Joiner, BS; Lindsay M. Andras, MD; David L. Skaggs, MD, MMM
 
Complications, Reoperation Rates, and Health-Care Cost Following Surgical Treatment of Lumbar Spondylolisthesis
Shivanand P. Lad, MD, PhD; Ranjith Babu, MS; Abdul A. Baker, MD; Beatrice Ugiliweneza, PhD, MSPH; Maiying Kong, PhD; Carlos A. Bagley, MD; Oren N. Gottfried, MD; Robert E. Isaacs, MD; Chirag G. Patil, MD; Maxwell Boakye, MD, MPH
 
Histologic, Serologic, and Tribologic Findings in Failed Metal-on-Metal Total Hip Arthroplasty: AAOS Exhibit Selection
Christopher E. Pelt, MD; Jill Erickson, PA-C; Ian Clarke, PhD; Thomas Donaldson, MD; Lester Layfield, MD; Christopher L. Peters, MD
 
Use of Porous Tantalum for Acetabular Reconstruction in Revision Hip Arthroplasty
Paul S. Issack, MD, PhD
 





Journal of the American Academy of Orthopaedic Surgeons
November 2013; 21 (11) 
Management of Septic Arthritis Following Anterior Cruciate Ligament Reconstruction: A Review of Current Practices and Recommendations
Edwin R. Cadet, Eric C. Makhni, Nima Mehran, and Brian M. Schulz
 
Foot Compartment Syndrome: Diagnosis and Management
Andrew Dodd and Ian Le
 
Hip Pathology in the Adolescent Athlete
Jeremy S. Frank, Peter L. Gambacorta, and Eric A. Eisner
 
Tendon Transfers for Radial, Median, and Ulnar Nerve Palsy
John G. Seiler III, Mihir J. Desai, and S. Houston Payne
 
Management of Metastatic Bone Disease of the Acetabulum
Paul S. Issack, Suhel Y. Kotwal, and Joseph M. Lane
 
Driving After Orthopaedic Surgery
Geoffrey S. Marecek and Michael F. Schafer

Clonidina-dexmedetomidina espinal/Spinal clonidine-dexmedetomidine

Efecto de dosis bajas de dexmedetomidina o clonidina sobre las características de la raquia con bupivacaína


Effect of low-dose dexmedetomidine or clonidine on the characteristics of bupivacaine spinal block.
Kanazi GE, Aouad MT, Jabbour-Khoury SI, Al Jazzar MD, Alameddine MM, Al-Yaman R, Bulbul M, Baraka AS.
Department of Anesthesiology, American University of Beirut-Medical Center, Beirut, Lebanon. gk05@aub.edu.lb
Acta Anaesthesiol Scand. 2006 Feb;50(2):222-7.
Abstract
BACKGROUND:The purpose of this study was to compare the onset and duration of sensory and motor block, as well as the hemodynamic changes and level of sedation, following intrathecal bupivacaine supplemented with either dexmedetomidine or clonidine.
METHODS:In a prospective, double-blind study, 60 patients undergoing transurethral resection of prostate or bladder tumor under spinal anesthesia were randomly allocated to one of three groups. Group B received 12 mg of hyperbaric bupivacaine, group D received 12 mg of bupivacaine supplemented with 3 microg of dexmedetomidine and group C received 12 mg of bupivacaine supplemented with 30 microg of clonidine. The onset times to reach peak sensory and motor levels, and the sensory and motor regression times, were recorded. Hemodynamic changes and the level of sedation were also recorded.RESULTS:Patients in groups D and C had a significantly shorter onset time of motor block and significantly longer sensory and motor regression times than patients in group B. The mean time of sensory regression to the S1 segment was 303 +/- 75 min in group D, 272 +/- 38 min in group C and 190 +/- 48 min in group B (B vs. D and B vs. C, P < 0.001). The regression of motor block to Bromage 0 was 250 +/- 76 min in group D, 216 +/- 35 min in group C and 163 +/- 47 min in group B (B vs. D and B vs. C, P < 0.001). The onset and regression times were not significantly different between groups D and C. The mean arterial pressure, heart rate and level of sedation were similar in the three groups intra-operatively and post-operatively. CONCLUSIONS:Dexmedetomidine (3 microg) or clonidine (30 microg), when added to intrathecal bupivacaine, produces a similar prolongation in the duration of the motor and sensory block with preserved hemodynamic stability and lack of sedation.
http://onlinelibrary.wiley.com/doi/10.1111/j.1399-6576.2006.00919.x/pdf



Evaluación de los efectos analgésicos de clonidina intratecal junto con bupivacaína en cesárea

Evaluation of analgesic effects of intrathecal clonidine along with bupivacaine in cesarean section.Kothari N, Bogra J, Chaudhary AK.
Department of Anesthesiology, CSMMU (erstwhile KGMC), Lucknow, Uttar Pradesh, India.
Saudi J Anaesth. 2011 Jan;5(1):31-5. doi: 10.4103/1658-354X.76499.
Abstract
AIMS AND CONTEXT: The objective of the present study was to evaluate the analgesic and adverse effects of intrathecal clonidine with hyperbaric bupivacaine in spinal anesthesia. SETTINGS AND DESIGN:Randomized single blind trial.METHODS:210 ASA I-II pregnant females undergoing emergency cesarean section were randomized in a single-blind fashion to one of the three groups. In group I (n=70) patients received 12.5 mg of 0.5% hyperbaric bupivacaine intrathecally. In group II (n=70) patients received intrathecal mixture of 0.5% hyperbaric bupivacaine (8 mg) and clonidine 50 μg. In group III (n=70), patients received 0.5% hyperbaric bupivacaine (10 mg) intrathecally along with 50 μg of clonidine. STATISTICAL ANALYSIS USED:Groups were compared using one-way ANOVA with the Bonferroni multiple comparison post hoc test. The proportion of adverse events was compared using the chi-square test (χ(2) =57.2410). RESULTS:On adding 50 μg clonidine, we were able to reduce intrathecal dose of bupivacaine for cesarean section to 8 mg. Patients receiving intrathecal clonidine along with bupivacaine had significantly long lasting analgesia with lower bupivacaine dose [246.21±5.15 min. (group II) vs 146.0±4.55 min (group I), P=0.021; 95% confidence interval: 238.01-257.40, group II and 134.99-157.0 group I]. CONCLUSIONS: Addition of intrathecal clonidine causes some sedation in the postoperative period, but it provides adequate analgesia and motor paralysis at lower dose of bupivacaine. It also significantly prolongs postoperative pain relief.
KEYWORDS:Cesarean section, bupivacaine, intrathecal clonidine

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101750/

http://www.saudija.org/downloadpdf.asp?issn=1658-354X;year=2011;volume=5;issue=1;spage=31;epage=35;aulast=Kothari;type=2




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Anestesiología y Medicina del Dolor
www.anestesia-dolor.org

ebooks. Alerta


Los 5 mejores eBooks de la semana ComputerHoy
Descubre nuestra selección de eBooks, te proponemos los 5 mejores libros electrónicos en castellano de esta semana para que los disfrutes en tu eReader: El ...
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ComputerHoy

El IVA de los e-books Francia podría haber sido distinto según éstos ... Xataka
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Xataka

Kindle Paperwhite, el mejor lector de ebooks PC Actual
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PC Actual

¿Cómo elegir un e-reader? Mirá todo lo que tenes que saber para ... El Diario 24
Este software gratuito y multiplataforma se baja desde http://calibre-ebook.com/ y permite realizar muchas tareas, como organizar la biblioteca de e-books, ...
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El Diario 24

La Biblioteca Pública de Huesca presta libros electrónicos 20minutos.es
Los ejemplares cuentan con un fondo de 1.000 títulos o e-books, muchos de ellos de autores clásicos como Sakespeare, Dickens, Kafka, Lovecraft, Tolstoi, ...
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Europa Press

Buscan detonar e-books en México El Norte.com (Suscripción)
Cd. de México (18 noviembre 2013).- La industria editorial en México buscará potenciar la adopción del libro digital, que no alcanza ni el 1.0 por ciento de las ...
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El Universal

Libro electrónico en Perú desata los miedos de las grandes editoriales Diario Gestión
Latinoamérica parece ser el último bastión del papel. Eso y la piratería hacen mínima la penetración local del e-book, dice la Cámara Peruana de Libro.
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Aprobado el uso del móvil en aviones durante el despegue y ... GSMspain
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Divagando entre líneas: IMM 42 (Arsénico), el de los ebooks Arsénico
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miércoles, 20 de noviembre de 2013

Despues de 3 años de MUCHO trabajo, ya estamos empezando a ver los resultados. Trabajo en poster aceptado para ORS!!!


domingo, 17 de noviembre de 2013

Miastenia gravis

Miastenia gravis: las nueva terapias dan mejoría sostenida


Myasthenia gravis: Newer therapies offer sustained improvement.
YUEBING LI, MD, PhD, YEESHU ARORA, MD, KERRY LEVIN, MD
CLEVELAND CLINIC JOURNAL OF MEDICINE VOLUME 80 * NUMBER 11 NOVEMBER 2013
Myasthenia gravis is a prototypical antibody-mediated autoimmune neuromuscular disorder. Treatments have improved over the past 30 years, leading to significantly fewer deaths and better quality of life. Future research should further elucidate its pathogenesis, reveal better ways to diagnose it, and yield new treatments.
http://www.ccjm.org/content/80/11/711.full.pdf


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Anestesiología y Medicina del Dolor
www.anestesia-dolor.org