En este día...

	Friday, January 07th The 007th day of 2011. There are 358 days left in the year. Go to a previous date.

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Today's Highlights in History
See a larger version of this front page.		On Jan. 7, 1979, Vietnamese forces captured the Cambodian capital of Phnom Penh, overthrowing the Khmer Rouge government. (Go to article.)On Jan. 7, 1873, Adolph Zukor, the American entrepreneur who built the Paramount movie empire, was born.Following his death on June 10,1976, his obituary appeared in The Times. (Go to obit. | Other Birthdays)
		On January 7, 1871, Harper's Weekly featured a cartoon about the German empire. (See the cartoon and read an explanation.)

On this date in:
1789	The first U.S. presidential election was held. Americans voted for electors who, a month later, chose George Washington to be the nation's first president.
1800	Millard Fillmore, the 13th president of the United States, was born in Summerhill, N.Y.
1927	Commercial transatlantic telephone service was inaugurated between New York and London.
1942	The World War II siege of Bataan began.
1953	President Harry S. Truman announced in his State of the Union address that the United States had developed a hydrogen bomb.
1955	Singer Marian Anderson made her debut with the Metropolitan Opera in New York, becoming the first black person to perform there as a member.
1959	The United States recognized Fidel Castro's new government in Cuba.
1972	Lewis F. Powell Jr. and William H. Rehnquist were sworn in as the 99th and 100th members of the Supreme Court.
1989	Japanese Emperor Hirohito died at age 87.
1996	A major blizzard paralyzed the eastern United States, claiming more than 100 lives.
1997	Newt Gingrich became the first Republican re-elected House speaker in 68 years.
1999	President Bill Clinton's impeachment trial began in the Senate.
2005	Actor Brad Pitt and actress Jennifer Aniston announced they were separating after four years of marriage.
2006	American journalist Jill Carroll was abducted in Iraq and a translator was killed. (Carroll was released unharmed after 82 days.)
2006	Rep. Tom DeLay, R-Texas, facing corruption charges, stepped down as House majority leader.

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Current Birthdays

Jeremy Renner turns 40 years old today.

AP Photo/Dan Steinberg Actor Jeremy Renner ("The Hurt Locker") turns 40 years old today.

73 Paul Revere Rock musician 65 Jann Wenner Magazine publisher (Rolling Stone) 63 Kenny Loggins Rock singer 55 David Caruso Actor ("CSI: Miami") 54 Katie Couric CBS News anchor 50 John Thune U.S. senator, R-S.D. 47 Nicolas Cage Actor 47 Rand Paul U.S. senator, R-Ky. 44 Nick Clegg Deputy British prime minister 37 John Rich Country musician (Big and Rich) 35 Alfonso Soriano Baseball player 29 Francisco Rodriguez Baseball player

Historic Birthdays
Adolph Zukor
1/7/1873 - 6/10/1976 American entrepreneur  (Go to obit.)
66	James Harrington 1/7/1611 - 9/11/1677 English political philosopher
63	Johann Christian Fabricius 1/7/1745 - 3/3/1808 Dutch entomologist
74	Millard Fillmore 1/7/1800 - 3/8/1874 13th president of the United States (1850-53)
35	Saint Bernadette of Lourdes 1/7/1844 - 4/16/1879 French nun
76	Herbert John Gladstone 1/7/1854 - 3/6/1930 English statesman
85	Émile Borel 1/7/1871 - 2/3/1956 French mathematician
64	Francis Poulenc 1/7/1899 - 1/30/1963 French composer
69	Aristotle Onassis 1/7/1906 (O.S.) - 3/15/1975 Greek shipping magnate
59	Henry Allen 1/7/1908 - 4/17/1967 American jazz musician
76	Charles Addams 1/7/1912 - 9/29/1988 American cartoonist

Go to a previous date.

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SOURCE: The Associated Press
Front Page Image Provided by UMI

2011: Aceleración tecnológica, ¿frenazo social?

2011: Aceleración tecnológica, ¿frenazo social?

Dolors Reig | Thursday, January 6th, 2011 | 2 Comentarios / Referencias »

Andaba leyendo en mi Flipboard (excepcional invento) y desde el CES 2011 que tiene lugar estos días en Las Vegas no paran de llegarnos novedades.

Tablets y más tablets,  avatares que se mueven a nuestro ritmo vía Kinect, cámaras de vídeo 3D, la mesa táctil de Microsoft amenazando los salones de cualquier geek que se precie, hacían saltar mi alarma, una sospecha que viene atacándome los últimos días… ¿No será  2011 un año de artificios tecnológicos variados que oculten la necesidad imperiosa de evolución social?

Es más fácil, aparente, rentable, vender equipos renovados, tablets en lugar de netbooks, queInnovación social. Vienen, creo, tiempos peores para los social media, que ya se han ganado a los adeptos sensibles, ya han captado (y a veces decepcionado) al público con sensibilidad social y tendrán más problemas ahora para vender, en algunos casos, el mismo humo.

Y es que lo “trendy”, lo actual, lo moderno, lo que puede distinguirnos de la competencia, por lo menos en lo aparente, puede que no vaya a ser ya pagar por una cara página en  Facebook, forzar una comunidad donde  no hay afecto social o ponerse en la difícil tesitura de tener que ser transparentes e interactuar, conversar con un usuario inteligente. Lo actual puede ser, en época de artificios tecnológicos, simplemente, plantar una surface en la sala de reuniones.

Y no es que no pueda dilucidar algunas de las ventajas de que las reuniones en la misma sala las tengan avatares “naturalizados”, entre otras la de que muchos/as dejen de tomarse tan en serio a sí mismos…, es que no sé si en tiempos de crisis será posible compaginar sofisticación social y tecnológica.

O tal vez no se trate de una disyuntiva y podamos seguir trabajando mucho y bien, intentando extraer y potenciar lo mejor de cada tecnología y su potencial para cambiar lo social. Hay que reconocer lo evidente, lo atractivo de un escenario de prosumidores (usuarios, opinólogos, analistas, hackers, amateurs, profesionales) aportando ideas, trabajando por algo común, que beneficie a la vez a individuos y grupo.

En otras palabras, tecnología y sociedad se realimentan mútuamente: tenemos más oportunidades de colaborar, de una forma más fácil, que nunca antes y eso tiene consecuencias en las tecnologías, cada vez más sofisticadas, que somos capaces de crear.

Es importante que no olvidemos lo que somos, que al fin y al cabo, como decía Kelly, la organización social es la primera de las tecnologías, sin la que el resto no sería posible.

Puede ayudar a recordar, a revivir el espíritu que nos mantiene anclados todas estas cosas, que faltan pocos días para el estreno de Life in a day, la Historia de un día en la tierra, de Ridley Scott y Kevin Macdonals. En el vídeo que os dejo hoy (también en el canal diario en la app de Android),  una niña de San Jaume dels Domenys, en la provincia catalana de Tarragona, participa en una de las que creo mejores y más antiguas metáforas de la colaboración: los “castells”.

Pura tecnología para hacernos más grandes:

¿Te ha gustado? Compártelo

MOVIE REVIEW

MOVIE REVIEW | 'THE TIME THAT REMAINS'

In Nazareth, Human Comedy as Wind Rustles the Olive Branches

By A. O. SCOTT

In Elia Suleiman's film "The Time That Remains," a son views his father's life and experiences in the first Arab-Israeli war.

•  Movie Overview | Trailers | Rate and Review

MOVIE REVIEW | 'IF I WANT TO WHISTLE, I WHISTLE'

Freedom Is No Guarantee for a Happily Ever After

By A. O. SCOTT

In "If I Want to Whistle, I Whistle," Romania's official submission for the best foreign language film Oscar, the protagonist is released from jail but has few prospects.

•  Movie Overview | Showtimes | Trailers | Rate and Review

MOVIE REVIEW | 'PHIL OCHS: THERE BUT FOR FORTUNE'

Aspiring to Musical Power and Glory

By STEPHEN HOLDEN

"Phil Ochs: There but for Fortune" is Kenneth Bowser's documentary about that protest singer's complicated and tragic life.

•  Related Article

MOVIE REVIEW | 'AMERICATOWN'

These United States

By JEANNETTE CATSOULIS

In the comedy "Americatown," our guides are Roosevelt Microsoft (Cory Howard) and Plymouth Rayban (Jonathan Guggenheim).

MOVIE REVIEW | 'SEASON OF THE WITCH'

Deserters From the Crusades

By JEANNETTE CATSOULIS

"Season of the Witch" is a 14th-century road movie with 21st-century cuss words.

•  Movie Overview | Showtimes | Trailers | Rate and Review

News & Features

New Doubts for a Film That Has Truth Issues

By MELENA RYZIK

A Swiss filmmaker claims some credit for "Exit Through the Gift Shop," the Banksy documentary that may get an Oscar nomination.

•  Related Article: How Real Does It Feel?

As a Hot Ticket, Will 'True Grit' Sway the Oscars?

By MICHAEL CIEPLY and BROOKS BARNES

As "True Grit" shows signs of being a breakout hit, it is reviving the question of whether the audience gets a vote.

•  Movie Review: 'True Grit' |  Carpetbagger Video

Pete Postlethwaite, an Actor With Broad Range, Dies at 64

By BRUCE WEBER

Memorable films included "Distant Voices, Still Lives" and "In the Name of the Father."

•   Critics' Picks: 'In the Name of the Father'

Hideko Takamine, Lauded Japanese Actress, Dies at 86

By DAVE KEHR

Ms. Takamine developed from an endearing child star into a powerful representative of the Japanese woman's search for identity and autonomy in the years after World War II.

THE OSCARS

Natalie Portman Embraces Monster and Victim

By A. O. SCOTT

"Black Swan" is at bottom a horror movie, an inky, unhinged fairy tale, a swirl of intuitions and sensations visited upon the body of its star, Natalie Portman.

•  Movie Review: 'Black Swan'

THE OSCARS

Christian Bale Summons a Fallen Man's Delusions

By MANOHLA DARGIS

In one minute of "The Fighter," Christian Bale - with help from the director, editor and cameraman - replays the tragic sweep of his character's life.

•  Movie Review: 'The Fighter'

Vino rojo: Una bebida para su corazón

Vino rojo: Una bebida para su corazón La mortalidad y morbilidad siguen siendo elevadas en la enfermedad cardiovascular (ECV). La isquemia miocárdica daño por reperfusión cual conduciría al infarto de miocardio es una de las causas más frecuentes de la muerte en los seres humanos. La aterosclerosis y la generación de especies reactivas de oxígeno a través del estrés oxidativo es el principal factor de riesgo de ECV. De la colección de literatura, se ha identificado que el consumo moderado de vino tinto ayuda a prevenir enfermedades cardiovasculares a través de varios mecanismos, incluyendo el aumento de la lipoproteína de alta densidad los niveles plasmáticos de colesterol, disminuye la agregación plaquetaria, por los efectos antioxidantes, y por la restauración de la función endotelial. El objetivo de esta revisión es discutir la evidencia acumulada que sugiere que el vino tinto posee una gran variedad de acciones biológicas y puede ser beneficioso en la prevención de las enfermedades cardiovasculares. Red wine: A drink to your heart TS Mohamed Saleem, S Darbar Basha Department of Pharmacology, Annamacharya College of Pharmacy, New Boyanapalli, Rajampet - 516 126, Andhra Pradesh, India Journal of Cardiovascular Disease Research 2010:1:171-176.  DOI: 10.4103/0975-3583.74259 Mortality and morbidity are still high in cardiovascular disease (CVD). Myocardial ischemia reperfusion injury leading to myocardial infarction is one of the most frequent causes of the death in humans. Atherosclerosis and generation of reactive oxygen species through oxidative stress is the major risk factor for CVD. From the literature collection, it has been identified that moderate consumption of red wine helps in preventing CVD through several mechanisms, including increasing the high-density lipoprotein cholesterol plasma levels, decreasing platelet aggregation, by antioxidant effects, and by restoration of endothelial function. The aim of this review is to discuss the accumulating evidence that suggests that red wine possesses a diverse range of biological actions and may be beneficial in the prevention of CVD. Artí­culo en PDF ¿Es el alcohol benéfico o dañino para la cardioprotección? Is alcohol beneficial or harmful for cardioprotection? Lakshman R, Garige M, Gong M, Leckey L, Varatharajalu R, Zakhari S. Lipid Research Laboratory, VA Medical Center, Washington, DC, 20422, USA, Genes Nutr. 2010:5:111-120 [Epub ahead of print] Abstract While the effects of chronic ethanol consumption on liver have been well studied and documented, its effect on the cardiovascular system is bimodal. Thus, moderate drinking in many population studies is related to lower prevalence of coronary artery disease (CAD). In contrast, heavy drinking correlates with higher prevalence of CAD. In several other studies of cardiovascular mortalities, abstainers and heavy drinkers are at higher risk than light or moderate drinkers. The composite of this disparate relation in several population studies of cardiovascular mortality has been a "U-" or "J-"shaped curve. Apart from its ability to eliminate cholesterol from the intima of the arteries by reverse cholesterol transport, another major mechanism by which HDL may have this cardioprotective property is by virtue of the ability of its component enzyme paraoxonase1 (PON1) to inhibit LDL oxidation and/or inactivate OxLDL. Therefore, PON1 plays a central role in the disposal of OxLDL and thus is antiatherogenic. Furthermore, PON1 is a multifunctional antioxidant enzyme that can also detoxify the homocysteine metabolite, homocysteine thiolactone (HTL), which can pathologically cause protein damage by homocysteinylation of the lysine residues, thereby leading to atherosclerosis. We demonstrated that moderate alcohol up regulates liver PON1 gene expression and serum activity, whereas heavy alcohol consumption had the opposite effects in both animal models and in humans. The increase in PON1 activity in light drinkers was not due to preferential distribution of high PON1 genotype in this group. It is well known that wine consumption in several countries shows a remarkable inverse correlation to local rates of CAD mortality. Significantly, apart from its alcohol content, red wine also has polyphenols such as quercetin and resveratrol that are also known to have cardioprotective effects. We have shown that quercetin also up regulates PON1 gene in rats and in human liver cells. The action of quercetin seems to be mediated via the active form of the nuclear lipogenic transcription factor, sterol-regulatory element-binding protein 2 (SREBP2) that is translocated from endoplasmic reticulum to the nucleus. However, the mechanism of action of ethanol-mediated up-regulation of PON1 gene remains to be elucidated. We conclude that both moderate ethanol and quercetin, the two major components of red wine, exhibit cardioprotective properties via the up-regulation of the antiatherogenic gene PON1. Enlace para leer el artículo completo: http://www.ncbi.nlm.nih.gov

Atentamente Anestesiología y Medicina del Dolor www.anestesia-dolor.org

Búsqueda bibliográfica

Búsqueda bibliográfica

El desarrollo actual de la “medicina basada en los hechos” (“medicina basada en la evidencia”
en español correcto significa exactamente lo contrario de lo que se pretende decir), así como
los proyectos de investigación en los que podemos participar hace que cada vez sea más
necesaria la consulta de la literatura científica.

Sea cual sea el método de búsqueda, esta puede ser de dos tipos:
Búsqueda bibliográfica. Consiste en la búsqueda de un tema concreto en respuesta a
una necesidad concreta. Es una búsqueda de tipo retrospectivo, se trata de hallar la
respuesta a nuestra pregunta entre los artículos ya publicados.
Alerta bibliográfica. Es la situación en que lo que nos interesa, es conocer lo que se va
publicando sobre el tema de nuestro interés. Se trata de una búsqueda prospectiva.
Las necesidades de información dentro de la profesión médica crecen, en la actualidad, al
mismo ritmo que la producción de información. La “explosión de la información” y la multitud de
revistas médicas que se necesita consultar hacen que los sistemas informatizados sean la mejor
opción a la hora de buscar la información que nos interesa.

Entre las fuentes de información en donde podemos hacer nuestra búsqueda, la más importante
hoy en día son las “bases de datos”. Estas pueden ser de varios tipos:

• Bases de datos bibliográficas. Contienen referencias de documentos.
• Bases de datos textuales. Contienen el texto íntegro de los documentos.
• Bases de datos mixtas. Contienen ambos tipos de datos.

El desarrollo de Internet y la introducción de las principales bases de datos en la red han
facilitado y abaratado su uso, mejorando la difusión y accesibilidad de la información de forma
impensable hace sólo unos años. Se puede acceder a las principales bases de datos médicas, en
muchos casos de forma gratuita y el acceso es posible desde cualquier lugar y a cualquier hora.
leer mas en http://www.semergen.es/semergen/microsites/manuales/internet/manual_15.pdf

TUTORIAL DE BÚSQUEDA BIBLIOGRÁFICA
http://fcm.uncu.edu.ar/4-Biblioteca/tutoriales/busqueda.htm

BVS >Bases bibliográficas

http://bases.bvsalud.org/public/scripts/php/page_show_main.php?home=true&lang=es&form=simple

Articulos Relacionados :

• Guía de Practica clínica
• Niveles de evidencia en estudios científicos
• Estudios Científicos

Estrategias de búsqueda de información sobre cirugía vascular en Internet

Estrategias de búsqueda de información sobre cirugía vascular en Internet

pulse sobre visualizar documento

Farmacología de la oxicodona: ¿Explica por qué la oxicodona se ha convertido en un opioide con fuerte éxito de venta?

Farmacología de la oxicodona: ¿Explica por qué la oxicodona se ha convertido en un opioide con fuerte éxito de venta? Pharmacology of oxycodone: does it explain why oxycodone has become a bestselling strong opioid? Kim K. Lemberga, Tarja E. Heiskanenb, Vesa K. Kontinena, Eija A. Kalsoa, Scandinavian Journal of Pain 1, S1 (2009) S18 S23 As morphine, oxycodone is a m-opioid receptor agonist with a significantly different pharmacokinetic profile compared with morphine. It seems that oxycodone is able to compensate its lower binding affinity for the m-opioid receptor compared with that of morphine by active transport to the central nervous system. Although the analgesic properties of oxycodone are mainly due to its own activity, cytochrome (CYP) inhibitors and inductors may change oxycodone-induced analgesia as a result of higher or lower, respectively, oxycodone concentrations. Enlace para leer el artículo completo: http://download.journals.elsevierhealth.com/pdfs/journals/1877-8860/PIIS1877886009700059.pdf   Nuevos principios terapéuticos de los efectos adversos sobre el tracto gastrointestinal alto y bajo en lo pacientes tratados con analgésicos opioides New therapeutic principles for adverse effects on upper and lower gastrointestinal tract in patients treated with opioid analgesics Torill Kaasa, Luis Romundstad, Harald Breivik University of Oslo and Rikshospitalet, Department of Anaesthesiology and Intensive Care, 0027 Oslo, Norway Scandinavian Journal of Pain 1, S1 (2009) S12 S17 Recent large scale surveys document that patients on opioid analgesics suffer adverse effects from increased tone in sphincters of both the upper and lower part of the gastrointestinal tract, decreased secretions into and increased absorption of fluids out of the bowel. These adverse effects often cause patients to discontinue opioid analgesics. Also patients treated with opioids for acute pain after surgery and in the intensive care units suffer gastrointestinal adverse effects. Constipation is the most common adverse effect of opioids. Most patients self-medicate with over-the-counter laxatives but suffer unpredictable responses and bothersome adverse effects of laxatives. Potent prescription laxatives may further adversely impact quality of life of chronic pain patients. Opioid-induced dysfunctions of the upper gastrointestinal tract are often misinterpreted by health care providers, and they are not relieved by laxatives. Two therapeutic developments make specific and effective prophylaxis and treatment possible: (1) Peripherally acting opioid antagonists that do not cross the blood brain barrier (methylnaltrexone and alvimopan), and (2) the opioid antagonist naloxone added to an opioid agonist in prolonged-release oral formulations (tilidin or oxycodone). Orally administered prolonged-release naloxone is almost completely eliminated during the first-pass through the liver and will therefore not reach opioid receptors in the central nervous system. These drugs relieve both upper and lower gastrointestinal adverse effects of opioid agonists, although their effects on constipation have been the focus of most clinical studies. These new pharmacological principles promise improved management of pain with opioids both for acute and chronic pain conditions. Enlace para leer el artículo completo: http://download.journals.elsevierhealth.com/pdfs/journals/1877-8860/PIIS1877886009700047.pdf  Papel de la oxicodona y de oxicodona/naloxona en al tratamiento del dolor por cáncer Role of oxycodone and oxycodone/naloxone in cancer pain management. Leppert W. Department of Palliative Medicine, Poznań University of Medical Sciences, Osiedle Rusa 25 A, PL 61-245 Poznań, Poland. wojciechleppert@wp.pl Pharmacol Rep. 2010;62(4):578-91. Abstract Oxycodone is a valued opioid analgesic, which may be administered either as the first strong opioid or when other strong opioids are ineffective. In case of insufficient analgesia and/or intense adverse effects such as sedation, hallucinations and nausea/vomiting a switch from another opioid to oxycodone might be beneficial. Oxycodone is administered to opioid-naive patients with severe pain and to patients who were unsuccessfully treated with weak opioids, namely tramadol, codeine and dihydrocodeine. Oxycodone effective analgesia may be attributed to its affinity to μ and possibly κ opioid receptors, rapid penetration through the blood-brain barrier and higher concentrations in brain than in plasma. Oxycodone displays high bioavailability after oral administration and may be better than morphine in patients with renal impairment due to the decreased production of active metabolites. Recently an oral controlled-release oxycodone formulation was introduced in Poland. Another new product that was launched recently is a combination of prolonged-release oxycodone with prolonged-release naloxone (oxycodone/naloxone tablets). The aim of this review is to outline the pharmacodynamic and pharmacokinetic properties, drug interactions, dosing rules, adverse effects, equianalgesic dose ratio with other opioids and clinical studies of oxycodone in patients with cancer pain. The potential role of oxycodone/naloxone in chronic pain management and its impact on the bowel function is also discussed. Enlace para leer el artículo completo: http://www.if-pan.krakow.pl/pjp/pdf/2010/4_578.pdf

Atentamente Anestesiología y Medicina del Dolor www.anestesia-dolor.org