Premio Nobel de química 2015

Octubre 8, 2015. No. 2108-AOctubre, mes de lucha contra cáncer de mama.

Premio Nobel de química Cellular secrets of DNA repair win Nobel Prize for chemistry Tomas Lindahl, Paul Modrich, and Aziz Sancar  HTML Control de calidad de la reparación del ADN. Quality control by DNA repair. Lindahl T, Wood RD. Science. 1999 Dec 3;286(5446):1897-905. Abstract Faithful maintenance of the genome is crucial to the individual and to species. DNA damage arises from both endogenous sources such as water and oxygen and exogenous sources such as sunlight and tobacco smoke. In human cells, base alterations are generally removed by excision repair pathways that counteract the mutagenic effects of DNA lesions. This serves to maintain the integrity of the genetic information, although not all of the pathways are absolutely error-free. In some cases, DNA damage is not repaired but is instead bypassed by specialized DNA polymerases.  PDF

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