Obesidade, força muscular diminuída e tromboembolismo venoso em pacientes idosos: Estudo InCHIANTI

Obesidade, força muscular diminuída e tromboembolismo venoso em pacientes idosos: Estudo InCHIANTI

São Paulo, 31 de Janeiro de 2011 Tanto a obesidade quanto ao declínio da força muscular, que frequentemente ocorrem com a idade, acompanham-se de alterações funcionais e metabólicas que podem alterar o risco de trombose. Pesquisadores italianos publicaram, recentemente, no Journal of Gerontology, American Biology Science Medicine Science, um estudo em que procuraram avaliar se obesidade e força muscular diminuída estão associadas ao tromboembolismo venoso (TEV). TEVs objetivamente confirmados foram avaliados em momento basal e após mais de seis meses de acompanhamento em 1045 participantes, incluídos no estudo InCHIANTI por mais de 60 anos. Em momento basal, 97 participantes apresentaram história positiva de TEV. Participantes obesos apresentaram tendência quase duas vezes maior (OR = 1,76; IC95% = 1,03 – 3,01) e participantes obesos com força muscular diminuída apresentaram tendência três vezes maior (OR = 2,99; IC95% = 1,56 – 5,73) de ter TEV, comparados a participantes magros com força muscular normal. No total, 55 casos de TEVs ocorreram durante o acompanhamento. Antecedente pessoal de TEV, obesidade e/ou força muscular diminuída foram preditores independentes de novos eventos de TEV. Em participantes com TEV prévia, o odds ratio (IC95%) para trombose foi de 6,64 (1,92 – 22,95) com força muscular diminuída, de 9,69 (3,13 – 30,01) em pacientes obesos e de 14,57 (5,16 – 41,15) em pacientes obesos com força muscular diminuída, comparados a participantes magros com força muscular normal. Os pesquisadores concluíram que obesidade, associada ou não à diminuição de força muscular, é um fator de risco para tromboembolismo venoso em pacientes idosos e amplifica significativamente o risco de recidiva da trombose. Uma resenha de Obesity, Poor Muscle Strength, and Venous Thromboembolism in Older Persons: The InCHIANTI Study- Journal of Gerontology, American Biology Science Medicine Science; 2010 Nov 26 [Epub ahead of print]

Síndromes autoinflamatórias hereditárias na faixa etária pediátrica

Síndromes autoinflamatórias hereditárias na faixa etária pediátrica

São Paulo, 31 de Janeiro de 2011 Objetivo: Descrever as principais síndromes autoinflamatórias hereditárias na faixa etária pediátrica. Fontes dos Dados: Foi realizada uma revisão da literatura nas bases de dados PubMed e SciELO, utilizando as palavras-chave "síndromes autoinflamatórias” e "criança”, e incluindo referências bibliográficas relevantes. Síntese dos Dados: As principais síndromes autoinflamatórias são causadas por defeitos monogênicos em proteínas da imunidade inata, sendo consideradas imunodeficiências primárias. Elas são caracterizadas clinicamente por sintomas inflamatórios sistêmicos recorrentes ou contínuos e devem ser diferenciadas das doenças infecciosas, autoimunes e outras imunodeficiências primárias. Nesta revisão, foram enfatizadas características epidemiológicas, manifestações clínicas, alterações laboratoriais, prognóstico e terapia das principais síndromes autoinflamatórias: febre familiar do Mediterrâneo; síndrome periódica associada ao receptor de fator de necrose tumoral; criopirinopatias; deficiência de mevalonato-quinase; artrite granulomatosa pediátrica; síndrome de pioderma gangrenoso, artrite piogênica e acne; síndrome de Majeed; e deficiência do antagonista do receptor de interleucina-1. As criopirinopatias discutidas foram: doença inflamatória multissistêmica de início neonatal ou síndrome neurológica, cutânea e articular crônica infantil, síndrome de Muckle-Wells e síndrome autoinflamatória familiar associada ao frio. Conclusões: É importante que o pediatra reconheça as síndromes autoinflamatórias hereditárias mais prevalentes, pois o encaminhamento ao reumatologista pediátrico pode permitir um diagnóstico precoce e uma instituição de tratamento adequado, possibilitando uma melhora da qualidade de vida dos pacientes.   Palavras-chave: Síndrome autoinflamatória; criança; febre familiar do Mediterrâneo; criopirinopatias; TRAPS; NOMID. Síndromes autoinflamatórias hereditárias na faixa etária pediátrica

WikiLeaks

• Times Topics: WikiLeaks

  News about WikiLeaks. Commentary and archival information about WikiLeaks from The New York Times.
• • 

  • WikiLeaks Angry About Former Staffer's Book

    10 Feb 2011 ... A tell-all book to be released Friday is highly critical of Julian Assange, and says the Web site was disabled by a spate of defections last ...February 11, 2011 - By RAVI SOMAIYA - World / Europe

• Qaddafi Blames WikiLeaks for Tunisia Unrest

  17 Jan 2011 ... The man who has ruled Libya with an iron fist for more than four decades says that sinister Western intelligence organization was behind the ...January 17, 2011 - The Lede
• • 

  • Former WikiLeaks Colleagues Forming New Web Site, OpenLeaks ...

    6 Feb 2011 ... The new site emerges from the ashes of a struggle between Julian Assange, the WikiLeaks founder, and many of his closest associates.February 7, 2011 - By RAVI SOMAIYA - World
• • 

  • VIDEO:WikiLeaks: The Back Story - Video Library

    26 Jan 2011 ... The executive editor, Bill Keller, and other journalists from The Times discuss dealing with Julian Assange, reporting on the leaks and the ...January 26, 2011
• • 

  • Wikileaks Founder in Court to Fight Extradition

    7 Feb 2011 ... The founder of WikiLeaks argued in a London court that extradition to Sweden could expose him to illegal rendition to the United States.February 8, 2011 - By JOHN F. BURNS and RAVI SOMAIYA - World / Europe

• Dispute Over Confinement of WikiLeaks Suspect Echoes Guantánamo ...

  25 Jan 2011 ... Claims that the confinement of Pfc. Bradley Manning is unnecessarily harsh bring to mind similar arguments made on behalf of Capt.January 25, 2011 - Atwar Blog

• Assange Accuses Prosecutors of Distorting Facts in Extradition Hearing

  8 Feb 2011 ... LONDON — Julian Assange, the WikiLeaks founder, said on Tuesday that the effort to extradite him to Sweden to face allegations of sexual ...February 9, 2011 - By RAVI SOMAIYA - World / Europe

• WikiLeaks: No Harm, No Foul

  19 Jan 2011 ... According to a congressional aide who spoke to Reuters, State Department officials concluded late last year that the publication of leaked ...January 19, 2011 - The Lede

• Russia Expels Journalist Who Covered WikiLeaks Cables

  7 Feb 2011 ... No reason was given for the expulsion of Luke Harding, who writes for The Guardian in London and has worked on coverage of the cables ...February 8, 2011 - By CLIFFORD J. LEVY - World / Europe

En este día....

ON THIS DAY

February 12

• See larger version »
• Buy a reproduction »

On Feb. 12, 1973, the first release of American prisoners of war from the Vietnam conflict took place.
Go to article »

On Feb. 12, 1809, Charles Darwin, who originated the theory of evolution by natural selection, was born. Following his death on April 19, 1882, his obituary appeared in The Times.

Go to obituary » | Other birthdays »

On This Date

1554	Lady Jane Grey, who had claimed the throne of England for nine days, was beheaded after being charged with treason.
1733	English colonists led by James Oglethorpe founded Savannah, Ga.
1809	Naturalist Charles Darwin was born in Shrewsbury, England.
1870	Women in the Utah Territory gained the right to vote.
1909	The National Association for the Advancement of Colored People was founded in New York.
1912	Pu Yi, the last emperor of China, abdicated, marking the end of the Qing Dynasty.
1915	The cornerstone for the Lincoln Memorial was laid in Washington, D.C.
1924	George Gershwin's "Rhapsody in Blue" premiered in New York City.
1999	The Senate voted to acquit President Bill Clinton on charges of perjury and obstruction of justice.
2000	Charles M. Schulz, creator of the "Peanuts" comic strip, died at age 77.
2000	Hall of Fame football coach Tom Landry died at age 75.
2001	The NEAR spacecraft touched down on Eros, completing the first landing on an asteroid.
2004	Defying a California law, San Francisco officials began performing weddings for same-sex couples.
2009	A commuter plane crashed into a suburban Buffalo, N.Y., home, killing all 49 aboard and a person in the house.

Current Birthdays

Former Sen. Arlen Specter, D-Pa., turns 81 years old today.

AP Photo/Gene J. Puskar

Actress Christina Ricci turns 31 years old today.

AP Photo/Dan Steinberg

1923	Franco Zeffirelli, Director, turns 88
1926	Joe Garagiola, Sportscaster, turns 85
1934	Bill Russell, Basketball Hall of Famer, turns 77
1936	Joe Don Baker, Actor, turns 75
1939	Ray Manzarek, Rock musician (The Doors), turns 72
1950	Steve Hackett, Rock musician (Genesis), turns 61
1952	Michael McDonald, Singer (The Doobie Brothers), turns 59
1953	Joanna Kerns, Actress ("Growing Pains"), turns 58
1955	Arsenio Hall, Actor, turns 56
1968	Josh Brolin, Actor ("W.," "No Country for Old Men"), turns 43
1968	Chynna Phillips, Singer (Wilson Philips), turns 43
1979	Jesse Spencer, Actor ("House"), turns 32

Historic Birthdays

Charles Darwin2/12/1809 - 4/19/1882English naturalist who documented evolution.Go to obituary »

53	Thomas Campion 2/12/1567 - 3/1/1620 English poet,composer and musical theorist
44	Caspar Bartholin 2/12/1585 - 7/13/1629 Danish physician/theologian
65	Cotton Mather 2/12/1663 - 2/13/1728 American Congregational minister/author
92	Peter Cooper 2/12/1791 - 4/4/1883 American inventor,manufacturer and philanthropist
56	Abraham Lincoln 2/12/1809 - 4/15/1865 16th President of the United States
40	John Graham Chambers 2/12/1843 - 3/4/1883 English sportsman and journalist
89	John L. Lewis 2/12/1880 - 6/11/1969 American labor leader and founder of the C.I.O.
96	Alice Roosevelt Longworth 2/12/1884 - 2/20/1980 American politically influential daughter of Theodore Roosevelt
66	Max Beckmann 2/12/1884 - 12/27/1950 German expressionist painter/printmaker
88	Omar Bradley 2/12/1893 - 4/8/1981 American general, 1st chairman of the Joint Chiefs of Staff
47	Louis Buchalter 2/12/1897 - 3/4/1944 American crime boss
81	Roy Harris 2/12/1898 - 10/1/1979 American composer/teacher
81	Joseph Alioto 2/12/1916 - 1/29/1998 Mayor of San Francisco

CDC updates meningococcal vaccine guidelines

Vaccine-Preventable Diseases

Posted February 1, 2011

CDC updates meningococcal vaccine guidelines

CDC. MMWR. 2011;60:72-75.

• Submit a Comment
• Email
• Print
• 

When the CDC releases its 2011 Child and Adolescent Immunization schedule on Feb. 11, it will include updated recommendations for the use of quadrivalent meningococcal conjugate vaccines in adolescents, according to today’s Morbidity and Mortality Weekly Report.

Based on a review of data that included the vaccine-effectiveness and cost-effectiveness of different vaccination strategies for adolescents, the CDC’s Advisory Committee on Immunization Practices now recommends routine vaccination of adolescents aged 11 or 12 years, with a booster dose at 16 years; and a two-dose primary series given 2 months apart for those aged 2 to 54 years with persistent complement component deficiency and functional or anatomic asplenia, and for adolescents with HIV.

Meningococcal conjugate vaccines were licensed in 2005. Since then, further data on bacterial antibody persistence, US trends in meningococcal disease epidemiology, and vaccine-effectiveness indicated that many vaccinated adolescents were only protected for 5 years. This meant a dose given at age 11 or 12 years may only provide immunity until age 16 years, when risk of the disease begins to peak.

Although the disease incidence rate has been on the decline since 2000, the peak in disease among 18-year-olds has persisted, even after routine vaccination. From 2000-2004 to 2005-2009, the number of serogroups C and Y cases, which represent most vaccine-preventable incidences of the disease, were down 74% in 11- to 14-year-olds; for 15- to 18-year-olds, the decrease was 27%. Cases of infected people who were vaccinated against the disease have also been reported.

A case-control study (case patients, n=108; controls, n=158) of a meningococcal conjugate vaccine (Menactra, Sanofi-Pasteur) showed the overall vaccine-effectiveness in those vaccinated 0 to 5 years before the study was 78% (95% CI, 29-93). The vaccine-effectiveness for those vaccinated less than 1 year earlier was 95% (95% CI, 10-100); vaccine-effectiveness for those vaccinated 1 year earlier was 91% (95% CI, 10-101); vaccine-effectiveness for those vaccinated 2 to 5 years earlier was 58% (95% CI, –72 to 89).