miércoles, 23 de enero de 2013

You Are Going to Die



http://www.smo.edu.mx/


http://opinionator.blogs.nytimes.com/2013/01/20/you-are-going-to-die/?src=me&ref=general



ANXIETY January 20, 2013, 9:00 pm560 Comments
You Are Going to DieBy TIM KREIDER


Anxiety: We worry. A gallery of contributors count the ways.

TAGS:

AGING, DEATH AND DYING,ELDERLY, LONGEVITY,RETIREMENT COMMUNITIES AND ASSISTED LIVING





My sister and I recently toured the retirement community where my mother has announced she’ll be moving. I have been in some bleak clinical facilities for the elderly where not one person was compos mentis and I had to politely suppress the urge to flee, but this was nothing like that. It was a very cushy modern complex housed in what used to be a seminary, with individual condominiums with big kitchens and sun rooms, equipped with fancy restaurants, grills and snack bars, a fitness center, a concert hall, a library, an art room, a couple of beauty salons, a bank and an ornate chapel of Italian marble. You could walk from any building in the complex to another without ever going outside, through underground corridors and glass-enclosed walkways through the woods. Mom described it as “like a college dorm, except the boys aren’t as good-looking.” Nonetheless I spent much of my day trying not to cry.

You are older at this moment than you’ve ever been before, and it’s the youngest you’re ever going to get.



At all times of major life crisis, friends and family will crowd around and press upon you the false emotions appropriate to the occasion. “That’s so great!” everyone said of my mother’s decision to move to an assisted-living facility. “It’s really impressive that she decided to do that herself.” They cited their own stories of 90-year-old parents grimly clinging to drafty dilapidated houses, refusing to move until forced out by strokes or broken hips. “You should be really relieved and grateful.” “She’ll be much happier there.” The overbearing unanimity of this chorus suggests to me that its real purpose is less to reassure than to suppress, to deny the most obvious and natural emotion that attends this occasion, which is sadness.

My sadness is purely selfish, I know. My friends are right; this was all Mom’s idea, she’s looking forward to it, and she really will be happier there. But it also means losing the farm my father bought in 1976, where my sister and I grew up, where Dad died in 1991. We’re losing our old phone number, the one we’ve had since the Ford administration, a number I know as well as my own middle name. However infrequently I go there, it is the place on earth that feels like home to me, the place I’ll always have to go back to in case adulthood falls through. I hadn’t realized, until I was forcibly divested of it, that I’d been harboring the idea that someday, when this whole crazy adventure was over, I would at some point be nine again, sitting around the dinner table with Mom and Dad and my sister. And beneath it all, even at age 45, there is the irrational, little-kid fear: Who’s going to take care of me? I remember my mother telling me that when her own mother died, when Mom was in her 40s, her first thought was: I’m an orphan.
Daehyun Kim

Plenty of people before me have lamented the way that we in industrialized countries regard our elderly as unproductive workers or obsolete products, and lock them away in institutions instead of taking them into our own homes out of devotion and duty. Most of these critiques are directed at the indifference and cruelty thus displayed to the elderly; what I wonder about is what it’s doing to the rest of us.

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Read previous contributions to this series.

Segregating the old and the sick enables a fantasy, as baseless as the fantasy of capitalism’s endless expansion, of youth and health as eternal, in which old age can seem to be an inexplicably bad lifestyle choice, like eating junk food or buying a minivan, that you can avoid if you’re well-educated or hip enough. So that when through absolutely no fault of your own your eyesight begins to blur and you can no longer eat whatever you want without consequence and the hangovers start lasting for days, you feel somehow ripped off, lied to. Aging feels grotesquely unfair. As if there ought to be someone to sue.

We don’t see old or infirm people much in movies or on TV. We love explosive gory death onscreen, but we’re not so enamored of the creeping, gray, incontinent kind. Aging and death are embarrassing medical conditions, like hemorrhoids or eczema, best kept out of sight. Survivors of serious illness or injuries have written that, once they were sick or disabled, they found themselves confined to a different world, a world of sick people, invisible to the rest of us. Denis Johnson writes in his novel “Jesus’ Son”: “You and I don’t know about these diseases until we get them, in which case we also will be put out of sight.”

My own father died at home, in what was once my childhood bedroom. He was, in this respect at least, a lucky man. Almost everyone dies in a hospital now, even though absolutely nobody wants to, because by the time we’re dying all the decisions have been taken out of our hands by the well, and the well are without mercy. Of course we hospitalize the sick and the old for some good reasons (better care, pain relief), but I think we also segregate the elderly from the rest of society because we’re afraid of them, as if age might be contagious. Which, it turns out, it is.

Because of all the stories we’ve absorbed, we vaguely imagine that our lives will take the shape of a narrative — the classic Aristotelian ramp diagram of gradual rising action (struggle and setbacks), climax (happy marriage, professional success), and a brief, cozy denoument (kicking back with family and friends, remembering the good times on a porch someplace pretty). But life is not shaped like a story; it’s an elongate and flattened bell curve, with an attenuated, anticlimactic decline as long as its beginning. Friends have described seeing their parents lose their faculties one by one, in more or less the reverse order that their young children are acquiring them.

Another illusion we can’t seem to relinquish, partly because large and moneyed industries thrive on sustaining it, is that with enough money and information we’ll be able to control how we age and die. But one of the main aspects of aging is the loss of control. Even people with the money to arrange to age in comfort can die in agony and indignity, gabbling like infants, forgetting their own children, sans everything. Death is a lot like birth (which people also gird themselves for with books and courses and experts) — everyone’s is different, some are relatively quick and painless and some are prolonged and traumatic, but they’re all pretty messy and unpleasant and there’s not a lot you can do to prepare yourself.

I’m not trying to romanticize the beauty of osteoporosis, the wisdom of Alzheimer’s or the dignity of incontinence. More than one old person has ordered me, “Do not get old.” They did not appear to be kidding. I’m not talking about Learning from the Invaluable Life Experience of Our Elders, or even suggesting we need to accept the inevitable with grace. I am all for raging against the dying of the light, and if they ever develop DNA rejuvenation or some other longevity technique I will personally claw, throttle and gouge my way through Warren Buffett, Rupert Murdoch and any number of other decrepit billionaires in order to be first in line.

But we don’t have a choice. You are older at this moment than you’ve ever been before, and it’s the youngest you’re ever going to get. The mortality rate is holding at a scandalous 100 percent. Pretending death can be indefinitely evaded with hot yoga or a gluten-free diet or antioxidants or just by refusing to look is craven denial. “Facing it, always facing it, that’s the way to get through,” Conrad wrote in “Typhoon.” “Face it.” He was talking about more than storms. The sheltered prince Siddartha Gautama was supposedly set on the path to becoming the Buddha when he was out riding and happened to see an old man, a sick man and a dead man. Today he’d be spared the discomfiture, and the enlightenment, unless he were riding mass transit.

Just yesterday my mother sent me a poem she first read in college — Langston Hughes’s “Mother to Son.” She said she could still remember where she was, in her dorm room at Goshen College, when she came across it in her American Lit book. The title notwithstanding, it does not make for Hallmark-card copy. Life for me ain’t been no crystal stair. It tells us that this life is not a story or an adventure or a journey of spiritual self-discovery; it’s a slog. And it orders us to keep going, don’t you dare give up, no matter what. Because I’m your mother, that’s why.

(Anxiety welcomes submissions at anxiety@nytimes.com. Unfortunately, we can only notify writers whose articles have been accepted for publication.)


Tim Kreider is the author of “We Learn Nothing,” a collection of essays and cartoons. His cartoon, “The Pain — When Will It End?” has been collected in three books by Fantagraphics.

This post has been revised to reflect the following correction:

Correction: January 21, 2013

An earlier version of this article misspelled Warren Buffett's surname.

lunes, 21 de enero de 2013

Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2012​

Más de melatonina/More melatonine

CMO en linea http://www.smo.edu.mx/

http://www.smo.edu.mx/


Melatonina y sus metabolitos: nuevos datos relacionados a su producción y las acciones de sus radicales libres
Melatonin and its metabolites: new findings regarding their production and their radical scavenging actions.
Reiter RJ, Tan DX, Terron MP, Flores LJ, Czarnocki Z.
Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio 78229-3900, USA.reiter@uthscsa.edu
Acta Biochim Pol. 2007;54(1):1-9. Epub 2007 Mar 9.
Abstract
This review summarizes some of the recent findings concerning the long-held tenet that the enzyme, N-acetyltransferase, which is involved in the production of N-acetylserotonin, the immediate precursor of melatonin, may in fact not always control the quantity of melatonin generated. New evidence from several different laboratories indicates that hydroxyindole-O-methyltransferase, which O-methylates N-acetylserotonin to melatonin may be rate-limiting in some cases. Also, the review makes the point that melatonin's actions are uncommonly widespread in organs due to the fact that it works via membrane receptors, nuclear receptors/binding sites and receptor-independent mechanisms, i.e., the direct scavenging of free radicals. Finally, the review briefly summarizes the actions of melatonin and its metabolites in the detoxification of oxygen and nitrogen-based free radicals and related non-radical products. Via these multiple processes, melatonin is capable of influencing the metabolism of every cell in the organism.
http://www.actabp.pl/pdf/1_2007/1.pdf


CMO en linea http://www.smo.edu.mx/

http://www.smo.edu.mx/


Revisión de melatonina y reproducción
Melatonin and reproduction revisited.
Reiter RJ, Tan DX, Manchester LC, Paredes SD, Mayo JC, Sainz RM.
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, USA. reiter@uthscsa.edu
Biol Reprod. 2009 Sep;81(3):445-56. doi: 10.1095/biolreprod.108.075655. Epub 2009 May 13.
Abstract
This brief review summarizes new findings related to the reported beneficial effects of melatonin on reproductive physiology beyond its now well-known role in determining the sexual status in both long-day and short-day seasonally breeding mammals. Of particular note are those reproductive processes that have been shown to benefit from the ability of melatonin to function in the reduction of oxidative stress. In the few species that have been tested, brightly colored secondary sexual characteristics that serve as a sexual attractant reportedly are enhanced by melatonin administration. This is of potential importance inasmuch as the brightness of ornamental pigmentation is also associated with animals that are of the highest genetic quality. Free radical damage is commonplace during pregnancy and has negative effects on the mother, placenta, and fetus. Because of its ability to readily pass through the placenta, melatonin easily protects the fetus from oxidative damage, as well as the maternal tissues and placenta. Examples of conditions in which oxidative and nitrosative stress can be extensive during pregnancy include preeclampsia and damage resulting from anoxia or hypoxia that is followed by reflow of oxygenated blood into the tissue. Given the uncommonly low toxicity of melatonin, clinical trials are warranted to document the protection by melatonin against pathophysiological states of the reproductive system in which free radical damage is known to occur. Finally, the beneficial effects of melatonin in improving the outcomes of in vitro fertilization and embryo transfer should be further tested and exploited. The information in this article has applicability to human and veterinary medicine.
http://www.biolreprod.org/content/81/3/445.full.pdf


CMO en linea http://www.smo.edu.mx/

http://www.smo.edu.mx/



La melatonina mitiga la disfunción mitocondrial


Melatonin mitigates mitochondrial malfunction.
León J, Acuña-Castroviejo D, Escames G, Tan DX, Reiter RJ.
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA.
J Pineal Res. 2005 Jan;38(1):1-9.
Abstract
Melatonin, or N-acetyl-5-methoxytryptamine, is a compound derived from tryptophan that is found in all organisms from unicells to vertebrates. This indoleamine may act as a protective agent in disease conditions such as Parkinson's, Alzheimer's, aging, sepsis and other disorders including ischemia/reperfusion. In addition, melatonin has been proposed as a drug for the treatment of cancer. These disorders have in common a dysfunction of the apoptotic program. Thus, while defects which reduce apoptotic processes can exaggerate cancer, neurodegenerative disorders and ischemic conditions are made worse by enhanced apoptosis. The mechanism by which melatonin controls cell death is not entirely known. Recently, mitochondria, which are implicated in the intrinsic pathway of apoptosis, have been identified as a target for melatonin actions. It is known that melatonin scavenges oxygen and nitrogen-based reactants generated in mitochondria. This limits the loss of the intramitochondrial glutathione and lowers mitochondrial protein damage, improving electron transport chain (ETC) activity and reducing mtDNA damage. Melatonin also increases the activity of the complex I and complex IV of the ETC, thereby improving mitochondrial respiration and increasing ATP synthesis under normal and stressful conditions. These effects reflect the ability of melatonin to reduce the harmful reduction in the mitochondrial membrane potential that may trigger mitochondrial transition pore (MTP) opening and the apoptotic cascade. In addition, a reported direct action of melatonin in the control of currents through the MTP opens a new perspective in the understanding of the regulation of apoptotic cell death by the indoleamine.
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-079X.2004.00181.x/pdf



Atentamente
Anestesiología y Medicina del Dolor
www.anestesia-dolor.org



CMO en linea http://www.smo.edu.mx/

http://www.smo.edu.mx/


CMO en linea http://www.smo.edu.mx/

3er Curso taller de diseño y elaboración de manuscritos médicos en ortopedia


Buenos días!!!
Recordando que para esta semana, este sábado, de 9 a 2 pm, tenemos el 3er Curso
taller de diseño y elaboración de manuscritos médicos en ortopedia, ademas de ser SIN COSTO, TIENE VALOR CURRICULAR, toda la información en el siguiente enlace:

http://www.smo.edu.mx/pdf/curso-taller_RMMO-CMO-2013.pdf






Remiifentanilo y analgesia obstétrica/Remifentanil in obstetrics

Seguridad y eficacia del remifentanilo por vía intravenosa mediante un sistema de analgesia controlada por la paciente durante el trabajo de parto


Jose Novoa Apumayta, Sergio Rodriguez Benavides
Actas Peruanas de Anestesiología
http://sisbib.unmsm.edu.pe/BVRevistas/actas_anestesiologia/v20n2/

pdf/a03v20n2.pdf


Analgesia con remifentanil controlada por el pacientes versus analgesia epidural en trabajo de parto. Estudio multicéntrico aleatorizado y controlado


Remifentanil patient controlled analgesia versus epidural analgesia in labour. A multicentre randomized controlled trial.
Freeman LM, Bloemenkamp KW, Franssen MT, Papatsonis DN, Hajenius PJ, van Huizen ME, Bremer HA, van den Akker ES, Woiski MD, Porath MM, van Beek E, Schuitemaker N, van der Salm PC, Fong BF, Radder C, Bax CJ, Sikkema M, van den Akker-van Marle ME, van Lith JM, Lopriore E, Uildriks RJ, Struys MM, Mol BW, Dahan A, Middeldorp JM.
Department of Obstetrics and Gynaecology, Leiden University Medical Centre, Leiden, the Netherlands. l.m.freeman@lumc.nl
BMC Pregnancy Childbirth. 2012 Jul 2;12:63. doi: 10.1186/1471-2393-12-63.
Abstract
BACKGROUND: Pain relief during labour is a topic of major interest in the Netherlands. Epidural analgesia is considered to be the most effective method of pain relief and recommended as first choice. However its uptake by pregnant women is limited compared to other western countries, partly as a result of non-availability due to logistic problems. Remifentanil, a synthetic opioid, is very suitable for patient controlled analgesia. Recent studies show that epidural analgesia is superior to remifentanil patient controlled analgesia in terms of pain intensity score; however there was no difference in satisfaction with pain relief between both treatments. METHODS/DESIGN: The proposed study is a multicentre randomized controlled study that assesses the cost-effectiveness of remifentanil patient controlled analgesia compared to epidural analgesia. We hypothesize that remifentanil patient controlled analgesia is as effective in improving pain appreciation scores as epidural analgesia, with lower costs and easier achievement of 24 hours availability of pain relief for women in labour and efficient pain relief for those with a contraindication for epidural analgesia.Eligible women will be informed about the study and randomized before active labour has started. Women will be randomly allocated to a strategy based on epidural analgesia or on remifentanil patient controlled analgesia when they request pain relief during labour. Primary outcome is the pain appreciation score, i.e. satisfaction with pain relief.Secondary outcome parameters are costs, patient satisfaction, pain scores (pain-intensity), mode of delivery and maternal and neonatal side effects.The economic analysis will be performed from a short-term healthcare perspective. For both strategies the cost of perinatal care for mother and child, starting at the onset of labour and ending ten days after delivery, will be registered and compared. DISCUSSION: This study, considering cost effectiveness of remifentanil as first choice analgesia versus epidural analgesia, could strongly improve the care for 180.000 women, giving birth in the Netherlands yearly by giving them access to pain relief during labour, 24 hours a day.
TRIAL REGISTRATION NUMBER: Dutch Trial Register NTR2551,http://www.trialregister.nl.



http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464937/pdf/1471-2393-12-63.pdf



Comparación entre remifentanil y meperidina en analgesia para trabajo de parto: revisión sistemática.
A comparison between remifentanil and meperidine for labor analgesia: a systematic review.
Leong WL, Sng BL, Sia AT.
Department of Anaesthesia, KK Women's and Children's Hospital, 100 Bukit Timah Rd., Singapore 228988. wlleong101@gmail.com
Anesth Analg. 2011 Oct;113(4):818-25. doi: 10.1213/ANE.0b013e3182289fe9. Epub 2011 Sep 2.
Abstract
BACKGROUND: Remifentanil is an ultrashort-acting opioid with favorable pharmacokinetic properties that make it suitable as a labor analgesic. Although it crosses the placenta freely, it is eliminated quickly in the neonate by rapid metabolism and redistribution. We aimed to determine whether remifentanil compared with meperidine is effective in reducing pain scores in laboring parturients. Other effects on the mother, the labor process, and the neonate were also examined. METHODS: MEDLINE, CINAHL, Embase, Cochrane CENTRAL, and Maternity and Infant Care databases were searched without language restriction using multiple keywords for labor analgesia, remifentanil, and meperidine. Published abstracts from 5 key research meetings and references from retrieved articles were examined for additional studies. Randomized controlled trials in laboring parturients comparing remifentanil with meperidine were selected. Risk of bias was assessed using criteria outlined in the Cochrane Handbook for Systematic Reviews of Interventions. We assessed for adequacy of sequence generation, allocation concealment, blinding, and completeness of follow-up. Data were extracted from each study using a standardized data collection form. The primary outcome was reduction in pain scores (visual analog scale [VAS], 0-100 mm). We also evaluated maternal side effects (sedation, oxygen desaturation, and bradypnea) and effects on the neonate (Apgar scores, umbilical cord pH, and Neurologic and Adaptive Capacity Scores). RESULTS: Seven studies (349 patients) were identified for inclusion; only 3 studies were suitable for quantitative synthesis in a meta-analysis (233 patients). We found that remifentanil reduces the mean VAS score at 1 hour by 25 mm more than meperidine (P < 0.001) (95% confidence interval = 19-31 mm). Limited conclusions can be made regarding the side-effect profile of remifentanil because of insufficient data. CONCLUSION: Compared with meperidine, remifentanil is superior in reducing mean VAS scores for labor pain after 1 hour.
http://www.anesthesia-analgesia.org/content/113/4/818.full.pdf



Atentamente
Anestesiología y Medicina del Dolor
www.anestesia-dolor.org


domingo, 20 de enero de 2013

Dolor postoperatorio

La implementación de la calidad de sistemas de manejo mejora el tratamiento del dolor postoperatorio: estudio prospectivo mediante preguntas pre/post intervención.


Implementation of the quality management system improves postoperative pain treatment: a prospective pre-/post-interventional questionnaire study.
Usichenko TI, Röttenbacher I, Kohlmann T, Jülich A, Lange J, Mustea A, Engel G, Wendt M.
Department of Anaesthesiology and Intensive Care Medicine.
Br J Anaesth. 2013 Jan;110(1):87-95. doi: 10.1093/bja/aes352. Epub 2012 Oct 9.
Abstract
BACKGROUND: An organizational approach is proposed as an immediate solution for improving postoperative pain (POP) management. The aim was to evaluate the clinical effectiveness of a quality management system (QMS), based on procedure-specific, multimodal analgesic protocols, modified to meet the individual patients' requirements. METHODS: Patients from the orthopaedic, gynaecological, visceral, and trauma surgery departments of the university hospital were involved in two prospective surveys. Survey 1 was performed at baseline and survey 2 was performed after the implementation of QMS within an interval of 1 year. The patients were asked to report pain intensity on the visual rating scale, incidence of analgesia-related side-effects, and incidence of pain interference with the items of life quality and their satisfaction with the treatment of POP. RESULTS: Patients from Survey 2 (n=251) reported 25-30% less pain than those from Survey 1 (n=269) (P<0.0001). Nausea was reported by 40% of the patients from Survey 1 vs 17% from Survey 2, vomiting by 25 vs 11% and fatigue by 76% in Survey 1 vs 30% in Survey 2 (P<0.0001). Life quality and patients' satisfaction improved in Survey 2 vs Survey 1 (P<0.001). CONCLUSIONS: The implementation of QMS allowed the reduction in POP intensity with a simultaneous decrease in analgesia-related side-effects. This has led to an increased quality of life and patient satisfaction.


http://bja.oxfordjournals.org/content/110/1/87.full.pdf


Atentamente
Anestesiología y Medicina del Dolor
www.anestesia-dolor.org


José Guadalupe Posada



El CMO en linea.....http://www.smo.edu.mx/




La muerte y la cultura popular Mexicana.
José Guadalupe Posada.
José Guadalupe Posada (Aguascalientes, 2 de febrero de 1852 - Ciudad de México, 20 de enero de 1913) fue un pintor, ilustrador y caricaturista mexicano. Célebre por sus dibujos de escenas costumbristas, folclóricas, de crítica socio-política y por sus ilustraciones de «calacas» o calaveras, entre ellas La Catrina. Litógrafo por excelencia, publicó caricaturas con críticas políticas, humor, drama, vida cotidiana de los mexicanos. Las calaveras y versos alusivos a la muerte fueron su expresión más característica.

http://comunicacion.sociales.uba.ar/tesinas_publicadas/1245.pdf

http://www.uacj.mx/IADA/dise%C3%B1o/dg/Documents/Portal%20de%20Lecturas/Nivel%20Intermedio/Grafica%20Nacional_Omar%20Morales/Grabadores%20mexicanos.pdf

José Guadalupe Posada (Aguascalientes, February 2, 1852 - Mexico City, January 20, 1913) was a Mexican painter, illustrator and cartoonist. Famous for his drawings of genre scenes, folklore, socio-political criticism and for his illustrations of skeletons and skulls, including his most famous named La Catrina. Quintessential lithographer, published cartoons with political criticism, humor, drama, daily life of Mexicans. The skulls and verses alluding to the death were his most characteristic expression

http://publicdomainreview.org/2012/11/02/the-calaveras-of-jose-guadalupe-posada/


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Qué.es
La Biblioteca Reina Sofía de la Universidad de Valladolid (UVA), inaugurada en junio de 1988 y ubicada en la antigua cárcel de la Chancillería, ha creado un blog con motivo de su 25 aniversario. 15 de enero de 2013. VALLADOLID, 15 (EUROPA PRESS) ...
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Visión 7: Tiflolibros, Biblioteca digital para ciegos
TVPublica Argentina
Informe especial de Verónica González sobre: Tiflolibros es la primera Biblioteca Digital para Ciegos de Habla Hispana. Se trata de un servicio gratuito y exclusivo para personas con discapacidad visual. Hoy cuenta con más de 41.600 ejemplares, ...
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Una biblioteca sin papel - www.remolacha.net
según Gabriela
Una biblioteca 100% digital. ''Si quieres saber cómo será, vete a una Apple Store''... [Seguir Leyendo]
www.remolacha.net

Website nobo pa biblioteca
ORANJESTAD -- Tabata tempo pa cambia e website di biblioteca. E compania YFMG web consulting a diseña un otro website pa biblioteca. E website ...
news.caribseek.com/.../34736-website-nobo-pa-biblioteca


BiblioTech, una biblioteca sin libros (físicos) - Error 500
En Gizmodo y DVice comentan el proyecto BiblioTech, la primera biblioteca pública de San Antonio (Estados Unidos) que nacerá sin libros físicos. El modelo es ...
www.error500.net/bibliotech-una-biblioteca-sin-libros-fisicos/


Ya es oficial: la Biblioteca Nacional fue bautizada "Doctor Mariano ...
La Prensa (Argentina)
15.01.2013 | Se promulgó la ley que había sido iniciativa de Ricardo Alfonsín. La Biblioteca Nacional tomará el nombre de uno de sus impulsores para "saldar la deuda histórica que tenemos con este personaje", según dijeron los diputado radicales que ...
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La Biblioteca Reina Sofía de la Universidad de Valladolid crea un ...
20minutos.es
Según informaron a Europa Press fuentes de la Institución académica, la dotación nació como unabiblioteca pionera en su momento y ahora, en esta línea, ha querido celebrar y recordar lo sucedido durante estos años con un blog creado especialmente ...
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Una iglesia convertida en biblioteca científica
Materia
Y sus palabras parecen flotar en el aire en la nueva biblioteca del Palacio de Doñana, recién creada en una antigua capilla propiedad del Consejo Superior de Investigaciones Científicas (CSIC) en pleno Parque Nacional, a caballo entre Huelva y Sevilla.
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Materia

La Biblioteca General de Navarra realizó 166.371 préstamos de ...
20minutos.es
La colección de la Biblioteca General de Navarra, ubicada en el barrio pamplonés de Mendebaldea, a 31 de diciembre de 2012, podía cifrarse en 500.000 documentos, de los cuales el número de ejemplares accesibles a través del catálogo automatizado ...
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Bibliotecas sin libros, el futuro de los libros en Estados Unidos
WebAdictos
Con la llegada de los libros electrónicos, es obvio que se ha dado un cambio significativo en la forma de comercializar y leer libros, sin embargo hablar de bibliotecas ficticias, o bibliotecas sin libros no es tan común, pero es la idea que tienen en ...
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Estados Unidos tendrá una biblioteca sin libros - FayerWayer
según Cony Sturm
Quienes asistan a la biblioteca podrán leer el libro que elijan en cualquiera de los dispositivos de labiblioteca, arrendar un e-reader por un periodo de tiempo, o llevar sus propios e-readers y cargar libros en ellos. La instalación realizará ...
FayerWayer

::Hipermedula.org :: Inscripciones para Taller La Biblioteca Inmaterial
Madrid, España. Del 23 al 25 de enero de 2013. La Biblioteca Inmaterial: Tradición oral y pertenencia. Relatos del Viento Museo de América Av. Reyes.
hipermedula.org/.../inscripciones-para-taller-la-biblioteca-inma...
La Biblioteca Municipal de Campana recibió obras literarias de ...
El Secretario de Cultura y Educación, Fito Tolassi, y la Coordinadora General Ejecutiva de laBiblioteca Pública Municipal, Marta Magistratti de Demousselle, ...
www.enlacecritico.com/.../la-biblioteca-municipal-de-campana...
El Club y Biblioteca Agustín Alvarez pone en marcha las inferiores y ...
El Club y Biblioteca Agustín Alvarez pone en marcha las inferiores y preinfantiles . Se inician a partir de mañana. El Club y Biblioteca Agustín Alvarez pone en ...
www.cadenanueve.com/.../el-club-y-biblioteca-pone-en-march...

CRASH-2



Prediciendo la muerte temprana en pacientes con sangrado por trauma: desarrollo y validación de un modelo pronóstico
Predicting early death in patients with traumatic bleeding: development and validation of prognostic model.
Perel P, Prieto-Merino D, Shakur H, Clayton T, Lecky F, Bouamra O, Russell R, Faulkner M, Steyerberg EW, Roberts I.
Clinical Trials Unit, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK. pablo.perel@lshtm.ac.uk
BMJ. 2012 Aug 15;345:e5166. doi: 10.1136/bmj.e5166.
Abstract
OBJECTIVE: To develop and validate a prognostic model for early death in patients with traumatic bleeding. DESIGN: Multivariable logistic regression of a large international cohort of trauma patients. SETTING: 274 hospitals in 40 high, medium, and low income countries. PARTICIPANTS:
Prognostic model development: 20,127 trauma patients with, or at risk of, significant bleeding, within 8 hours of injury in the Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage (CRASH-2) trial. External validation: 14,220 selected trauma patients from the Trauma Audit and Research Network (TARN), which included mainly patients from the UK. OUTCOMES: In-hospital death within 4 weeks of injury. RESULTS: 3076 (15%) patients died in the CRASH-2 trial and 1765 (12%) in the TARN dataset. Glasgow coma score, age, and systolic blood pressure were the strongest predictors of mortality. Other predictors included in the final model were geographical region (low, middle, or high income country), heart rate, time since injury, and type of injury. Discrimination and calibration were satisfactory, with C statistics above 0.80 in both CRASH-2 and TARN. A simple chart was constructed to readily provide the probability of death at the point of care, and a web based calculator is available for a more detailed risk assessment (http://crash2.lshtm.ac.uk). CONCLUSIONS: This prognostic model can be used to obtain valid predictions of mortality in patients with traumatic bleeding, assisting in triage and potentially shortening the time to diagnostic and lifesaving procedures (such as imaging, surgery, and tranexamic acid). Age is an important prognostic factor, and this is of particular relevance in high income countries with an aging trauma population.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419468/pdf/bmj.e5166.pdf




CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage). Estudio de sangrado intracranial: efecto del ácido tranexámico en el daño cerebral traumático.


CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injury--a nested randomised, placebo-controlled trial.
Perel P, Al-Shahi Salman R, Kawahara T, Morris Z, Prieto-Merino D, Roberts I, Sandercock P, Shakur H, Wardlaw J.
London School of Hygiene and Tropical Medicine, London, UK.pablo.perel@lshtm.ac.uk
Health Technol Assess. 2012;16(13):iii-xii, 1-54. doi: 10.3310/hta16130.
Abstract
BACKGROUND: Tranexamic acid (TXA) has been shown to reduce blood loss in surgical patients and the risk of death in patients with traumatic bleeding, with no apparent increase in vascular occlusive events. These findings raise the possibility that it might also be effective in traumatic brain injury (TBI). OBJECTIVE: The Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage Intracranial Bleeding Study (CRASH-2 IBS) was conducted to quantify the effect of an early short course of TXA on intracranial haemorrhage and new focal cerebral ischaemic lesions in patients with TBI. DESIGN: CRASH-2 IBS was a prospective randomised controlled trial nested within the CRASH-2 trial. Randomisation was balanced by centre, with an allocation sequence based on a block size of eight. We used a local pack system that selected the lowest numbered treatment pack from a box containing eight numbered packs. Apart from the pack number, the treatment packs were identical. The pack number was recorded on the entry form, which was sent to the international trial co-ordinating centre in London, UK. Once the treatment pack number was recorded, the patient was included in the trial whether or not the treatment pack was opened or the allocated treatment started. All site investigators and trial co-ordinating centre staff were masked to treatment allocation. SETTING: Ten hospitals: (India) Aditya Neuroscience Centre, Sanjivani Hospital, CARE Hospital, Christian Medical College, Medical Trust Hospital, Jeevan Jyoti Hospital and (Colombia) Hospital Universitario San Vicente de Paul, Hospital Pablo Tobón Uribe, Hospital Universitario San José de Popayán and Fundación Valle del Lili. PARTICIPANTS: The trial was conducted in a subset of 270 CRASH-2 trial participants. Patients eligible for inclusion in the CRASH-2 IBS fulfilled the inclusion criteria for the CRASH-2 trial, and also had TBI [Glasgow Coma Scale score of ≤ 14 and a brain computerised tomography (CT) scan compatible with TBI]. Pregnant women and patients for whom a second brain CT scan was not possible were excluded. INTERVENTIONS: Participants were randomly allocated to receive either a loading dose of 1 g of TXA infused over 10 minutes followed by an intravenous infusion of 1 g over 8 hours or matching placebo.
MAIN OUTCOME MEASURE: The primary outcome was the increase in size of intracranial haemorrhage growth between a CT scan at hospital admission and a second scan 24-48 hours later. RESULTS: One hundred and thirty-three patients were allocated to TXA and 137 to placebo, of whom information on the primary (imaging) outcome was available for 123 (92%) and 126 (92%) respectively. The analysis suggested that TXA was likely to be associated with a reduction in haemorrhage growth [adjusted difference -3.8 ml, 95% credibility interval (CrI) -11.5 ml to 3.9 ml], fewer focal ischaemic lesions [adjusted odds ratio (OR) 0.54, 95% CrI 0.20 to 1.46] and fewer deaths (adjusted OR 0.49, 95% CrI 0.22 to 1.06). CONCLUSIONS: This was the first randomised controlled study to evaluate the effect of TXA in TBI patients and it found that neither moderate benefits nor moderate harmful effects can be excluded. However, although uncertainty remains, our analyses suggest that TXA administration might improve outcome in TBI patients and provide grounds for evaluating this hypothesis in future research.
TRIAL REGISTRATION: Current Controlled Trials ISRCTN86750102.
SOURCE OF FUNDING: This project was funded by the NIHR Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 16, No. 13. See the HTA programme website for further project information.


http://www.hta.ac.uk/execsumm/summ1613.htm



Atentamente
Anestesiología y Medicina del Dolor
www.anestesia-dolor.org

viernes, 18 de enero de 2013

Books Update NYT


January 18, 2013
Books Update

On the Cover of Sunday's Book Review

'Going Clear: Scientology, Hollywood, and the Prison of Belief'
By LAWRENCE WRIGHT
Reviewed by MICHAEL KINSLEY


In "Going Clear," Lawrence Wright uses vast research and reporting to make clear that Scientology is like no church on Earth.


Also in the Book Review

Jared Diamond: By the Book


The author of "The World Until Yesterday" says that if he had to recommend one book of geography to children, he would suggest his own "Guns, Germs, and Steel."
By the Book: Archive

'Foundation: The History of England From Its Earliest Beginnings to the Tudors'
By PETER ACKROYD
Reviewed by WALTER OLSON


Peter Ackroyd looks at England's long, tumultuous formative period.

'The River Swimmer'
By JIM HARRISON
Reviewed by RON CARLSON


The men in two novellas by Jim Harrison experience the triumph and torment of being alive, at 17 and at 60.

'My Beloved World'
By SONIA SOTOMAYOR
Reviewed by EMILY BAZELON


Sonia Sotomayor recalls her early life and the road toward the court.

'Missing Out'
By ADAM PHILLIPS
Reviewed by SHEILA HETI


In these essays, Adam Phillips explores the alternative "lives we could be leading but for some reason are not."
Up Front: Sheila Heti

ON POETRY
Louise Glück's Metamorphoses
By DAVID ORR


The relationship between poetry and mythology is central to Louise Glück's "Poems 1962-2012."

'Farewell, Fred Voodoo'
By AMY WILENTZ
Reviewed by BEN FOUNTAIN


Amy Wilentz further explores Haiti, a country that continues to confound.

'Black Dahlia & White Rose'
By JOYCE CAROL OATES
Reviewed by RANDY BOYAGODA


The title story in Joyce Carol Oates's collection involves two aspiring starlets.

'The Voice Is All: The Lonely Victory of Jack Kerouac'
By JOYCE JOHNSON
Reviewed by JAMES CAMPBELL


Joyce Johnson explores Jack Kerouac's heritage and early career.

CRIME
Dead Reckoning
By MARILYN STASIO


In "Standing in Another Man's Grave," Ian Rankin's incorruptible but moody hero, John Rebus, investigates a series of missing persons cases.

Fiction Chronicle
By JAN STUART


New books by Yan Lianke, Henning Mankell, Peter Hoeg, Laird Hunt and Susan Isaacs.

[Identidad Bibliotecaria] Por mucho tiempo persistirá el libro impreso

• Ante las nuevas tecnologías y la evolución hacia una textualidad y un soporte distintos del impreso en papel, Elsa Margarita Ramírez Leyva, del IIBI de la UNAM, hizo una evaluación de cómo se... lee en México, derivada de sus indagaciones.

• El libro electrónico aún conserva la mayor parte de las características del otro, pero presenta una variante: la interactividad.

Te invitamos a leer el boletín completo:
http://www.dgcs.unam.mx/boletin/bdboletin/2013_034.html

Renovación de la galería fotográfica del CMO


Renovación de la galería fotográfica del CMO

Hola, buenas tardes, como parte de la renovación de la galería de imágenes de la pagina del CMO, les pido a todos mis amigos en el blog, que puedan colaborar, enviando imágenes radiográficas, de resonancia, TAC´s, o de las que dispongan, que sean de su propiedad y quieran compartirlas, que a juicio de ustedes sean interesantes en el área de la ortopedia y traumatología, les pido que dichas imágenes me las manden con titulo y una pequeña descripción a :

bibliomanazteca@yahoo.com.mx

Como siempre les agradezco su colaboración.

Colegio Mexicano de Ortopedia y Traumatología en linea.....


visita nuestra pagina : http://www.smo.edu.mx/


Daño hepático inducido por drogas: presente y futuro

Daño hepático inducido por drogas: presente y futuro
Drug-induced liver injury: present and future.
Suk KT, Kim DJ.
Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea.
Clin Mol Hepatol. 2012 Sep;18(3):249-57. doi: 10.3350/cmh.2012.18.3.249. Epub 2012 Sep 25.
Abstract
Liver injury due to prescription and nonprescription medications is a growing medical, scientific, and public health problem. Worldwide, the estimated annual incidence rate of drug-induced liver injury (DILI) is 13.9-24.0 per 100,000 inhabitants. DILI is one of the leading causes of acute liver failure in the US. In Korea, the annual extrapolated incidence of cases hospitalized at university hospital is 12/100,000 persons/year. Most cases of DILI are the result of idiosyncratic metabolic responses or unexpected reactions to medication. There is marked geographic variation in relevant agents; antibiotics, anticonvulsants, and psychotropic drugs are the most common offending agents in the West, whereas in Asia, 'herbs' and 'health foods or dietary supplements' are more common. Different medical circumstances also cause discrepancy in definition and classification of DILI between West and Asia. In the concern of causality assessment, the application of the Roussel Uclaf Causality Assessment Method (RUCAM) scale frequently undercounts the cases caused by 'herbs' due to a lack of previous information and incompatible time criteria. Therefore, a more objective and reproducible tool that could be used for the diagnosis of DILI caused by 'herbs' is needed in Asia. In addition, a reporting system similar to the Drug-Induced Liver Injury Network (DILIN) in the US should be established as soon as possible in Asia.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467427/pdf/cmh-18-249.pdf


Atentamente
Anestesiología y Medicina del Dolor
www.anestesia-dolor.org