Codeína / Codeine

Septiembre 2, 2017. No. 2799

Codeína y metabolismo opioide: implicaciones y alternativas para el manejo pediátrico del dolor. Codeine and opioid metabolism: implications and alternatives for pediatric pain management. Chidambaran V1, Sadhasivam S, Mahmoud M. Author information Curr Opin Anaesthesiol. 2017 Jun;30(3):349-356. doi: 10.1097/ACO.0000000000000455. Abstract PURPOSE OF REVIEW: Use of perioperative opioids for surgical pain management of children presents clinical challenges because of concerns of serious adverse effects including life-threatening respiratory depression. This is especially true for children with history of obstructive sleep apnea. This review will explore current knowledge of clinically relevant factors and genetic polymorphisms that affect opioidmetabolism and postoperative outcomes in children. RECENT FINDINGS: Within the past several years, an increasing number of case reports have illustrated clinically important respiratory depression, anoxic brain injuries and even death among children receiving appropriate weight-based dosages of codeine and other opioids for analgesia at home setting particularly following tonsillectomy. Several national and international organizations have issued advisories on use of codeine in pediatrics, based on cytochrome P450 family 2 subfamily D type 6 (CYP2D6) pharmacogenetics. We have discussed the pros and cons of alternatives to codeine for pain management. SUMMARY: Although routine preoperative genotyping to identify children at risk and personalized opioid use for pediatric perioperative painmanagement is still a distant reality, current known implications of CYP2D6 pharmacogenetics on codeine use shows that pharmacogenetics has the potential to guide anesthesia providers on perioperative opioid selection and dosing to maximize efficacy and safety. PDF Codeína: Momento de decir "No" Codeine: Time to Say "No". Tobias JD, Green TP, Coté CJ; SECTION ON ANESTHESIOLOGY AND PAIN MEDICINE; COMMITTEE ON DRUGS. Collaborators (11) Pediatrics. 2016 Oct;138(4). pii: e20162396. Epub 2016 Sep 19. Abstract Codeine has been prescribed to pediatric patients for many decades as both an analgesic and an antitussive agent. Codeine is a prodrug with little inherent pharmacologic activity and must be metabolized in the liver into morphine, which is responsible for codeine's analgesic effects. However, there is substantial genetic variability in the activity of the responsible hepatic enzyme, CYP2D6, and, as a consequence, individual patient response to codeine varies from no effect to high sensitivity. Drug surveillance has documented the occurrence of unanticipated respiratory depression and death after receiving codeine in children, many of whom have been shown to be ultrarapid metabolizers. Patients with documented or suspected obstructive sleep apnea appear to be at particular risk because of opioid sensitivity, compounding the danger among rapid metabolizers in this group. Recently, various organizations and regulatory bodies, including the World Health Organization, the US Food and Drug Administration, and the European Medicines Agency, have promulgated stern warnings regarding the occurrence of adverse effects of codeine in children. These and other groups have or are considering a declaration of a contraindication for the use of codeine for children as either an analgesic or an antitussive. Additional clinical research must extend the understanding of the risks and benefits of both opioid and nonopioid alternatives for orally administered, effective agents for acute and chronic pain. PDF XIV Congreso Virtual Mexicano de Anestesiología 2017 Octubre 1-Diciembre 31, 2017 Información / Information Video informativo California Society of Anesthesiologists Reuniones / Events Informacion / Information

Anestesiología y Medicina del Dolor 52 664 6848905 vwhizar@anestesia-dolor.org anestesia-dolor.org

Abordaje anterior para cadera

http://www.artroscopiayreemplazos.com.mx/academia/abordaje-anterior-para-cadera/

Anterior approach to the Hip

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Courtesy:Mock FRCS Cardiff, Saqib Masud FRCS, John Davies FRCS

Mock FRCS Cardiff

Publicado el 21 ago. 2016

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#abordaje anterior#cadera

Libro sobre sepsis / Book on sepsis

Septiembre 4, 2017. No. 2801

Sepsis Edited by Vijay Kumar, ISBN 978-953-51-3396-4, Print ISBN 978-953-51-3395-7, 158 pages, Publisher: InTech, Chapters published August 23, 2017 under CC BY 3.0 license DOI: 10.5772/65611 Edited Volume The book entitled Sepsis will provide a great and up-to-date information in this field to students and researchers involved in sepsis research with its chapters targeting host-pathogen interaction at a metabolic level during sepsis pathogenesis, how age affects sepsis pathogenesis and its outcome in old-age population as compared to young population, sepsis-associated acute organ injury mainly targeting acute kidney injury in sepsis, and kallistatin as host-derived immunomodulatory mechanism during sepsis, along with developments in techniques required for early diagnosis of sepsis and sepsis-associated encephalitis, a devastating medical condition observed during severe sepsis. The book is written by experts in their fields associated with sepsis, a critical condition needing great medical attention. Libro / Book XIV Congreso Virtual Mexicano de Anestesiología 2017 Octubre 1-Diciembre 31, 2017 Información / Information Video informativo Convocatoria para el Curso de Posgrado en Medicina del Dolor y Paliativa 2018 para Mexicanos y extranjeros. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Informes (52) 55 5487 0900 ext. 5011 de lunes a viernes de 9.00 a 14 h (hora de Ciudad de México).  Informes / Information

Anestesiología y Medicina del Dolor 52 664 6848905 vwhizar@anestesia-dolor.org anestesia-dolor.org

Frente a cirugía, técnica española resulta menos invasiva al tratar pie equinovaro

http://www.ortopediainfantil.com.mx/academia/frente-a-cirugia-tecnica-espanola-resulta-menos-invasiva-al-tratar-pie-equinovaro/

En entrevista con La Jornada, el doctor Juan Agustín Valcárcel León, coordinador del equipo encargado de aplicar esta técnica en el Hospital de Ortopedia Victorio de la Fuente Narváez, explicó que como el pie equinovaro es fácilmente identificable desde el nacimiento, es posible comenzar a tratarlo a edades muy tempranas…. 

#Método Ponseti#pie equinovaro