jueves, 11 de agosto de 2011

Ketorolaco intratecal

Efectos del ketorolaco intratecal en el dolor humano experimental

Effects of intrathecal ketorolac on human experimental pain.
Eisenach JC, Curry R, Tong C, Houle TT, Yaksh TL.
Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1009, USA. eisenach@wfubmc.edu
Anesthesiology. 2010 May;112(5):1216-24.
Abstract
BACKGROUND: Nonsteroidal antiinflammatory drugs, the most commonly used analgesics, reduce pain not only by inhibiting cyclooxygenase at peripheral sites of inflammation but also by potentially inhibiting cyclooxygenase in the central nervous system, especially the spinal cord. Animal studies suggest that products of cyclooxygenase in the spinal cord do not alter pain responses to acute noxious stimuli but reduce pain and sensitization after peripheral inflammation. We used a spinal injection of small doses of the cyclooxygenase inhibitor ketorolac to survey the role of spinal cyclooxygenase in human experimental pain and hypersensitivity states. METHODS: After regulatory agency approval and informed consent, we examined the effect of 2.0 mg intrathecal ketorolac in 41 healthy volunteers to acute noxious thermal stimuli in normal skin and to mechanical stimuli in skin sensitized by topical capsaicin or ultraviolet burn. We also examined the effect of intravenous ketorolac. RESULTS: Intrathecal ketorolac reduced hypersensitivity when it was induced by a combination of ultraviolet burn plus intermittent heat and, according to one of the two analytical strategies, when it was induced by ultraviolet burn alone. CONCLUSIONS: These data suggest a more limited role for spinal cord cyclooxygenase in human pain states than predicted by studies in animals.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924167/pdf/nihms189919.pdf

Papel de la ciclooxigenasa espinal en el dolor humano postoperatorio y crónico

Role of spinal cyclooxygenase in human postoperative and chronic pain.
Eisenach JC, Curry R, Rauck R, Pan P, Yaksh TL.
Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1009, USA. eisenach@wfubmc.edu
Anesthesiology. 2010 May;112(5):1225-33.
Abstract
BACKGROUND:
Nonsteroidal antiinflammatory drugs are commonly used to treat postoperative and chronic pain. Animal studies suggest that these drugs act, in part, by blocking prostaglandin production in the spinal cord. The authors tested intrathecal ketorolac in patients with chronic or postoperative pain. METHODS: After approval of the institutional review board and the Food and Drug Administration, three clinical studies were performed. First, 15 patients receiving chronic intrathecal morphine received 0.5-2.0 mg of intrathecal ketorolac. Second, 12 patients receiving chronic intrathecal morphine received, in a double-blinded, randomized, cross-over design, intrathecal saline or 2.0 mg of ketorolac, with pain intensity as the primary outcome measure. Third, 30 patients undergoing total vaginal hysterectomy received, in a double-blinded, randomized, controlled design, intrathecal saline or 2.0 mg of ketorolac, with bupivacaine with time to first morphine dose after surgery as the primary outcome measure. RESULTS: Patients with chronic pain had many symptoms before intrathecal injection, without worsening of these symptoms from ketorolac. Pain intensity was reduced by intrathecal ketorolac, but this did not differ from placebo. In the first study, pain was reduced by intrathecal ketorolac in patients with high cerebrospinal fluid prostaglandin E2 concentrations but not in those with normal concentrations. Intrathecal ketorolac did not alter time to first morphine after surgery. CONCLUSIONS: Intrathecal ketorolac did not relieve chronic pain or extend anesthesia or analgesia from intrathecal bupivacaine administered at the beginning of surgery. Under the conditions of these studies, it seems that spinal cylcooxygenase activity does not contribute to chronic or postoperative pain.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892621/pdf/nihms189917.pdf

Atentamente
Anestesiología y Medicina del Dolor

www.anestesia-dolor.org

On This Day: August 11

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On Aug. 11, 1965, deadly rioting and looting broke out in the predominantly black Watts section of Los Angeles.

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On Aug. 11, 1921, Alex Haley, who chronicled generations of struggles and accomplishments of American blacks, was born. Following his death on Feb. 10, 1992, his obituary appeared in The Times.

Go to obituary » | Other birthdays »

On This Date

1954	A formal peace took hold in Indochina, ending more than seven years of fighting between the French and the Communist Vietminh.
1965	Deadly rioting and looting broke out in the predominantly black Watts section of Los Angeles.
1998	British Petroleum purchased Amoco for $49 billion.
2000	Pat Buchanan won the Reform Party presidential nomination.
2002	US Airways filed for Chapter 11 bankruptcy protection.
2003	NATO took command of the 5,000-strong peacekeeping force in Afghanistan.
2003	Charles Taylor resigned as Liberia's president and went into exile in Nigeria.
2006	The Transportation Security Administration banned all liquids, gels and aerosols from passenger cabins on airliners one day after a thwarted terrorist attack.
2009	Eunice Kennedy Shriver, sister of President John F. Kennedy and founder of the Special Olympics, died at age 88.

Current Birthdays

Actress Viola Davis turns 46 years old today.

AP Photo/Evan Agostini

Ashley Jensen, Actress (“Ugly Betty,” “Extras”)

Actress Ashley Jensen ("Ugly Betty," "Extras") turns 43 years old today.

AP Photo/Dan Steinberg

1949	Eric Carmen, Singer, turns 62
1953	Hulk Hogan, Wrestler, actor, turns 58
1954	Joe Jackson, Rock singer, turns 57
1967	Joe Rogan, Actor, host ("Fear Factor"), turns 44
1968	Charlie Sexton, Rock musician, turns 43
1993	Alyson Stoner, Actress, turns 18

Historic Birthdays

Alex Haley8/11/1921 - 2/10/1992American author.Go to obituary »

74	Friedrich Ludwig Jahn 8/11/1778 - 10/15/1852 German known as the "father of gymnastics"
76	Eduard Devrient 8/11/1801 - 10/4/1877 German dramatist
92	James Bryan Herrick 8/11/1861 - 3/7/1954 American cardiologist; studied sickle-cell anemia
74	Joe Weber 8/11/1867 - 5/10/1942 American comedian
64	Bertram Mills 8/11/1873 - 4/16/1938 English circus entrepreneur
72	Rodolfo Graziani 8/11/1882 - 1/11/1955 Italian field marshal; adherent of Mussolini
86	Hugh MacDiarmid 8/11/1892 - 9/9/1978 Scottish poet
72	Louise Bogan 8/11/1897 - 2/4/1970 American poet and literary critic
83	Lloyd Nolan 8/11/1902 - 9/27/1985 American television, film and stage actor
40	Ian Charleson 8/11/1949 - 1/6/1990 English actor of stage, screen and television

El Futuro de la Medicina: Reflexiones 2.0

miércoles, 10 de agosto de 2011

Foto para buena causa

Sergio Orozco

"COPIA Y PEGA ESTE MENSAJE A 10 PERSONAS EN LA VENTANA DE SU CHAT SOLICITANDO EL VOTO PARA ESTA FOTO Y QUE A SU VEZ LO HAGAN CON 10 PERSONAS ,

ES PARA UNA BUENA CAUSA, GRACIAS! "http://apps.facebook.com/contestshq/contests/135970/voteable_entries/26313775?ref=nf
http://wildfireapp.com/fb/127/contests/135970/voteable_entries/26313775?ref=nf

On This Day: August 10

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On Aug. 10, 1977, David Berkowitz, the suspect in the "Son of Sam" murders, was arrested.

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On Aug. 10, 1874, Herbert Hoover, 31st president of the United States, was born. Following his death on Oct. 20, 1964, his obituary appeared in The Times.

Go to obituary » | Other birthdays »

On This Date

1821	Missouri became the 24th state.
1846	Congress chartered the Smithsonian Institution, named after English scientist James Smithson, whose bequest of $500,000 made it possible.
1874	Herbert Clark Hoover, the 31st president of the United States, was born in West Branch, Iowa.
1885	America's first commercially operated electric streetcar began operation in Baltimore.
1921	Franklin D. Roosevelt was stricken with polio at his summer home on the Canadian island of Campobello.
1944	American forces overcame Japanese resistance on Guam during World War II.
1949	The National Military Establishment was renamed the Department of Defense.
1969	Leno and Rosemary LaBianca were murdered in their Los Angeles home by members of Charles Manson's cult, one day after actress Sharon Tate and four other people were slain.
1988	President Ronald Reagan signed a measure providing $20,000 payments to Japanese-Americans interred by the U.S. government during World War II.
1993	Ruth Bader Ginsburg was sworn in as the second female Supreme Court justice.
2006	British authorities announced they had thwarted a terrorist plot to simultaneously blow up 10 aircraft heading to the United States.
2008	American swimmer Michael Phelps won the first of a record eight gold medals at the Beijing Olympics by smashing his own world record in the 400-meter individual medley.

Current Birthdays

Actor Antonio Banderas turns 51 years old today.

AP Photo/Lionel Cironneau

Actress JoAnna Garcia turns 32 years old today.

AP Photo/Peter Kramer

1923	Rhonda Fleming, Actress, turns 88
1943	Ronnie Spector, Singer (The Ronettes), turns 68
1947	Ian Anderson, Rock singer, musician (Jethro Tull), turns 64
1959	Rosanna Arquette, Actress, turns 52
1962	Julia Fordham, Rock singer, turns 49
1964	Neneh Cherry, R&B singer, turns 47
1972	Angie Harmon, Actress, turns 39

Historic Birthdays

Herbert Hoover8/10/1874 - 10/20/196431st president of the United States.Go to obituary »

89	Eugenius Bulgaris 8/10/1716 - 6/10/1806 Greek Orthodox theologian and scholar
83	Jay Cooke 8/10/1821 - 2/18/1905 American financier
67	Charles Keene 8/10/1823 - 1/4/1891 English artist and illustrator for Punch magazine
83	Joseph McKenna 8/10/1843 - 11/21/1926 American Supreme Court justice (1898-1925)
70	Aleksandr Glazunov 8/10/1865 - 3/21/1936 Russian symphonic composer
75	Douglas Stuart Moore8//1893 - 7/25/1969 American composer of folk operas
52	Dorothy Jacobs Bellanca 8/10/1894 - 8/16/1946 Latvian-born American labor leader
55	Eugene Dennis 8/10/1905 - 1/31/1961 American Communist Party leader and labor organizer
81	Leo Fender 8/10/1909 - 3/21/1991 American inventor and manufacturer of musical instruments

BIBLIOTECA MEDICA

OMS espera 1.700 millones de dosis para la gripe en el 2015

Posted: 09 Aug 2011 02:56 PM PDT

La Organización Mundial de la Salud (OMS) informó que para 2015 habrá 1.700 millones de dosis de la vacuna contra la gripe interestacional en todo el mundo, si avanzan satisfactoriamente sus planes para aumentar la producción de esta vacuna en los países en desarrollo. La cifra supone un incremento de más del doble respecto a la capacidad actual de 800 millones de vacunas anuales para la

Tenes problemas de insomnio? trotá

Posted: 09 Aug 2011 12:55 PM PDT

Un estudio de la Universidad de Stanford, California, sugiere que correr puede ayudar a combatir el insomnio o los problemas con el sueño. Entonces, si no estás durmiendo como te gustaría, quizás 30 minutos diarios de ejercicio aeróbico de bajo impacto (un trote ligero o una caminata rápida y constante) pueden ser tu solución! Correr no sólo libera endorfinas que mejoran tu humor, sino

Ataque al corazon: señales de alarma y consejos

Posted: 09 Aug 2011 12:55 PM PDT

¿Qué es un ataque al corazón? Un ataque al corazón (también llamado infarto al miocardio) es cuando parte del músculo cardiaco se daña o muere porque no está recibiendo suficiente oxígeno. Normalmente, el oxígeno es transportado al corazón en la sangre que fluye a través de las arterias (arterias coronarias) que nutren el músculo cardiaco. La mayoría de ataques al corazón son por causa de

Actividad física en la vida diaria

Posted: 09 Aug 2011 12:55 PM PDT

La actividad física regular se define como el ejercicio dinámico que hace intervenir a grandes grupos musculares durante al menos 30 minutos en el día, todos los días de la semana con una intensidad moderada. Ésta es una de las formas más sencillas de mejorar la salud y mantenerse sano. Tiene la facultad de prevenir y controlar ciertas enfermedades. La actividad física aumenta la energía y

martes, 9 de agosto de 2011

¿Sabes que es un blog?

Buenas tardes, esta infográfia se me hace muy interesante, pero en este blog, aunque realmente no se si lo sea, porque expreso lo que esta de acuerdo con mi corriente de pensamiento y no necesariamente lo comento o elaboro una critica, mas bien creo que es una mezcla de blog con sitio web, incluso un archivo personal donde voy adicionando todo lo que me interesa a mí o al circulo donde me desarrollo intelectualmente, creo que es muy difícil estar escribiendo todo los días de algo, pero en esta sociedad del conocimiento donde la remezcla de información en una dirección crea o termina creando algo de interes para un determinado sector de gente.

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