Update WFSA 2008 y 2007 en Español

La función del Comité de Publicaciones de la WFSA es promover la producción y distribución de materiales educativos de buena calidad a anestesiólogos que trabajan con pocos suministros de libros y revistas actualizados. Update in Anaesthesia es la publicación oficial de la WFSA esta edición presenta algunos cambios importantes con miras a presentar una visión futura más eficaz de anestesia. Gracias a un grupo de colegas Latinoamericanos que encabeza el Dr. Gustavo Adolfo Elena de Argentina, es que la versión en Inglés de Update in Anaesthesia se ha estado traduciendo al Español y se nos ha autorizado a difundir esta versión a través de nuestro proyecto educativo. A medida que las traducciones estén listas, se le enviaran a su correo electrónico y además estarán enlistadas en nuestro portal para consulta libre. Si desea ver las ediciones originales en Inglés de esta revista puede ingresar al siguente enlace http://update.anaesthesiologists.org/ Update 2008:24(1) junio Seguridad quirúrgica de los pacientes OMS Pentazocina Hipertermia maligna Anestesia pediátrica en ONG Bloqueo del plano abdominal transverso Manejo de lesiones agudas de la columna cervical Anestesia para cirugía del pié y tobillo http://www.anestesia-dolor.org/revistas/Update24_es_WFSA_2008.pdf   Update 2007;23  Anestesia en cesárea Paracetamol Sepsis Dispersión de anestésicos locales espinales Cefalea postpunción dural Neuroanestesia Muchos más.... http://www.anestesia-dolor.org/revistas/Update23_es_WFSA_2007.pdf

Atentamente Anestesiología y Medicina del Dolor www.anestesia-dolor.org

Blog del CMO

Visita el blog del CMO !!!!!

http://colegiomexicanodeortopediaytrauma.blogspot.mx/

Un paso más hacia el diseño de fármacos contra el dolor y la adicción

Fuente: http://www.madrimasd.org/informacionidi/noticias/noticia.asp?id=52013 Un paso más hacia el diseño de fármacos contra el dolor y la adicción Un equipo de científicos ha conseguido describir la estructura de la proteína que inicia la respuesta del sistema nervioso central a la acción del opio y sus derivados, un hallazgo que permitirá avanzar en el diseño de fármacos contra el dolor y las adicciones. FUENTE | Agencia EFE 22/03/2012

Compartir noticia

La investigación, dirigida por científicos de la Universidad de Stanford (Estados Unidos) y en la que ha participado el investigador del Laboratorio de Medicina Computacional de la Unidad de Bioestadística de laUniversidad Autónoma de Barcelona (UAB) Leonardo Pardo, se publica en la revista Nature. Las drogas más utilizadas para combatir y aliviar el dolor son el opio y sus derivados, la morfina y la codeína, unos fármacos que, sin embargo, todavía tienen efectos secundarios, ha explicado a Efe el investigador español.  De hecho, estos medicamentos no sólo tienen efecto analgésico, sino que también sirven para la sedación y pueden, incluso, generar dependencia en el paciente o consumidor. La acción de estos medicamentos comienza cuando estas drogas se enlazan a los receptores de opioides, presentes en las células del sistema nervioso central, y de los que hay fundamentalmente tres tipos: "mu", "delta", y "kappa".  El "mu" produce el efecto analgésico mayor y también los mayores efectos indeseables, en tanto que el "kappa" da una respuesta analgésica menor, y el "delta" modula el efecto de los receptores "mu", puntualiza Pardo. En el trabajo, los investigadores han logrado descifrar la estructura cristalina tridimensional del receptor "mu", así como su interacción con los otros receptores de opioides. "Conocer esta estructura permite saber dónde deben interaccionar los fármacos analgésicos, y así poder diseñar estructuras químicas de nuevos medicamentos", agrega.  No obstante, puntualiza el investigador, a partir de ahora, son los químicos terapéuticos y los farmacólogos los que deberán manejar esta información y buscar derivados de la morfina más "efectivos, selectivos, y con menores efectos indeseables".

http://geeksroom.com/2012/08/la-posiciones-del-cuerpo-al-dormir-dicen-mucho-mas-de-lo-que-piensas/64879/#.UB7EX02Tsrc

La posiciones del cuerpo al dormir dicen mucho más de lo que piensas

Publicado el 4 agosto 2012 por Hector Russo
______________________________________________________________________________________________________________________

Hace unos días atrás les hablé sobre los colores que nos gustan y usamos.  Cada color tiene un significado y según investigaciones pueden llegar a develar que tipo de personalidad es la nuestra.    Ahora vamos a ver algo parecido, pero esta vez no son colores, sino la posición en que dormimos.

Esta Infografía fue creada por Carlos Patino para el sitio Wedo, que llevó a cabo una investigación acerca de la forma de dormir de las personas.

Las posiciones de dormir y lo que muestran de la personalidad de las personas que asumen esa posición al dormir son las siguientes,

• Foetus Personas bruscas, pero con un gran corazón.  Aparentan ser personas duras, pero son sensitivas.
• Log Personas relajadas y muy sociables.
• Yearner Personas reservadas, abiertas a nuevas cosas, pero muy sospechosas y cínicas.
• StarFish Muy buenos oyentes, muy amigables, aunque no les gusta ser el centro de atención.
• Soldado Personas reservadas y quietas, se imponen metas muy altas.
• Freefaller Confidentes pero con una personalidad muy nerviosa.  Responden mal a las críticas. Muy buenos al momento de tomar decisiones rápidas

A continuación tienen la infografía que nos muestra algunas cifras, hechos y nos explica cuales son las mejores y peores posiciones para dormir.

[Fuente BitRebels]

Resveratrol Stimulates the Expression of Beneficial Fat Hormone / Up-regulation of Adiponectin by Resveratrol

Fuente: http://www.ahealthblog.com/resveratrol-stimulates-the-expression-of-beneficial-fat-hormone.html

Resveratrol Stimulates the Expression of Beneficial Fat Hormone

Resveratrol Stimulates the Expression of Beneficial Fat Hormone

Resveratrol, a compound in grapes, displays antioxidant and other positive properties. Researchers describe a novel way in which resveratrol exerts these beneficial health effects.

Resveratrol stimulates the expression of adiponectin, a hormone derived from cells that manufacture and store fat, the team found. Adiponectin has a wide range of beneficial effects on obesity-related medical complications, said senior author Feng Liu.

Both adiponectin and resveratrol display anti-obesity, anti-insulin resistance and anti-aging properties.

“Results from these studies should be of interest to those who are obese, diabetic and growing older,” Dr. Liu said. “The findings should also provide important information on the development of novel therapeutic drugs for the treatment of these diseases.”

Previous studies

In July 2009 in the journal Nature, the Barshop Institute and collaborators reported that the compound rapamycin extended life in mice. Rapamycin, like resveratrol, is under scrutiny for its beneficial health effects.

In 2010, Dr. Liu and colleagues announced that resveratrol inhibits activity of the mammalian target of rapamycin (mTOR). This discovery was included in the prestigious Faculty of 1000 (F1000), a service that identifies and evaluates the most important articles in biology and medical research publications. The selection process involves a peer-nominated global “faculty” of the world’s leading scientists and clinicians who rate the best of the articles they read and explain their importance.

A reviewer said the study, which appeared in the Journal of Biological Chemistry, would open up work in a new area: explaining how resveratrol and rapamycin synergistically achieve their results.

Reference for: Resveratrol Stimulates the Expression of Beneficial Fat Hormone

Fuente:   http://www.jbc.org/content/286/1/60

Up-regulation of Adiponectin by Resveratrol

THE ESSENTIAL ROLES OF THE Akt/FOXO1 AND AMP-ACTIVATED PROTEIN KINASE SIGNALING PATHWAYS AND DsbA-L*

1. Anping Wang^‡§, 
2. Meilian Liu^§,¹, 
3. Xianling Liu^‡, 
4. Lily Q. Dong^¶,
5. Randolph D. Glickman^‖, 
6. Thomas J. Slaga^§, 
7. Zhiguang Zhou^‡ and
8. Feng Liu^‡§,²

+Author Affiliations

1. From the ^‡Metabolic Syndrome Research Center, Second Xiangya Hospital, Central South University, Hunan 410011, China and
2. the Departments of ^§Pharmacology,
3. ^¶Cellular and Structural Biology, and
4. ^‖Ophthalmology, University of Texas Health Science Center, San Antonio, Texas 78229

1. 1 To whom correspondence may be addressed. E-mail: lium2@uthscsa.edu.
2. 2 To whom correspondence may be addressed. E-mail: liuf@uthscsa.edu.

Abstract

The natural polyphenol resveratrol (RSV) displays a wide spectrum of health beneficial activities, yet the precise mechanisms remain to be fully elucidated. Here we show that RSV promotes the multimerization and cellular levels of adiponectin in 3T3-L1 adipocytes. The stimulatory effect of RSV was not affected by knocking out Sirt1, but was diminished by suppressing the expression levels of DsbA-L, a recently identified adiponectin-interactive protein that promotes adiponectin multimerization. Suppression of the Akt signaling pathway resulted in an increase in the expression levels of DsbA-L and adiponectin. On the other hand, knocking out FOXO1 or suppressing the activity or expression levels of the AMP-activated protein kinase (AMPK) down-regulated DsbA-L and adiponectin. The stimulatory effect of RSV on adiponectin and DsbA-L expression was completely diminished in FOXO1-suppressed and AMPK-inactivated 3T3-L1 adipocytes. Taken together, our results demonstrate that RSV promotes adiponectin multimerization in 3T3-L1 adipocytes via a Sirt1-independent mechanism. In addition, we show that the stimulatory effect of RSV is regulated by both the Akt/FOXO1 and the AMPK signaling pathways. Last, we show that DsbA-L plays a critical role in the promoting effect of RSV on adiponectin multimerization and cellular levels.

• Adipocyte
 
• Akt PKB
 
• AMP-activated Kinase (AMPK)
 
• Insulin
• Resveratrol
 
• DsbA-L
 
• Adiponectin

Footnotes

• ↵* This work was supported, in whole or in part, by National Institutes of Health Grants RO1 DK76902 (to F. L.) and DK69930 (to L. Q. D.) and a Research Award from the San Antonio Life Sciences Institute (SALSI) (to T. J. S., R. D. G., and F. L.).

• Received September 23, 2010.
• Revision received October 25, 2010.

• © 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

Articles citing this article

• The Polyphenols Resveratrol and S17834 Prevent the Structural and Functional Sequelae of Diet-Induced Metabolic Heart Disease in MiceCirculation 2012 125: 1757-1764.
  • Abstract
  • Full Text
  • Full Text (PDF)

XXIII Congreso internacional cubano de Ortopedia y Traumatología, la III Reunión binacional Cuba-México y el I Simposio cubano - argentino

Fuente: http://promociondeeventos.sld.cu/ortopedia2012/

03-08-2012

Sesionará en La Habana el XXIII Congreso internacional cubano de Ortopedia y Traumatología en septiembre del 2012 en La Habana

Sesionarán en La Habana el XXIII Congreso internacional cubano de Ortopedia y Traumatología, la III Reunión binacional Cuba-México y el I Simposio cubano - argentino, que tendrán lugar del 24 al 29 de septiembre de 2012, en el Centro de Eventos ORTOP, del Complejo científico ortopédico internacional Frank País. Entre las temáticas principales de este encuentro se encuentran: Artroscopía de miembros superiores, fijación externa en los desastres naturales, avances en la artroplastia total en miembros superiores y complicaciones de las fracturas en niños y traumatología y sus resultados en el deporte.

Convocatoria

Estimados Colegas,

Es un gran honor para nosotros anunciarles nuestro XXIII Congreso Internacional Cubano de Ortopedia y Traumatología y la III Reunión Binacional Cuba-México y el I Simposio Cubano – Argentino, que tendrán lugar del 24 al 29 de septiembre de 2012, en el Centro de Eventos ORTOP, del Complejo Científico Ortopédico Internacional “Frank País”, en La Habana, Cuba.

El XXIII Congreso Internacional Cubano de Ortopedia y Traumatología y la III Reunión Binacional Cuba-México está organizado por la Sociedad Cubana de Ortopedia y Traumatología (SCOT) y auspiciado por Asociación Mexicana de Ortopedia y Traumatología (AMOT), la Federación Mexicana  de Cirugía Ortopédica y Traumatológica (FEMECOT), y la Sociedad Internacional de Cirugía Ortopédica y Traumatológica (SICOT).

Este evento está dirigido a reunir a toda la familia de ortopédicos para estrechar lazos y actualizar criterios y conceptos relacionados con la ortopedia mundial, y así establecer las bases para futuras colaboraciones y programas de desarrollo en conjunto.

Entre las temáticas principales de este encuentro se encuentran: la artroscopía de miembros superiores, la fijación externa en los desastres naturales, los avances en la artroplastia total en miembros superiores y las complicaciones de las fracturas en niños, la traumatología y sus resultados en el deporte.

Atentamente,

Prof. Dr. Sc. Rodrigo Álvarez Cambras
Presidente de la Sociedad Cubana de Ortopedia y Traumatología
Delegado de Cuba a la SICOT
Presidente del Congreso

Fuente: http://well.blogs.nytimes.com/2012/02/27/knee-replacement-may-be-a-lifesaver-for-some/

FEBRUARY 27, 2012, 5:49 PM 113 Comments

Knee Replacement May Be a Lifesaver for Some

By TARA PARKER-POPE

Stuart Bradford

By the time 64-year-old Laura Milson decided to undergo total knee replacement after 12 years of suffering from arthritis, even a short walk to the office printer was a struggle.

After her surgery last August at the Rothman Institute at Thomas Jefferson University in Philadelphia, Ms. Milson spent a week in rehabilitation and says she hasn’t stopped walking since. “My son says to me, ‘You have to slow down,’ and I say, ‘No, I have to catch up!,’ ” she said. “It’s a whole different life.”

For Ms. Milson, who lives in Shrewsbury, Pa., replacing the joint in her right knee came with a surprising bonus: a 20-pound weight loss in two months. “I joked with my doctor, ‘I think you put a diet chip in my knee,’ ” she said. “The weight just sort of came off.”

Now she has joined Weight Watchers to drop a few extra pounds and is training for a three-day breast cancer walk in October.

For years surgeons have boasted of the pain relief and improved quality of life that often follow knee replacement. But now new research suggests that for some patients, knee replacement surgery can actually save their lives.

In a sweeping study of Medicare records, researchers from Philadelphia and Menlo Park, Calif., examined the effects of joint replacement among nearly 135,000 patients with new diagnoses of osteoarthritis of the knee from 1997 to 2009. About 54,000 opted for knee replacement; 81,000 did not.

Three years after diagnosis, the knee replacement patients had an 11 percent lower risk of heart failure. And after seven years, their risk of dying for any reason was 50 percent lower.

The study, presented this month at the annual meeting of the American Academy of Orthopedic Surgeons, was financed with a grant from a knee replacement manufacturer. It was not randomized, so it may be that these patients were healthier and more active to start with.

Still, the researchers did try to control for differences in age and overall health. And the findings are consistent with large studies of knee replacement and mortality in Scandinavia. Given the big numbers in the study and the size of the effect, the data strongly suggest that knee replacement may lead to improvements in health and longevity.

The theory behind knee replacement, said the study’s lead author, Scott Lovald, senior associate at Exponent, a scientific consulting firm in Menlo Park, is that it improves quality of life. “At the end of the day, we’re trying to figure out if quantity of life increases as well,” he added, noting that the team was conducting a similar review of Medicare data on the long-term benefits of hip replacement surgery.

The founder of the Rothman Institute, Dr. Richard H. Rothman, who has performed 25,000 joint replacement surgeries in his career, urged caution in interpreting data that are not randomized and controlled. Not every patient with knee arthritis is a candidate for joint replacement surgery, he said.

“People can tolerate a lot of knee disability for reasons we don’t totally understand,” he went on, adding, “If the pain is acceptable, you live with it; if it’s not acceptable, we’ll operate on you.”

Dr. Rothman said that whether patients experience better health after surgery depends on motivation — how motivated they were to stay fit before surgery and how motivated they are now to become more active.

“For the motivated patient, it allows them to walk through that portal and become better conditioned and lose weight,” he said. “It’s not a weight-reduction program. It’s a potential avenue to improve your level of fitness, weight, cardiovascular health and mental health.”

Edward Moore, a 94-year-old retired chemist in Woodbury, N.J., underwent knee replacement three years ago after pain began limiting his activity. Given his age, his own daughter had worried that the recovery would be too difficult. But Dr. Rothman agreed he was healthy enough for the procedure.

“I didn’t do much mulling about it,” Mr. Moore said. “It just seemed like the knee would be hampering me for the rest of my life, and that sounded like a bad idea.”

Mr. Moore said he had an uneventful recovery, and in September, two days after his 94th birthday, he took his wind surfer to Lakes Bay near Atlantic City. “I got up on the board, and I sailed,” he said.

William Mills, 63, of Philadelphia, had been suffering for about four years with severe pain in both knees when he opted for double knee replacement in 2006. He said his activity had dropped off, and while he could still play golf, he could no longer walk the course. Even going to a restaurant had become a burden if he couldn’t find a parking space nearby.

“I think one of the things people don’t understand about knees is how bad it is,” said Mr. Mills, a bank executive. “It changes everything. I couldn’t walk two city blocks. It was just slowly but surely changing my life where I was unable to really enjoy things.”

But while the rehabilitation of both knees was “the hardest thing I’ve ever done in my life,” he has no regrets. Six months after surgery he took part in a 250-mile bike ride in Germany. He has made a few compromises — he no longer skis, and plays doubles tennis instead of singles — but he says he now rarely thinks about his knees.

“Before surgery, I felt like I was 10 or 15 years older than I was,” he said. “Now I probably feel like I’m 10 or 15 years younger than I am.

“I can understand why people might live longer, because you want to. You really feel good again.”