Ondansetron y prurit

Noviembre 7, 2015. No. 2138

Estudio comparativo con ondansetron i.v. y dosis subhipnóticas de propofol en el manejo de prurito inducido por sufentanil espinal en cesárea electiva The comparative study of intravenous Ondansetron and sub-hypnotic Propofol dose in control and treatment of intrathecal Sufentanil-induced pruritus in elective caesarean surgery. Hirmanpour A, Safavi M, Honarmand A, Hosseini AZ, Sepehrian M. J Res Pharm Pract. 2015 Apr-Jun;4(2):57-63. doi: 10.4103/2279-042X.155751. Abstract OBJECTIVE: Pruritus is a common and disturbing side effect of neuraxial opioids after cesarean section. The purpose of this study was to compare the efficacy of intravenous ondansetron and sub-hypnotic dose of propofol in control and treatment of intrathecal sufentanil induced pruritus in cesarean surgery. METHODS: Totally, 90 parturient with American Society of Anesthesiology physical status grade I-II, undergoing spinal anesthesia with 2.5 μg sufentanil and 10 mg bupivacaine 0.5% were enrolled to this randomized, prospective, double-blind study. The women were randomly assigned to two groups who received 8 mg ondansetron or 10 mg propofol to treat pruritus grade ≥3. The patient was evaluated after 5 min and in the lack of successful treatment, the doses of two drugs repeated and if the pruritus is on-going, the exact treatment with naloxone was done. FINDINGS: The incidence of pruritus was 69.3%. Both groups were well-matched. The peak time pruritus was 30-75 min after injection. The percentage of individuals consumed naloxone were 6.8% and 15.9% in ondansetron and propofol groups, respectively (P = 0.18). The mean score of satisfaction (according to visual analog scale criteria) was 9.09 ± 1.1 in ondansetron group and 9.3 ± 1.07 in the propofol group (P = 0.39). CONCLUSION: Ondansetrone and sub-hypnotic dose of propofol are both safe and well-tolerated. Due to their same efficacy in the treatment of intrathecal sufentanil-induced pruritus, they can be widely used in clinical practice. KEYWORDS: Caesarean surgery; Ondansetron; Propofol; intrathecal opioid; pruritus PDF Adminsitración profiláctica de ondansetron en la prevención de prurito y emesis inducidos por morfina espinal en cesárea Prophylactic administration of ondansetron in prevention of intrathecal morphine-induced pruritus and post-operative nausea and vomiting in patients undergoing caesarean section. Koju RB, Gurung BS, Dongol Y. BMC Anesthesiol. 2015 Feb 17;15:18. doi: 10.1186/1471-2253-15-18. Abstract BACKGROUND: Intrathecal morphine is commonly used for post caesarean analgesia. However, their use is frequently associated with the incidence of troublesome side effects such as nausea, vomiting and pruritus. Various mechanisms have been postulated for the opioid-induced pruritus, with a variety of medications with different mechanisms of actions formulated for the prevention and treatment. But, the results are inconsistent and hence the prevention and treatment of opioid-induced pruritus still remains a challenge. Ondansetron which is antiemetic, non-sedative and has no antianalgesic effect is an antagonist to 5-HT3 receptor, the receptor with which opioids interacts and imparts its effects. Ondansetron, thus, would be an attractive treatment strategy for both opioid-induced pruritus and post-operative nausea and vomiting. METHODS: After the approval from institutional review committee and written consent received from the patient, 50 healthy parturients of ASA I and II physical status undergoing caesarean section under spinal anaesthesia were enrolled for the study. They were randomly categorized into placebo group (2 ml normal saline) and treatment group (2 ml of 4 mg ondansetron), each group containing 25 patients. Pruritus and post-operative nausea and vomiting scores were recorded up to 24 hours after the administration of intrathecal morphine. Statistical analysis was performed using chi-square test. RESULTS: The incidence, severity and necessity of treatment for pruritus in the treatment group was significantly reduced compared to the placebo group (16% vs 88%). Similarly, the risk of post-operative nausea and vomiting in the treatment group was less compared to the placebo group (8% vs 56%). CONCLUSION: Prophylactic administration of ondansetron to parturients receiving intrathecal morphine for post-operative analgesia provides a significant reduction of intrathecal morphine-induced pruritus and nausea and vomiting. PDF  Comparación del efecto de droperidol y ondansetron profilácticos sobre el prurito inducido por morfina intratecal Comparison of droperidol and ondansetron prophylactic effect on subarachnoid morphine-induced pruritus. Brião FF, Horta ML, Horta BL, de Barros GA, Behrensdorf AP, Severo I, Nunes MA, Boabaid R, Real A. Braz J Anesthesiol.2015 Jul-Aug;65(4):244-8. doi: 10.1016/j.bjane.2013.11.005. Epub 2015 Apr 28. Abstract BACKGROUND AND OBJECTIVES: The prophylactic effect of ondansetron on subarachnoid morphine-induced pruritus is controversial, while evidence suggests that droperidol prevents pruritus. The aim of this study is to compare the effects of droperidol and ondansetron on subarachnoid morphine-induced pruritus. METHODS: 180 ASA I or II patients scheduled to undergo cesarean sections under subarachnoid anesthesia combined with morphine 0.2mg were randomized to receive, after the child's birth, metoclopramide 10mg (Group I - control), droperidol 2.5mg (Group II) or ondansetron 8mg (Group III). Postoperatively, the patients were assessed for pruritus (absent, mild, moderate or severe) or other side effects by blinded investigators. Patients were also blinded to their group allocation. The tendency to present more severe forms of pruritus was compared between groups. NNT was also determined. RESULTS: Patients assigned to receive droperidol [Proportional odds ratio: 0.45 (95% confidence interval 0.23-0.88)] reported less pruritus than those who received metoclopramide. Ondansetron effect was similar to metoclopramide [Proportional odds ratio: 0.95 (95% confidence interval 0.49-1.83)]. The NNT for droperidol and ondansetron was 4.0 and 14.7, respectively. CONCLUSIONS: Ondansetron does not inhibit subarachnoid morphine-induced pruritus. PDF

Anestesiología y Medicina del Dolor 52 664 6848905 vwhizar@anestesia-dolor.org anestesia-dolor.org Copyright © 2015

Anestesia para cesárea/Anesthesia for C-section

Noviembre 6, 2015. No. 2137

Anestesia espinal versus general para cesárea en pacientes con anemia de células falciformes Spinal versus general anesthesia for Cesarean section in patients with sickle cell anemia. Bakri MH, Ismail EA, Ghanem G, Shokry M. Korean J Anesthesiol. 2015 Oct;68(5):469-75. doi: 10.4097/kjae.2015.68.5.469. Epub 2015 Sep 30. Abstract BACKGROUND: Sickle cell anemia (SCA) increases the rate of maternal and fetal complications. This pilot study was designed to compare the maternal and fetal outcomes of spinal versus general anesthesia (GA) for parturients with SCA undergoing cesarean delivery. METHODS: Forty parturients with known SCA scheduled for elective Cesarean delivery were randomized into spinal anesthesia (n = 20) and GA groups (n = 20). Perioperative hemodynamic parameters were recorded. Postpartum complications were followed up. Opioid consumption was calculated. Blood loss during surgery and the number of patients who received intraoperative or postpartum blood transfusion were recorded. Patient satisfaction with the type of anesthesia was assessed. The Apgar score at 1 and 5 min, neonatal admission to the intensive care unit, and mortality were also recorded. RESULTS: Blood loss was significantly higher in the GA than spinal group (P = 0.01). However, the number of patients who received an intraoperative or postpartum blood transfusion was statistically insignificant. Significantly more patients developed intraoperative hypotension and bradycardia in the spinal than GA group. Opioid use during the first 24 h was significantly higher in the GA than spinal group (P < 0.0001). More patients had vaso-occlusive crisis in the GA than spinal group without statistical significance (P = 0.4). There was one case of acute chest syndrome in the GA group. No significant differences were observed in postoperative nausea and/or vomiting, patient satisfaction, or hospital length of stay. Neonatal Apgar scores were significantly better in the spinal than GA group at 1 and 5 min (P = 0.006 and P = 0.009, respectively). Neonatal intensive care admission was not significantly different between the two groups, and there was no neonatal mortality. CONCLUSIONS: Spinal anesthesia may have advantages over GA in parturients with SCA undergoing Cesarean delivery. KEYWORDS: Apgar score; Cesarean section; General anesthesia; Sickle cell anemia; Spinal anesthesia PDF

Anestesiología y Medicina del Dolor 52 664 6848905 vwhizar@anestesia-dolor.org anestesia-dolor.org Copyright © 2015

Analgesia peridural en cirugía hepática/Epidural analgesia in liver surgery

Noviembre 5, 2015. No. 2136

Analgesia epidural es efectiva en el dolor de pacientes con cirugía abierta de hígado Epidural analgesia provides effective pain relief in patients undergoing open liver surgery. Ganapathi S, Roberts G, Mogford S, Bahlmann B, Ateleanu B, Kumar N. Br J Pain. 2015 May;9(2):78-85. doi: 10.1177/2049463714525140. Abstract BACKGROUND: Epidural analgesia has been the reference standard for the provision of post-operative pain relief in patients recovering from major upper abdominal operations, including liver resections. However, a failure rate of 20-32% has been reported. AIM: The aim of the study was to analyse the success rates of epidural analgesia and the outcome in patients who underwent liver surgery. METHODS: We collected data from a prospectively maintained database of 70 patients who underwent open liver surgery by a bilateral subcostal incision during a period of 20 months (February 2009 to September 2010). Anaesthetic consultants with expertise in anaesthesia for liver surgery performed the epidural catheter placement. A dedicated pain team assessed the post-operative pain scores on moving or coughing using the Verbal Descriptor Scale. The outcome was measured in terms of epidural success rates, pain scores, post-operative chest infection and length of hospital stay. RESULTS: The study group included 43 males and 27 females. The indication for resection was liver secondaries (70%), primary tumours (19%) and benign disease (11%). While major (≥3 segments) and minor resections (≤ 2 segments) were performed in 44% and 47% respectively, 9% of patients were inoperable. Epidural analgesia was successful in 64 patients (91%). Bacterial colonisation of epidural tip was noticed in two patients. However, no neurological complications were encountered. Five patients (7%) had radiologically confirmed chest infection. Four patients (6%) developed wound infection. One patient died due to liver failure following extended right hepatectomy and cholecystectomy for gall bladder cancer. The median length of stay was 6 days (3-27 days). The extent of liver resection (p = 0.026) and post-operative chest infection (p = 0.012) had a significant influence on the length of stay. CONCLUSION: Our experience shows that epidural analgesia is safe and effective in providing adequate pain relief following open liver surgery. KEYWORDS: Epidural analgesia; acute pain; drug therapy; liver surgery; prevention and control PDF

Anestesiología y Medicina del Dolor 52 664 6848905 vwhizar@anestesia-dolor.org anestesia-dolor.org Copyright © 2015

Bibliotecas populares. Noticias

bibliotecas populares

NOTICIAS

Bibliotecas populares recibirán subsidios de 30 mil pesos
El Litoral
El jueves 15 en el Salón Amarillo de Casa de Gobierno a las 10 se otorgarán subsidios a 28 bibliotecas populares de distintos puntos de la provincia.



Entregaron subsidios a las Bibliotecas Populares de toda la provincia
El Litoral
Entregaron hoy subsidios a Bibliotecas Populares de toda la provincia de Corrientes por una suma cercana al millón de pesos, que serán destinados ...
Bibliotecas populares recibieron subsidios para refacciones y libros - El Litoral
La Provincia entregó subsidios a bibliotecas populares por casi $ 1 millón - Diario La República
Casi un millón de pesos a bibliotecas populares - hoycorrientes.com
Cobertura total de la noticia



Bibliotecas Populares aprendieron sobre Comunicación Comunitaria
Tiempo de San Juan
Este primer encuentro, se espera que sea el puntapié para comenzar a debatir sobre la comunicación comunitaria en el ámbito de las Bibliotecas ...




Infoblancosobrenegro (Comunicado de prensa)

Inauguraron la 1ra sede de la “Red de Bibliotecas Populares Néstor Kirchner” en La Plata
Infoblancosobrenegro (Comunicado de prensa)
En el marco de las actividades por la campaña "Scioli presidente", se inauguró ayer la primera sede en esta Ciudad de la "Red de Bibliotecas ...




Diario La Provincia SJ

Las Bibliotecas Populares se interiorizaron sobre Comunicación Comunitaria
Diario La Provincia SJ
En la exposición se abordaron temas vinculados a la metodología para la producción de contenidos desde la Comunicación Popular y el ...




Infoblancosobrenegro (Comunicado de prensa)

Inauguran en La Plata la 1ra sede de la “Red de Bibliotecas PopularesNéstor Kirchner”
Infoblancosobrenegro (Comunicado de prensa)
Estará ubicada en el local ubicado en calle 51 entre 16 y 17, que pertenece al Movimiento San Martín. El evento comenzará a las 19 horas y habrá un ...



Misiones OnLine

Distintos talleres bibliográficos anticiparon el III Encuentro de Agentes deBibliotecas y ...
Misiones OnLine
Graciela Perrone, directora de la Biblioteca Nacional de los Maestros. ... (BNM) y de la Comisión Nacional de Bibliotecas Populares (CoNaBiP).



La Biblioteca Alberdi le dará un "abrazo a la cultura bandeña"
El Liberal Digital
Publicado el 16/10/2015 - Desde la Biblioteca Popular ?Juan Bautista Alberdi? invitaron a toda la comunidad al ?Abrazo a la cultura bandeña?, un ...



Misiones OnLine

Bibliotecarios del Mercosur, en busca de un modelo de gestión y defensa de la identidad cultural
Misiones OnLine
“Gestionando bibliotecas hoy” es la temática del tercer año consecutivo que ... en las bibliotecas populares, en la biblioteca pública, en las bibliotecas ...



Feria del Libro 2015 en Mendoza: el programa para viernes, sábado y domingo
Diario Uno
Narradoras orales de la Biblioteca Pública General San Martín (infantil y ... Bibliotecas Populares y Equipo de emergencias de sonrisas (clown) ...