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Revisiones bibliográficas. Documentación científica en Ortopedia y Traumatología, medicina deportiva, artroscopia, artroplastia y de todas las patologías del sistema Músculo-Esquelético
domingo, 5 de agosto de 2012
Un paso más hacia el diseño de fármacos contra el dolor y la adicción
La posiciones del cuerpo al dormir dicen mucho más de lo que piensas
http://geeksroom.com/2012/08/la-posiciones-del-cuerpo-al-dormir-dicen-mucho-mas-de-lo-que-piensas/64879/#.UB7EX02Tsrc
La posiciones del cuerpo al dormir dicen mucho más de lo que piensas
Hace unos días atrás les hablé sobre los colores que nos gustan y usamos. Cada color tiene un significado y según investigaciones pueden llegar a develar que tipo de personalidad es la nuestra. Ahora vamos a ver algo parecido, pero esta vez no son colores, sino la posición en que dormimos.
Esta Infografía fue creada por Carlos Patino para el sitio Wedo, que llevó a cabo una investigación acerca de la forma de dormir de las personas.
Las posiciones de dormir y lo que muestran de la personalidad de las personas que asumen esa posición al dormir son las siguientes,
- Foetus Personas bruscas, pero con un gran corazón. Aparentan ser personas duras, pero son sensitivas.
- Log Personas relajadas y muy sociables.
- Yearner Personas reservadas, abiertas a nuevas cosas, pero muy sospechosas y cínicas.
- StarFish Muy buenos oyentes, muy amigables, aunque no les gusta ser el centro de atención.
- Soldado Personas reservadas y quietas, se imponen metas muy altas.
- Freefaller Confidentes pero con una personalidad muy nerviosa. Responden mal a las críticas. Muy buenos al momento de tomar decisiones rápidas
A continuación tienen la infografía que nos muestra algunas cifras, hechos y nos explica cuales son las mejores y peores posiciones para dormir.
[Fuente BitRebels]
Resveratrol Stimulates the Expression of Beneficial Fat Hormone / Up-regulation of Adiponectin by Resveratrol
Fuente: http://www.ahealthblog.com/resveratrol-stimulates-the-expression-of-beneficial-fat-hormone.html
Resveratrol Stimulates the Expression of Beneficial Fat Hormone
Resveratrol Stimulates the Expression of Beneficial Fat Hormone
Resveratrol, a compound in grapes, displays antioxidant and other positive properties. Researchers describe a novel way in which resveratrol exerts these beneficial health effects.
Resveratrol stimulates the expression of adiponectin, a hormone derived from cells that manufacture and store fat, the team found. Adiponectin has a wide range of beneficial effects on obesity-related medical complications, said senior author Feng Liu.
Both adiponectin and resveratrol display anti-obesity, anti-insulin resistance and anti-aging properties.
“Results from these studies should be of interest to those who are obese, diabetic and growing older,” Dr. Liu said. “The findings should also provide important information on the development of novel therapeutic drugs for the treatment of these diseases.”
Previous studies
In July 2009 in the journal Nature, the Barshop Institute and collaborators reported that the compound rapamycin extended life in mice. Rapamycin, like resveratrol, is under scrutiny for its beneficial health effects.
In 2010, Dr. Liu and colleagues announced that resveratrol inhibits activity of the mammalian target of rapamycin (mTOR). This discovery was included in the prestigious Faculty of 1000 (F1000), a service that identifies and evaluates the most important articles in biology and medical research publications. The selection process involves a peer-nominated global “faculty” of the world’s leading scientists and clinicians who rate the best of the articles they read and explain their importance.
A reviewer said the study, which appeared in the Journal of Biological Chemistry, would open up work in a new area: explaining how resveratrol and rapamycin synergistically achieve their results.
Fuente: http://www.jbc.org/content/286/1/60
Up-regulation of Adiponectin by Resveratrol
THE ESSENTIAL ROLES OF THE Akt/FOXO1 AND AMP-ACTIVATED PROTEIN KINASE SIGNALING PATHWAYS AND DsbA-L*
- Anping Wang‡§,
- Meilian Liu§,1,
- Xianling Liu‡,
- Lily Q. Dong¶,
- Randolph D. Glickman‖,
- Thomas J. Slaga§,
- Zhiguang Zhou‡ and
- Feng Liu‡§,2
+Author Affiliations
- 1 To whom correspondence may be addressed. E-mail: lium2@uthscsa.edu.
- 2 To whom correspondence may be addressed. E-mail: liuf@uthscsa.edu.
Abstract
The natural polyphenol resveratrol (RSV) displays a wide spectrum of health beneficial activities, yet the precise mechanisms remain to be fully elucidated. Here we show that RSV promotes the multimerization and cellular levels of adiponectin in 3T3-L1 adipocytes. The stimulatory effect of RSV was not affected by knocking out Sirt1, but was diminished by suppressing the expression levels of DsbA-L, a recently identified adiponectin-interactive protein that promotes adiponectin multimerization. Suppression of the Akt signaling pathway resulted in an increase in the expression levels of DsbA-L and adiponectin. On the other hand, knocking out FOXO1 or suppressing the activity or expression levels of the AMP-activated protein kinase (AMPK) down-regulated DsbA-L and adiponectin. The stimulatory effect of RSV on adiponectin and DsbA-L expression was completely diminished in FOXO1-suppressed and AMPK-inactivated 3T3-L1 adipocytes. Taken together, our results demonstrate that RSV promotes adiponectin multimerization in 3T3-L1 adipocytes via a Sirt1-independent mechanism. In addition, we show that the stimulatory effect of RSV is regulated by both the Akt/FOXO1 and the AMPK signaling pathways. Last, we show that DsbA-L plays a critical role in the promoting effect of RSV on adiponectin multimerization and cellular levels.
Footnotes
- ↵* This work was supported, in whole or in part, by National Institutes of Health Grants RO1 DK76902 (to F. L.) and DK69930 (to L. Q. D.) and a Research Award from the San Antonio Life Sciences Institute (SALSI) (to T. J. S., R. D. G., and F. L.).
- Received September 23, 2010.
- Revision received October 25, 2010.
- © 2011 by The American Society for Biochemistry and Molecular Biology, Inc.
Articles citing this article
XXIII Congreso internacional cubano de Ortopedia y Traumatología, la III Reunión binacional Cuba-México y el I Simposio cubano - argentino
03-08-2012
Sesionará en La Habana el XXIII Congreso internacional cubano de Ortopedia y Traumatología en septiembre del 2012 en La Habana
Sesionarán en La Habana el XXIII Congreso internacional cubano de Ortopedia y Traumatología, la III Reunión binacional Cuba-México y el I Simposio cubano - argentino, que tendrán lugar del 24 al 29 de septiembre de 2012, en el Centro de Eventos ORTOP, del Complejo científico ortopédico internacional Frank País. Entre las temáticas principales de este encuentro se encuentran: Artroscopía de miembros superiores, fijación externa en los desastres naturales, avances en la artroplastia total en miembros superiores y complicaciones de las fracturas en niños y traumatología y sus resultados en el deporte.Convocatoria
Estimados Colegas,
Es un gran honor para nosotros anunciarles nuestro XXIII Congreso Internacional Cubano de Ortopedia y Traumatología y la III Reunión Binacional Cuba-México y el I Simposio Cubano – Argentino, que tendrán lugar del 24 al 29 de septiembre de 2012, en el Centro de Eventos ORTOP, del Complejo Científico Ortopédico Internacional “Frank País”, en La Habana, Cuba.
El XXIII Congreso Internacional Cubano de Ortopedia y Traumatología y la III Reunión Binacional Cuba-México está organizado por la Sociedad Cubana de Ortopedia y Traumatología (SCOT) y auspiciado por Asociación Mexicana de Ortopedia y Traumatología (AMOT), la Federación Mexicana de Cirugía Ortopédica y Traumatológica (FEMECOT), y la Sociedad Internacional de Cirugía Ortopédica y Traumatológica (SICOT).
Este evento está dirigido a reunir a toda la familia de ortopédicos para estrechar lazos y actualizar criterios y conceptos relacionados con la ortopedia mundial, y así establecer las bases para futuras colaboraciones y programas de desarrollo en conjunto.
Entre las temáticas principales de este encuentro se encuentran: la artroscopía de miembros superiores, la fijación externa en los desastres naturales, los avances en la artroplastia total en miembros superiores y las complicaciones de las fracturas en niños, la traumatología y sus resultados en el deporte.
Atentamente,
Prof. Dr. Sc. Rodrigo Álvarez Cambras
Presidente de la Sociedad Cubana de Ortopedia y Traumatología
Delegado de Cuba a la SICOT
Presidente del Congreso
Presidente de la Sociedad Cubana de Ortopedia y Traumatología
Delegado de Cuba a la SICOT
Presidente del Congreso
Knee Replacement May Be a Lifesaver for Some
Knee Replacement May Be a Lifesaver for Some
By TARA PARKER-POPE
By the time 64-year-old Laura Milson decided to undergo total knee replacement after 12 years of suffering from arthritis, even a short walk to the office printer was a struggle.
After her surgery last August at the Rothman Institute at Thomas Jefferson University in Philadelphia, Ms. Milson spent a week in rehabilitation and says she hasn’t stopped walking since. “My son says to me, ‘You have to slow down,’ and I say, ‘No, I have to catch up!,’ ” she said. “It’s a whole different life.”
For Ms. Milson, who lives in Shrewsbury, Pa., replacing the joint in her right knee came with a surprising bonus: a 20-pound weight loss in two months. “I joked with my doctor, ‘I think you put a diet chip in my knee,’ ” she said. “The weight just sort of came off.”
Now she has joined Weight Watchers to drop a few extra pounds and is training for a three-day breast cancer walk in October.
For years surgeons have boasted of the pain relief and improved quality of life that often follow knee replacement. But now new research suggests that for some patients, knee replacement surgery can actually save their lives.
In a sweeping study of Medicare records, researchers from Philadelphia and Menlo Park, Calif., examined the effects of joint replacement among nearly 135,000 patients with new diagnoses of osteoarthritis of the knee from 1997 to 2009. About 54,000 opted for knee replacement; 81,000 did not.
Three years after diagnosis, the knee replacement patients had an 11 percent lower risk of heart failure. And after seven years, their risk of dying for any reason was 50 percent lower.
The study, presented this month at the annual meeting of the American Academy of Orthopedic Surgeons, was financed with a grant from a knee replacement manufacturer. It was not randomized, so it may be that these patients were healthier and more active to start with.
Still, the researchers did try to control for differences in age and overall health. And the findings are consistent with large studies of knee replacement and mortality in Scandinavia. Given the big numbers in the study and the size of the effect, the data strongly suggest that knee replacement may lead to improvements in health and longevity.
The theory behind knee replacement, said the study’s lead author, Scott Lovald, senior associate at Exponent, a scientific consulting firm in Menlo Park, is that it improves quality of life. “At the end of the day, we’re trying to figure out if quantity of life increases as well,” he added, noting that the team was conducting a similar review of Medicare data on the long-term benefits of hip replacement surgery.
The founder of the Rothman Institute, Dr. Richard H. Rothman, who has performed 25,000 joint replacement surgeries in his career, urged caution in interpreting data that are not randomized and controlled. Not every patient with knee arthritis is a candidate for joint replacement surgery, he said.
“People can tolerate a lot of knee disability for reasons we don’t totally understand,” he went on, adding, “If the pain is acceptable, you live with it; if it’s not acceptable, we’ll operate on you.”
Dr. Rothman said that whether patients experience better health after surgery depends on motivation — how motivated they were to stay fit before surgery and how motivated they are now to become more active.
“For the motivated patient, it allows them to walk through that portal and become better conditioned and lose weight,” he said. “It’s not a weight-reduction program. It’s a potential avenue to improve your level of fitness, weight, cardiovascular health and mental health.”
Edward Moore, a 94-year-old retired chemist in Woodbury, N.J., underwent knee replacement three years ago after pain began limiting his activity. Given his age, his own daughter had worried that the recovery would be too difficult. But Dr. Rothman agreed he was healthy enough for the procedure.
“I didn’t do much mulling about it,” Mr. Moore said. “It just seemed like the knee would be hampering me for the rest of my life, and that sounded like a bad idea.”
Mr. Moore said he had an uneventful recovery, and in September, two days after his 94th birthday, he took his wind surfer to Lakes Bay near Atlantic City. “I got up on the board, and I sailed,” he said.
William Mills, 63, of Philadelphia, had been suffering for about four years with severe pain in both knees when he opted for double knee replacement in 2006. He said his activity had dropped off, and while he could still play golf, he could no longer walk the course. Even going to a restaurant had become a burden if he couldn’t find a parking space nearby.
“I think one of the things people don’t understand about knees is how bad it is,” said Mr. Mills, a bank executive. “It changes everything. I couldn’t walk two city blocks. It was just slowly but surely changing my life where I was unable to really enjoy things.”
But while the rehabilitation of both knees was “the hardest thing I’ve ever done in my life,” he has no regrets. Six months after surgery he took part in a 250-mile bike ride in Germany. He has made a few compromises — he no longer skis, and plays doubles tennis instead of singles — but he says he now rarely thinks about his knees.
“Before surgery, I felt like I was 10 or 15 years older than I was,” he said. “Now I probably feel like I’m 10 or 15 years younger than I am.
“I can understand why people might live longer, because you want to. You really feel good again.”
sábado, 4 de agosto de 2012
Finding Inspiration in a Doctor’s Legacy
Fuente: http://www.nytimes.com/2011/11/02/giving/charity-helps-children-with-clubfoot-without-surgery.html?pagewanted=all
Finding Inspiration in a Doctor’s Legacy
By BARRY MEIER
Published: November 1, 2011
MY morning sprint through the pages of this newspaper typically goes like this: the front page, the corrections, the sports section (during baseball season) and the obituaries.
Stephen Mally for The New York Times
A 5K race for a clubfoot charity included Trista Thompson, 6, once a patient. More Photos »
Multimedia
Two years ago, a photograph on the obituary page stopped me cold. It showed what looked like a display of talismans, objects that resembled “milagros,” the tiny tin replicas of legs, arms and other body parts that supplicants in Mexico and Central America pin to religious statues in the hope of curing a loved one.
These were medical tools, though, miniature plaster casts used to treat infants born with clubfoot, a crippling birth defect. The obituary, beautifully written by my colleague Douglas Martin, recounted the life of Dr. Ignacio Ponseti, a Spanish-born orthopedic expert who had created a nonsurgical cure for clubfoot.
As a reporter covering medicine, I often see its disheartening sides: overhyped drugs, “breakthrough” procedures that prove disastrous and the consequences that the financial dance between doctors and industry can have on patients.
I have also encountered heroes, and Dr. Ponseti soon joined them, his life a testament to the value of service and the power of simplicity. It made me think about what I could do to help make things a bit better.
Bear with me, though, because this is a confession, not a shoulder pat.
Clubfoot, which affects about 200,000 infants a year, is a horribly disabling birth defect, one that can doom a child born in a poor country to a marginal life. In the condition, one or both feet are turned inward and down, forcing afflicted people to walk clumsily on the sides of their feet.
The cure developed by Dr. Ponseti in the 1950s relies on physical manipulation. In each step of the treatment, a child’s clubfoot is stretched and turned slightly outward, and a hip-to-foot plaster cast, like the ones shown in the photograph, is then applied. After about five weeks, the foot is remolded; a child then wears a brace for a few years while bones mature.
Dr. Ponseti’s story was even more compelling because the medical establishment had ignored him, not just for a few years but for five decades. Surgery remained the treatment of choice, though it was performed largely only in wealthier countries and could leave a patient with a limp.
As Dr. Ponseti put it, surgeons love “their little knives.” The parents of children cured using his technique helped change things about a decade ago by taking to the Internet to spread the word. And it even gets better: the Ponseti method, as it is known, can be taught to nondoctors, making it a treatment that can be readily transferred anywhere in the world.
As I finished the physician’s obituary, my head was spinning. In 2006, three years before the doctor’s death at age 95, the Ponseti International Association was created at the University of Iowa, where Dr. Ponseti had practiced. Its mission is simple — to train doctors and health care workers in the Ponseti method.
So I wondered, how could I help? How much money should I donate? Could I learn the technique? And if so, where would I go? For weeks, such thoughts and fantasies kept rolling around. Then, as can happen with our better instincts, they disappeared beneath the immediate demands of family, work and self.
Now, fast-forward to this fall, around the start of the Jewish New Year. An editor asked me, or so I thought, what I was doing for “forgiving.” I thought it was a reference to the holidays, then realized it was invitation to contribute to this section, Giving.
I immediately though of Dr. Ponseti, and my enthusiasm and regrets about him welled up. Here was a chance to write about the philanthropic legacy of his work.
That story is also an inspiring one, filled with people, including disciples of Dr. Ponseti, who are training hundreds of medical professionals in his technique. But the philanthropic support for that effort, much like the fate that befell the Ponseti method for so long, remains very much in the shadows.
In recent years, the Ponseti International Association has received only about $350,000 annually, with $250,000 of that sum coming from a couple in Minneapolis, Robert and Molly Whitmore. (By comparison, the Smile Train, a charity that works to treat another common birth defect, cleft palate, received $102 million in contributions and grants in 2009 and has celebrity supporters like Christie Brinkley, Tom Brokaw and Helena Bonham Carter.)
Mr. Whitmore, the chief technology officer of Seagate, a maker of computer hardware, said he and his wife were inspired to get involved by his father, an orthopedic specialist who had studied under Dr. Ponseti.
Since his retirement in 2006, Dr. William Whitmore, now 79, has traveled to Greece, Rwanda and the Philippines to train people in the Ponseti method.
“The thing that floored us was my dad,” Mr. Whitmore said. “It is a perfect thing to eradicate clubfoot, a terrible deformity, in such an inexpensive, low-tech way.”
Mr. Whitmore said he had also tried to help the organization with his business expertise, helping it to devise a fund-raising plan. It hasn’t been easy, he added, because Dr. Ponseti, while he was alive, was more interested in research than promoting his work. That role has fallen to his protégé, Dr. Jose Morcuende, who is now the chief medical officer of the Ponseti International Association.
Dr. Morcuende said the organization’s program was growing. Discussions are under way to start a training program throughout Mexico, and similar efforts have started or are about to start in the Philippines, Romania and India.
The organization’s vision, Dr. Morcuende explained, is to create a cadre of trained doctors and health care workers in every country, a permanent medical infrastructure to treat the 200,000 new cases of clubfoot that will occur every year.
“We need about 4,000 to 5,000 good, well-trained people,” he said. Currently, that group stands about 1,500 strong and he estimates that it will take seven to 10 years and about $20 million to bring it to full force.
Some children with clubfoot will continue to require surgery. But Dr. Morcuende said studies have indicated that the Ponseti method works in up to 98 percent of cases, though it needs to be performed precisely and followed up rigorously to prevent a relapse. By medical standards, such success is impressive and some of Dr. Ponseti’s disciples have found that the technique has been used on older children, including some who were teenagers.
A doctor is needed to perform a minor procedure after the work of manipulating and casting the foot has finished. So as I spoke to Dr. Morcuende, I worked our conversation around to the issue about which I had obsessed when reading his mentor’s obituary: Could anyone be trained in the Ponseti method?
No, was his answer. One needed to understand the foot’s complex anatomy, and so physical therapists or hospital workers skilled in making casts are best suited for training.
I was a little disappointed. But that’s O.K. There is always writing and donating money. And that’s good, because those are things I can do.
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