Tratamiento farmacológico de la obesidad

Farmacoterapia para la obesidad: pasado, presente y futuro  Pharmacotherapies for obesity: past, current, and future therapies. Ioannides-Demos LL, Piccenna L, McNeil JJ. Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Centre, Commercial Road, Melbourne, VIC 3004, Australia. J Obes. 2011;2011:179674. Epub 2010 Dec 12. Abstract Past therapies for the treatment of obesity have typically involved pharmacological agents usually in combination with a calorie-controlled diet. This paper reviews the efficacy and safety of pharmacotherapies for obesity focusing on drugs approved for long-term therapy (orlistat), drugs approved for short-term use (amfepramone [diethylpropion], phentermine), recently withdrawn therapies (rimonabant, sibutamine) and drugs evaluated in Phase III studies (taranabant, pramlintide, lorcaserin and tesofensine and combination therapies of topiramate plus phentermine, bupropion plus naltrexone, and bupropion plus zonisamide)........http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006492/pdf/JOBES2011-179674.pdf http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006492/?tool=pubmed    Fármacos presentes y futuros en el manejo del peso  Current and future drug targets in weight management. Witkamp RF. Division of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV Wageningen, The Netherlands. renger.witkamp@wur.nl Pharm Res. 2011 Aug;28(8):1792-818. Epub 2010 Dec 23. Abstract Obesity will continue to be one of the leading causes of chronic disease unless the ongoing rise in the prevalence of this condition is reversed. Accumulating morbidity figures and a shortage of effective drugs have generated substantial research activity with several molecular targets being investigated. However, pharmacological modulation of body weight is extremely complex, since it is essentially a battle against one of the strongest human instincts and highly efficient mechanisms of energy uptake and storage. This review provides an overview of the different molecular strategies intended to lower body weight or adipose tissue mass. Weight-loss drugs in development include molecules intended to reduce the absorption of lipids from the GI tract, various ways to limit food intake, and compounds that increase energy expenditure or reduce adipose tissue size. A number of new preparations, including combinations of the existing drugs topiramate plus phentermine, bupropion plus naltrexone, and the selective 5-HT(2C) agonist lorcaserin have recently been filed for approval. Behind these leading candidates are several other potentially promising compounds and combinations currently undergoing phase II and III testing. Some interesting targets further on the horizon are also discussed. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130908/pdf/11095_2010_Article_341.pdf http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130908/?tool=pubmed

Atentamente Anestesiología y Medicina del Dolor www.anestesia-dolor.org

Nuevos artículos publicados en "Evidencias en Pediatría" (avance nº de septiembre)

Hola a tod@s

En las últimas tres semanas se han publicado en la web de "Evidencias en Pediatría"http://www.evidenciasenpediatria.es/ los siguientes artículos valorados críticamente:

• Las xantinas siguen siendo el tratamiento de elección de la apnea de la prematuridad

• En un mismo curso académico los niños más pequeños tienen más riesgo de ser diagnosticados de TDAH

• El sobrepeso-obesidad durante la primera infancia se asocia a mayor riesgo de asma bronquial a los ocho años

• Seguimos sin pruebas sobre la prevención de la infección urinaria con arándanos en niños 

Os recordamos que para suscribirse al boletín de novedades de "Evidencias en Pediatría" basta con que os suscribais desde el enlace "Suscripción gratuita al boletín de novedades", desde la página principal de la revista, http://www.evidenciasenpediatria.es  , a la derecha de vuestra pantalla.

Un saludo.

Equpo editorial de "Evidencias en Pediatría"
http://www.evidenciasenpediatria.es/

En Twitter: https://twitter.com/evidpediatria
En Facebook: http://www.facebook.com/pages/Evidencias-en-Pediatria/396993320672

Science. NYT

http://www.nytimes.com/pages/science/index.html

ENERGY RUSH

Drillers in Utah Have a Friend in a U.S. Land Agency

By ERIC LIPTON

Jim Wilson/The New York Times

In the Nine Mile Canyon area, which is known for petroglyphs, a natural gas company is installing a pipeline despite concerns of archaeologists.

An obscure branch of the Bureau of Land Management wields great influence on local land-use decisions in the state, usually to the benefit of the energy industry.

• Graphic: America’s Biggest Landlord
• Slide Show: Bureau of Land Management’s Divided Mission
• Documents: Over Drilling Rights, a Cozy Relationship Between Public and Private Interests

In Blackouts, Drones and iPads May Come to Rescue

By MATTHEW L. WALD

Utility companies are experimenting with iPad apps and aerial robots to help get the lights back on faster after storms by providing information and logistical support.

Genetic Data and Fossil Evidence Tell Differing Tales of Human Origins

By NICHOLAS WADE

Geneticists’ new finding that a previously unknown archaic species of human mingled with early modern humans in Africa has been met with skepticism because no fossil evidence exists.

• Read Comments (143)

Storms Threaten Ozone Layer Over U.S., Study Says

By HENRY FOUNTAIN

The risk of damage may increase as the climate warms and storms grow more intense and more frequent, the study said.

• Read Comments (273)

SCIENTIST AT WORK BLOG

Leaving the Reefs of Carrie Bow

By DUSTIN R. RUBENSTEIN

As scientists prepare to leave Belize, they discuss reasons for the disappearance of eusocial shrimp in Caribbean reefs.

OBSERVATORY

Aging Termites That Go Out With a Bang

By SINDYA N. BHANOO

In one species of termites, aging workers develop a unique defense mechanism: external structures on their backs that are toxic to an attacker.

• More Observatory Columns »

Leading the Search for a Self-Reliant Bloom

By LISA W. FODERARO

Peter E. Kukielski, of the New York Botanical Garden, is part of a movement to identify and promote rose varieties that will thrive without chemical intervention.

Weather Extremes Leave Parts of U.S. Grid Buckling

By MATTHEW L. WALD and JOHN SCHWARTZ

From highways to power plants, the concrete, steel and engineering that undergird the nation’s infrastructure are being dangerously taxed by heat, drought and storms.

• Read Comments (553)

Rare Burst of Melting Seen in Greenland’s Ice Sheet

By KELLY SLIVKA

The extent expanded from about 40 percent to 97 percent over four days, a first in 30 years of satellite observations but in line with a historical pattern.

SALLY RIDE | 1951-2012

American Woman Who Shattered Space Ceiling

By DENISE GRADY

Dr. Ride was the first American woman in space, flying on two missions on the shuttle Challenger.

• Slide Show | Times Topic
• Post a Comment | Read (332)

• California Envisions Fix to Water Distribution

• Russian Craft Has Glitch in Docking With Space Station

Science Times: July 24, 2012

With Warming, Peril Underlies Road to Alaska

By CORNELIA DEAN

Guy Dore/Laval University

NOT SO PERMANENT A pool of permafrost meltwater has formed along the Alaska Highway near Beaver Creek, Yukon.

The Alaska Highway, built in haste during World War II, is facing big challenges, including the effects of climate change on the underlying permafrost.

• Many Wonders (but Few Amenities) on a Legendary Highway
• In Road-Building, Black Soldiers Defied Prejudice

SIDE EFFECTS

How Brown and Polar Bears Split Up, but Continued Coupling

By JAMES GORMAN

Comparing the DNA of related species can work as a kind of microscope to see how the species separated — events that are otherwise lost in deep time.

• More Side Effects Columns »
• Read Comments (16)

Frozen Sperm Offer a Lifeline for Coral

By MICHELLE NIJHUIS

Scientists hope that building what is essentially a coral sperm bank will someday help restore damaged reefs.

OUT THERE

Mystery Tug on Spacecraft Is Einstein’s ‘I Told You So’

By DENNIS OVERBYE

A new explanation for the mysterious force that slowed down the Pioneer 10 and 11 space probes in the 1980s indicates that the old sage was doubly right.

Health News

THE AGENDA: HEALTH

Too Much Medical Care?

By TARA PARKER-POPE

The United States spends an estimated $210 billion annually on unnecessary medical services. For patients, this often means getting pulled into a cycle of repeated lab work, scans and other medical tests.

• Post a Comment | Read
• Exploring the Issues Behind the 2012 Campaign
• The Agenda: Assessing the Trade-Offs Between Security and Civil Liberties

Robert S. Ledley, Who Revolutionized Radiology, Is Dead at 86

By KATIE HAFNER

A dentist turned biomedical researcher, Dr. Ledley invented the first CT scanner capable of producing cross-sectional images of any part of the human body.

• The Anxiety of Waiting for Test Results

• Well: Choosing 'Watchful Waiting' for Prostate Cancer

• New Paint Wipes Out Infestation in a Village

SCIENTIST AT WORK BLOG

The Darker Side of Elephant Country

By CAITLIN O'CONNELL-RODWELL

Scientists find that elephants, normally known for their gentle nature, sometimes turn against members of their own family in times of limited resources and duress.

THE AGENDA

A Climate and Energy Stalemate

By JOHN M. BRODER

Attuned to the public’s ambivalence, both political parties and their presidential candidates are playing down the climate issue.

• Post a Comment | Read
• The Agenda: Exploring the Issues Behind the 2012 Campaign

Elephant Teenagers, Testing Boundaries

July 25, 2012

A Last Dive for Glowing Animals

July 24, 2012

In Caribbean Reefs, Social Shrimp Disappear

July 24, 2012

Go to Blog »

Keystone Pipeline Advances

July 27, 2012

Readers Jump Into the Climate Fray

July 27, 2012

On Our Radar: A Twist on Eating Local

July 27, 2012

Go to Blog »

Science Columns

OBSERVATORY

Mating Leaves Flies Most Vulnerable to Bats

By SINDYA N. BHANOO

Bats depend on flies for much of their diet, and a new study of a European bat suggests that the flies betray themselves while they mate.

OBSERVATORY

Tiny Outsider Seems to Help Mosses Reproduce

By KATE YANDELL

A new study shows that mosses appear to emit smelly compounds to attract tiny arthropods that carry sperm from plant to plant.

OBSERVATORY

Birds Switch Gears to Stay on Course

By SINDYA N. BHANOO

A new study suggests that hummingbird keep flying through a downpour by adjusting their posture and increasing the frequency of their wing beats.

• More Observatory Columns »

Q & A

Vaccine vs. Virus

By C. CLAIBORNE RAY

Why didn’t viruses like polio and other diseases mutate to become immune to vaccines?

• More Q & A Columns »

Podcast: Science Times

The permafrost challenge; diving the coral reefs; and treatment options for prostate cancer.

  Science Times Podcast

• play
• max volume

30:54

Health Columns

PERSONAL HEALTH

The Ideal and the Real of Breast-Feeding

By JANE E. BRODY

Some dispute the message that "breast is best" and cite concerns for the pressure and guilt it heaps on working mothers.

• More Personal Health Columns »

REALLY?

The Claim: In a Heat Wave, an Electric Fan Can Cool You Off

By ANAHAD O'CONNOR

Some experts have questioned whether electric fans might actually hamper efforts to cool down.

• More Really? Columns »

Opinion

DOT EARTH BLOG

Can Universities Credibly Probe Gas Impacts When Industry Foots the Bill?

By ANDREW C. REVKIN

A foe of fracking sees big problems if hidden conflicts of interest in energy analysis become the norm.

More From Dot Earth »

WORDPLAY BLOG

Numberplay: Three Containers

By GARY ANTONICK

How can you pour water between three glasses to end up with two equal amounts?

Letters

• Turn Down the Volume (1 Letter)

• Footsteps to Decline? (2 Letters)

• Defining ‘Low Fat’ (1 Letter)

• Goals of I.V.F. Treatment (1 Letter)

Telemedicina. Alerta

Telemedicina en la Cirugía de Feminización Facial | FACIAL ... Facial Team ofrece a pacientes interesadas en la Cirugía de Feminización Facial en soluciones deTelemedicina para consultas, pre y post-operatorio, etc. facialteam.eu/telemedicina-feminizacion-facial/

InTouch y iRobot desarrollan dispositivos de telemedicina para la ... InTouch Health, un nombre importante entre los dispositivos de telemedicina y iRobot , el famoso fabricante de la aspiradora robótica Roomba y de los. medgadget.es/.../intouch-y-irobot-desarrollan-dispositivos-de-t...

RP-VITA, un robot para la telemedicina de los creadores de Roomba

http://www.animeaf.com/2012/07/26/rp-vita-un-robot-para-la-telemedicina-de-los-creadores-de-roomba/

RP-VITA, un robot para la telemedicina de los creadores de Roomba

 julio 26th, 2012  Super

La telemedicina se ha convertido en un campo de investigación bastante interesante a la hora de desarrollar soluciones y aplicaciones de todo tipo. Todavía está un poco verde y es que las limitaciones que supone la distancia a veces son muy grandes. Sin embargo eso no quita que para ciertos casos cumpla con su cometido y sea útil.

En este mundillo existen muchos proyectos entre ellos uno que está llevando a cabo los creadores de Roomba. Con el nombre de RP-Vita, y seis millones de dólares de inversión, nace un robot para hospitales que permitirá a los médicos comunicarse con sus pacientes y poder realizar algunas pruebas y análisis sin necesidad de estar en la sala.

En la parte más visual nos encontramos con una pantalla a través de la cual el paciente podrá ver al médico a través de una videoconferencia. Debajo de esta se podrá acoplar un tablet o un ordenador para realizar diferentes acciones. La intención de este robot no es sólo ser un televisor andante sino realmente ser útil.

Para ello, será equipado con diferentes equipos que permitirá hacer diferentes pruebas y análisis para enviar la información al doctor, a la vez que esta se archiva en el historial del paciente. Eso sí, de momento no es completamente independiente y para algunas tareas necesitaremos a un asistente al lado del paciente para poder utilizar el robot.

Su autonomía de cinco horas nos hace pensar que este robot de momento sólo se utilizará para casos puntuales y no de forma más intensa. Aun así es un caso bastante interesante ya que además cuando vaya a terminarse la carga, como ocurre con las aspiradoras robóticas, volverá automáticamente a su base a conectarle a la alimentación.

De momento no hay planes para integrar este equipo en los hospitales así que tendremos que esperar para cruzarnos con este robot en el pasillo de nuestro centro médico más cercano. Lo cierto es que como solución para poblaciones pequeñas puede ser útil o cuando no hay un médico en la zona. Sin embargo, habrá que ver hasta que punto puede ser eficaz y si realmente es capaz de diagnosticar algo más que catarros.

Vía | Mashable