Terapia con células madre

Terapia con células madre: Una modalidad de tratamiento novedosa y futurista para las lesiones por desastres Stem cell therapy: A novel & futuristic treatment modality for disaster injuries Gurudutta GU, Satija NK, Singh VK, Verma YK, Gupta P, Tripathi RP. Indian J Med Res [serial online] 2012 [cited 2012 Mar 1];135:15-25.   Stem cell therapy hold the potential to meet the demand for transplant cells/tissues needed for treating damages resulting from both natural and man-made disasters. Pluripotency makes embryonic stem cells and induced pluripotent stem cells ideal for use, but their teratogenic character is a major hindrance. Therapeutic benefits of bone marrow transplantation are well known but characterizing the potentialities of haematopoietic and mesenchymal cells is essential. Haematopoietic stem cells (HSCs) have been used for treating both haematopoietic and non-haematopoietic disorders. Ease of isolation, in vitro expansion, and hypoimmunogenecity have brought mesenchymal stem cells (MSCs) into limelight. Though differentiation of MSCs into tissue-specific cells has been reported, differentiation-independent mechanisms seem to play a more significant role in tissue repair which need to be addressed further. The safety and feasibility of MSCs have been demonstrated in clinical trials, and their use in combination with HSC for radiation injury treatment seems to have extended benefit. Therefore, using stem cells for treatment of disaster injuries along with the conventional medical practice would likely accelerate the repair process and improve the quality of life of the victim. http://www.ijmr.org.in/text.asp?2012/135/1/15/93419  Precondicionamiento de células madres para el tratamiento del infarto del miocardio  Preconditioning of stem cells for the treatment of myocardial infarction. Lu HH, Li YF, Sheng ZQ, Wang Y. Department of Cardiology, the Second Affiliated Hospital, Nantong University, Nantong, Jiangsu 226601, China (Email: lhh226001@126.com). Chin Med J (Engl). 2012 Jan;125(2):378-84. Abstract OBJECTIVE: Poor stem cell survival is one of the obstacles for cell regeneration therapy post myocardial infarction (MI) and responsible for unsatisfactory therapeutic effectiveness. Various approaches to improve the status of these cells and increase cell survival have become research foci. The following article is a mini-review on the utilization of cell preconditioning for stem cell survival. DATA SOURCES: The data used in this review were mainly from the articles in Medline and PubMed published from 1990 to 2010. The search terms included "preconditioning, stem cell and myocardial infarction". STUDY SELECTION: Original articles and critical reviews selected were relevant to the review's theme.RESULTS: The harsh ischemic and inflammatory microenvironment in the infarcted myocardium offers a significant challenge to the transplanted donor stem cells. Survival of stem cells following transplantation is affected by many factors, such as limited blood supply, nutritional deficiency, hypoxia, oxidative stress, and inflammation. Preconditioning methods have potent cytoprotective effects, which enables cells to maintain a "standby state" through programmed initiation of cell survival pathways. CONCLUSIONS: The findings suggest that cell preconditioning can be used as an effective anti-apoptotic strategy and enable cells to withstand and survive the harsh environment after transplantation. http://www.cmj.org/Periodical/PDF/201212055801560.pdf   Fuera del quirófano: direcciones ilimitadas en investigación y más allá Outside the operating room: unlimited directions in research and beyond. Waterman R, Betancourt A. Ochsner J. 2011 Spring;11(1):14-6. Abstract The anesthesiologist's role often extends beyond the operating room and includes the realm of research. Recently, interest in investigating mesenchymal stem cells (MSCs) as therapy for myriad diseases has grown. MSCs are adult stem cells traditionally found in bone marrow that hone to damaged tissues and contribute to the tissues' repair by secreting chemokines, cytokines, and extracellular matrix proteins. Research has established a connection between the stimulation of specific Toll-like receptors and the immune-modulating responses of human MSCs, which allows for the polarization of MSCs into either a pro-inflammatory or an anti-inflammatory phenotype. It is anticipated that MSC-based therapies polarized into the anti-inflammatory phenotype will treat painful inflammatory diseases, such as diabetic peripheral neuropathy or rheumatoid arthritis. These new cell-based therapies will be another tool for anesthesiologists to employ while treating patients with chronic pain  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096162/pdf/i1524-5012-11-1-14.pdf   Utilización de Células Madre en Terapia Regenerativa Cardíaca F. Prósper, A. Pérez, J. Cosín, A. Panizo, J. Rifón, M. Hernández, J. Pérez-Calvo, G. Rábago, S. Inogés, E. Rocha, J. Herreros Servicio de Hematología y Area de Terapia Celular. Departamento de Anatomía Patológica y Departamento de Cardiología y Cirugía Cardiovascular. Clínica Universitaria. Facultad de Medicina. Universidad de Navarra REV MED UNIV NAVARRA/VOL. 46, Nº2, 2002, 24-28 Resumen La posibilidad de utilizar células madre en el tratamiento de diversas enfermedades humanas como la diabetes, la enfermedad de Parkinson, la cardiopatía isquémica constituye uno de los retos mas importantes de la medicina moderna. Sin embargo, antes de que los resultados de los estudios con células madre se traduzcan clínicamente existen múltiples problemas que deben ser resueltos. A continuación trataremos de exponer algunos conceptos relacionados con las células madre y su potencial, centrándonos principalmente en las células madre adultas tal como han sido recientemente descritas por el grupo de Catherine Verfaillie. Además resentaremos resultados de alguno de los primeros estudios clínicos realizados con células madre adultas como forma de terapia regenerativa cardíaca. En dichos trabajos se han empleado células madre de músculo (células satélite) autólogas en pacientes con infarto de miocardio, inyectándose directamente dichas células en la periferia de la cicatriz secundaria al infarto. Palabras clave: Mioblasto. Células Madre Adultas. Regeneración Cardíaca. http://www.unav.es/revistamedicina/46_2/celulasmadre.PDF

Atentamente Anestesiología y Medicina del Dolor www.anestesia-dolor.org

Diagnostico Visual del mes de Marzo

Pueden revisar en la Pagina de Conapeme:  Diagnostico visual del mes  de marzo

http://www.conapeme.org/v1/index.php/modules-menu/diagnostico-visual/caso-actual 

participen en el pool

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Juego de fin de semana...

En la Feria Internacional del libro de Buenos Aires de este año, los lectores elegirán su favorito…

Los lectores elegirán su libro favorito en la Feria Internacional de este año. Se votará por Internet, entre libros editados en 2011. Vienen Eduardo Galeano, Pilar Sordo y David Grossman.

"Un futuro con libros” es el lema. Así, la 38 edición de la Feria Internacional del Librode Buenos Aires apuntará en 2012 a acercar las nuevas tecnologías a los lectores. También se buscará la participación del público a través de una votación en la que podrán elegir su libro del año.

Sí, esta vez los que premien serán los lectores: la Feria les pidió a los libreros una preselección de 20 títulos publicados en 2011, entre los que el público votará uno en la página web de la Fundación El Libro, durante marzo y abril. De esa votación saldrá el Premio del Lector .

Como todos los años, habrá escritores de otros países. Buena parte de las miradas estarán posadas en el uruguayo Eduardo Galeano. La organización prevé poner pantallas gigantes fuera de la sala para seguir su presentación.

También será convocante el israelí David Grossman. Durante la invasión de Israel al Líbano en 2006, Grossman dijo, en una conferencia de prensa, que “Por interés en el futuro de Israel y en nuestro lugar aquí, la lucha debe detenerse ahora, para dar lugar a las negociaciones”. Dos días después, su hijo Uri moría en combate.

En la agenda de autores extranjeros sobresale Daniel Pennac, que nació en Marruecos y es uno de los más importantes escritores franceses de la actualidad. Es el autor de los famosos “derechos del lector”, donde reclama, por ejemplo, la potestad de “no leer”, “saltarnos páginas”, “releer” y “hojear”.

Estará Norman Manea, un judío rumano nacido en 1936, que ahora vive en Estados Unidos y escribe sobre el Holocausto y la Rumania comunista. Y Federico Moccia, el best-seller italiano, autor dePerdona si te llamo amor.

Otra visitante destacada será Viola Di Grado, una siciliana de 23 años que fue un éxito el año pasado con Setenta acrílico, treinta lana, una novela sobre un caso de “anorexia verbal”.

Desde Chile, llegarán la chilena Lina Meruane –no se pierdan su libro Las infantas – y su compatriota, la psicóloga Pilar Sordo. La estadounidense Sandra Cisneros –representante destacada de la literatura “chicana”– también será de la partida.

Del plano local estarán Alejandro Dolina, Alberto Manguel, Felipe Pigna, Gabriel Rolón, Miguel Bonasso y José Pablo Feinmann, además de Cristian Alarcón, Lola Arias, Juan José Becerra, Oliverio Coelho, Pola Oloixarac, Romina Paula y Hernán Ronsino. Daniel Roncoli, con su biografía de Martín Karadagián, publicada recientemente, será otro de los atractivos.

Como en la vida, las nuevas tecnologías de lectura van ganando lugar en la Feria. Su directora Gabriela Adamo, detalla: “No sólo van a estar los libros digitales para que la gente los pueda usar, tocar, ver; la intención es que también que participen en debates y se vinculen con lo que tiene que ver con la lectura en el siglo XXI”. Algo nuevo aparece: “El cambio que veo este año en la Feria es que las editoriales tienen clarísima conciencia de las nuevas tecnologías y cada una, a su manera, está viendo la forma de reaccionar o liderar el proceso, según sus propias características”.

Pero, por más que avance la tecnología, sin humanos no hay lectores. Por eso, Adamo, no teme exagerar: “Vamos a cuidar al lector de todas las maneras posibles y vamos a tratar de que vea que leer es lo mejor que le puede pasar en la vida”.

Fuente:

 http://www.clarin.com/sociedad/lectores-elegiran-libro-favorito-Feria_0_660534044.html

Papel del sugamadex en el desarrollo y modificación de la respuesta alérgica al rocuronio: evidencia de un modelo subcutáneo

Papel del sugamadex en el desarrollo y modificación de la respuesta alérgica al rocuronio: evidencia de un modelo subcutáneo The role of sugammadex in the development and modification of an allergic response to rocuronium: evidence from a cutaneous model. R. C. Clarke,P. H. M. Sadleir1 and P. R. Platt Consultant Anaesthetist, Department of Anaesthesia, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia Anaesthetic Allergy Referral Centre of Western Australia, Perth, Western Australia, Australia Anaesthesia 2012, 67, 266-273 Summary The availability of sugammadex as a selective encapsulating agent for rocuronium has led to speculation that it may be useful in mitigating rocuronium-induced anaphylaxis. Off-label use of sugammadex for this indication has already been documented in case reports although there are theoretical objections to the likelihood of an allergen-binding agent's being able to attenuate the immunological cascade of anaphylaxis. Using a cutaneous model of anaphylaxis in rocuronium-sensitised patients, we were unable to demonstrate that sugammadex was effective in attenuating the type-1 hypersensitivity reaction after it has been triggered by rocuronium, but we were able to demonstrate that these patients are anergic to sugammadex-bound rocuronium. These findings demonstrate that a cyclodextrin can bind an allergen and exclude it from interacting with the immune system, and may potentially lead to novel applications in other allergic diseases. However, there is no evidence that sugammadex should be used for the treatment of rocuronium-induced anaphylaxis, and clinical management should follow established protocols. http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2044.2011.06995.x/pdf

Atentamente Anestesiología y Medicina del Dolor www.anestesia-dolor.org

Bibliotecarios

María Moliner, sinónimo de bibliotecaria y lexicógrafa Noticias Castilla y León La UNED ofrece una exposición sobre la figura y la obra de María Moliner, bibliotecaria y lexicógrafa comprometida con su profesión y autora del Diccionario de Uso del Español Se puede visitar desde el día 5 al 15 de marzo, en horario de mañana y tarde ... Ver todos los artículos sobre este tema »

Web social para profesionales de la información: estar y saber estar ... según Julian_Marquina Conocer las principales iniciativas y casos destacables de bibliotecas y centros de información denominados Bibliotecas 2.0. Manejar las herramientas de la Web 2.0 y saber aplicarlas en la mejora y la creación de los servicios bibliotecarios. RecBib - Recursos Bibliotecarios

México | RecBib - Recursos Bibliotecarios Sólo una de cada diez bibliotecas escolares en México es coordinada por un maestro bibliotecariodesignado y capacitado para tal función; en tres cuartas ... webcahe.www.recbib.es/noticias/mexico

Info Bolivia - Estos sí que son voluntarios. Bibliotecarios en Bolivia ... l►► Noticias Bolivia : Estos sí que son voluntarios. Bibliotecarios en Bolivia. ( Plataforma para la creación del Colegio Oficial de...) - Encuentra toda la ... www.info-bolivia.com/estos-si-que-son-voluntarios-bibliotecar...

Digital.CSIC: Habilidades de los bibliotecarios: nuevos roles; diseño ... Autor : Cárdenas García, Juan. Palabras clave : IHSM UMA-CSIC Memoria IHSM www IHSM Rolesbibliotecarios. Edición digital. Information management ... digital.csic.es/handle/10261/46654

Books Update

On the Cover of Sunday's Book Review 'Gods Without Men' By HARI KUNZRU Reviewed by DOUGLAS COUPLAND In Hari Kunzru's fourth novel, an autistic boy disappears in the California desert and many lives intersect around a rock formation called the Pinnacles.  Up Front: Douglas Coupland Also in the Book Review 'Lost Kingdom: Hawaii's Last Queen, the Sugar Kings, and America's First Imperial Adventure' By JULIA FLYNN SILER Reviewed by MALIA BOYD Julia Flynn Siler traces Hawaii's fraught history, from Captain Cook to American annexation. 'Enchantments' By KATHRYN HARRISON Reviewed by SUSANN COKAL In Kathryn Harrison's novel of late imperial Russia, Rasputin's sway doesn't end with his death. 'No Cheating, No Dying' By ELIZABETH WEIL Reviewed by MAGGIE SCARF A writer embarks on a project of marital enhancement. 'House of Stone' By ANTHONY SHADID Reviewed by PATRICK COCKBURN Anthony Shadid rebuilt his ancestors' house in Lebanon. 'The Escape Artists: How Obama's Team Fumbled the Recovery' By NOAM SCHEIBER Reviewed by PAUL M. BARRETT Noam Scheiber takes us behind the scenes with President Obama's economic team. 'That Woman: The Life of Wallis Simpson, Duchess of Windsor' By ANNE SEBBA Reviewed by LIESL SCHILLINGER This new book looks at the life of Wallis Simpson, for whom Edward VIII abdicated. 'The Power of Habit' By CHARLES DUHIGG Reviewed by TIMOTHY D. WILSON A look at the science of how we form habits and how we can break them. 'Beautiful Souls' By EYAL PRESS Reviewed by LOUISA THOMAS Eyal Press looks at ordinary people who resisted the status quo to follow their own convictions. CRIME Strangers Abroad By MARILYN STASIO In Chris Pavone's "The Expats," a burned-out C.I.A. operative moves to Luxembourg and begins investigating her husband's activities there. ON POETRY Versions By DAVID ORR The English versions of the Nobel Prize winner Tomas Transtromer's poems raise issues that go to the heart of the translator's function. Fiction Chronicle By JOHN WILLIAMS New fiction by Richard Mason, Anna Funder, Alex George, Helen Simpson and Jonathan Odell. Children's Books Honest, Fair, Courageous and Strong By CANDACE FLEMING It's Women's History Month, and four picture books introduce children to some real-life heroines. The Finer Points of the Game By MATT de la PEÑA Basketball, in these two novels, is a path to success and a means of escape. Bookshelf: Poetry By PAMELA PAUL Five new picture books introduce children to the art of poetry.   Slide Show: Poetry Bookshelf 'After the Snow' By S. D. CROCKETT Reviewed by JULIANNA BAGGOTT In S. D. Crockett's dystopian novel, a teenager navigates frozen terrain in search of his family. 'The Glass Collector' By ANNA PERERA Reviewed by JOSHUA HAMMER This novel's hero belongs to a group of trash scavengers who prowl Cairo's filthy streets.

sesión del CMO 7/III/2012

Transmisión enviada en vivo y ahora compartida, los por menores de sesión, nuestro principal problerma la velocidad de la conexión a internet.

Watch live streaming video from bibliomanazteca_platicas_medicas at livestream.com

El ABC de los tumores oseos

Romeo Tecualt CURSO DE TUMORES OSEOS "EL ABC DE LOS TUMORES DEL 
Programa

SISTEMA MUSCULOESQUELETICO.
OAXACA, OAX. 01 Y 02 DE NOV. DEL 2012. HOTEL MISION DE LOS ANGELES.

APROVECHEMOS LAS FECHAS PARA PARTICIPAR DE ESTA CIUDAD LLENA DE FOLKLOR Y ATRACTIVOS. 

Mujer...

No hay mujer más inteligente, que la que sabe darse a respetar.
No hay mujer más bella, que la que tiene un gran corazon .
No hay mujer más fuerte, que la que cree en si misma.
No hay mujer más admirable, que la que tiene dignidad.
No hay mujer más elegante, que la que es una dama.
No hay mujer más sana, que la que realmente se conoce.
No hay mujer más feliz, que la que sabe valorar. 

FELIZ DÍA INTERNACIONAL DE LA MUJER

FELIZ DÍA INTERNACIONAL DE LA MUJER 
Es el deseo de un amigo

 
con una pequeña muestra de las pinturas de Leonid Afremov
 



 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 



 

 

programas de control malaria en la región Amazónica

Buen articulo sobre la valoración de los programas de control malaria en la región Amazónica, Incluye al Perú.
usa indicadores muy interesantes.

http://www.malariajournal.com/content/pdf/1475-2875-10-379.pdf

http://www.malariajournal.com/content/pdf/1475-2875-10-379.pdf

Estatinas y succinilcolina

Consecuencias de la administración de succinilcolina a pacientes usando estatinas Consequences of succinylcholine administration to patients using statins. Turan A, Mendoza ML, Gupta S, You J, Gottlieb A, Chu W, Saager L, Sessler DI. Department of Outcomes Research, Cleveland Clinic, Cleveland, Ohio, USA.alparslanturan@yahoo.com Anesthesiology. 2011 Jul;115(1):28-35. Abstract BACKGROUND: Statins cause structural changes in myocytes and provoke myotoxicity, myopathy, and myalgias. Thus, patients taking statins may be especially susceptible to succinylcholine-induced muscle injury. The authors tested the hypothesis that succinylcholine increases plasma concentrations of myoglobin, potassium, and creatine kinase more in patients who take statins than in those who do not and that succinylcholine-induced postoperative muscle pain is aggravated in statin users. METHODS: Patients who took statins for at least 3 months and those who had never used statins were enrolled. General anesthesia was induced and included 1.5 mg/kg succinylcholine for intubation. The incidence and degree of fasciculation after succinylcholine administration were recorded. Blood samples were obtained before induction and 5 and 20 min and 24 h after succinylcholine administration. Patients were interviewed 2 and 24 h after surgery to determine the degree of myalgia. RESULTS: The authors enrolled 38 patients who used statins and 32 who did not. At 20 min, myoglobin was higher in statin users versus nonusers (ratio of medians 1.34 [95% CI: 1.1, 1.7], P = 0.018). Fasciculations in statin users were more intense than in nonusers (P = 0.047). However, plasma potassium and creatine kinase concentrations were similar in statin users and nonusers, as was muscle pain. CONCLUSIONS: The plasma myoglobin concentration at 20 min was significantly greater in statin users than nonusers, although the difference seems unlikely to be clinically important. The study results suggest that the effect of succinylcholine given to patients taking statins is likely to be small and probably of limited clinical consequence http://journals.lww.com/anesthesiology/pages/articleviewer.aspx?year=2011&issue=07000&article=00013&type=abstract   La succinilcolina debe de evitarse en pacientes con terapia con estatinas Succinylcholine should be avoided in patients on statin therapy. Lee C. Anesthesiology. 2011 Jul;115(1):6-7. http://journals.lww.com/anesthesiology/Citation/2011/07000/Succinylcholine_Should_Be _Avoided_in_Patients_on.8.aspx   Miopatías inducidas por estatinas Statin-induced myopathies. Tomaszewski M, Stępień KM, Tomaszewska J, Czuczwar SJ. Department of Cardiology, Medical University of Lublin, Jaczewskiego 8, PL 20-954 Lublin, Poland. mdtomaszewski@yahoo.com Pharmacol Rep. 2011;63(4):859-66. Abstract Statinsare considered to be safe, well tolerated and the most efficient drugs for the treatment of hypercholesterolemia, one of the main risk factor for atherosclerosis, and therefore they are frequently prescribed medications. The most severe adverse effect of statins is myotoxicity, in the form of myopathy, myalgia, myositis or rhabdomyolysis. Clinical trials commonly define statin toxicity as myalgia or muscle weakness with creatine kinase (CK) levels greater than 10 times the normal upper limit. Rhabdomyolysis is the most severe adverse effect of statins, which may result in acute renal failure, disseminated intravascular coagulation and death. The exact pathophysiology of statin-induced myopathyis not fully known. Multiple pathophysiological mechanisms may contribute to statin myotoxicity. This review focuses on a number of them. The prevention of statin-related myopathy involves using the lowest statin dose required to achieve therapeutic goals and avoiding polytherapy with drugs known to increase systemic exposure and myopathy risk. Currently, the only effective treatment of statin-induced myopathy is the discontinuation of statin use in patients affected by muscle aches, pains and elevated CK levels. http://www.if-pan.krakow.pl/pjp/pdf/2011/4_859.pdf

Atentamente Anestesiología y Medicina del Dolor www.anestesia-dolor.org