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viernes, 13 de mayo de 2011

Diario Pediátrico en español Viernes, May. 13, 2011


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Tema

rubengp
El Día de la Madre se celebra en una gran mayoría de países en diferentes fechas a lo largo del mes de mayo. Una de las motivaciones de este blog y origen de su nombre es servir de homenaje y testi...
 hijosdeevayada...
Salud

jmartinezal
Hace años, cuando trabajaba en una clínica con otros compañeros, entro una señora todavía embarazada para interesarse por quien iba a atender a su futuro bebe. Pregunto en el mostrador después de u...
 elmedicodemihi...
Cultura y Espectáculos

evidpediatria
La enfermedad meningocócica es la infección más grave en la edad pediátrica. A pesar de los avances en prevención, como la vacuna contra el meningococo C, y la mejoría en el tratamiento intensivo, ...
 evidenciasenpe...

DarinelGomez
Dr Ernesto Jiménez BalderasFIDENCIA 135-1CENTRO C. P. 86000VILLAHERMOSA TABASCOCEL. 9933114074pediatra@yahoo.comRIESGO DE OBESIDAD ASOCIADO A LA ALIMENTACIÓN CON BIBERÓNRecientemente salió en una p...
 conapemeparapa...

Pediatria
A falta de una cura o una vacuna, los antivirales pueden tener la solución para frenar la transmisión del VIH. La última evidencia en este sentido es un estudio con 1.736 parejas heterosexuales en ...
 elpais.com
Salud

Pediatria
Objetivo: comparar la eficacia y la seguridad indometacina (Indo), ibuprofeno (Ibu) y placebo (P) en el cierre del conducto arterial persistente (CAP) del prematuro. Diseño: revisión sistemática (R...
 evidenciasenpe...

mipediatra
La información sobre salud de los CDC está a su alcance en su celular o aparato móvil. Visite http://m.cdc.gov/es  para consultar artículos especiales de salud, información sobre la influenza estac...
 cdc.gov
Tecnología

HSJDBCN
(Things to Expect When Your Mom is Pregnant)Quizá siempre has querido tener un hermanito o una hermanita y tus padres te acaban de decir que tu deseo se va a hacer realidad.Quizá siempre te ha gust...
 kidshealth.org
Cultura y Espectáculos

doctorin
1 week agoLoading…Flash Player 9 (or above) is needed to view presentations. We have detected that you do not have it on your computer. To install it, go here.Like this presentation?Aplicaciones sa...
 slideshare.net
Tecnología

Pallapupas
Extracto Cada día, millones de personas conversamos, bromeamos, compartimos vídeos y fotos o marcamos muchos “Me gusta” en Facebook. Pero ¿y si también pudiéramos hacer cosas que merezcan la pena? ...
 lanzanos.com
Tecnología

Pallapupas
Santiago Ambrosio i Xavier Ariza Vicedegà i Coordinador de Semiologia, Facultat de Medicina de la Universitat de Barcelona “Pot ser més fàcil curar un mal físic que un emocional” Pallapupas...
 pallapupas.org

giordanopg
Photo: Starstruck in SF (2008)More Previous The Walking GalleryKaiser Permanente Center for Total Health, Washington, DCOn the evening of Tuesday June 7th 2011 the Kaiser Permanente Center for Tota...
 tedeytan.com
Negocios

Pallapupas
  Llévatelo al móvil Enviando un SMS Envia un sms al 27331 con el texto   IVOOX 648563 Servicio sólo disponible en España. El precio del mensaje es de 1,4 euros, iva incluido. Servicio SMS gestiona...
 ivoox.com
Tecnología

mipediatra
INVESTIGACIÓNMejores destrezasSilvia R. Taberné | MadridUn estudio de EEUU pone el acento en los beneficios que tiene ser músico para mejorar los típicos problemas de oído al llegar a la vejez.PSIC...
 elmundo.es
Cultura y Espectáculos

alonsofer
Hay dos lecturas posibles sobre el discurso de Cristina en José C. Paz. Una es humana y la otra es política. La primera refleja una verdad que quedó desnuda hasta el desgarro con la muerte súbita d...
 tiempo.elargen...
Cultura y Espectáculos

renapred_mexico
Temas Si estás pensando embarazarte o ya estás embarazada, es necesario que te alimentes de la manera correcta. Tú y tu bebé afrontarán una prueba grande e importante.   El estado nutricional de la...
 renapred.org.mx
Salud

renapred_mexico
Temas El Tamiz Neonatal es una prueba mediante la cual se pueden descubrir y tratar de manera oportuna enfermedades graves e irreversibles como el hipotiroidismo congénito. ¿Por qué es importante r...
 renapred.org.mx
Salud

droncoped
RedacciónCiudad de Méxicojueves, 12 de mayo de 2011 | 18:09El púgil estadounidense 'Sugar' Shane Mosley escribió en su cuenta de twitter que un ex sparring de Manny Pacquiao confesó que le inyectab...
 mx.sports.yaho...
Deportes

odsciberesp
The striking geographical pattern of gastric cancer mortality in Spain: environmental hypotheses revisited Área de investigación: Territorio y Salud Año: 2009 Tipo de publicación: Artículo Palabras...
 ods-ciberesp.es
Salud

alonsofer
Viernes 13 de mayo de 2011 | Publicado en edición impresa El crepúsculo de un ídolo Por Michel Onfray TaurusTrad.: Horacio Pons499 páginas$ 99 ¿Por qué tanto odio? Por Élisabeth Roudinesco Libros d...
 lanacion.com.ar
Publicado por Bibliomanazteca en 23:12 0 comentarios
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Book Review


On the Cover of Sunday's Book Review

'To End All Wars'

By ADAM HOCHSCHILD
Reviewed by CHRISTOPHER HITCHENS
Adam Hochschild's stirring account of World War I concentrates on the appalling losses in the ranks and on the extraordinary courage of the dissenters.

Also in the Book Review

The easy part: Kissinger, Nixon, Secretary of State William P. Rogers and Prime Minister Zhou Enlai in 1972.

'On China'

By HENRY KISSINGER
Reviewed by MAX FRANKEL
China and America have become mutually dependent economic giants, Henry Kissinger argues, but they need an overarching strategic design of partnership.
Stanley Ann Dunham with her son.

'A Singular Woman'

By JANNY SCOTT
Reviewed by ELIZA GRISWOLD
This biography of Barack Obama's mother presents a more complex picture than the president offered in his own books.
A protestor in Washington on Sept. 11, 2007.

'Among the Truthers'

By JONATHAN KAY
Reviewed by JACOB HEILBRUNN
A journalist travels the world of conspiracy theories, about everything from President Obama's birthplace to 9/11 to vaccines.
A Mary Delany collage of a Magnolia grandiflora.

'The Paper Garden'

By MOLLY PEACOCK
Reviewed by ANDREA WULF
A biography of an 18th century a widow who, in her 70s, invented a new way to depict flowers.

'Caleb's Crossing'

By GERALDINE BROOKS
Reviewed by JANE SMILEY
In Geraldine Brooks's historical novel, a missionary's daughter forms a bond with a scholarly Indian.

'The Sly Company of People Who Care'

By RAHUL BHATTACHARYA
Reviewed by DINAW MENGESTU
The narrator of this novel journeys into Guyana's interior to seek answers about the country's past.

'What's Gotten Into Us?: Staying Healthy in a Toxic World'

By MCKAY JENKINS
Reviewed by ELIZABETH ROYTE
An effort to come to terms with the unknown consequences that synthetic chemicals may hold for consumers.
Edna O'Brien

'Saints and Sinners: Stories'

By EDNA O'BRIEN
Reviewed by LIESL SCHILLINGER
Some of the restless, searching people in Edna O'Brien's stories confront political violence, others reflect on disappointing loves.
Bernard Madoff entering court, 2009.

'The Wizard of Lies'

By DIANA B. HENRIQUES
Reviewed by LIAQUAT AHAMED
A Times journalist explains how Bernard Madoff pulled off history's greatest Ponzi scheme, and how he got away with it for so long.
Lincoln Steffens, circa 1920.

'I Have Seen the Future'

By PETER HARTSHORN
Reviewed by KEVIN BAKER
This biography of Lincoln Steffens traces the convictions and delusions of one of the original "muckrakers."
Gilbert Gottfried

'Rubber Balls and Liquor'

By GILBERT GOTTFRIED
Reviewed by PETER KEEPNEWS
The sometimes controversial comedian Gilbert Gottfried looks back on the performances that brought him attention.
Publicado por Bibliomanazteca en 23:08 0 comentarios
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Engineered proteins for fighting flu


Comment on this news story
By Cristina Luiggi

Engineered proteins for fighting flu

In a feat of computational biology, researchers design novel proteins capable of neutralizing a key influenza protein


[Published 12th May 2011 06:37 PM GMT]

Computational biologists designed and produced two novel proteins that strongly bind to a crucial flu protein that enables the virus to enter cells. The new creations, built with the help of more than 200,000 personal computers around the world, may one day serve as effective antiviral therapies, according to a study published today (May 12) in Science. 
Model of hemagglutinin stem (gray and 
yellow) with design protein bound (green) 
Image courtesy of David Baker
"This study is remarkable," said John Karanicolas, a University of Kansas computational biologist who did not contribute to the research. "This is a method which in the long run may absolutely be a useful complement to antibody technology both for diagnostics and therapeutics." 

To design proteins to interact with a desired target, such as a pathogen's protein, researchers can scan extensive libraries of protein structures in search of a few that roughly complement the target molecule, then tweak those structures slightly to produce a tighter fit. Alternatively, they can introduce the pathogen to an animal to coerce its immune system to respond to the target, and then select from the antibodies that are generated. 

While the former approach grants researchers control over where and how the designed proteins will bind to the target, they may not bind as strongly to the target. The latter, more "natural" approach, on the other hand, may yield antibodies that have a high affinity for the target molecule, but researchers have little control over the dynamics of binding. 

But with quickly-evolving target molecules such as the influenza virus's surface protein, hemagglutinin, which has a large area that is constantly mutating and changing to evade antibody binding, even antibodies that bind well are often rendered obsolete in time. 

To tackle this challenge, computational biologist David Baker of the University of Washington and his colleagues decided to focus on a region of hemagglutinin that tends to be quite stable and is conserved among many influenza strains. Antibodies that bind to this region have been shown to prevent the virus from fusing its membrane with a host cell's and cause infection. 

To target this region of the protein, the researchers had to work on the problem in reverse, first searching for "nooks and crannies" in that region where a protein would be able to take hold, Baker explained, and then identifying strings of amino acids that could fit in those spaces and act as hooks. 

Once they created an entire library of these hooks, they searched proteins with known structures for those that would roughly fit the conformation of hemagglutinin and serve as the main protein bodies to hold the hooks. 

The researchers then modified the orientation and sequence of these scaffold proteins to hold the hooks in positions so that they could interact with hemagglutinin. For this critical, time-consuming step, the researchers reached out to the public for help in solving and optimizing the 3D structures of the proteins. Around 250,000 volunteers downloaded free software developed by Baker's lab called Rosetta@home, which allowed their personal computers at home to contribute computing power for the complex calculations. 

"The design approach was really extraordinary," said Tanja Kortemme, a computational biologist at University of California, San Francisco, who did not participate in the study. "They turned the problem around by first finding the amino acid side chains that formed the interactions that they wanted, and then finding a backbone that could display those side chains." 

All in all, the researchers came up with around 80 novel proteins. When expressed on the membranes of yeast, however, only two were able to bind to hemagglutinin, and the binding strength had to be further improved by slightly tinkering with the amino acid sequences. 
X-ray structure of one of the design 
proteins bound to hemagglutinin 
Image courtesy of David Baker
"The success rate is still very low," Baker said. But comparing a crystal structure of one of the two designs that bound to hemagglutinin with the initial computational model from which the protein was designed, he found they were essentially superimposable, an extremely rare accomplishment in de novo protein design. Thus, although the model still needs improvement, it was able to successfully predict an interaction between two proteins. 

The fact that the researchers produced two very different designs that worked for the same target is also cause for great optimism, added Karanicolas, who did his postdoc in Baker's lab at the University of Washington. "The real strength of this method is that it allows control of the design in the very early stages." 


Fleishman, S.J., et al., "Computational design of proteins targeting the conserved stem region of influenza hemagglutinin," Science, 332:816-21, 2011 


Related stories: Single-handed flu combat? 
[23rd February 2009] Foldit for fun 
[23rd May 2008] Proteins by design 
[July 2006]


Read more: Engineered proteins for fighting flu - The Scientist - Magazine of the Life Sciences http://www.the-scientist.com/news/display/58171/#ixzz1MGvpTvf
Publicado por Bibliomanazteca en 23:02 0 comentarios
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