Book review

On the Cover of Sunday's Book Review 'House of Holes ' By NICHOLSON BAKER Reviewed by SAM LIPSYTE Nicholson Baker's hilarious, extremely dirty novel is an episodic assortment of fantasies that celebrate desire, frailty and the comedy of life.  Up Front: Sam Lipsyte  Profile of Nicholson Baker Also in the Book Review 'One Day I Will Write About This Place' By BINYAVANGA WAINAINA Reviewed by ALEXANDRA FULLER Finding refuge in fiction, Binyavanga Wainaina becomes a writer in this coming-of-age memoir.  Excerpt: 'One Day I Will Write About This Place' 'The Devil All the Time' By DONALD RAY POLLOCK Reviewed by JOSH RITTER The characters in Donald Ray Pollock's violence-soaked novel march in a parade of betrayals, sacrifices, suicides, rapes and executions.  Excerpt: 'The Devil All the Time'  Profile of Donald Ray Pollock 'My Faraway One: Selected Letters of Georgia O'Keeffe and Alfred Stieglitz' Edited by SARAH GREENOUGH Reviewed by DEBORAH SOLOMON An annotated selection of the voluminous correspondence between the painter and the photographer. 'The Beginning of Infinity' By DAVID DEUTSCH Reviewed by DAVID ALBERT The inexhaustibly curious physicist David Deutsch offers views on everything from subatomic particles to the shaping of the universe itself. 'The Echo Chamber' By LUKE WILLIAMS Reviewed by JAN STUART In this novel, a shy writer with tinnitus embraces the quiet relief of storytelling. 'Ghost in the Wires' By KEVIN MITNICK Reviewed by J. D. BIERSDORFER A pioneer of the corporate-computer break-in recounts the hacking exploits that led him on a nearly 20-year cat-and-mouse game with law enforcement. 'All About Love' By LISA APPIGNANESI Reviewed by JUDITH SHULEVITZ Lisa Appignanesi examines the "unruly emotion" of love and its impact throughout the course of our lives. 'The Big Scrum' By JOHN J. MILLER Reviewed by JUDY BATTISTA This history of football's early years examines how, over a century ago, the sport's opponents wanted it banned; then Theodore Roosevelt stepped into the huddle. 'Retromania' By SIMON REYNOLDS Reviewed by TOM PAYNE Simon Reynolds laments how pop culture feeds on its own history, borrowing from a past that is ever more immediate. 'If Sons, Then Heirs' By LORENE CARY Reviewed by ROY HOFFMAN Lorene Cary's latest novel explores a family's struggle involving race and inheritance in the South. 'Rules of Civility' By AMOR TOWLES Reviewed by LIESL SCHILLINGER The characters in Amor Towles's first novel try to reinvent themselves in 1930s New York. Nonfiction Chronicle By TARA McKELVEY Books about the Monty Python actor Michael Palin, sex abuse within the Mormon Church and murder and racial issues in 1960s New York; and a collection of essays by Edward Hoagland.

VIDEO: Babar at 80 Pamela Paul, the Book Review's children's books editor, sits down with Laurent de Brunhoff, who has kept his father's Babar character alive for 80 years. BEST SELLERS Combined Print & E-Book Fiction Combined Print & E-Book Nonfiction Hardcover Fiction Hardcover Nonfiction Paperback Trade Fiction Paperback Mass-Market Fiction Paperback Nonfiction All the Lists RELATED COLUMNS TBR: Inside the List Editors' Choice Paperback Row Back Page ESSAY Dragons Ascendant: George R. R. Martin and the Rise of Fantasy By DAVID ORR The titanic success of George R. R. Martin's gritty "Song of Ice and Fire" series has swept away the traditional, "aren't we a little old for this?" view of fantasy. Book Review Podcast Featuring Sam Lipsyte on Nicholson Baker's "House of Holes"; and Deborah Soloman on the letters of Georgia O'Keeffe and Alfred Stieglitz. The 80th Anniversary of Babar Sales Soar for Newly Minted Poet Laureate A New York Poem by the New Poet Laureate REVIEWS BY THE TIMES'S CRITICS 'The Persistence of the Color Line' by Randall Kennedy 'A First-Rate Madness' by Nassir Ghaemi 'The Long Night ' by Steve Wick 'Playing With Fire' by Pamela Constable 'House of Holes: A Book of Raunch' by Nicholson Baker

Does Age Impact the Obese Asthma Phenotype?: Longitudinal Asthma Control, Airway Function and Airflow Perception among Mild Persistent Asthmatics

Does Age Impact the Obese Asthma Phenotype?: Longitudinal Asthma Control, Airway Function and Airflow Perception among Mild Persistent Asthmatics

Jason E. Lang, M.D

Chest

; Prepublished online July 28, 2011;

Antecedentes: La relación entre la obesidad y el asma sigue siendo definidos de forma adecuada. Estudios presentan conflictos acerca de cómo la obesidad afecta al control del asma y la función pulmonar. Enfoque adicional sobre el efecto de la edad como un modificador puede hacer más clara la interacción entre la obesidad y el fenotipo de asma.

Métodos: Un estudio longitudinal fue utilizado para determinar si la edad afecta a la relación entre la obesidad y las características del asma, incluyendo la espirometría, el control del asma, y la percepción de los cambios de flujo de aire.

Resultados: El efecto de la obesidad sobre los resultados del asma cambios con la edad y el género. Obesos 11.6 años de edad mostraron la mayor reducción de la función pulmonar, pero informó relativamente menos síntomas de asma en comparación con similares no obesos asmáticos. Obesos 12-17 años de edad mostró una tendencia hacia una mayor obstrucción al flujo aéreo y síntomas de asma en comparación con los no obesos asmáticos. Los adultos, el sexo femenino entre los 12-17 y 18-44 años de edad se asoció con un mayor deterioro del asma relacionada con la obesidad.

Conclusiones: La edad es un modificador de efecto significativo en la relación entre la obesidad y el fenotipo de asma. Con la edad, la influencia de la obesidad sobre el fenotipo de asma es generalmente reducida. El fenotipo de asma pueden ser más afectados por la obesidad entre los niños y las mujeres.

ARTÍCULOS RELACIONADOS:

The obesity phenotype in children with asthma.

Jensen ME.  Paediatr Respir Rev. 2011 Sep;12(3):152-9.

Childhood overweight and asthma symptoms, the role of pro-inflammatory proteins M. B. M. Bekkers  Clinical & Experimental Allergy Early View  1 AUG 2011

Effect of obesity on asthma phenotype is dependent upon asthma severity.

Raviv S. J Asthma. 2011 Feb;48(1):98-104.

Sex differences: implications for the obesity-asthma association.

Sood A. Exerc Sport Sci Rev. 2011 Jan;39(1):48-56. Review.

Obesity and asthma: co-morbidity or causal relationship?

van Huisstede A, Arch Chest Dis. 2010 Sep;73(3):116-23. Review.

An official American Thoracic Society Workshop report: obesity and asthma.

Dixon AE, Holguin F, Sood A, Salome CM, Pratley RE, Beuther DA, Celedón JC, Shore SA; American Thoracic Society Ad Hoc Subcommittee on Obesity and Lung Disease.

Proc Am Thorac Soc. 2010 Sep;7(5):325-35.
DRA. MARILYN URRUTIA PEREIRA
URUGUAIANA BR

En este día...

ON THIS DAY

On This Day: August 12

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On Aug. 12, 1898, the peace protocol ending the Spanish-American War was signed.

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On Aug. 12, 1881, Cecil B. DeMille, a leading American movie producer and director for over 40 years, was born. Following his death on Jan. 21, 1959, his obituary appeared in The Times.

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On This Date

1851	Isaac Singer was granted a patent on his sewing machine.
1880	Baseball Hall of Famer Christy Mathewson was born in Factoryville, Pa.
1898	The peace protocol ending the Spanish-American War was signed.
1898	Hawaii was formally annexed to the United States.
1944	Joseph P. Kennedy Jr., eldest son of Joseph and Rose Fitzgerald Kennedy, was killed when an explosives-laden Navy plane blew up over England during World War II.
1953	The Soviet Union conducted a secret test of its first hydrogen bomb.
1960	The first balloon satellite, Echo 1, was launched by the United States from Cape Canaveral, Fla.
1966	John Lennon apologized at a news conference in Chicago for saying "the Beatles are more popular than Jesus."
1977	The space shuttle Enterprise passed its first solo flight test by taking off atop a Boeing 747, separating and then touching down in California's Mojave Desert.
1981	IBM introduced its first personal computer, the model 5150.
1998	Swiss banks agreed to pay $1.25 billion as restitution to Holocaust survivors to settle claims for their assets.
2000	The Russian nuclear submarine Kursk and its 118-man crew were lost during naval exercises in the Barents Sea.
2004	New Jersey Gov. James E. McGreevey announced his resignation and proclaimed himself "a gay American."
2004	The California Supreme Court voided the nearly 4,000 same-sex marriages sanctioned in San Francisco earlier in the year.
2008	Russia halted its devastating five-day assault on Georgia that left homes in smoldering ruins and uprooted 100,000 people.

Current Birthdays

New York Jets wide receiver Plaxico Burress turns 34 years old today.

AP Photo/Julio Cortez

Actress Rebecca Gayheart turns 39 years old today.

AP Photo/Dan Steinberg

1925	Dale Bumpers, Former U.S. senator, D-Ark., turns 86
1939	George Hamilton, Actor, turns 72
1941	Dana Ivey, Actress, turns 70
1949	Mark Knopfler, Rock singer, musician (Dire Straits), turns 62
1950	Kid Creole, Singer, turns 61
1954	Pat Metheny, Jazz guitarist, turns 57
1956	Bruce Greenwood, Actor, turns 55
1963	Sir Mix-A-Lot, Rapper, turns 48
1965	Peter Krause, Actor ("Six Feet Under"), turns 46
1971	Michael Ian Black, Actor, comedian ("Ed"), turns 40
1971	Yvette Nicole Brown, Actress ("Community"), turns 40
1971	Pete Sampras, Tennis player, turns 40
1975	Casey Affleck, Actor, turns 36
1980	Maggie Lawson, Actress, turns 31
1980	Dominique Swain, Actress, turns 31