Las drogas agonistas de los receptores alfa2 adrenérgicos -clonidina y dexmedetomidina- tienen un papel farmacológico muy interesante y versátil en anestesiología y medicina del dolor. Hay aun muchas controversias con el uso de ambas drogas, en especial con las indicaciones y dosis de la clonidina por vía espinal. Esta droga es el único alfa2 agonista aprobado para uso neuroaxial. En los siguientes días le enviaremos información sobre este interesante tema, iniciando con una revisión reciente elaborada en nuestro grupo de trabajo.
Alpha2-adrenergic agonist drugs -clonidine and dexmedetomidine- have a very interesting and versatile pharmacological role in anesthesiology and pain medicine. There are still many controversies with the use of both drugs, especially with the indications and doses of spinal clonidine. This is the only alpha2 agonist drug approved for neuraxial use. In the following days we will e-mail you information on this interesting subject, starting with a recent review written by our group.
As drogas agonistas alfa 2-adrenérgico clonidina e dexmedetomidina- têm um papel farmacológico muito interessante e versátil em anestesiologia e medicina da dor. Ainda há muitas controvérsias com o uso das duas drogas, especialmente com as indicações e doses de clonidina administrada por via peridural. Esta é a única droga aprovada para uso neuroaxial. Nos dias seguintes, nós lhe enviaremos as informações sobre este assunto interessante, começando com uma revisão recente desenvolvido em nosso grupo de trabalho.
داروهای آگونیست کلونیدین ALPHA2 آدرنرژیک و dexmedetomidina- نقش دارویی بسیار جالب و همه کاره در بیهوشی و پزشکی درد داشته باشد. هنوز هم وجود دارد بسیاری از اختلاف با استفاده از هر دو دارو، به خصوص با نشانه و دوز کلونیدین اپیدورال تجویز اداره می شود. این تنها دارو برای استفاده neuraxial تایید شده است. در روزهای پس ما اطلاعات در مورد این مطلب جالب ارسال، با شروع با یک بررسی اخیر توسعه یافته در گروه کاری ما.
Clonidina intratecal como adyuvante intratecal. ¿Existe una dosis mágica?
Intrathecal Clonidine as Spinal Anaesthesia Adjuvant - Is there a Magical Dose?
Víctor M. Whizar-Lugo, Juan C. Flores-Carrillo and Susana Preciado-Ramírez
Topics in Spinal Anaesthesia, Dr. Víctor Whizar-Lugo (Ed.), ISBN: 978-953-51-1720-9, InTech, DOI: 10.5772/58712.
Introducction
Clonidine was synthesized in 1962 as nasal decongestant, and marketed as antihypertensive in 1972. Bloor and Flacke in 1982 [1] demonstrated in mongrel dogs that intravenous clonidine 5 and 20 µg/kg decreased halothane MAC by 42% and 48% respectively. Since then, clonidine
has been used by anaesthesiologists as an anaesthetic adjunct to provide increased perioperative cardiovascular and sympathoadrenal stability, to enhance general and regional anaesthesia, as well as sedation and analgesia. [2, 3] In 1999, dexmedetomidine, a novel selective and specific alpha2 agonist, was approved for postoperative sedation in intensive care patients,and has also been investigated in general anaesthesia, regional anaesthesia and pain treatment. Basic research in animals and clinical studies in humans performed with epidural clonidine have shown its analgesic effects, with less side effects than any other neuroaxial anaesthesia adjuvant. Similar results were also obtained with intrathecal injection of clonidine. Due to the short duration of analgesic action by the latter route, the extradural administration is the most studied. Epidural administration of clonidine has been widely utilized; indeed, the FDA has
only approved peridural use of clonidine infusion in chronic pain patients. There are many publications with epidural clonidine for intraoperative surgical pain as an adjunct to general anaesthesia and epidural anaesthesia, postoperative pain, pediatrics, and labour analgesia. It
has been used alone, or in combination with local anaesthetics, opioids, in bolus, or by continuous infusion.
http://cdn.intechopen.com/pdfs-wm/47057.pdf
Atentamente
Anestesiología y Medicina del Dolor
www.anestesia-dolor.org
Alpha2-adrenergic agonist drugs -clonidine and dexmedetomidine- have a very interesting and versatile pharmacological role in anesthesiology and pain medicine. There are still many controversies with the use of both drugs, especially with the indications and doses of spinal clonidine. This is the only alpha2 agonist drug approved for neuraxial use. In the following days we will e-mail you information on this interesting subject, starting with a recent review written by our group.
As drogas agonistas alfa 2-adrenérgico clonidina e dexmedetomidina- têm um papel farmacológico muito interessante e versátil em anestesiologia e medicina da dor. Ainda há muitas controvérsias com o uso das duas drogas, especialmente com as indicações e doses de clonidina administrada por via peridural. Esta é a única droga aprovada para uso neuroaxial. Nos dias seguintes, nós lhe enviaremos as informações sobre este assunto interessante, começando com uma revisão recente desenvolvido em nosso grupo de trabalho.
داروهای آگونیست کلونیدین ALPHA2 آدرنرژیک و dexmedetomidina- نقش دارویی بسیار جالب و همه کاره در بیهوشی و پزشکی درد داشته باشد. هنوز هم وجود دارد بسیاری از اختلاف با استفاده از هر دو دارو، به خصوص با نشانه و دوز کلونیدین اپیدورال تجویز اداره می شود. این تنها دارو برای استفاده neuraxial تایید شده است. در روزهای پس ما اطلاعات در مورد این مطلب جالب ارسال، با شروع با یک بررسی اخیر توسعه یافته در گروه کاری ما.
Clonidina intratecal como adyuvante intratecal. ¿Existe una dosis mágica?
Intrathecal Clonidine as Spinal Anaesthesia Adjuvant - Is there a Magical Dose?
Víctor M. Whizar-Lugo, Juan C. Flores-Carrillo and Susana Preciado-Ramírez
Topics in Spinal Anaesthesia, Dr. Víctor Whizar-Lugo (Ed.), ISBN: 978-953-51-1720-9, InTech, DOI: 10.5772/58712.
Introducction
Clonidine was synthesized in 1962 as nasal decongestant, and marketed as antihypertensive in 1972. Bloor and Flacke in 1982 [1] demonstrated in mongrel dogs that intravenous clonidine 5 and 20 µg/kg decreased halothane MAC by 42% and 48% respectively. Since then, clonidine
has been used by anaesthesiologists as an anaesthetic adjunct to provide increased perioperative cardiovascular and sympathoadrenal stability, to enhance general and regional anaesthesia, as well as sedation and analgesia. [2, 3] In 1999, dexmedetomidine, a novel selective and specific alpha2 agonist, was approved for postoperative sedation in intensive care patients,and has also been investigated in general anaesthesia, regional anaesthesia and pain treatment. Basic research in animals and clinical studies in humans performed with epidural clonidine have shown its analgesic effects, with less side effects than any other neuroaxial anaesthesia adjuvant. Similar results were also obtained with intrathecal injection of clonidine. Due to the short duration of analgesic action by the latter route, the extradural administration is the most studied. Epidural administration of clonidine has been widely utilized; indeed, the FDA has
only approved peridural use of clonidine infusion in chronic pain patients. There are many publications with epidural clonidine for intraoperative surgical pain as an adjunct to general anaesthesia and epidural anaesthesia, postoperative pain, pediatrics, and labour analgesia. It
has been used alone, or in combination with local anaesthetics, opioids, in bolus, or by continuous infusion.
http://cdn.intechopen.com/pdfs-wm/47057.pdf
Atentamente
Anestesiología y Medicina del Dolor
www.anestesia-dolor.org
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